Dr. Gabrielle Lyon Links Muscle Loss to Mortality Risk

The Anti-Obesity Doctor: If You Don't Exercise, This Is What's Happening To You! - Gabrielle Lyon — The Diary Of A CEO

The Diary Of A CEO

Maintaining skeletal muscle mass through targeted resistance training and optimal protein intake prevents chronic disease and preserves lifelong cognitive function.

AI-assisted summary of The Anti-Obesity Doctor: If You Don't Exercise, This Is What's Happening To You! - Gabrielle Lyon — original source. Check the original for full context.

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## Background Published on September 26, 2024, on YouTube by The Diary Of A CEO, this interview features Dr. Gabrielle Lyon, founder of 'Muscle-Centric Medicine' and author of 'FOREVER STRONG'. The video details an in-depth conversation on how muscle health, strength training, and proper nutrition impact aging, brain health, hormonal balance, and long-term longevity.

## TL;DR Dr. Gabrielle Lyon asserts that skeletal muscle is the primary organ of longevity and the true foundation for preventing age-related diseases like Alzheimer's, cardiovascular decline, and metabolic dysfunction. She reframes muscle as a voluntary metabolic sink and endocrine organ, emphasizing that strength training and high-quality protein are crucial to maintaining healthspan and independence. Lyon also breaks down common health myths around GLP-1 weight-loss drugs, low testosterone, and diet, arguing that discipline and non-negotiable personal standards are essential to breaking psychological barriers to change. Ultimately, the discussion highlights that protecting muscle health is the single most powerful tool for achieving physical freedom, cognitive sharpness, and overall vitality.

## Atmosphere & style The conversation carries an authoritative yet deeply passionate and empathetic tone, driven by Dr. Lyon's urgent desire to correct public health misperceptions. Host Steven Bartlett guides the dialogue with engaging curiosity, allowing space for personal clinical anecdotes from Lyon's work with elite military operators, geriatric patients, and high performers. The atmosphere feels insightful, grounding complex physiology with deeply practical advice and serious reflections on aging, disease, and human potential.

## Key takeaways - [00:00](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=0s) Skeletal muscle mass and strength serve as the fundamental organ of longevity, with low strength increasing all-cause mortality risk by 50%. - [04:34](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=274s) High performers often experience severe neurochemical dopamine dips following major achievements, which can derail workout and nutrition habits if unmanaged. - [09:39](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=579s) The primary psychological barrier preventing people from making lasting health changes is an underlying belief of unworthiness, rather than a lack of discipline. - [22:17](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=1337s) Addressing underlying psychological trauma is necessary for physiological healing, as unresolved stress directly fuels physical resistance and health issues. - [46:48](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=2808s) Cardiovascular exercise alone is insufficient to prevent sarcopenia, as resistance training is required to preserve fast-twitch Type 2 muscle fibers as humans age. - [05:33:29](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=20009s) Physical inactivity causes rapid metabolic damage, leading healthy skeletal muscle to become insulin resistant and redirect excess glucose to the liver as fat. - [01:09:57](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=4197s) Weight-loss medications like Ozempic do not directly waste muscle; muscle loss occurs only when GLP-1 therapy lacks adequate dietary protein and resistance training. - [01:09:57](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=4197s) To prevent muscle loss and support muscle protein synthesis, daily protein intake should be targeted at 0.7 to 1.0 grams per pound of ideal body weight. - [01:15:15](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=4515s) Heavy resistance training upregulates muscle androgen receptors, helping mitigate low testosterone levels caused by modern stress, poor sleep, and environmental toxins. - [01:21:30](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=4890s) Long-term health consistency is best achieved by establishing non-negotiable daily standards rather than setting arbitrary goals. - [01:42:58](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=6178s) Skeletal muscle functions as an endocrine organ, releasing brain-protective myokines during contraction that reduce inflammation and enhance cognitive function.

## Detailed walkthrough ### [00:00](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=0s) Introduction: Muscle as the Organ of Longevity

The episode opens with a sharp, compelling thesis from Dr. Gabrielle Lyon: modern medicine is obsessively focused on obesity, but obesity is not our core issue. The true foundation of health and longevity lies in **skeletal muscle mass**—what she terms the "organ of longevity."

Dr. Lyon emphasizes that skeletal muscle is the only organ system under voluntary human control. Falling into the lower third of muscle strength carries a staggering cost: a **50% greater risk of all-cause mortality**. Despite this, a mere **6% to 8% of the population** meets the recommended resistance training guidelines, while the vast majority lives an entirely sedentary lifestyle.

``` +-----------------------------------+ | Lower 1/3 of Muscle Strength | +-----------------------------------+ | v +-----------------------------------+ | 50% Increased Mortality Risk | +-----------------------------------+ ```

When host Steven Bartlett asks what his health will look like at age 61 if he remains seated in his chair with zero strength training for the next 30 years, Dr. Lyon paints a stark, realistic portrait: * **Elevated Disease Risk:** High likelihood of developing Alzheimer's disease and cardiovascular disease. * **Hormonal & Reproductive Decline:** Suppressed testosterone levels and compromised sperm quality, highlighting a direct link between muscle mass and fertility in both men and women. * **Physical & Brain Deterioration:** Severe breathlessness from basic movement (like climbing stairs), alongside visceral obesity and sleep apnea—a combination that directly degrades metabolic and cognitive function.

> "When it comes down to your health, it shouldn't be about how you look. It should be about how you perform. And there's no replacement for resistance training and skeletal muscle mass."

---

[02:39](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=159s) What Dr. Gabrielle Lyon Does: Removing Physical Restrictions

Dr. Lyon explains that her primary role as a physician is to eliminate physical restrictions so people can perform at their highest level. Over her 20-year career—which included specialized fellowship training in geriatrics and nutritional sciences—she has worked across the spectrum from frail elderly patients to high-performing "mavericks" who change the world.

Her current concierge medical practice serves high achievers, including former podcast guests like Evy Poumpouras and racing driver Danica Patrick, as well as Tier-1 military operators (such as Navy SEALs) and corporate CEOs.

``` Dr. Gabrielle Lyon's Practice | +--------------------------+--------------------------+ | | v v +------------------+ +------------------+ | Military/Special | | CEOs & Cultural | | Operators | | Innovators | +------------------+ +------------------+ | | +--------------------------+--------------------------+ | v +----------------------------+ | Optimized Muscle Health | +----------------------------+ ```

Dr. Lyon observes that while high performers possess an extraordinary ability to push through physical pain, low energy, gut dysfunction, and hormonal imbalances, this drive comes at a steep, predictable physiological cost. Health, alongside aging, acts as the ultimate equalizer: no one can out-perform their underlying biological state.

* **Key Client Populations:** Geriatric patients, Navy SEALs and Tier-1 operators, Fortune 500 CEOs, and elite athletes. * **Core Objective:** Removing physiological restrictions (inflammation, poor body composition, hormone imbalances) so clients can fulfill their potential unencumbered.

---

[04:34](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=274s) Why High Performers Seek Help & The Danger of Post-Achievement Dips

When elite clients seek out Dr. Lyon, they rarely present with an obvious disease. Instead, they share a persistent intuition that "something is still left on the table"—that their energy, sleep quality, and cognitive drive could be substantially sharper. Many have visited top-tier medical facilities like the Mayo Clinic without finding actionable answers.

A critical pattern Dr. Lyon identifies in Type-A individuals is the **post-achievement physiological dip**. After massive milestones—such as a major product event in Las Vegas, a successful book launch, or a record-breaking podcast episode—high performers experience a profound crash.

``` High Energy / Dopamine Peak (Event Launch) /\ / \ / \ / \ ----/--------\---------------------- Baseline \ Severe Dip \ (Depression / Disruption) \/ ```

Rather than dropping back to baseline, their neurochemistry plunges into a state of depression and disengagement, causing them to abandon their workouts, break their nutrition plans, and search frantically for the next high.

> "As high as you go, after a big launch or event, there's a dip. And you don't go back to baseline... It's a very big high and a very big low. Nothing will take someone off a health journey faster than those lows."

* **The Underlying Cause:** Driven primarily by neurochemical dynamics (specifically dopamine surges during intense preparation) rather than pure psychology. * **The Solution:** Cultivating a "neutral mindset" and managing dopamine dynamics through controlled intensity rather than wild emotional peaks and valleys.

---

[09:39](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=579s) The Hidden Block to Taking Action: The Worthiness Problem

Addressing why millions of people consume self-improvement and health content without taking action, Dr. Lyon dismisses standard explanations like a lack of discipline or motivation. Motivation is a "perishable feeling" that should never be relied upon, and discipline is a trainable skill. The true root barrier to long-term change is **worthlessness**.

``` +--------------------------------+ | Information & Advice Received | +--------------------------------+ | v +--------------------------------+ | Internal Worthiness Filter | +--------------------------------+ / \ [Feels Worthy] [Feels Unworthy] / \ v v +------------------------+ +------------------------+ | Execution & Sustained | | Self-Sabotage & Disuse | | Health Gain | | of Resources | +------------------------+ +------------------------+ ```

If an individual does not believe at their core that they deserve to feel vibrant, healthy, and energized, they will sub-consciously sabotage their own progress. Dr. Lyon points to elite military operators—such as her husband, a former Navy SEAL—who master "controlled intensity." They can turn their drive on and off at will because they feel worthy of the outcome and clear in their identity.

* **Core Premise:** Self-sabotage occurs when health advice collides with a hidden belief that one is unworthy of feeling good. * **Discipline vs. Motivation:** Motivation is fleeting; discipline is easily built once the emotional belief of self-worth is established.

---

[12:25](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=745s) Re-Engaging the Distracted & The Real Cost of Neglecting Health

When working with clients who exhibit subtle signs of low self-worth or chronic procrastination, Dr. Lyon begins by examining their biological foundations—evaluating sleep quality, dietary triggers, gut health, and comprehensive blood work. She outlines a practical diagnostic plan:

1. Comprehensive blood panels and metabolic testing 2. Sleep architecture assessment (overnight sleep studies) 3. Direct identification of food sensitivities and gastrointestinal issues

``` +---------------------+ +---------------------+ +---------------------+ | Comprehensive Blood | ---> | Sleep Architecture | ---> | Gastrointestinal | | Workup | | Analysis | | Sensitivity | +---------------------+ +---------------------+ +---------------------+ ```

For busy executives who claim they lack the time to run diagnostic tests or stick to a fitness program, Dr. Lyon presents a sharp counter-perspective:

> "If people don't have time for health and wellness, how are they going to have time for sickness? That's so much more time-consuming."

``` Option A: Proactive Health Option B: Reactive Sickness +----------------------------------+ vs. +-----------------------------------+ | Short, daily workouts | | Protracted medical visits | | Strategic nutrition & testing | | Hospitalization & immobility | | High energy & focus | | Chronic fatigue & loss of autonomy| +----------------------------------+ +-----------------------------------+ ```

Dr. Lyon notes a major cultural failure: society treats aging and severe illness as unpredictable surprises rather than predictable consequences of present choices. Aging is inevitable, but frailty, loss of independence, and metabolic deterioration are largely within human control.

* **Archetype Dynamics:** Corporate leaders often delay preventative action for 3 to 6 months citing busy schedules, but once a physical symptom forces their hand, their high-execution mindset allows them to adopt the routines long-term. * **Anti-Aging Shift:** True longevity work is not about chasing superficial anti-aging trends; it is about building physical reserves—primarily muscle—to prevent catastrophic events like fall-induced hip fractures later in life.

[017:02] Stress Responses and Rethinking "Fight or Flight"

Dr. Gabrielle Lyon explains that patients who feel a deep sense of unworthiness or carry unresolved trauma often experience extreme resistance when attempting to make lifestyle changes. Trauma can take many forms, ranging from "little T" traumas—such as a parent leaving during childhood—to "big T" horrific events. A major factor keeping people stuck is the pervasive belief that all stress is inherently damaging and purely driven by a "fight or flight" response. Lyon points out that humans actually evolved to manage and mitigate stress, and how a person perceives an experience directly dictates their physiological response.

To demonstrate this mind-body connection, Lyon references the famous hotel housekeeper study. In that experiment, one group of housekeepers was informed that their daily work met or exceeded physical activity guidelines, while a control group was given no such context. At the end of the study, the housekeepers who were told their work counted as exercise experienced actual physical improvements: lower blood pressure, improved insulin sensitivity, better glucose regulation, and slight weight loss. Their physical reality shifted simply because their internal interpretation of their daily work changed.

Lyon criticizes the modern narrative that paints the entire world as an unbearable source of "fight or flight" stress. In English, the word "stress" is forced to describe vastly different situations—spilling coffee on a white sofa, losing a pet, or experiencing the death of a spouse. This single blanket term severely limits people's perception of their own capacity. Beyond fight or flight, Lyon highlights two far more adaptive stress responses:

- **Tend and Befriend:** Driven by oxytocin, this response prompts individuals to seek connection and help others during times of intense pressure. - **The Courage Response:** Often observed in elite military operators, this response channels high-stress moments directly into decisive action.

To illustrate the courage response, Lyon offers a personal comparison: if she and her husband (a Navy SEAL) were about to jump out of an airplane, she would experience fear and fight-or-flight, whereas he would experience excitement and courage. Upon landing, her husband would be immediately capable of taking on the next task because his courage response mitigated the physiological strain, whereas Lyon would need hours or days to recalibrate.

- **Key Insight:** Fear is a natural involuntary reaction, but choosing courage in the face of stress is a learned habit that can be cultivated to protect physiological health.

---

[022:17] Addressing Trauma and Rebuilding the Doctor-Patient Relationship

When host Steven Bartlett asks how a physician can help a patient whose lack of motivation stems from deep childhood trauma or feelings of unworthiness, Lyon emphasizes that she never gives up on a patient. However, she stresses the critical importance of knowing "where physiology ends and psychology begins." While Lyon spent two years training in psychiatry—an experience that fueled her current work with military populations—she frequently collaborates with mindset coaches, such as Jim Kwik, to help patients work through deep-seated psychological blocks.

Lyon illustrates this boundary by sharing the story of a female patient who suffered from severe, unexplained insomnia and physical restlessness. Lyon's team conducted a comprehensive medical workup: a sleep apnea test came back negative, environmental factors were optimized for absolute rest, and hormone replacement therapy was administered. Despite resolving her physiological markers, the woman's heart rate continued to spike uncontrollably every night when she got into bed. It was eventually uncovered that the woman had suppressed memories of a past sexual assault. Lyon recognized that until the patient addressed this underlying trauma through specialized psychological care, no amount of medical or physical intervention could fix her sleep.

Lyon argues that modern medicine has become far too transactional, reducing patient interactions to brief 15-minute appointments. She advocates for restoring the traditional, honorable role of the physician—akin to how doctors operated in the 1800s as trusted, long-term counselors. Healing requires a true therapeutic relationship where the doctor acts as an invested teammate, helping patients uncover their hidden vulnerabilities so they can achieve total health.

- **Historical Perspective:** Physician-patient dynamics have shifted from long-term, trusted advisory partnerships to quick, transactional intake visits. - **Therapeutic Approach:** Long-term physiological wellness cannot be achieved without diagnosing and addressing underlying psychological wounds.

---

[025:40] Tap into Service to Motivate Action

When discussing how to motivate patients to change, Bartlett suggests that many people need to hit rock bottom—experiencing severe pain, fear, or a terrible health diagnosis—before their "why" becomes strong enough to trigger action. Lyon agrees that pain is a powerful motivator, but she insists that people do not need to wait for a catastrophic health breakdown before making a pivot.

In her practice working with high performers, CEOs, and elite operators, Lyon finds that the most effective way to unlock lasting motivation is by shifting the focus from *self-service* to *other-service*. Extraordinary performers are rarely motivated purely by aesthetics or self-interest; they are driven by a desire to serve their families, lead their teams, and build a lasting legacy. When Lyon frames physical health, muscle retention, and lifestyle changes as essential prerequisites for carrying out their mission and serving others, patients willingly confront their vulnerabilities and execute the necessary lifestyle changes.

---

[028:00] Why Dr. Lyon Fights Misinformation: Lessons from Palliative Care

Asked why she is so passionately dedicated to her work after seeing thousands of patients over two decades, Lyon explains that, outside of her family, her greatest joy comes from being of service. Her drive was deeply shaped by the emotional toll of her medical training and geriatrics fellowship, where she worked grueling hours and witnessed constant death.

She vividly recalls the heartbreak of caring for dying patients who would never leave the hospital. One memory that remains etched in her mind is an 18-year-old patient with cystic fibrosis who was actively planning her dream wedding from her hospital bed—choosing a dress and arranging details for an event everyone knew she would never live to see.

Experiencing such profound loss daily drove Lyon to step into the public eye and utilize social media in 2015. Coming out of her fellowship, she was horrified by the widespread health misinformation proliferating online, including fad cleanses, fake diets, and anti-protein narratives that encouraged people to degrade their skeletal muscle. Having spent 17 years in higher education, Lyon felt a moral obligation to speak out:

> "The information was so wrong that I felt a responsibility to say something, and if I didn't, I would be contributing to the same problem."

Caring so deeply comes at a personal and emotional cost. Lyon admits to taking patient calls at midnight or 1:00 AM, constantly striving to balance her professional devotion with protecting her family life. However, she notes that her practice today is much more uplifting than her fellowship days; rather than managing end-of-life care, she now helps patients navigate complex, solvable challenges like toxic mold exposure, Lyme disease, thyroid imbalances, or optimizing longevity.

- **Educational Background:** Lyon completed 17 years of rigorous medical and nutritional education, including specialized training in psychiatry and a fellowship in geriatrics and nutritional sciences. - **Pivot to Public Advocacy:** Spurred in 2015 by the contrast between hospital end-of-life realities and the misleading, trendy diet advice dominating social media.

---

[033:41] Mind Viruses: The Trap of Physical Comparison and Certainty

Bartlett asks Lyon to identify the "mind viruses"—the toxic limiting beliefs—that prevent people from becoming optimal performers. Lyon splits her answer into physical and psychological traps, pointing to **external physical comparison** as one of the most damaging mindsets.

People who constantly compare their bodies to others or obsess over maintaining their youthful appearance remain trapped in an external validation loop. Lyon notes that while this tendency often fades as people mature into their late 30s and 40s, staying overly focused on external physical markers creates a false sense of certainty.

To illustrate the danger of relying purely on physical capability, Lyon shares an insight from her husband regarding Navy SEAL training (BUD/S). Counterintuitively, the elite college athletes with flawless physiques are often among the very first to quit or wash out. Because these athletes spent their lives excelling in predictable physical environments—where throwing a ball or running fast yielded guaranteed results—they never developed the psychological fortitude required to navigate extreme mental uncertainty, pain, and chaos.

- **Key Takeaway:** Physical strength without mental resilience leaves an individual fragile when confronted with unpredictable adversity.

[35:30](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=2130s) Shifting from External Looks to Physical Readiness

Dr. Gabrielle Lyon and host Steven Bartlett examine the self-defeating trap of chasing purely external aesthetic goals—such as plastic surgery, wrinkle reduction, facial treatments, or blow-drys—as a primary motivation for fitness. Dr. Lyon points out that purely externally focused individuals struggle heavily with aging because physical decay is an inevitable biological reality. Relying exclusively on appearance creates a continuous cycle of comparison and dissatisfaction, which ultimately bleeds into overall psychological well-being.

To build a resilient mindset, Dr. Lyon urges shifting the primary goal toward **physical readiness**, skill acquisition, and strength rather than aesthetic appearance alone. Viewing skeletal muscle as the ultimate "organ of longevity" shifts the purpose of exercise toward training for life—ensuring one remains capable of performing fundamental physical movements like running, squatting, and bench pressing.

* **Long-Term vs. Short-Term Incentives:** Short-term superficial choices (e.g., spending time on cosmetice services) divert finite time away from building lifelong strength. * **The Regret of Distraction:** End-of-life observations routinely show that people regret superficial distractions rather than missing out on cosmetic pampering. * **Mind-Body Connection:** A strong physical body cannot be built or maintained without cultivating mental strength and discipline to resist short-term distractions.

---

[42:05](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=2525s) Redefining the Strong Body and Universal Fitness Benchmarks

Dr. Lyon defines physical strength through functional autonomy and physical sovereignty—the capability to maneuver through life self-sufficiently without relying on others for assistance. Basic functional standards include the ability to perform a pull-up, complete at least 10 proper push-ups, and run a mile efficiently. Society as a whole is becoming increasingly physically weak, with rising rates of obesity extending even to younger generations. Maintaining physical accountability through measurable strength milestones is vital to counteract this systemic decline.

``` PHYSICAL READINESS FRAMEWORK +-------------------------------------------------------------------------+ | Core Standards | | • Pull-ups (minimum 1) | | • Push-ups (10+ reps) | | • 1-Mile Run (executed with good form) | +-------------------------------------------------------------------------+ | v +-------------------------------------------------------------------------+ | Resistance Training Minimums | | • Frequency: 3–4 Days per Week | | • Volume: 10–20 Sets per Muscle Group / Week | | • Goal: Hypertrophy & Strength (Compound Exercises) | +-------------------------------------------------------------------------+ ```

To optimize longevity and halt muscle wasting, Dr. Lyon outlines specific, baseline standards for resistance training that everyone—regardless of age—should strive to achieve:

* **Baseline Frequency:** Resistance training **3 to 4 days per week** using weights, body weight, or resistance bands. * **Standard Guidelines vs. Ideal Goals:** While standard health guidelines recommend 150 minutes of moderate activity and 2 days of strength training, Dr. Lyon stresses that this minimum is only sufficient for basic mobility, not for optimal aging or physical evolution. * **Hypertrophy Training Volume:** Target **10 to 20 sets per muscle group per week** to promote muscle hypertrophy (growth). * **Effective Split Styles:** Recommended routines include upper/lower splits, push/pull splits, or full-body compound workouts (utilizing exercises like squats and deadlifts).

---

[46:48](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=2808s) Why Muscle Mass and Strength Dictate Survival and Longevity

Dr. Lyon presents a compelling argument for prioritizing resistance training: skeletal muscle functions as a vital metabolic sink and physical "body armor." It serves as the primary site for glucose disposal and fatty acid oxidation, making it indispensable for maintaining metabolic health and preventing insulin resistance. The statistical evidence linking strength to survival is striking—individuals falling into the lower third of strength metrics face a **50% greater risk of all-cause mortality** compared to those in higher brackets.

> "If you are in the lower one-third for strength, those that are in the lower one-third... have a 50% greater risk of dying from nearly anything."

The narrative that aging inevitably leads to weakness and frailty is fundamentally flawed. Regardless of age, the human body retains the ability to adapt, build muscle, and gain strength through targeted physical training.

---

[48:45](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=2925s) Breaking Generational Expectations and the Priority of Muscle Over Cardio

People often accept physical decline as an unavoidable genetic trajectory simply because they witnessed their parents lose muscle, gain visceral belly fat, and slow down. Dr. Lyon explains that humans frequently misinterpret repetition as truth, assuming that passive aging is natural because it is commonly observed. The modern medical system has historically separated muscle health from general wellness, misclassifying resistance training as an activity strictly meant for bodybuilders ("the bros").

``` AGE-RELATED MUSCLE DECLINE (WITHOUT RESISTANCE TRAINING)

Type 2 Muscle Fibers Type 1 Muscle Fibers (Fast-Twitch / Power / Size) (Slow-Twitch / Endurance) │ ▲ │ Transition via Sarcopenia │ └────────────────────────────────────┘ │ v Loss of Power & Metabolic Sinks (Increased Risk of Type 2 Diabetes) ```

While cardiovascular exercise provides undeniable cardiovascular benefits, Dr. Lyon asserts that cardiovascular training alone cannot replace resistance exercise. As individuals age without strength training, fast-twitch **Type 2 muscle fibers** (responsible for strength, power, and hypertrophy) progressively degrade and convert into **Type 1 fibers**. Solely performing cardiovascular exercises fails to stimulate or preserve these vital Type 2 fibers. Preserving muscle mass remains the fundamental biological buffer against sarcopenia, metabolic dysregulation, and elevated blood sugar levels.

* **Muscle vs. Cardio:** Cardiovascular exercise lacks the necessary mechanical tension to preserve fast-twitch Type 2 muscle fibers during aging. * **Metabolic Defense:** Loss of muscle directly correlates with decreased glucose disposal, driving up blood sugar levels and increasing the risk of Type 2 diabetes.

[05:33:29](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=20009s) The Science of Muscle, Carbohydrates, and the "Healthy Sedentary" Myth

Dr. Gabrielle Lyon explains the critical metabolic relationship between carbohydrate intake and skeletal muscle tissue. When an individual consumes carbohydrates and sugars, healthy skeletal muscle acts as the primary reservoir to absorb and store those nutrients as glycogen. However, in the absence of adequate muscle mass or activity, excess glucose is redirected toward the liver and stored as fat, accelerating metabolic decline. Lyon refutes the common medical trope of a "healthy sedentary person," insisting that true physical health cannot coexist with a physical lifestyle that lacks resistance exercise.

To support this, Lyon references a landmark study from Yale University where researchers monitored 18-year-old college students classified as lean and healthy based on traditional metrics. When subjected to a protocol of physical inactivity, these lean students rapidly developed skeletal muscle insulin resistance and accumulated metabolic byproducts despite showing zero outward signs of weight gain or obesity. Because inactive muscle fails to turn over its stored glycogen, it progressively deteriorates at a cellular level. To age well, Lyon emphasizes that everyone must stimulate their muscle tissue through resistance exercise—whether using simple bodyweight movements, resistance bands, or yoga—rather than chasing extreme maximum lifts.

- **Glucose Sink:** Skeletal muscle serves as the primary metabolic site for glucose disposal in the body. - **Myosteatosis:** Inactivity causes fat infiltration within muscle tissue, leaving muscle fibers marbled and dysfunctional. - **Yale Study Findings:** Lean, normal-weight 18-year-olds developed silent muscle insulin resistance purely from a lack of physical activity. - **Activity Stats:** Only 6% to 8% of the population meets official guidelines for resistance training. - **Inactivity Rate:** Over 50% of Americans do not work out at all, and roughly 75% fail to meet the combined standard recommendations for both cardiovascular and strength training.

[05:56:00](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=21360s) Autonomy, Muscle Span, and the Hidden Costs of Convenience

Addressing the common argument that modern life expectancy has historically trended upward despite poor physical activity metrics, Lyon clarifies the critical distinction between lifespan and *healthspan*. While modern medical interventions can keep an individual technically alive on bed rest, high quality of life and physical autonomy are impossible without high-quality skeletal muscle. She points out everyday indicators of physical decline that have become normalized, such as adults struggling to lift an overhead suitcase on an airplane or feeling strained while placing luggage on a airport security conveyor belt.

``` "You cannot have a high-quality life without high-quality muscle." ```

Comparing Western societal decline to her father’s community in Ecuador, Lyon notes how her 74-year-old father routinely walks three hours without second thoughts. In such communities, continuous physical activity protects "muscle span"—the timeframe in a person's life where they retain functional, high-quality skeletal muscle. In modern societies, convenient environments full of escalators, elevators, and vehicles continuously entice people toward the path of least resistance, compounding physical degradation over time.

[05:59:41](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=21581s) Belly Fat, Body Recomposition, and Muscle as an Appetite Regulator

When asked how she approaches a client seeking standard aesthetic goals like losing stubborn belly fat, Lyon cautions against hyper-fixating on body fat removal procedures like liposuction. Instead, her clinical strategy addresses underlying behavioral root causes—such as stress eating, alcohol overconsumption, or sleep deprivation—and redirects the primary objective toward body recomposition by building new muscle. Rather than framing obesity management solely around weight loss, she argues medical culture must shift toward optimizing skeletal muscle health.

Lyon hints at emerging, unpublished observational research from her colleagues suggesting that skeletal muscle plays a direct role in appetite regulation through specific surface receptors. Beyond just increasing caloric expenditure during physical exertion, expanding healthy muscle mass appears to send regulatory signals back to the brain to help manage hunger.

[01:02:16](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=3736s) Ozempic, Anabolics, and the Stigma Around Muscle Growth

The discussion turns to weight-loss medications like Ozempic, Mounjaro, and the broader class of GLP-1 and GIP receptor agonists. Lyon acknowledges that these medications are here to stay and hold genuine clinical utility for individuals struggling with long-term metabolic dysfunction. However, she calls out a striking cultural double standard: society readily accepts administering pharmaceuticals to decrease body fat, yet reacts with intense stigma toward utilizing anabolic therapies—such as targeted testosterone or its derivatives—to build or protect skeletal muscle.

Addressing the popular belief that Ozempic directly causes muscle tissue wasting, Lyon clarifies that there is no direct biochemical mechanism by which GLP-1 drugs degrade muscle tissue. In fact, evidence suggests these medications can support overall tissue health. The actual cause of muscle loss on weight-loss medications is poor patient behavior: users dramatically cut calories without maintaining proper dietary protein intake or engaging in resistance training.

- **Appetite and Binge Control:** GLP-1 agonists assist by quieting obsessive "food noise" and curbing compulsions toward binge eating or alcohol intake. - **Clinical Tracking:** In Lyon’s medical practice, patients using GLP-1 medications show zero muscle loss when dietary protein targets and resistance training routines are systematically maintained. - **The True Cost:** The main risk of weight-loss drugs occurs when patients titrate off without having built sound habits or addressed psychological triggers, leading to immediate weight regain.

[01:09:57](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=4197s) The Dietary Protein Foundation and Longevity Protocol

When structuring a nutrition plan to optimize body composition and manage calories, Lyon builds everything on a foundation of dietary protein, calling it the most unnecessarily controversial macronutrient in modern media. Protein naturally stimulates the body's endogenous release of GLP-1 meal-to-meal, directly increasing satiety and regulating blood sugar balance.

``` "You cannot out-medicate poor behavior." ```

For optimal muscle protein synthesis and appetite control, Lyon recommends a daily target of **0.7 to 1.0 grams of protein per pound of ideal body weight**. Individuals relying on highly bioavailable, nutrient-dense animal proteins can comfortably aim for the lower end (0.7 g/lb), whereas those relying entirely on plant-based protein sources should target the higher end (1.0 g/lb) to compensate for lower amino acid density and digestibility. She emphasizes that aging adults actually require up to double the baseline minimum protein recommendations to prevent anabolic resistance and maintain functional independence.

[01:11:44](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=4304s) Anabolic Resistance and the Rising Epidemic of Low Testosterone

Dr. Gabrielle Lyon details the specific scientific recommendations for dietary protein, contrasting standard minimums with optimal needs. The baseline recommendation sits at 0.8 grams per kilogram (roughly 0.37 grams per pound) of body weight, which means a 115-pound person would only require 45 grams of protein daily—a figure that represents the bare minimum just to prevent a clinical deficiency. However, as people age, their skeletal muscle experiences "anabolic resistance," becoming significantly less efficient at utilizing dietary protein than it was in their teenage years or twenties.

When Steven Bartlett shares his own history of building muscle—noting that while he played sports whole-heartedly, putting on size felt difficult in his early twenties due to accidentally under-eating calories before it smoothed out around age 25 to 27—Dr. Lyon highlights that his body is currently highly anabolic and sensitive to exercise and diet stimuli. Steven brings up male friends around ages 27 to 29 who claim they do everything right but cannot gain muscle mass. Beyond standard checks into their caloric intake, sleep, and training split, Dr. Lyon offers a candid clinical perspective: she is witnessing a startling surge in abnormally low testosterone levels among young men.

This drop in testosterone strips young men of their natural anabolic (building) potential. When asked if one can spot low testosterone simply by looking at someone, Dr. Lyon acknowledges that while some colleagues might debate it, physical cues often include sparse leg hair, diminished overall muscle mass, and physical characteristics that reflect a higher ratio of estrogen relative to testosterone.

- **Baseline Protein RDA:** 0.8 g/kg (0.37 g/lb) of body weight (45 g/day for a 115 lb individual is merely a deficiency-prevention threshold). - **Anabolic Resistance:** The age-related drop in skeletal muscle's efficiency at absorbing and utilizing amino acids for muscle protein synthesis. - **Root Causes of Low Testosterone in Young Men:** - Poor sleep hygiene and high stress. - Diets dominated by ultra-processed foods and inadequate protein. - Use of recreational drugs. - Environmental toxin exposure (heavy metals like lead and mercury affecting the endocrine system and fertility).

---

[01:15:15](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=4515s) Environmental Heavy Metals and Optimizing Receptor Sensitivity

To naturally optimize testosterone without resorting to hormone therapy injections, Dr. Lyon emphasizes auditing fundamental lifestyle habits first. While heavy weight resistance training does not directly manufacture testosterone on its own, it plays a vital role by upregulating androgen receptors throughout skeletal muscle, making the body far more responsive to existing hormone levels.

In her clinical practice, Dr. Lyon performs extensive heavy metal screening and frequently uncover high environmental exposures that sabotage hormone health and fertility. While everyday stainless steel cups are safe, toxins like lead and mercury often enter the body through aluminum cans, heavy consumption of high-trophic seafood, or specific occupational/hobby exposures like handling firearms and lead ammunition.

---

[01:16:16](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=4576s) Dr. Gabrielle Lyon’s Daily Workout & Fasted Routine

Lifting the curtain on her personal lifestyle, Dr. Lyon outlines the exact routine that keeps her in peak physical condition. Waking up between 5:30 AM and 6:00 AM (often after her husband gets up at 4:00 AM), she heads out to train three days a week—Mondays, Wednesdays, and Fridays—for an hour with her coach, Carlos Mana. She jokingly admits she is roughly five minutes late every single time because of the morning shuffle with her two young children, aged three and five. Rather than letting parenting interrupt her fitness, she embeds her kids right into the process.

> "People and children, they don't care what you say. They care what you do."

Her kids have their own kettlebell sets, and her five-year-old is enrolled in jiujitsu. Dr. Lyon trains in a fasted state, fueled primarily by a high intake of coffee. On non-lifting days (Tuesdays and Thursdays), she incorporates roughly 20 minutes of cardio depending on her recovery state. She maintains high non-exercise activity thermogenesis (NEAT) throughout the day, frequently wearing a weighted vest during work calls, pacing while talking, and staying in perpetual motion.

- **Lifting Frequency:** 3 days a week (1-hour high-intensity weight training sessions on Monday, Wednesday, Friday). - **Cardio / Active Recovery:** 20 minutes of light or intense cardio on Tuesday and Thursday; optional 4th session on Saturday; group workout on Sunday. - **Daily Movement Habits:** Pacing while on phone calls, wearing weighted vests (ranging from 5 lb, 7 lb, to 20 lb), and continuous daily activity.

---

[01:18:37](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=4717s) Daily Meal Structure, Nutrition Protocols, and Alcohol Abstinence

Weighing roughly 110 pounds, Dr. Lyon consumes around 120 grams of protein and 110–120 grams of carbohydrates daily. After training fasted (save for occasional collagen powder stirred into her coffee for skin, hair, and nail health—which she explicitly notes has a protein quality score of zero and does not stimulate muscle protein synthesis), her first real meal arrives as a 30 to 50-gram whey protein shake.

Her second meal consists of high-quality lean beef accompanied by complex carbohydrates such as rice or potatoes and green vegetables. She rounds out her day at approximately 7:00 PM with a family dinner that delivers another 30 to 50 grams of protein and around 50 grams of carbohydrates. She maintains total abstinence from alcohol, explaining straightforwardly that she has never drank because it tastes like rubbing alcohol to her, alongside her medical awareness of its neurotoxic effects.

> "Every single time you eat, you have an opportunity to improve your health."

- **Protein Intake:** ~120 g per day divided into 3 major protein-centric feedings (30–50 g per meal). - **Carbohydrate Intake:** 110–120 g per day (rice, potatoes). - **Collagen Clarification:** Considered an incomplete protein (protein quality score of 0) that does not trigger muscle protein synthesis.

---

[01:21:30](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=4890s) Practical Tips to Build Muscle Without a Gym

For individuals seeking to build muscle and increase physical output without living in a traditional gym, Dr. Lyon breaks down effortless, low-friction habits. The most accessible strategy is weighted rucking—adding a 5 to 7-pound weighted vest while taking phone calls or going for walks, then progressively overloading the weight over time.

To overcome sedentary habits and the natural friction of changing behaviors, she recommends gamifying physical activity at home, especially with children. Instead of sitting down for video games after school, her family runs push-up challenges, holds Nerf gun battles, or hosts spontaneous dance parties to high-energy music like Beyoncé's line-dancing hit "Texas Hold 'Em."

---

[01:23:41](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=5021s) Goals vs. Standards: The Mindset of Discipline

When Steven reflects on how his past fitness goals were often superficial and bound to specific calendar dates, Dr. Lyon challenges the premise of setting traditional goals altogether. Instead, she preaches the concept of establishing unshakeable **standards**.

> "I don't think we should set goals... I think we should set standards. When you set a goal, you can either reach that goal or not. But if you set a standard then you will always keep your standard."

Goals create a binary outcome of success or failure, whereas standards dictate non-negotiable daily behaviors regardless of travel, stress, or environment. Her standards involve hitting her 110–120g protein and carbohydrate targets every day and maintaining designated movement windows no matter where she is in the world.

When Steven asks what part of her own advice she struggles with, Dr. Lyon admits that sleep is her biggest vulnerability. With two young children, she purposefully chooses to give them her undivided attention in the evening, which forces her to work an extra 2 to 3 hours after they go to bed.

Addressing the debate over whether people can truly "have it all," Dr. Lyon rejects the victim mindset. While acknowledging that trade-offs and sacrifices are required, she insists that people often hide behind excuses because facing the truth of their own internal choices is uncomfortable. She attributes her success not to being inherently special, but to executing strict, radical discipline without overthinking it.

<ElicitationsGroup message="Explore related topics from this transcript:"> <Elicitation label="How anabolic resistance changes dietary protein requirements with age" query="How does anabolic resistance change dietary protein requirements with age according to Dr. Gabrielle Lyon?"/> <Elicitation label="Dr. Gabrielle Lyon's exact workout and nutrition routine" query="What is Dr. Gabrielle Lyon's exact daily workout and nutrition routine?"/> <Elicitation label="The difference between fitness goals and lifestyle standards" query="How does Dr. Gabrielle Lyon distinguish between setting fitness goals and establishing lifestyle standards?"/> </ElicitationsGroup>

[01:27:46](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=5266s) No Excuses, Meaningful Consequences, and the Two Steves

Steven points out that many people struggle with personal responsibility and can get easily offended by strict advice—often joining the "what about" gang that raises endless edge cases. Dr. Lyon acknowledges this reality, yet shares her own demanding life as proof that excuses are a choice: she runs three businesses, cares for high-profile patients, hosts a podcast, is writing two books, and is a mother without full-time help. She asserts, "The one thing I don't find is I don't find excuses. I figure out ways to get it done because if it matters, you find ways to get it done." She illustrates this with a hypothetical scenario: if eating another cupcake meant something catastrophic would happen to your dog, you would never touch a cupcake again. The issue isn't capability; it is whether the consequence is meaningful enough. For Dr. Lyon, her drive comes from witnessing the ultimate consequence in her clinical work: watching people suffer and die from preventable diseases.

To highlight this choice, Steven proposes contrasting two versions of himself 30 years in the future at age 61: "Sedentary Steve" (who sits in a chair, eats processed food, and does zero resistance training) versus "Dr. Lyon Steve." Starting with Sedentary Steve, Dr. Lyon delivers a blunt assessment. Even at age 30, the underlying processes of Alzheimer's and cardiovascular disease are likely already starting if someone is inactive. She emphasizes that skeletal muscle is "the only organ system that you have direct voluntary control over," making it our primary tool for intervention.

- **Consequence Drives Action:** Behavioral change happens when the stakes and consequences are clear and personally meaningful. - **Root Cause of Aging Diseases:** Chronic age-related conditions like cardiovascular disease and dementia are deeply tied to the baseline health and mass of skeletal muscle. - **Voluntary Control:** Unlike the heart or inner organ functions, skeletal muscle is unique in being fully under our conscious, voluntary control.

---

[01:31:45](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=5505s) The Downward Spiral of "Sedentary Steve"

Dr. Lyon paints a detailed picture of what happens to Sedentary Steve over three decades of physical neglect. Contracting skeletal muscle acts as an endocrine organ, releasing signaling molecules and boosting blood flow to the brain. Without exercise, neural connections weaken, setting the stage for cognitive decline, memory loss, and conditions like "Type 3 diabetes"—a term used to describe brain insulin resistance linked to systemic metabolic dysfunction. Sedentary Steve would experience reduced lung and cardiovascular capacity, getting winded doing simple tasks like walking upstairs or standing up from a chair.

As the years roll on, Sedentary Steve develops central obesity and sleep apnea, further eroding both his brain and metabolic health. His testosterone levels crash, and his fertility and sperm quality suffer throughout his life due to poor metabolic health and physical inactivity.

- **Brain-Muscle Connection:** Lack of resistance training reduces brain blood flow and critical signaling, accelerating memory loss and cognitive impairment. - **Insulin Resistance:** Inactivity causes insulin resistance in both skeletal muscle and the brain. - **Functional Loss:** Everyday movements—like standing out of a chair or carrying a 15 lb grocery bag—become major physical burdens.

---

[01:34:52](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=5692s) Muscle, Metabolic Health, and Fertility

Steven asks about the link between muscle mass, exercise, and fertility in both men and women. Dr. Lyon explains that skeletal muscle accounts for roughly 40% of body weight and serves as the primary sink for glucose disposal. When you exercise, muscle contracts and absorbs glucose from the bloodstream without requiring insulin—an insulin-independent process. This mechanism is critical for conditions like polycystic ovary syndrome (PCOS), where skeletal muscle insulin resistance plays a major role. Managing muscle mass and restoring insulin sensitivity can help resolve PCOS symptoms in many women.

Steven references a Harvard study showing that men who regularly lifted heavy weights or objects at work had a 46% higher sperm concentration and a 44% higher total sperm count compared to those in less physically demanding jobs. Dr. Lyon confirms that exercise, metabolic health, and muscle mass directly influence sperm health and male fertility.

By contrast, when imagining "Dr. Lyon Steve" at age 61—someone who followed her protocols for 30 years—she describes a thriving, highly functional individual with a six-pack who is full of vitality. When Steven asks for the healthiest older person she knows, she names her 74-year-old father. Through a decade of following her recommendations, he maintains a testosterone level around 800 ng/dL without hormone replacement, displays excellent fasting blood sugar and hemoglobin A1c, and remains strong and capable.

- **Harvard Study on Male Fertility:** Heavy lifting at work correlated with a **46% higher sperm concentration** and a **44% higher total sperm count**. - **PCOS and Muscle:** Exercise allows glucose uptake directly into muscles without insulin, helping treat the underlying insulin resistance associated with PCOS. - **Biological Aging Example:** Dr. Lyon's 74-year-old father boasts a **800 ng/dL testosterone level** (no TRT) and optimal metabolic markers due to consistent muscle-centric habits.

---

[01:38:19](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=5899s) Setting an Example for the Next Generation

Dr. Lyon stresses that prioritizing skeletal muscle as the "organ of longevity" is about more than just personal health—it is a responsibility to our children. Society has normalized supersizing both food portions and body sizes, while screen time and digital connection have displaced genuine, face-to-face human interaction. Parents must advocate for their own physical health to serve as living role models for the youth.

Turning to her book, *Forever Strong: A New, Science-Based Strategy for Aging Well*, Steven asks about key dietary and physical takeaways. Dr. Lyon recaps that while dietary protein can be controversial, it remains non-negotiable for building and preserving muscle. Carbohydrates, meanwhile, are "earned through activity." For individuals with metabolic dysfunction, she suggests starting around 100 grams of carbohydrates daily and adjusting up or down based on activity levels.

- **Modeling Health for Children:** Physical health builds mental resilience, providing a crucial standard for younger generations facing an environment of physical inactivity and hyper-processed foods. - **Carbohydrate Threshold:** A baseline of **100 grams of carbohydrates per day** serves as a practical starting point for metabolically unhealthy individuals, titrated according to their physical activity.

---

[01:40:36](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=6036s) Rapid Muscle Loss and Muscle Memory

Steven asks how quickly muscle mass is lost when training stops. Dr. Lyon reveals that muscle loss occurs with alarming speed under bed rest or severe stress: patients in an intensive care unit (ICU) or highly catabolic states can lose up to 2% of their muscle mass per day. Even in a young, healthy individual, seven days of complete bed rest can result in losing up to 2 pounds of pure skeletal muscle mass, with strength declining before total volume drops.

While muscle memory allows previously trained individuals to regain mass faster than building it the first time, simply resuming basic daily activities after a period of illness or hospital stay is not enough to rebuild lost tissue. Dedicated resistance training is required. Steven shares his own struggles during intense shooting schedules for television shows like *Dragons' Den* (the UK counterpart to *Shark Tank*), where sitting in a chair for 10 hours a day drains his motivation to exercise, creating a downward spiral.

- **ICU Muscle Loss Rate:** Up to **2% of muscle mass per day** can be lost in acute catabolic states or ICU bed rest. - **1-Week Bed Rest Impact:** A young, healthy person can lose **2 lbs of skeletal muscle mass** in just **7 days of bed rest**. - **Strength vs. Mass:** Neuromuscular strength declines first, followed rapidly by muscle tissue atrophy.

---

[01:42:58](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=6178s) Muscle as an Endocrine Organ and Lunch-Break Training

Dr. Lyon explains the biological mechanism behind Steven's slump during long, sedentary shooting days. Skeletal muscle functions as an endocrine organ that produces and secretes "myokines"—such as interleukin-6 (IL-6) and interleukin-15 (IL-15)—during physical contraction. Depending on the intensity and duration of exercise, these myokines circulate throughout the body, crossing into the brain to enhance mood, promote neurogenesis, reduce systemic inflammation, and enable vital cross-talk between organs like the liver and kidneys. When a person stops moving, this chemical signaling drops off, causing fatigue and loss of motivation.

When Steven mentions having only a lunch break during 10-hour filming days, Dr. Lyon offers zero sympathy for skipping workouts: "You should be training on that lunch break. I don't care how tired you are." When Steven replies that he is hungry during lunch, she responds bluntly: "Then you should eat in 10 minutes and get to training."

- **Key Myokines:** Muscle contraction releases signaling proteins like **IL-6** and **IL-15** that act systemically across the brain, liver, and kidneys. - **Brain & Mood Support:** Myokines stimulate neurogenesis, improve mood, and directly counterbalance inflammation. - **No-Excuses Solution:** Long sedentary days require fitting short, intense training sessions into available breaks—such as spending 10 minutes eating and the remainder of the hour exercising.

[01:44:42](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=6282s) Forward Planning and Scheduling Workouts

Dr. Gabrielle Lyon and Steven Bartlett discuss the vital role of intentional forward planning when managing intense schedules. Gabrielle points out that demanding days—such as filming continuously for ten hours—are entirely predictable. Because you know the physical and emotional drain is coming, you must establish an action plan beforehand. Failing to plan leaves you dealing with predictable downstream consequences: diminished motivation, compromised nutrition, and a slump in overall mood.

Steven admits to a major personal oversight: he does not actually schedule his workouts. Instead, physical training acts as a "residual beneficiary," receiving whatever leftover time remains in his day—sometimes forcing him to work out near midnight right before an international flight. Although he acknowledges his privilege in being able to have an assistant block out training time, he wonders how many people actively schedule their exercise. Gabrielle firmly asserts that high performers always schedule their health, stating that she can look at someone's calendar and accurately predict what they will look like in ten years. She emphasizes that setting non-negotiable fitness standards—even just three days a week—is fundamental because managing physical health directly dictates a person's long-term capacity and impact.

- "Show me your habits and I will tell you how successful you will be able to continue to be in the long run." - "Nothing is going to be more critical for your impact than being able to manage your health."

---

[01:46:52](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=6412s) Vision for the Future and Family Standards

Looking forward 30 years, Steven asks Gabrielle what success will look like in the broader public health conversation. Gabrielle envisions a complete paradigm shift where society no longer talks endlessly about obesity as the primary issue. Instead, obesity becomes a mere afterthought because the cultural focus has shifted entirely to physical and mental strength, recognizing muscle health as a controllable, actionable solution. On a personal level, she hopes her children grow up happy, resilient, and capable of enduring life's challenges.

When Steven jokingly asks what she would do if her husband stopped taking care of himself, Gabrielle laughs, noting that while she would say something "totally inappropriate and somewhat aggressive" in private, her husband would never let himself slip. She explains that taking care of one's health is a non-negotiable responsibility to serve as a strong example for their children.

- Gabrielle envisions a future where obesity is merely an "afterthought" while muscle strength takes center stage. - She believes parents have a fundamental duty to model physical discipline and resilience for their kids.

---

[01:48:04](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=6484s) Reflecting on Meaningful Regrets and Personal Drive

Steven introduces the traditional closing question left by the previous podcast guest: *"Regret can occur due to action taken or action not taken. In light of that, what is your biggest meaningful regret and why?"* Gabrielle pauses to reflect deeply, questioning whether she genuinely holds any real regrets, as she strongly believes people are ultimate owners of their choices.

When Steven rephrases the prompt around "mistakes," Gabrielle ponders her intense, lifelong internal drive. She contemplates whether she could have placed less pressure on herself over the years in her relentless pursuit to contribute meaningfully to the world. However, she quickly questions whether easing that pressure would have altered her outcomes or diminished her diligence, concluding that her intense drive was necessary for her mission.

- Gabrielle struggles to identify a true regret because of her belief in absolute personal responsibility for one's life choices. - She reflects on the extreme pressure she places on herself to contribute to society, but questions if she would change it.

---

[01:49:34](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=6574s) The True Purpose: Health as a Gateway to Freedom

Steven expresses deep gratitude to Gabrielle for leading the global movement around muscle health and longevity, highlighting how her educational efforts have positively transformed millions of lives. The conversation brings Steven to reflect on his own childhood memories, vividly recalling watching his mother run repeatedly back and forth on their street when he was four or five years old—an enduring image of health discipline that shaped his perspective on life.

Gabrielle responds by clarifying the core philosophical core of her work. She emphasizes that her mission extends far beyond biology, workouts, or muscle tissue. For her, medicine and muscle health are simply gateways to grant individuals true personal autonomy and happiness, allowing them the physical freedom to pursue whatever they desire in life.

- Steven shares a childhood memory of his mother running outside their home, realizing how parental modeling silently shapes a child's lifelong values. - "Muscle is the way in. Medicine is the way in, but what I really want for people is I want them to have freedom. And that freedom is happiness."

## Notable quotes > [00:00](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=0s) When it comes down to your health, it shouldn't be about how you look. It should be about how you perform. And there's no replacement for resistance training and skeletal muscle mass. — Dr. Gabrielle Lyon

> [04:34](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=274s) As high as you go, after a big launch or event, there's a dip. And you don't go back to baseline... It's a very big high and a very big low. Nothing will take someone off a health journey faster than those lows. — Dr. Gabrielle Lyon

> [12:25](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=745s) If people don't have time for health and wellness, how are they going to have time for sickness? That's so much more time-consuming. — Dr. Gabrielle Lyon

> [28:00](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=1680s) The information was so wrong that I felt a responsibility to say something, and if I didn't, I would be contributing to the same problem. — Dr. Gabrielle Lyon

> [46:48](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=2808s) If you are in the lower one-third for strength, those that are in the lower one-third... have a 50% greater risk of dying from nearly anything. — Dr. Gabrielle Lyon

> [05:56:00](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=21360s) You cannot have a high-quality life without high-quality muscle. — Dr. Gabrielle Lyon

> [01:09:57](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=4197s) You cannot out-medicate poor behavior. — Gabrielle Lyon

> [01:16:16](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=4576s) People and children, they don't care what you say. They care what you do. — Gabrielle Lyon

> [01:18:37](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=4717s) Every single time you eat, you have an opportunity to improve your health. — Gabrielle Lyon

> [01:21:30](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=4890s) I don't think we should set goals... I think we should set standards. When you set a goal, you can either reach that goal or not. But if you set a standard then you will always keep your standard. — Gabrielle Lyon

> [01:44:42](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=6282s) Show me your habits and I will tell you how successful you will be able to continue to be in the long run. — Gabrielle Lyon

> [01:44:42](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=6282s) Nothing is going to be more critical for your impact than being able to manage your health. — Gabrielle Lyon

> [01:49:34](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=6574s) Muscle is the way in. Medicine is the way in, but what I really want for people is I want them to have freedom. And that freedom is happiness. — Gabrielle Lyon

## Mentioned Dr. Gabrielle Lyon, Steven Bartlett, Evy Poumpouras, Danica Patrick, Jim Kwik, Mayo Clinic, Yale University, Navy SEALs, The Diary Of A CEO, FOREVER STRONG: A New, Science-Based Strategy for Aging Well, Gabrielle Lyon, Carlos Mana, Ozempic, Mounjaro, GLP-1, GIP, PCOS, Harvard University, Forever Strong: A New, Science-Based Strategy for Aging Well, Dragons' Den, Shark Tank, Beyoncé

[Source](https://www.youtube.com/watch?v=2j3T4oYJPfI)

中文简报

Gabrielle Lyon 医生指出肌肉流失与死亡风险密切相关 通过针对性的抗阻训练和最佳蛋白质摄入维持骨骼肌质量,可预防慢性疾病并终身维护认知功能。 Gabrielle Lyon 医生断言,骨骼肌是关乎长寿的核心器官,也是预防阿尔茨海默病、心血管衰退与代谢紊乱等衰老相关疾病的根本基础。她将肌肉重新定义为受自主意识控制的代谢库兼内分泌器官,强调力量训练和优质蛋白质对于维持健康寿命与独立自理能力至关重要。此外,Lyon 还破除了围绕 GLP-1 减肥药、低睾酮和饮食的常见健康误区,指出自律和不可动摇的个人标准对于突破心理障碍、促成改变必不可少。整场讨论最终强调,维护肌肉健康是实现身体自由、认知敏锐以及全面活力的最强有力工具。 骨骼肌质量与力量是决定长寿的核心器官,力量处于后三分之一的人群,其全因死亡风险会增加50%。 (0:00) 阻碍人们践行长期健康改变的根本心理障碍往往是潜意识里的自我不配得感,而非缺乏自律或动力。 (9:39) 单纯的有氧运动无法替代抗阻训练;随着年龄增长,必须依靠力量训练来防止快肌纤维(Type 2)退化萎缩并预防肌肉减少症。 (48:45) 身体长期不活动会迅速导致骨骼肌出现胰岛素抵抗,使多余的葡萄糖无法储存为肌糖原,转而流向肝脏堆积为脂肪。 (55:29) 为了促进肌肉蛋白质合成并防止肌肉流失,日常蛋白质摄入量建议达到每磅理想体重0.7至1.0克。

Reading summary

Dr. Gabrielle Lyon contends that modern medicine focuses excessively on obesity rather than skeletal muscle mass, which she designates as the primary voluntary organ of longevity. She argues that sustaining muscular strength and metabolic capacity through progressive resistance training and adequate dietary protein is essential to prevent chronic metabolic and cognitive decline. Muscle Mass as the Foundation of Metabolic Health (0:00) Dr. Lyon asserts that skeletal muscle, making up roughly 40% of body weight, serves as the human body's primary site for glucose disposal and fatty acid oxidation. Individuals falling into the lower third of muscle strength face a 50% higher risk of all-cause mortality, yet only 6% to 8% of the population meets standard resistance training guidelines. Highlighting a Yale University study on lean 18-year-olds subjected to physical inactivity, Lyon notes that sedentary muscle rapidly develops silent insulin resistance and myosteatosis—intramuscular fat infiltration—without visible weight gain. Beyond basic mechanics, contracting skeletal muscle functions as an endocrine organ. During physical exertion, muscle tissue releases chemical messengers called myokines, including interleukin-6 (IL-6) and interleukin-15 (IL-15). These signaling proteins cross the blood-brain barrier to promote neurogenesis, regulate mood, attenuate systemic inflammation, and coordinate metabolic communication between the liver and kidneys. Resistance Training Standards for Preserving Physical Autonomy (42:05) To counteract age-related sarcopenia, Lyon argues that cardiovascular exercise cannot substitute for mechanical resistance training. Without targeted loading, fast-twitch Type 2 muscle fibers atrophy and convert to Type 1 fibers, degrading physical power and reducing glucose sinks. She outlines functional readiness benchmarks that include performing at least one pull-up, completing ten strict push-ups, and running a mile with sound form. For ongoing maintenance, Lyon recommends resistance training three to four days per week, performing 10 to 20 sets per muscle group weekly using compound exercises. She cautions that muscle tissue atrophies rapidly under disuse: acute catabolic conditions or intensive care bed rest can trigger up to 2% muscle loss per day, while seven days of complete bed rest in a healthy young adult can waste roughly two pounds of skeletal muscle before total volume visually appears diminished. Protein Targets, Anabolic Resistance, and Medication (69:57) To overcome age-related anabolic resistance—a state where skeletal muscle requires higher concentrations of amino acids to trigger muscle protein synthesis—Lyon recommends consuming 0.7 to 1.0 grams of dietary protein per pound of ideal body weight daily. Individuals eating bioavailable animal proteins can aim for the lower threshold (0.7 g/lb), while those relying on plant proteins require the upper threshold (1.0 g/lb) to compensate for lower amino acid density and digestibility. Lyon also addresses weight-loss drugs like GLP-1 receptor agonists, disputing claims that these medications directly waste muscle. She observes that muscle deterioration during GLP-1 therapy occurs because patients severely restrict calories without meeting protein minimums or lifting weights. In her clinical practice, patients adhering to structured resistance training and prescribed protein intake retain their muscle mass while benefiting from reduced appetite cues. Psychological Worthiness and Adaptive Stress Responses (9:39) Lyon identifies low self-worth, rather than poor discipline or fleeting motivation, as the primary barrier preventing people from executing health advice. Individuals who subconsciously feel undeserving of health often sabotage their own regimens. Furthermore, she criticizes the modern framing of all stress as damaging 'fight or flight' arousal, pointing to adaptive evolutionary responses such as 'tend and befriend' (oxytocin-mediated affiliation) and the 'courage response' (decisive action under pressure). Lyon cites a landmark experiment involving hotel housekeepers: when informed that their daily labor met physical activity guidelines, the housekeepers exhibited measurable improvements in blood pressure, glucose regulation, and body composition purely through altered cognitive framing. Where underlying psychological trauma or deep-seated resistance blocks behavior, Lyon stresses that physicians must clearly recognize where physiological optimization ends and specialized psychiatric counseling begins. Lyon concludes that treating muscle health as a non-negotiable personal standard rather than a discretionary goal provides the ultimate gateway to lifelong autonomy and freedom. However, her framework faces ongoing public health obstacles, including systemic sedentary habits, environmental endocrine disruptors contributing to low testosterone in young men, and the difficulty of resolving deeply rooted patient traumas within short, transactional medical appointments.

精炼阅读摘要

老年医学与营养科学专家 Gabrielle Lyon 博士指出,现代医学过度聚焦于肥胖本身,但健康的真正根基在于骨骼肌这一受人类意识自主支配的“长寿器官”;力量处于后三分之一的人群全因死亡风险高出50%,缺乏抗阻训练将直接导致代谢失调、心脑血管疾病以及生殖与认知功能的全面衰退。 骨骼肌作为代谢与内分泌器官的生理机制 (46:48) 骨骼肌约占人体体重的40%,是体内葡萄糖处置的首要代谢池和脂肪酸氧化场所。Lyon 博士阐述,肌肉收缩时能以不依赖胰岛素的机制直接从血液中吸收葡萄糖,这对改善胰岛素抵抗及多囊卵巢综合征(PCOS)至关重要。同时,骨骼肌属于内分泌器官,在收缩过程中分泌白细胞介素-6(IL-6)与白细胞介素-15(IL-15)等肌动蛋白(myokines),穿过血脑屏障促进神经发生、提升情绪并抑制全身慢性炎症。若缺乏阻抗刺激,快肌纤维(II型纤维)会逐步萎缩并转化为慢肌纤维(I型纤维),导致肌内脂肪浸润(myosteatosis)。 久坐与缺乏力量训练会引发隐性代谢危机。耶鲁大学针对体型消瘦且外表健康的18岁大学生的研究表明,仅仅经过一段时间的久坐不动,受试者在体重未增加的情况下迅速产生了骨骼肌胰岛素抵抗。而在极端制动或重症监护状态下,人体每日可损失高达2%的肌肉质量;即便健康的年轻人完全卧床7天,纯骨骼肌流失也可达2磅。Lyon 强调,肌肉萎缩将切断关键的神经内分泌保护,显著提高阿尔茨海默病(又称3型糖尿病)和心血管疾病的发病概率。 合成代谢阻抗与高蛋白营养干预策略 (69:57) 随着年龄增长,人体骨骼肌会出现“合成代谢阻抗”(anabolic resistance),对利用循环氨基酸合成肌肉的效率明显下降。Lyon 指出,官方推荐的每日每公斤体重0.8克(约每磅0.37克)蛋白质摄入量,仅是防止临床缺乏症的最低基准,无法支撑抗衰老与功能性独立。她建议每日摄入量应提高至理想体重每磅0.7至1.0克:依赖高生物利用度动物蛋白的人群可保持在0.7克/磅,而全植物性饮食者因氨基酸密度与消化率不足,需达到1.0克/磅。为最大化触发肌肉蛋白质合成并利用其刺激内源性 GLP-1 释放以控制食欲,每餐蛋白质应集中达到30至50克。 针对以 Ozempic 为代表的 GLP-1 受体激动剂,Lyon 澄清药物本身并不直接导致肌肉组织分解。临床中观察到的肌肉流失,源于患者盲目大幅削减总热量而未同步摄入足够蛋白质或进行抗阻训练;若营养和抗阻训练到位,用药期间可维持肌肉不减。此外,碳水化合物必须通过身体活动来“赚取”,对于代谢受损人群,建议每日碳水化合物摄入量从100克起步,并根据日常运动量进行增减。 力量训练基准与年轻一代雄激素衰退 (42:05) 维持肌力与快肌纤维储备无法通过纯有氧运动完成。Lyon 提出了全民应当达到的基础身体机能标准:至少完成1次引体向上、10次标准俯卧撑以及高效完成1英里跑。在训练方案上,她建议每周进行3至4天抗阻训练,每个肌群每周累计完成10至20组有效负荷,采用推拉、上下肢分化或复合动作训练。然而统计显示,全美目前仅有6%至8%的人口达到官方抗阻训练指南,超过50%的人完全不锻炼,约75%的人未达到有氧与力量的综合运动推荐。 抗阻训练还对内分泌受体具有调控作用。虽然举重本身不直接生成睾酮,但能显著上调骨骼肌中的雄激素受体密度,增强机体对现有激素的响应敏感度。Lyon 在临床中发现年轻男性睾酮水平异常低下已成趋势,与超加工饮食、睡眠不良、心理压力以及铅、汞等环境重金属暴露密切相关。哈佛大学的研究亦佐证了负重与生殖机能的关联:工作中经常搬运重物的男性,其精子浓度较轻体力者高出46%,精子总数高出44%。 自我价值感障碍与行为标准的建立 (9:39) 许多人摄取了海量健康知识却无法付诸行动,Lyon 认为其根源往往不是缺乏自律或意志力,而是潜意识中深层的“不配得感”(unworthiness)。当个体内心不认为自己配得上充沛精力与健康体魄时,便会产生隐性自我破坏。她提出不能依赖极易消退的情绪化“动机”,而应将健康习惯确立为“不可妥协的生活标准”(standards)。传统目标设定往往伴随非成即败的挫败感,而行为标准无论在差旅、工作压力或恶劣环境下都必须执行,例如每日锁定蛋白质摄入窗口与日常负重活动。 在心理机制上,Lyon 批评了将所有压力统归为破坏性“战或逃”的现代观念。人脑对压力的诠释直接改变生理指标,正如酒店保洁研究证明,仅仅意识到日常劳动符合锻炼标准,受试者的血压和胰岛素敏感性便发生显著改善。除战或逃外,人类还拥有由催产素驱动的“关怀与结盟”以及特种作战人员常见的“勇气反应”。对于高成就者与普通大众而言,跳脱纯粹外貌攀比的虚荣循环,将维持体能的动机锚定在服务家庭、团队以及为下一代树立榜样的利他责任上,是驱动持续行为改变的最有力支点。 Lyon 强调,医学与肌肉健康的终极目的并非追求肤浅的体相审美或繁复的抗衰潮流,而是通过掌握这一唯一受意志控制的器官,赋予个体在漫长生命中免于衰弱的身体主权与行动自由。然而,在便利设施泛滥和生活方式极度久坐的现代环境中,如何在缺乏病痛警示的早期阶段,促使绝大多数处于力量劣势的人群打破拖延并建立长期自律,依然是临床医学与公众认知转变面临的核心挑战。

Detailed notes — zh

## Background 本期节目由 YouTube 频道《The Diary Of A CEO》(主持人 Steven Bartlett)于 2024 年 9 月 26 日发布。访谈邀请了“以肌肉为核心医学”(Muscle-Centric Medicine)创始人、《Forever Strong》作者加布里埃尔·里昂博士(Dr. Gabrielle Lyon),深入剖析了如果缺乏力量与抗阻训练,人体将面临的代谢衰退、肌肉流失与早亡危机,旨在唤醒大众对骨骼肌健康与科学衰老的认知。 ## TL;DR 加布里埃尔·里昂博士在访谈中颠覆了传统以减脂为焦点的健康认知,指出骨骼肌不仅是身体的运动杠杆,更是决定代谢稳态、生殖内分泌与认知机能的人体首要“长寿器官”,肌力薄弱会使全因死亡风险骤增 50%。她深入剖析了人们知而不行的深层心理机制,指出配得感缺失与借口主义是阻碍行动的核心枷锁,真正的改变需要依靠不可动摇的底线“标准”而非飘忽的“目标”。针对现代社会的虚弱危机,她提出每周至少进行 3 天抗阻训练、摄入每磅理想体重 0.7 至 1.0 克优质蛋白,并理性看待 Ozempic 等药物以防肌肉流失。保护骨骼肌的终极目的不仅是获得强韧体魄与对抗衰老,更是为了赢得掌控人生的终极自由,并为后代树立卓越的生命榜样。 ## Atmosphere & style 整场对话兼具现代循证医学的严谨锐利与直击灵魂的警醒力量,毫无空洞说教,却时刻带着一种逼人直面真相的压迫感。里昂博士雷厉风行、铁血实干的医者作风,与主持人巴特利特真诚反思自身作息、层层递进的追问形成了极具代入感的互动张力。从临终病房目睹死亡沉重的感伤回溯,到拆解生活借口时的当头棒喝,整期节目在沉重与振奋之间起伏,带给听众一种既对生理衰老心生敬畏、又急迫想要穿上鞋立刻去举铁重夺身体主权的激昂心力。 ## Bulletin - [00:00](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=0s) 肌肉力量处于人群后三分之一的个体,全因死亡风险高出50%;然而全球仅有6%至8%的人口达标抗阻训练指南标准。 - [01:42:27](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=6147s) 骨骼肌是人体内唯一可受自主意识控制的内分泌代谢器官,其收缩释放的肌动蛋白(Myokines)能直接穿透血脑屏障,改善神经发生与情绪调控。 - [01:04:37](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=3877s) GLP-1类减肥药(如Ozempic)本身并不破坏肌肉,用药期间的肌肉流失本质上是食欲被抑制后缺乏抗阻训练与蛋白质摄入不足所致。 - [53:26](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=3206s) 耶鲁大学研究证实根本不存在“健康久坐者”:精瘦年轻人在短期久坐后即可迅速出现骨骼肌胰岛素抵抗,为阿尔茨海默病(大脑3型糖尿病)埋下病理隐患。 ## Key takeaways - [00:00](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=0s) 骨骼肌是人体的核心“长寿器官”,而肥胖只是肌萎缩与代谢衰竭的下游表象,公共健康必须从“减脂”转向“增肌”。 - [09:11](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=551s) 知而不行的底层心理症结并非自律缺失,而是潜意识里的“配得感”(Worthiness)匮乏引发的自我破坏行为。 - [13:15](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=795s) “没有时间关注健康,哪来时间去生病”:现代人常常短视地假设自己不会衰老或生病,忽视了疾病所消耗的时间与毁灭性代价。 - [17:46](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=1066s) 除“战或逃”外,人类还演化出了“照料与结盟”(释放催产素)及“勇气反应”等更高级的抗压机制,保持勇敢能显著减轻应激生理损耗。 - [33:41](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=2021s) 无休止的外在容貌比较是一场注定满盘皆输的游戏,健康的核心锚点应转向“身体备战状态”(Physical Readiness)与真实功能表现。 - [43:53](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=2633s) 每周至少进行3至4天抗阻力量训练是通用底线;单纯的心血管有氧训练无法逆转负责爆发力与代谢的Type II快肌纤维萎缩。 - [01:34:34](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=5674s) 肌肉约占人体体重的40%,是最大的血糖缓冲池;肌肉收缩具备非胰岛素依赖的糖代谢通路,能有效改善代谢综合征与PCOS。 - [01:09:28](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=4168s) 膳食蛋白质每日应达到每磅理想体重0.7至1.0克,以克服中老年期由于衰老带来的骨骼肌“合成代谢抵抗”(Anabolic Resistance)。 - [01:14:52](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=4492s) 年轻男性睾酮水平断崖式下跌与久坐、缺乏抗阻以及铅、汞等环境重金属毒素暴露密切相关,重训能上调肌肉雄激素受体密度。 - [01:23:40](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=5020s) 长久健康依赖不可妥协的“标准”(Standards)而非二元易变且带来松懈的“目标”(Goals)。 - [01:42:27](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=6147s) 骨骼肌机械收缩释放白细胞介素-6(IL-6)等肌动蛋白,在全身抗炎、神经发生及打破久坐低动力恶性循环中起核心作用。 - [01:44:37](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=6277s) 必须将锻炼以最高优先级锁入日常日程表,拒绝让健康管理成为“时间的残留受益者”。 ## Detailed walkthrough ### [00:00](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=0s) 骨骼肌:被忽视的长寿器官与衰老危机 世人至今仍在将所有焦点放在肥胖问题上,但肥胖其实只是表象,真正的危机在于肌肉力量与肌肉量的流失。流行病学数据显示,如果一个人的肌肉力量处于人群中较弱的后三分之一,其死于几乎任何疾病的全因死亡风险都会飙升50%。骨骼肌不仅负责运动,它本质上是人体最重要的“长寿器官”,并且是人体唯一受自主意识控制的器官系统。然而,现代人对肌肉刺激的认识极为匮乏,目前全球仅有6%到8%的人群达到了最低限度的阻力训练指南标准,绝大多数个体长期处于久坐不动的生活方式中。 面对“如果一个30岁的人在接下来的30年里完全不进行任何阻力训练、每天坐在椅子上,到61岁时会变成什么样”的尖锐提问,加布里埃尔·里昂博士(Dr. Gabrielle Lyon)勾勒了一幅令人心惊的生理衰退图景:在这个无形加速衰老的过程中,阿尔茨海默病与心血管疾病的发生风险急剧攀升;整个生命周期中的睾酮水平将长期处于低下状态,精子质量大幅下滑,这直接证明了男女性的生育能力与肌肉量之间存在着不可分割的强关联。到了60岁出头,爬楼梯都会让人气喘吁吁,肥胖与睡眠呼吸暂停综合征随之而来,从而进一步侵蚀大脑认知与代谢系统。当下微小的行为选择,最终将以生理崩塌的形式决定人生的结局。 - 关键致死风险:肌肉力量处于最低三分之一区间的人群,全因死亡率增加 50%。 - 运动达标率危机:仅有 6%~8% 的人达到推荐的阻力训练标准,大部分人群呈现严重久坐状态。 - 长期缺乏肌肉刺激的生理连锁反应: - 代谢紊乱与肥胖、睡眠呼吸暂停综合征。 - 阿尔茨海默病与心血管疾病风险激增。 - 睾酮水平低下,生殖细胞质量与生育力受损。 --- ### [02:11](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=131s) 消除身体束缚:顶尖成就者背后的健康平衡器 作为拥有20年临床经验、主攻老年医学与抗衰老研究的执业医生,加布里埃尔·里昂博士建立了自己的高端私人医疗诊所。她的使命极为纯粹——“为那些改变世界的人扫除一切生理束缚”。在她的患者名单中,既有顶尖运动员、特种部队一级作战人员(如海豹突击队 Navy SEALs)、财富百强企业首席执行官,也有知名赛车手丹妮卡·帕特里克(Danica Patrick)与前特勤局特工埃维·庞珀拉斯(Evy Poumpouras)。这些超高成就者具备一种异于常人的能力:无论身体承受何种痛苦或疲惫,他们都能凭借意志力硬扛过去。然而,这种硬扛带来的生理代偿和隐性代价是完全可以预测的。 许多患者在辗转求医于梅奥诊所(Mayo Clinic)等顶级医疗机构未果后找到她,他们最普遍的倾诉并非患有某种特定疾病,而是一种深层的生理直觉:“我知道自己的状态绝不该仅止于此,我本该拥有更充沛的精力、更好的睡眠和更出色的表现,还有很多潜能被落在了桌上。”无论是由于环境毒素暴露、荷尔蒙失衡、胃肠功能紊乱,还是步入中年后的慢性低度炎症与身体成分恶化,这些生理障碍都在削弱高阶个体的表现力。里昂博士强调,无论一个人在社会层面取得多大成就,没有人能超越自身生理机能的承载上限——健康与年龄,才是人类最终极的平等器。 --- ### [05:28](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=328s) 洞察人性模式:多巴胺过山车与“中性心态”的破局 在制定医疗干预方案时,最复杂的环节往往不是肉体层面的药物或营养干预,而是心智模式的重塑。普通医生擅长识别疾病的生化病理模式,而顶级医生必须能够洞悉人性的行为模式。高成就群体(通常为强烈的 A 型人格)有着高度可预测的心理和生理周期:他们对“追求更多”充满执念,在准备重大事件时会调动全部的神经系统资源与多巴胺分泌,将自身推向极致亢奋的顶峰。然而,当重大事件尘埃落定——无论是新书发布、破纪录的播客播出,还是赚取数百万美元的盛大活动圆满结束——伴随而来的往往不是平稳回落,而是一场断崖式的生理低谷。 ```mermaid flowchart LR accTitle: 高成就者的多巴胺过山车与耗竭循环 accDescr: 展示高成就者从极致兴奋到多巴胺断崖下跌,导致健康习惯崩溃并陷入职业倦怠的生理机制。 subgraph Phase1["峰值驱动期"] A["重大目标投入<br/>(高唤醒 / 极致期待)"] --> B["多巴胺激增<br/>(极度亢奋 / 神经紧绷)"] end subgraph Phase2["生理崩溃期"] B --> C["目标达成与落幕<br/>(多巴胺断崖式暴跌)"] C --> D["深渊体验<br/>(抑郁感 / 能量耗竭)"] end subgraph Phase3["行为偏轨"] D --> E["健康系统崩盘<br/>(暴饮暴食 / 放弃训练)"] E --> F["陷入职业倦怠<br/>(渴望下一剂刺激)"] end ``` 里昂博士以一位每年在拉斯维加斯举办超大型商业盛会的患者为例:每次活动大获成功后,患者都会准时打来电话陷入深度抑郁,饮食失控、停止锻炼,感觉整个人彻底脱轨。很多人将这种现象归咎于纯粹的心理落差,但从神经生物学角度看,这本质上是一种生理反应——多巴胺系统的过度透支引发了神经递质水平的剧烈下挫。人们常挂在嘴边的“职业倦怠”(Burnout),正是源于这种盲目追求刺激峰值的内驱力。要打破这一恶性循环,高成就者必须学会将心态锚定在“中性状态”(Neutral Mindset),不因极度的峰值而狂喜过载,亦不因峰值之后的退潮而坠入深渊,唯有平稳驾驭自身生理系统,才能保证执行力不受情绪风暴的摧毁。 --- ### [09:11](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=551s) 为什么知而不行?行动阻碍底层的“配得感” 无数听众听过无数关于健康、认知优化和身体机能提升的科学建议,但在现实中,真正能够将知识付诸实践的人寥寥无几。许多人以为这关乎自律或动力机制的强弱,但里昂博士指出,在一切表层借口之下,无法将健康建议转化为行动的核心阻碍是**配得感(Worthiness)**。从根本上说,症结在于患者内心深处是否真正觉得自己“配得上”拥有渴望中的卓越健康与丰沛状态。 如果一个人潜意识里缺乏这种自我价值的认同与配得感,无论外界提供的健康方案与锻炼计划多么完美无瑕,他都会在执行过程中下意识地进行自我破坏(Self-sabotage)。只有当个体认清这种可预测的人性防御机制,并学会在生活波动中保持不偏不倚的中性心态,才可能撕开自我设限的枷锁,真正开启通往健康与长寿的生理重塑。 ### [10:09](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=609s) 改变的底层核心:配得感与自控强度 在谈及行为改变与执行力时,加布里埃尔·里昂博士(Dr. Gabrielle Lyon)深入剖析了人们为何常常无法将健康建议转化为实际行动。她指出,此前个案中那位成功维持中立心态的来访者,最根本的特质在于“他发自内心地觉得自己配得上拥有极佳的状态”。在这类成功案例中,人们往往懂得运用间歇性奖赏、不为每一次小胜过度庆祝,并且能够有意识地随时开启或关闭专注模式——这是一种高度受控的动态表达。里昂博士提到自己的丈夫曾是一名海豹突击队队员(Navy SEAL),她在海豹突击队这类顶尖群体身上频繁观察到这种特质:他们具备极强的“受控强度”(controlled intensity)。 反观那些似乎永远无法好转的人,里昂博士强调,任何试图改变的人都必须叩问内心深处的一个核心问题:“我是否觉得自己配得上?”如果一个人未能在内心深处解决配得感(worthiness)的问题,不觉得自己配得上将接收到的大量有益建议付诸实践,那么真正的改变永远不会发生。 在里昂博士看来,人们常常挂在嘴边的自律和动机并不是最根本的障碍。自律其实并不难,它是一种可以通过后天刻意练习掌握的技能;尽管脑海中的某些惯性机制会让人觉得赖床或逃避健身房更轻松,但自律本身完全可控。而动机则是一种极易消逝的情绪,真正成事的人绝不会干坐着等待动机降临。如果不解决配得感,改变就无从谈起。很多人每天都在对自我进行负面叙事,将周围环境的一切都解读为压力,进而陷入压力的困扰中,甚至觉得自己根本不配采取行动去摆脱这种压迫感。 ### [12:18](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=738s) 面对自暴自弃的求诊者:从基础生理排查到面对现实 主持人史蒂芬·巴特利特(Steven Bartlett)顺着这个逻辑发问:如果一个表现出毫无配得感、充满自我贬低的人坐在诊室里,通过肢体语言和言语不断看轻自己,医生该从何下手?里昂博士回答,第一步是绝不强行说教,而是引导对方自己得出结论。她会从最基础、最务实的生理状态切入:“史蒂芬,你最近睡得怎么样?是真的睡得好吗?”她通常能料到对方肯定睡得不好——往往是深夜辗转反侧、大脑飞速运转、焦虑不已。 紧接着,她会排查一系列具体的生活基线:饮食状况、消化系统表现、日常环境暴露等,随后为对方布置一组非常具体的任务清单: - 完成全面的血液常规与生化检测 - 进行专业的睡眠监测评估(sleep study) - 排查肠道健康与食物不耐受反应 ```mermaid flowchart TD accTitle: 评估与干预阻抗患者的临床路径 accDescr: 展示加布里埃尔博士如何通过客观生理指标引导缺乏配得感的患者走向自我觉察 subgraph Phase1["第一阶段:基线排查"] A["生理状态询问<br/>睡眠 / 饮食 / 消化"] --> B["客观指标检测<br/>验血 / 睡眠监测 / 肠道筛查"] end subgraph Phase2["第二阶段:现实碰撞"] B --> C{"患者是否执行?"} C -- "拖延/逃避" --> D["身体亮起红灯<br/>症状迫使面对现实"] C -- "完成检测" --> E["获得客观数据指标"] D --> E end subgraph Phase3["第三阶段:认知重塑"] E --> F["正视配得感<br/>为长期目标释放健康潜能"] end ``` 许多人嘴上会敷衍应承,保证自己“准备好改变了”,但里昂博士清楚这往往只是口头应付。真正的转折点在于这些客观检测拿到结果的时刻——数据不会说谎。一旦客观证据摆在眼前,关于配得感、关于长期战略的严肃对话才真正开始。要想充分兑现人生潜能、在事业上大展拳脚,唯一的基石就是将健康彻底解放出来,“你绝不可能靠硬撑绕过你身体的真实感受”。 ### [13:15](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=795s) “没有时间关注健康,哪来时间去生病?”与三大患者画像 史蒂芬指出,很多人明明拥有一切资源与时间,却依然无法改变,往往拿“太忙没时间”当借口。里昂博士立刻反驳了这种短视逻辑,提出了一句振聋发聩的反问:“如果一个人连关注健康的时间都没有,那他怎么可能有时间去生病?”生病所消耗的时间、精力和代价,远比维持健康要庞大得多。然而现代人的文化盲区在于,绝大多数人从不假设自己会生病,仿佛疾病总是一场突如其来的意外。短视的决策模式表明,大多数人活着的时候,潜意识里根本不相信自己会衰老、生病或死亡。 里昂博士痛心地谈到,这种认知是文化的巨大失败。以骨折衰老为例,很多人因从未进行抗阻训练、从未照顾好这具独一无二的身体,最终摔倒导致髋关节骨折,余生只能困在病床上。衰老本身并不是疾病,它是一个必然的过程,但我们如何衰老,主动权很大程度上掌握在自己手中。如果人们能将未来的自我具象化到现在,理解未来不仅需要充沛的体力,更需要强大的心智,行动才会真正发生。 在多年临床实践中,里昂博士能极快地判断一个人是否会落实建议,她将人群归纳为三种典型画像: - **企业高管与CEO画像**:极具预见性地会把健康计划推脱3到6个月,借口总是“太忙”。但健康是绝对的“终极平等器”,直到胃部泛酸、整夜失眠、身体彻底报警时,他们才会折返求助并乖乖完成检查。而一旦开始执行,他们往往能持之以恒,因为他们明白极致的体魄是实现野心的唯一公约数。 - **求医受挫型画像**:往往已经辗转看过十几位医生,在医疗体制中屡屡碰壁、彻底丧失了信任与希望;或是曾被某位医生冷酷的言辞深深刺伤。面对方案时他们最初极度抗拒,但只要医生能够重新赢得他们的信任,他们就会坚定地执行到底。 - **配得感缺失与创伤型画像**:内心渴望进化,但被过去的创伤(无论是父亲离家这种“小t创伤”,还是更为严重的重大暴力“大T创伤”)牢牢困住,身体和情绪被锁死在防御姿态中。 ### [17:46](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=1066s) 重新定义压力:斯坦福酒店保洁研究与被忽视的应对本能 对于那些困于心理创伤与压力的人,里昂博士指出,大众对压力的认知存在严重偏差。人们普遍认为压力就等于“战或逃”(fight or flight),唯一的解法就是逃避压力、泡个热水澡放松。但从演化生物学来看,人类天生具备应对与缓解压力的强大机制,人体的韧性远超自我认知。 她引用了斯坦福大学等机构开展的经典心理学实验——“酒店客房保洁员研究”(Hotel Caretaker Study)。研究人员将酒店清洁工分为两组: - **认知干预组**:被明确告知他们每天的工作(铺床、吸尘、搬运)本身就是极佳的体育锻炼,完全达到了健康活动量的标准。 - **对照组**:仅仅照常工作,未被赋予这种运动认知。 实验结束时,日常工作量完全相同的干预组仅仅因为对自身处境的“认知转变”,生理指标就发生了显著改善:他们的血压明显下降、血糖调控能力增强、胰岛素敏感度提升,甚至伴随了体重减轻。这有力证明了信念对生理反应的直接塑造作用。 里昂博士感叹,英语语境中用单一词汇“压力”(stress)来统领上百万种截然不同的处境,是一种严重的认知局限。宠物离世被称为压力,孩子把咖啡泼在昂贵的白色沙发上被称为压力,情侣分手甚至配偶去世也被笼统地称为压力。将所有负荷都归结为“战或逃”,严重限制了人类的生理潜力与应对容量。 实际上,除了“战或逃”,人类还演化出了另外两种更具建设性与赋能意义的压力反应机制: - **照料与结盟(Tend and Befriend)**:面对高压时,体内会释放催产素(oxytocin),促使个体产生更强的连接感、同理心与行动力。许多人在遭遇危机时会本能地第一时间冲出去帮助他人,这种通过关怀他人来应对压力的模式,同样是人类演化出的高级压力反应。 - **勇气反应(The Courage Response)**:直接调动内在力量,迎难而上面对挑战,而非一味退缩防御。 ### [20:29](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=1229s) 恐惧与勇气的抉择:应激反应如何重塑生理状态 加布里埃尔·里昂博士(Dr. Gabrielle Lyon)从特种作战人员的应激反应谈起,指出这些人在面临危急关头时,能够本能且迅速地采取行动。为了更生动地阐释这种心理机制的差异,她举了自己和丈夫准备跳伞的例子:在同一架飞机舱门前,面对完全相同的外部环境,她自己感到惊恐万分,陷入了典型的“战斗或逃跑”(fight or flight)应激状态;而她的丈夫却兴奋不已,展现出由内而外的勇气。当两人真正跳出舱门落地后,谁能更快调整状态投入下一项任务显而易见——她的丈夫可以立刻起身行动,而她则可能需要数小时,甚至整整一天或一周的时间,才能从应激反应的生理损耗中彻底平复。 这种“勇敢”并非不可触及的天赋,而是一种可以通过后天刻意培养的反应模式。加布里埃尔强调,当一个人展现出勇气而非单纯的恐惧应激时,其不仅能够从容探索全新体验、持续前行,更能显著减轻原本因神经内分泌激增所带来的生理伤害。在她看来,恐惧是人类面对未知时再正常不过的本能反应,但“保持勇敢则是一种主动的选择”。 ### [21:47](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=1307s) 心理与生理的边界:深层创伤与无法入眠的病人 主持人史蒂芬·巴特利特(Steven Bartlett)由此提出一个诊疗实践中的核心难题:当病人带着根深蒂固的童年创伤走入诊室,因自卑和“配得感”(worthiness)缺失而彻底失去改变的内在动机时,医生无法穿越时空抹去过去的伤害,究竟该如何破局?加布里埃尔坚决地表示,她绝不会放弃任何一个病人。在处理这种深度心理阻碍时,她会借助顶尖导师的力量,例如她长期合作的脑力教练吉姆·奎克(Jim Kwik),由专业人士深入解构患者的心结。 加布里埃尔指出,医生必须清晰辨明“生理学的终点与心理学的起点”。她本人曾接受过长达两年的精神医学训练,对人类心智机制的迷恋正是她后来涉足军方医疗支持工作的起点。为了说明心理创伤对生理状态的隐秘侵蚀,她分享了一位饱受失眠折磨的女患者的真实病例: ```mermaid flowchart TD accTitle: 复杂失眠病例的排查与根因路径 accDescr: 展示从常规生理干预到最终发现潜意识创伤引起的夜间心率飙升的完整过程。 subgraph Physiology["常规生理与环境排查"] A["顽固性严重失眠"] --> B["睡眠呼吸暂停监测(结果阴性)"] B --> C["激素替代疗法(未见根本改善)"] C --> D["睡眠环境优化(遮光与作息调整)"] end subgraph DeepTrauma["潜意识创伤识别"] D --> E["每逢就寝即现心率异常飙升"] E --> F["深层记忆解构:曾遭受人身暴力侵害"] F --> G["创伤未决导致自主神经系统持续警觉"] end ``` 该患者几乎试遍了所有现代医学手段:接受专业睡眠监测排除了呼吸暂停综合征;即便使用了激素替代疗法、严格遵循了打造全黑卧室等顶尖睡眠专家的建议(正如安迪·加尔平博士 Andy Galpin 所提倡的策略),其睡眠障碍依然毫无起色。深入探究后才发现,患者曾经遭遇过人身侵犯,尽管她在显意识层面选择性遗忘了这段往事,但每当躺到床上关灯准备入睡时,身体的创伤记忆就会激活,导致心率猛烈飙升。加布里埃尔强调,这已经超越了单纯的营养或生理医学范畴,若想从根本上好转,患者必须直面并彻底拆解这段心理创伤。 - **现代医疗体制的弊病**:加布里埃尔批评当前医疗往往沦为单次 15 分钟或半小时的流水线交易,医生看一眼就换下一个病人。 - **重塑医患同盟**:她主张重拾 19 世纪传统医者的荣誉感,医生不应是冷漠的开药者,而应扮演患者身边的核心参谋与人生队友,唯有建立深度的真实连接,才能陪伴脆弱的个体走向身心完整。 ### [25:11](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=1511s) 动机的公式:痛苦临界点与超越自我的使命感 对话随后切入驱动改变的核心动能。史蒂芬观察到,许多人往往需要承受足够的恐惧、痛苦或拿到一份糟糕的体检报告,其行动的“为什么”(Why)才会被无限放大,从而爆发“去他的,我现在就必须做点什么”的决绝转变。加布里埃尔完全认同这一规律,但她同时警示,身体与精神的崩溃临界点是极其精准且可预测的,明智的做法是提前建立危机感走在崩溃前面,而非被动等待灾难降临。 在长年接诊全球顶尖精英与非凡成就者的过程中,加布里埃尔洞察到一个惊人的共通特质:那些真正做出非凡成就的人,其底层心理特征其实高度一致——他们绝非被狭隘的“利己主义”(self-service)所驱使,而是拥有极强烈的“利他服务意识”(other-service)。当她需要推动这些顶尖人物正视自身被长期忽视的脆弱与健康短板时,最有效的切入点从来不是自私的养生,而是明确告诉他们:“如果你想要真正扩大自身的影响力、延续个人传奇并改变这个世界,你就必须回头解决那些被你完全忽视的生理基石。” ### [27:31](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=1651s) 见证死亡的洗礼:从临终病房走向公众科普 当被问及为何看过数千名病人后依然保持着旺盛的执业热情时,加布里埃尔直言,除了丈夫和孩子,为他人服务是她生命中最大的快乐来源。她坦承自己天生就带着照顾他人的出厂设置,并且内心深处有一股坚定的信念——在照顾达妮卡(Danica)等各界精英患者时,她相信“没有人能比我把这件事做得更好,也没有人会比我付出更多的关切”。 然而,这种强烈的职业使命感是在极其沉重的死亡阴影中锻造出来的。加布里埃尔回忆起自己在专科培训(Fellowship)期间经历的漫长低谷: - **直面终末期的绝望**:2015 年前后,她每天在高强度轮转中需要照护多达 30 位重症患者,病房里充斥着大剂量的止痛药,几乎所有人都注定无法活着走出医院。 - **18 岁女孩的婚纱梦**:最令她心碎的是一位年仅 18 岁的囊性纤维化晚期女孩。现代医学对女孩的病情已回天乏术,女孩明知自己永远不可能有结婚的机会,却依然在生命的最后时刻认真挑选婚纱、筹备虚拟的婚礼,试图在想象中体验一段永无可能实现的人生。 走出临终病房后,加布里埃尔在 2015 年首次接触社交媒体,却震惊地发现网络上充斥着荒谬绝伦的养生谎言:从毫无根据的“排毒果汁”到倡导过度削减膳食蛋白质、进而摧毁人体骨骼肌健康的伪科学饮食。接受过长达 17 年严苛医学专业教育的她感到出离愤怒与沉重责任感:“生死终点无可避免,而决定生命质量的关键恰恰在起点与终点之间。如果明知真相却选择沉默,我就是在对这种混乱与伤害推波助澜。”正是这种不愿同流合污的责任感,促使她走上面向大众普及科学健康理念的道路。 在对话的最后,史蒂芬温和地追问这种毫无保留的倾注是否伴随着巨大代价。加布里埃尔坦言,从来没有人这样问过她,但答案是绝对的——哪怕在半夜十二点或凌晨一点,只要患者有生死攸关的需求,她依然会毫不犹豫地冲在前面。这份深刻的关怀,确实让她自己和她的家庭付出了沉重的代价。 ### [31:49](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=1909s) 从临终关怀到功能医学:二十年医者心智的容量沉淀 主持人 Steven 提出一个深刻的疑问:每天面对他人的痛苦、疾病、困境甚至死亡,医者在心理与情感上究竟要付出多大的代价?如果自己每天深陷于他人的困境中,一旦倾注心血后却迎来糟糕的结局,很容易陷入“我究竟还能做什么”的自责与内耗,这种职业消耗该如何建立心理防御策略? Gabrielle 坦言,与过去从事姑息与临终关怀不同,如今她诊所面对的病患基本不再处于生死攸关的紧要关头。日常处理的病症往往是环境或慢性健康问题:比如居住在有毒霉菌(toxic mold)环境下、患有莱姆病(Lyme disease)、在华盛顿州感染了 COVID-19 需要调配抗病毒药物 Paxlovid、严重的感情受挫,或是甲状腺功能失调。尽管偶尔仍需将急性患者送往医院急诊,但整体工作早已转向积极改善健康与功能表现。她强调,经过长达 20 年的临床行医历练,这种情绪与心理的“承载容量”(capacity)早已在日积月累中被构建得格外坚韧。 - **行医重心的转变**:从早期的生命末期照护(end-of-life care)转向以预防、恢复与优化机能为主的临床实践。 - **常见诊治范畴**:包括霉菌毒素、莱姆病等隐匿感染,病毒性疾病的远程医疗干预,内分泌异常,以及心理应激伴随的身心失调。 --- ### [33:41](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=2021s) 困住你的心智病毒:外在比较与海豹突击队的淘汰启示 Steven 将能够重塑认知的好思想比作“思维疫苗”,能清除潜伏在人脑中、限制生命潜能的“心智病毒”。他借此询问 Gabrielle,在她的长期观察中,究竟是哪些神话与认知陷阱阻碍了人们成为最佳版本的自己?Gabrielle 直言,必须从生理学(physiology)和心理学(psychology)的双重视角来看待这个问题。在身体与外在层面,最具毁灭性的心智病毒就是**“无休止的外在比较”**。 这种比较通常深植于对“青春永驻”的虚妄执念中。许多人随着三四十岁的心智成熟会逐渐放下,但若无法释怀,就会陷入对确定性外表的病态控制。Gabrielle 援引了丈夫常讲的美国海军海豹突击队(Navy SEALs)选拔特训案例:在残酷的选拔中,最先被淘汰出局的往往不是身体条件平庸的人,反而是那些在体能和运动技巧上极其拔尖的传统运动员。原因在于,这些顶尖运动员习惯了“确定性”——扔球、奔跑、按既定规则发力,他们从未在精神上为不可预知的精神折磨与心智韧性(mental fortitude)做好准备。 ```mermaid flowchart TD accTitle: 比较陷阱与心智衰退模型 accDescr: 对比以外在为导向的追求与以心智机能为导向的成长路径 subgraph External["外在聚焦(死胡同)"] A["外在比较与容貌焦虑"] --> B["追求确定性与即时满足"] B --> C["面对不可逆衰老失控"] C --> D["陷入精神崩塌与虚无"] end subgraph Readiness["内在机能(长寿路径)"] E["关注身体备战与技能获取"] --> F["锤炼精神韧性与承受力"] F --> G["骨骼肌与机能持续增益"] G --> H["从容应对衰老与生命挑战"] end ``` 如果一个人所有的注意力都投注在“看起来是否火辣”、“是否练出某种身材”、做多少次医美整形、消除了多少皱纹上,他实际上在参与一场注定满盘皆输的游戏。时间是冷酷的法则,衰老是必然的物理事实。当 31 岁的 Steven 被 Gabrielle 打趣“年纪也不小了”时,她严肃地指出:一个完全被外在定义的人,随着年岁渐长到 50 岁、80 岁,面临外表不可逆的下行衰退,必定会陷入巨大的心理崩塌与空虚,因为“你如何管理心理,就决定了你如何管理生理”。 --- ### [37:34](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=2254s) 转向“身体备战状态”:为什么骨骼肌是长寿器官 既然不能把外在容貌和他人评价作为锚点,我们究竟应该用什么尺度来衡量自己的健康成果?Gabrielle 给出的答案是**“身体备战状态”(Physical Readiness)**与真实机能表现(Performance)。 在她看来,身体维度的核心目标应当是“技能的习得与力量的获取”,而非镜子里的虚荣投影。她明确指出:“骨骼肌是长寿的核心器官”(skeletal muscle is the organ of longevity)。锻炼的真正意图不是为了在沙滩上展示腹肌,而是为了生命而训练——拥有能够随时奔跑、深蹲、卧推,并在生活中承担战术性、实际身体需求的能力。 面对 Steven 提出的现实反驳——现代人往往被即时奖赏所支配(比如下班后做个美发吹风、做个脸,能在办公室吸引潜在伴侣的目光,远比举铁来得立竿见影),Gabrielle 用时间的稀缺性给出了反击: 1. **时间的不可逆**:人的生命时间极其有限,如何分配时间直接决定了最终所能企及的生命厚度与全局力量(Global Strength)。 2. **弥留之际的真相**:在长年陪伴临终患者的经历中,她听过无数关于生命的遗憾与悔恨,但“从未有任何一个人在生命终点时遗憾自己当初少做了一次头发造型”。 3. **抵御即时多巴胺**:消费主义与快节奏社会不断诱导人们去争夺眼前的蛋糕与豪车(Gabrielle 顺势调侃丈夫想买路虎卫士(Defender)被她无情拒绝),但唯有从长者与智者的回望中,人才能看清什么才是不可替代的终身资产。 --- ### [41:12](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=2472s) 没有强大的内心,就没有强健的肉体:给“短视者”的警钟 Steven 分享了一个身边近 40 岁朋友的真实切片:这位朋友极度渴望找到伴侣,把所有业余时间都砸在美黑喷雾(spray tan)和沙龙做头发上,却对健身房避之不及,缺乏最基础的身体训练。面对这种将表象当做终极武器的行为模式,究竟该如何破局? Gabrielle 斩钉截铁地表示:“如果你的内心是孱弱的,你绝不可能拥有一具真正强健的身体”("You cannot have a strong physical body if you are mentally weak")。过度依赖外表粉饰,本质上是由于精神软弱而逃入即时分心的避难所,而这种对分心生活的妥协,最终会毫不留情地剥夺一个人的未来。 当 Steven 追问她究竟如何定义所谓“强健的身体”时,Gabrielle 剥离了所有关于体脂率和维度的浮夸标准,给出了极为清晰、扎实的基础生理机能指标: - **引体向上**:能否在自重状态下完成至少一次标准的引体向上? - **俯卧撑门槛**:作为基础推力表现,能否至少完成 10 个标准的俯卧撑? - **有氧耐力基线**:当面临突发需求或测试时,能否毫不费力、高质量地完成 1 英里(约 1.6 公里)的持续奔跑? 身体能力的建立没有任何捷径可走,它不仅考验肌纤维的做功,更是一场对抗懈怠、逃避与虚荣的心智磨炼。 ### [42:23](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=2543s) 身体自主权与全社会的虚弱危机 Gabrielle Lyon 博士深入探讨了拥有“身体自主权”(physical sovereignty)的核心意义——即有能力完全掌控自己的身体,保持强壮,在日常生活中无需依赖他人的协助。虽然普通人不可能单凭肉身去抬起一辆汽车或沉重的大床,但这种独立掌控身体的能力对于当前日益老龄化的社会而言至关重要。 她直言不讳地指出,当今社会正变得愈发虚弱。不仅绝大多数成年人正在滑向肥胖,儿童群体的肥胖率也在持续攀升。从纯粹的身体机能角度来看,现代人根本没有达到他们本应拥有的强壮程度。因此,每个人都必须为自己的身体素质设定明确且可量化的问责目标,无论是深蹲、硬拉还是跑步。 ```mermaid flowchart TD accTitle: 现代社会的体能恶性循环 accDescr: 展示缺乏身体问责导致社会虚弱与疾病风险上升的过程 A["缺乏身体自主权与体能目标"] --> B["肌肉量下降与体脂攀升"] B --> C["社会整体走向肥胖与虚弱"] C --> D["老龄化人口丧失独立自理能力"] D --> E["全因死亡风险与代谢疾病剧增"] ``` --- ### [43:53](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=2633s) 每周 3 天抗阻训练:超越官方底线标准的增肌法宝 当主持人 Steven Bartlett 询问不同年龄段(如 30、40 岁与 50、60 岁)具体应当设定怎样的体能目标时,Gabrielle 强调,有一条核心底线是跨越所有年龄段通用的:**每周至少进行 3 天力量与抗阻训练(Resistance Training)**。她打趣地提到上一期做客节目的 Mike Israetel 博士——身材练得极其魁梧健壮,"甚至能单手拎起 Steven,用小拇指挑起 Gabrielle"。 面对 Steven 关于官方活动指南的追问(目前公共健康推荐标准通常为每周 150 分钟中高强度运动加上 2 天抗阻训练),Gabrielle 犀利地反驳道:2 天的训练量或许勉强能保住日常行走的能力,但绝对不足以让身体进化并抵御衰老的侵蚀。人们必须对自己提出更高的标准,在理想状态下应当保证每周 3 至 4 天的抗阻锻炼。 - **抗阻训练的定义**:克服某种阻力移动身体或负荷的动作,包括使用杠铃哑铃做深蹲、卧推,或者使用自重与弹力带。 - **肌肥大训练目标**:以增肌(Hypertrophy)为导向,建议每个肌群每周累计完成 **10 到 20 个正式组(sets)**。 - **训练动作拆分**:可以采用上下肢分化(Upper/Lower Split)、推拉分化(Push/Pull)或全身复合动作(如深蹲、硬拉)。Gabrielle 强调,即便是像她身在厄瓜多尔的父亲那样,在 FaceTime 通话前用弹力带做二头弯举,也完全是值得鼓励的有效抗阻运动。 --- ### [46:46](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=2806s) 肌肉是“长寿器官”与抵御死亡的身体铠甲 针对“为什么要坚持每周练 3 天”的疑问,Gabrielle 坚定地表示:"你这一生绝不会后悔让自己变得更强壮。" 骨骼肌不仅仅关乎穿泳装时身材好看与否,它本质上是一个至关重要的“长寿器官”(organ of longevity)。从代谢角度看,骨骼肌是人体进行葡萄糖代谢与脂肪酸氧化的核心场所,充当着整个身体的“葡萄糖水槽”(glucose sink);只要你想摄入碳水化合物并且在乎代谢健康,就必须维持充足的肌肉。 更令人震惊的是力量水平与生存率之间的直接关联: - **致命的肌力差距**:研究数据显示,力量处于人群中后三分之一(Lower 1/3)的个体,其面临的**全因死亡风险(All-Cause Mortality)比前三分之一的人高出约 50%**。换言之,虚弱的肌肉力量会直接大幅增加因几乎任何原因致死的几率。 - **身体铠甲(Body Armor)**:强大的肌肉群不仅维持代谢,更是在跌倒、外伤和重大疾病面前保护生命的坚韧盾牌。 --- ### [48:14](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=2894s) 破除衰老神话:我们注定会变成父母那副虚弱模样吗? 当 Steven 扮演 58 岁的中年人提出质疑——认为上了年纪必然会发福、流失肌肉、变得衰弱,这不过是“不可抗拒的自然规律”时,Gabrielle 首先幽默祝贺对方活到了 58 岁,随后斩钉截铁地予以驳斥:科学文献完全不支持这种宿命论,**任何人在任何年龄阶段都具备增强力量和增加肌肉的能力**。 Steven 坦言,大众之所以陷入这种误区,是因为我们一代代看着父母老去,将其视为了设定预期的参照物。当看到父亲们随着年纪增长挺起啤酒肚、步履蹒跚、稍微走两步就气喘吁吁时,人们便默认这是基因带来的必然宿命。 Gabrielle 解释道,人类是一种奇怪的生物,倾向于将“不断重复听到和看到的事物误认为真理”。过去,传统观念往往把抗阻力量训练局限在“健身房肌肉男(Gym Bros)”的狭隘圈子里,错误地将骨骼肌健康与大众整体健康及长寿剥离了开来。作为一名兼具 7 年营养科学研究背景的资深老年病学专家(Geriatrician),Gabrielle 给出结论:纵观生命全局,肌肉越少、身体越虚弱,过早死亡的几率就呈断崖式上升。 --- ### [51:30](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=3090s) 力量训练 vs 有氧运动:为什么跑步机无法拯救萎缩的快肌纤维 当被问及“就抗老而言,肌肉量是否比心血管有氧运动更重要”这一尖锐问题时,Gabrielle 坦言两者皆不可或缺,但明确指出:**心血管有氧训练绝无法替代抗阻训练与肌肉量**。 随着年龄增长,缺乏锻炼的老年人群体不仅肌肉量锐减,陷入肌少症(Sarcopenia),其肌纤维类型还会发生不可逆的退化转变: 1. **快肌纤维(Type II)的萎缩流失**:快肌纤维是负责力量、爆发力和肌肥大的较粗肌纤维。随着衰老,若没有抗阻力量训练的持续刺激与“滋养”,快肌纤维会逐渐退化萎缩,并向慢肌纤维(Type I)转变。 2. **单纯有氧的局限性**:慢跑等纯心血管有氧运动无法为 Type II 快肌纤维提供足够的超负荷刺激,因而无法阻止这类粗壮肌纤维的萎缩流失。 3. **代谢崩溃的链式反应**:随着关键骨骼肌的不可逆萎缩,人体清除葡萄糖和氧化脂肪酸的能力急剧下降,直接引发血糖激增、胰岛素抵抗,最终滑向 2 型糖尿病的深渊。 | 训练类型 | 对 Type II 快肌纤维的影响 | 代谢与控糖收益 | 能否单独抵抗肌少症 | |:--- |:--- |:--- |:--- | | **抗阻训练(每周 3-4 天)** | 提供高强度超负荷刺激,促进肥大与保留 | 强力扩充外周葡萄糖水槽,改善胰岛素敏感度 | **能**,是唯一的根本手段 | | **纯心血管有氧运动** | 无法提供有效张力刺激,无法逆转快肌纤维退化 | 增强心肺耐力与即时热量消耗,但水槽容量有限 | **否**,无法替代抗阻刺激 | ### [53:26](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=3206s) 骨骼肌的缓冲机制与“健康久坐者”的伪命题 骨骼肌在人体代谢中扮演着至关重要的“缓冲池”角色,负责缓冲摄入的各类食物。当摄入大量糖分与碳水化合物时,充沛且健康的肌肉组织能够迅速将葡萄糖以糖原形式储存起来;一旦缺乏足够的肌肉,多余的糖分便无处可去,只能涌入肝脏并转化为体脂。缺乏训练会导致骨骼肌发生“大理石纹样变性”,即肌脂肪浸润(Myosteatosis),代谢机能随之崩塌。即便有人辩称更多肌肉是否意味着可以更肆无忌惮地吃碳水而免受惩罚,答案虽基本偏向肯定,但前提必须是拥有通过训练保持代谢活性的健康肌肉。 加布里埃尔医生直截了当地指出,文献中常出现的“健康久坐者”(healthy sedentary person)完全是一个伪命题,世界上根本不存在所谓的健康久坐人群。耶鲁大学曾开展过一项极具说服力的研究:研究人员选取了一批身材精瘦、体检指标看似完全正常的 18 岁大学新生,仅让他们经历一段时期的久坐不动,这群年轻人便迅速发展出骨骼肌胰岛素抵抗,而此时他们的体表甚至还没有出现任何肥胖或脂肪堆积的迹象。如果不保持活动,体内的肌糖原就无法更新代谢,各类代谢副产物不断堆积,肌肉质量会随时间持续恶化。抗阻训练是无法逃避的生存底线,这并不要求每个人都去挑战极限大重量(One Rep Max),即便是徒手自重训练、瑜伽或弹力带训练,也必须对肌肉组织施加实质性的负荷刺激。 ```mermaid flowchart TD accTitle: 碳水化合物在体内的代谢去向对比 accDescr: 对比健康活动肌肉与久坐缺乏肌肉时碳水化合物在人体内的不同代谢路径 subgraph Healthy["健康活动人群(拥有充足活性肌肉)"] A1["摄入碳水与糖分"] --> B1["骨骼肌高效摄取"] B1 --> C1["糖原快速更新与储备"] C1 --> D1["维持胰岛素敏感性与代谢健康"] end subgraph Sedentary["久坐不动人群(肌肉萎缩/脂肪浸润)"] A2["摄入碳水与糖分"] --> B2["骨骼肌无法有效缓冲"] B2 --> C2["代谢副产物堆积与肌脂肪浸润"] C2 --> D2["异位脂肪沉积(脂肪肝、内脏脂肪)"] D2 --> E2["引发骨骼肌胰岛素抵抗"] end ``` ### [55:33](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=3333s) 令人触目惊心的运动达标率与衰老中的“生活自理能力” 现代社会的运动达标现状严峻得令人震惊。当被问及目前有多少人能够达到推荐的运动指南时,加布里埃尔给出了极其灰暗的数据: - 全人群中仅有大约 **6% 至 8%** 的人能达到阻力训练指南的要求; - 超过 **50%** 的美国人完全没有任何形式的锻炼习惯; - 约有 **75%** 的人不符合有氧与抗阻相结合的综合运动建议,绝大多数人口彻底沦为久坐一族。 针对史蒂文提出的“虽然运动数据糟糕,但人类预期寿命不是一直在提升吗”的疑问,加布里埃尔犀利地反问:我们追求的究竟是单纯的寿命数字,还是生命质量?医学完全可以通过全天候卧床维持一个人的生命体征,但那绝非高质量的生活。"You cannot have a high-quality life without high-quality muscle."(没有高质量的肌肉,你绝不可能拥有高质量的生命)。人到晚年最核心的诉求是自主自理能力(Autonomy)。年轻人往往把充沛的体能视作理所当然,但这种身体机能是一项需要终身锤炼的技能,稍有松懈,人体就会滑向不可逆的衰老轨迹。加布里埃尔在现实中观察到,如今大量中老年人甚至连把随身行李箱举到飞机机舱行李架、或是把行李放到安检传送带上的力气都没有,这种机能衰退绝不应被视作衰老的“正常现象”。 ### [57:34](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=3454s) 厄瓜多尔父亲的启示与“肌肉寿命”的争夺战 并非所有人类群体都陷入了这种脆弱不堪的衰老模式。加布里埃尔分享了她 74 岁父亲在厄瓜多尔生活的真实案例:在父亲居住的社区里,凡是步行 3 小时以内能到的地方,老人们都会选择走过去。加布里埃尔开玩笑说自己甚至有点怕去探望父亲,因为那里的步行运动量实在太惊人。那些终身保持高频体力活动的族群展现出了惊人的健康状态,这印证了“肌肉寿命”(muscle span)的概念——即个体能够维持高品质骨骼肌功能的生理年限。 生活环境高度舒适化是导致肌肉退化的元凶。现代人随时可以选择乘手扶梯、坐电梯、打车代步,系统让每件事都变得轻而易举。然而,阻击肌肉衰退必须依靠主动而刻意的努力。每一次在“亲力亲为消耗体力”与“选择省力的捷径”之间妥协,就如同向银行里存入了一枚注定贬值成废纸的硬币,持续积累的结果便是身体机能无可挽回的崩塌。 ### [59:12](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=3552s) 减掉腹部脂肪的真相:从减脂执念转向肌肉重塑 面对许多人“医生我只想减掉小肚子变漂亮,该抽脂还是节食”的普遍迷思,加布里埃尔给出了专业诊疗的第一反应:首先必须评估骨骼肌质量。她绝不会立刻开出饮食清单,而是探究导致现状的战术性行为根源——是否存在情绪性进食、长期睡眠剥夺或饮酒过量。明确阻碍后,核心任务绝不是急于抽脂,而是通过饮食与训练启动身体成分重塑(Body Recomposition)。她调侃史蒂文如果真想抽脂,自己确实认识很棒的整形外科医生,但那对于长期健康毫无意义。 全社会目前陷入了一种对体脂率的病态痴迷,舆论焦点全部被减肥药和脂肪数字绑架。加布里埃尔呼吁将讨论的核心从“如何让人减少肥胖”彻底扭转为“如何让人建立健康的骨骼肌”。骨骼肌是人体葡萄糖处置(glucose disposal)的首要场所,肌肉量提升直接优化了代谢通路,减少多余糖分转化为腹部脂肪的概率。此外,她透露了一项尚未正式发表但前景极其震撼的前沿研究:部分同行科学家在观察性数据中发现,骨骼肌表面存在特定的受体通道,肌肉本身很可能具有直接调控机体食欲的生理反馈功能。 ### [01:01:47](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=3707s) 司美格鲁肽(Ozempic)与社会偏见的双重标准 谈及当下风靡全球的 Ozempic(司美格鲁肽)和 Mounjaro 等 GLP-1/GIP 减肥药物时,加布里埃尔认可它们在临床治疗中具有一席之地,这些药物已经成为不可逆转的医学现实,但她对大众舆论的“双标”态度提出了极为尖锐的伦理审视。在身体成分干预领域,给肥胖患者开具药物来消除脂肪在社会层面上被广泛接受且备受推崇;然而,如果医生建议使用睾酮(Testosterone)等同化类药物或其衍生物来帮助衰弱患者合成肌肉、改善肌少症,整个社会舆论却会视其为洪水猛兽,投以巨大的道德污名与偏见。 面对史蒂文提到此前节目嘉宾因滥用类固醇和雄激素导致情绪暴躁并产生极端阴暗想法的反例,加布里埃尔澄清指出,那是极少数处于竞技顶峰的职业健美运动员在超生理剂量下付出的“职业代价”,极限竞技层面的药物滥用绝不等于科学健康的机体调控。她主张彻底打破这种思维禁锢:医学界不应只将目光狭隘地局限在用药物“消减脂肪”上,如何合理利用科学手段提升患者的骨骼肌质量,同样应该成为被正视和讨论的治疗方案。 ### [01:04:37](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=3877s) Ozempic 与肌肉流失的真实机制 针对“Ozempic(司美格鲁肽)这类药物是否会导致肌肉流失”这一常见疑虑,Gabrielle Lyon 医生给出了明确的反驳。从药理机制来看,没有任何直接证据表明 Ozempic 会对骨骼肌造成负面破坏;相反,现有科学证据显示,这类药物甚至可能对骨骼肌健康起到支持作用。患者在使用此类药物期间出现肌肉萎缩的真正根源,在于食欲被压制后严重缺乏抗阻训练以及膳食蛋白质摄入不足。骨骼肌的刺激途径本质上只有两种:抗阻训练与充足的蛋白质,任何药物都无法弥补不良生活行为造成的赤字——“你无法靠药物来弥补糟糕的行为习惯(You cannot out-medicate poor behavior)”。 在 Lyon 医生的临床诊所中,这类药物被频繁使用,团队会严密追踪患者的身体成分(Body Composition)和肌肉量。数据表明,只要患者摄入足量的蛋白质并坚持规律力量训练,骨骼肌质量完全不会下降。此外,这类药物对特定心理状态的患者具有深远的解脱意义:许多人长达十年、二十年甚至三十年饱受身材焦虑和食物杂音(Food Noise)的折磨,这种心理内耗严重剥夺了他们专注于现实生活的能力。GLP-1 受体激动剂能够从生理层面遏制暴饮暴食的冲动,甚至在一定程度上削弱对酒精的渴望,从而为患者带来前所未有的“身体自由”。 ```mermaid flowchart TD accTitle: GLP-1药物与骨骼肌维护机制 accDescr: 展示GLP-1药物如何抑制食欲以及维持肌肉量的两个核心支柱 subgraph GLP1Effects["GLP-1 药物作用机制"] A["使用 GLP-1 激动剂 (如 Ozempic)"] --> B["延缓胃排空 & 产生饱腹感"] B --> C["消除暴食与食物杂音 (实现身体自由)"] B --> D["食欲急剧下降 (食物总摄入骤减)"] end subgraph MuscleOutcome["骨骼肌走向分歧"] D -->|错误行为: 蛋白质不足 + 缺乏训练| E["肌肉量明显流失 (不良行为后果)"] D -->|正确方案: 足量优质蛋白 + 抗阻训练| F["维持骨骼肌健康 (身体成分优化)"] end ``` - 骨骼肌的两大核心刺激来源:抗阻力量训练(Resistance Training)与足量膳食蛋白质。 - 药物的心理助益:切断针对体重和进食的病态心理执念,缓解暴饮暴食及酒精成瘾倾向。 --- ### [01:06:21](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=3981s) 停药反弹的隐患与潜在代价 当主持人 Steven Bartlett 追问“既然世上没有免费的午餐,Ozempic 的真正代价是什么”时,Lyon 医生首先打趣地指出 Steven 本人体格强健,根本不需要 Ozempic、Mounjaro(替尔泊肽)或 Zepbound。她预测,未来将这类药物与激素替代疗法(HRT)相结合,很可能成为长寿医学的重要路径。至于潜在代价,许多人担忧的胃排空减缓本身就是该药的预设药理作用,且该类药物在临床上已存在了十至二十年,并非毫无根据的新生事物。 在 Lyon 医生看来,真正的代价发生在“停药阶段”。随着药物逐步减量直至停用,正常的饥饿信号必然会全面回归。如果患者在用药期间没有建立起稳固的生活方式策略,极易陷入体重反弹的泥潭。然而在她的诊所中,停药患者并没有出现报复性反弹,原因在于团队执行了非常密集的生活方式干预,并深挖患者最初陷入肥胖与暴食的深层心理诱因。如果患者曾将暴饮暴食作为应对旧有创伤(Trauma)或情绪压力的代偿手段,就必须直面并解决这些心理根源,学会对自己的身体成分负责。 - 药物历史背景:GLP-1 类药物在临床上的应用已有 10 到 20 年的长期数据支持。 - 避免停药反弹的关键:在用药期间建立严谨的饮食训练习惯,并彻底解开导致情绪化进食的创伤性心理机制。 --- ### [01:09:28](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=4168s) 蛋白质基准与合成代谢抵抗 在探讨节食与减脂策略时,Lyon 医生强调任何优质营养方案的基石都必须建立在膳食蛋白质之上。令人费解的是,在当今社交媒体的放大效应下,蛋白质竟然演变成了争议最多的宏量营养素,各种舆论总在寻找借口试图将其从日常饮食中剔除。事实上,进食蛋白质本身也能刺激人体内源性 GLP-1 的释放,从而自然提升每餐之间的饱腹感,同时在碳水化合物受控时平稳维持血糖水平。 关于日常摄入量,Lyon 医生给出了明确标准:以每磅理想体重(Ideal Body Weight)摄入 0.7 至 1.0 克蛋白质为基准。以高营养密度的动物性食品为主者可贴近 0.7 克的下限,纯素食者则需摄入接近 1.0 克的上限。她严肃指出,目前官方推荐的每日摄入量(每公斤体重 0.8 克,或每磅体重 0.37 克)仅仅是“防止发生营养缺乏症的最低底线”,绝非优化健康的指标。随着年龄增长,人体骨骼肌会出现“合成代谢抵抗(Anabolic Resistance)”,肌肉利用氨基酸合成蛋白质的效率大幅衰减,中老年人对蛋白质的实际需求往往需要达到防缺乏最低标准的两倍之多。 | 指标类型 | 推荐数值(按体重计算) | 适用场景与机制说明 | |:--- |:--- |:--- | | **官方最低防缺乏推荐量** | 0.8 g/kg(约 0.37 g/lb) | 维持生存、防止蛋白质严重缺乏症的底线标准(如 115 磅体重仅需 45 克)。 | | **Lyon 医生推荐基准(动物蛋白为主)** | 0.7 g/lb 理想体重 | 适合摄入高营养密度动物蛋白的人群,饱腹感强且氨基酸利用率高。 | | **Lyon 医生推荐基准(植物蛋白为主)** | 1.0 g/lb 理想体重 | 适合不吃动物产品的素食人群,弥补植物蛋白生物利用度与亮氨酸含量的不足。 | | **中老年人群实际需求** | 达到官方最低推荐量的 2 倍 | 克服衰老导致的骨骼肌合成代谢抵抗(Anabolic Resistance)。 | --- ### [01:12:18](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=4338s) 年轻男性增肌困境与睾酮断崖 对话转向肌肉增长的难易程度。Steven Bartlett 分享了自身的经历:他在 25 至 27 岁之前增肌感觉并不容易,后来才意识到是热量摄入不足,纠正后身体便展现出极强的合成代谢能力。随后 Steven 提到他身边有两位年仅 27 岁和 29 岁的朋友,无论如何努力锻炼都无法增加肌肉。当被问及原因时,Lyon 医生坦言,除了常规的饮食热量、蛋白质和睡眠等问题外,她在临床实践中观察到了一个惊人的趋势:年轻男性群体中低睾酮水平(Low Testosterone)的发生率正在急剧攀升。 睾酮水平低下直接导致身体处于低合成代谢状态,丧失了高效构建肌肉组织的能力。当 Steven 试探性地询问是否能仅凭肉眼观察就判断一个人是否存在睾酮低下时,Lyon 医生给出了几个潜在的体貌线索: - 下肢体毛稀疏减少(如腿毛明显偏少)。 - 基础骨骼肌量异常偏低。 - 体态呈现雌激素相对偏高的特征(如脂肪在特定部位堆积、缺乏阳刚轮廓)。 这一临床画像让 Steven 颇为吃惊,坦言其朋友的真实身体状态与这些特征完全吻合。年轻一代雄性激素断崖式的下滑,正在成为阻碍年轻人增肌与代谢健康的隐形杀手。 ### [01:14:52](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=4492s) 无需注射:如何通过生活方式与排毒提升睾酮水平 当被问及男性是否有办法在不接受针剂注射(如睾酮替代疗法 TRT)的情况下刺激自体睾酮分泌时,加布里埃尔·里昂博士给出了十分笃定的肯定答复。她指出,首要且核心的干预手段永远是审视基础生活方式:个体的饮食营养是否均衡充足?是否存在严重睡眠剥夺?是否摄入了可能扰乱内分泌的消遣性药物?此外,训练本身虽然不一定直接大幅凭空制造睾酮分子,但抗阻力量训练能显著增加骨骼肌细胞上的雄激素受体(Androgen Receptors)数量与敏感度,让循环中的雄激素发挥实质生理作用。 另一个常被常规医学忽略、偏向“跳出框框思考”的隐藏推手是环境毒素暴露。里昂博士在临床上开展大量的重金属筛查,频繁发现铅(Lead)和汞(Mercury)等重金属超标,这些毒素对男女性的生育力与激素分泌具有显著的抑制破坏作用。重金属摄入的常见途径包括易拉罐容器、重金属富集的大型海鲜鱼类;对于部分特殊人群(如军警或射击爱好者),在靶场进行武器训练时产生的铅暴露也是常见原因。 ```mermaid flowchart TD accTitle: 睾酮与代谢调节生活方式机制 accDescr: 展示提升体内睾酮受体及分泌的生活方式与环境排毒路径 subgraph Lifestyle ["基础生活方式管理"] A["充足高质量睡眠"] B["高蛋白与未加工营养饮食"] C["抗阻力量训练"] end subgraph Environment ["环境毒素排查与干预"] D["筛查重金属(铅、汞)"] E["减少易拉罐/高汞海鲜/铅尘接触"] end subgraph Outcomes ["内分泌及生理收益"] F["提升骨骼肌雄激素受体密度"] G["恢复自体激素平衡与生育力"] end Lifestyle --> Outcomes Environment --> Outcomes ``` - **雄激素受体调节**:抗阻力量训练的核心价值之一在于上调骨骼肌的雄激素受体密度,增强机体利用现有激素的能力。 - **环境毒性来源**:日常接触易拉罐、富集汞的海鲜,或是实弹射击武器训练释放的铅尘,均会直接毒害内分泌与生殖系统。 --- ### [01:16:23](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=4583s) 里昂博士的日常作息:空腹重训、育儿融入与高能量消耗 谈及自身保持极佳体态的秘诀,里昂博士毫无保留地分享了自己的完整一日作息。她通常在清晨 5:30 至 6:00 之间起床(她打趣道自己的丈夫更极端,凌晨 4:00 就会起来)。起床后,她会查看 3 岁和 5 岁的两个孩子是否醒着,随后准备训练。每周有三天(周一、周三、周五),她会前往教练卡洛斯·马纳(Carlos Mana)那里进行高强度的硬核器械举重训练,时长约为 1 小时。由于早晨两个孩子经常会临时起意决定是否要陪妈妈一起去,她自嘲每次去训练都会迟到 5 分钟。她坚定地将孩子融入到自己的运动生活中:5 岁的孩子已经开始练巴西柔术,家里还备有专门的儿童壶铃,“因为孩子和大众一样,从不在乎你怎么说,只在乎你怎么做”。 里昂博士习惯空腹训练,并且极度依赖咖啡因。在非力量训练日(周二、周四),她会根据身心状态安排约 20 分钟轻度到中高强度的有氧运动。而在日常生活中,她自称是一个“永远无法坐定的人”,朋友们常调侃她每时每刻都在动。她不仅在打电话时全程走动,甚至常常身穿负重背心办公,维持着极高的全天非运动性身体活动(NEAT)与日常能量消耗。 --- ### [01:18:37](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=4717s) 高蛋白摄入原则与严格滴酒不沾的饮食自律 里昂博士的日常饮食极为清晰、高效且极具一致性。她的体重约为 110 磅(约 50 公斤),全天蛋白质摄入量稳定维持在 120 克左右: * **第一餐(训练后/早晨)**:通常是一份含有 30 至 50 克乳清蛋白的蛋白粉奶昔。早晨喝咖啡时她有时会加入胶原蛋白肽,但她特别严谨地澄清,胶原蛋白是不完全蛋白质,蛋白质评分(Protein Score)为零,无法有效刺激肌肉合成,仅用于维持毛发、皮肤与指甲的健康。 * **第二餐(午间)**:多为瘦牛肉(Lean Beef),搭配优质碳水化合物(白米饭或土豆)以及大量绿叶蔬菜。 * **第三餐(晚间约 19:00)**:与家人一同进食,摄入 30 至 50 克蛋白质以及接近 50 克的优质碳水化合物。 在谈到生活习惯时,她强调自己滴酒不沾,且天生没有任何甜食瘾。当主持人好奇追问她是否曾喝过酒时,里昂博士坦言自己这辈子从未喝过酒,因为觉得酒精的味道极度难喝,“尝起来就像医用外用酒精一样”。尽管从医学角度看酒精具有明确的神经大脑毒性,但她不饮酒的最直接理由就是发自内心厌恶其口感。她深信“每一次进食,都是一次改善身体健康的宝贵契机”,食物对于她而言从不复杂,而是实现身体功能最直接高效的工具。 --- ### [01:21:30](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=4890s) 碎片化增肌法:负重徒步、打破久坐惯性与家庭趣味运动 针对大众普遍抱怨“没有时间去健身房”的借口,里昂博士指出,普通人完全可以将微型阻力训练无缝融入日常琐碎活动中。她力推负重徒步(Rucking)或在打工作电话时穿上负重背心行走。这种方式起步门槛极低,初学者可以从 5 磅或 7 磅的超轻背心起步,随着适应程度逐步加码到 20 磅以上。她反问大家:“打电话为什么一定要开静止不动的 Zoom 视频会议?完全可以戴上耳机,边走动边沟通。” 里昂博士剖析了人类行为的惰性机制:人体天生倾向于坐下休息,久坐不动会逐渐固化为一种机械性的条件反射,久坐越久,改变现状所需的心理与生理阻力(Friction)就越大。要想破局,就必须人为降低阻力,将运动游戏化: - 接送孩子放学后,拒绝立刻陷入电子游戏,而是全家开展俯卧撑挑战赛。 - 播放碧昂丝(Beyoncé)的热门乡村金曲《Texas Hold 'Em》,全家一起跟着节奏跳排舞(Line dance)。 - 拿起 Nerf 玩具枪在后院奔跑追逐,或是举办客厅即兴舞蹈派对。 只要跳出“运动必须穿上装备去健身房苦练一小时”的思维限制,生活中处处都是维持高能代谢的训练场。 --- ### [01:23:40](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=5020s) 摒弃目标思维:为什么长久健康依赖的是“底线标准”而非“阶段目标” 针对如何树立长期健康导向的问题,主持人反思自己过往经常设立一些与特定截止日期挂钩的虚荣指标(Superficial goals)。对此,里昂博士提出了一个深刻的认知重构:“我认为我们根本不该设定目标(Goals),我们应该设定标准(Standards)。” 目标的本质是二元的,人们要么达成,要么失败;达成后往往陷入松懈或方向迷失,未达成则容易自暴自弃。但“标准”关乎自我身份认同与不可妥协的日常底线: - **目标 vs. 标准**:标准永远不会因为外部环境波动而动摇,只要守住行为底线,达成各类生理与体态目标只是水到渠成的副产品。 - **标准的实践**:例如里昂博士为自己确立的标准就是“早起并保持每天运动”,且每周保质保量执行 3 天极高强度的力量训练。标准定义了生活方式的下限,确保个体绝不偏离健康轨道。 ### [01:24:26](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=5066s) 个人标准与妥协:自律的营养训练与睡眠困境 加布里埃尔·里昂博士(Dr Gabrielle Lyon)详细拆解了自己的每周安排:周六可能会进行第四天的抗阻力量训练,而周日全家则会参与团体健身运动。她强调,自己依靠的不是飘忽不定的“目标”,而是坚定不移的“标准”。无论日常出差还是旅行下榻酒店,在踏入房间之前,她就已经明确了当天的活动安排与底线,因此绝不会存在“今天能不能达标”的犹豫。在饮食营养方面,她的标准同样严苛而精准:每天保证摄入 110 至 120 克优质蛋白质,以及 110 至 120 克碳水化合物,日复一日从不偏离这一基准。 然而,当主持人斯蒂芬·巴特利特(Steven Bartlett)问及她是否在某些方面也难以践行自己的医嘱时,里昂博士坦白承认自己最大的短板在于睡眠。面对分别只有三岁和五岁的两个年幼孩子,她每天都必须做出取舍:是下班后全心全意、不受打扰地陪伴孩子,还是继续处理繁重的工作?她的选择是把黄金时间全部留给家庭,直到孩子们彻底入睡后,自己再熬夜工作两到三个小时。尽管她心里明白应该更科学地统筹安排、学着相信“事情终究会做完”,但高标准的工作与为人母的责任让她不得不牺牲掉一部分睡眠。 - **营养摄入标准**:每日稳定维持在 110–120 克蛋白质与 110–120 克碳水化合物,形成不可妥协的进食纪律。 - **作息矛盾**:高质量陪伴 3 岁与 5 岁幼儿导致工作顺延,孩子睡后仍需高强度工作 2 至 3 小时,成为睡眠不足的主要诱因。 --- ### [01:25:46](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=5146s) 借口、纪律与有意义的后果:为什么我们总是在自欺欺人 针对很多人常说的“女性无法兼顾一切”,里昂博士给出了坚定的肯定回答:“你能做到,只是需要付出代价并直面真相。”许多人之所以停滞不前,本质上是在用各种内部选择构建借口。里昂博士坦言,自己的家庭生活同样充斥着混乱,“如果你来我家看看,我保证你至少五年内不敢生孩子”,生活永远不可能像精心编排的样板间那样完美,自己也没有任何超能力,唯一的差异就在于极高水平的“自律”。当斯蒂芬探讨大众该如何获取这种自律时,她一针见血地指出:自律不需要过度思考,核心在于直接执行——不要纠结,明确你到底想要什么,并诚实面对自己正在哪一方面掉链子。 许多人习惯用“那又怎么说”(Whataboutism)的受害者心态来逃避个人责任。里昂博士现身说法:她一边抚养两个孩子,一边打理三家不同业务的企业,照顾临床患者,主持个人播客,同时还在撰写两部新书,且没有全职保姆协助。如果一件事情真正重要,人就会想尽办法把它做成。为了说明为什么大多数人缺乏动力,她举了一个极端的假设例子:如果对一个极度嗜甜的人说“只要你再吃一个纸杯蛋糕,你的爱犬就会遭遇灭顶之灾”,那个人绝对连看都不会再看甜食一眼。这证明了人类的行为取决于“后果是否足够沉重且有意义”。正因为她作为医生看透了衰老、疾病与死亡的残酷结局,明白无人可以幸免,所以行动的纪律对她而言才变得清晰且毫不动摇。 ```mermaid flowchart TD accTitle: 动机与纪律的心理机制 accDescr: 展示从感知模糊后果转变为明确严峻后果如何消除借口并驱动执行力。 subgraph Mindset["借口模式 (低动机)"] A["设定模糊目标"] --> B["过度思考与拖延"] B --> C["借口频出: '我没有时间'"] C --> D["后果遥远/无痛感"] end subgraph Discipline["纪律执行模式 (里昂博士准则)"] E["看清不可逆后果<br/>(衰老/疾病/死亡)"] --> F["建立不可妥协的底线标准"] F --> G["果断执行,停止内耗"] G --> H["实现长远健康结果"] end D -.->|重构认知: 赋予有意义的后果| E ``` --- ### [01:30:05](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=5405s) 三十年后的双轨人生:“久坐的斯蒂芬”与阿尔茨海默病阴影 面对斯蒂芬提出的假设——如果一名 30 岁的年轻人从现在起连续 30 年久坐不动、大吃超加工食品且零抗阻训练,到 60 岁时会变成什么模样?里昂博士给出了令人震惊的临床预警:衰退并不是在 60 岁突发的,而是在 30 岁这一刻就已经悄然启动。阿尔茨海默病和心血管疾病的病理进程,在年轻久坐期就已埋下祸根。骨骼肌是人体内唯一可以直接通过意识自主控制的器官系统;人们无法凭意念让心脏从容跳动在每分钟 45 次,但却能完全支配自己的肌肉。如果放弃锻炼这唯一的内分泌代谢器官,大脑的退化便不可逆转。 里昂博士与脑健康专家路易莎·尼古拉(Louisa Nicola)合作撰写的叙述性文献综述表明,肌肉收缩具有强大的内分泌调节功能,抗阻训练不仅能极大增加脑部血流量,还能维持神经突触连接的坚韧度。绝大多数痴呆症都属于阿尔茨海默病痴呆,而这在代谢层面上被广泛称为“大脑的 3 型糖尿病”。久坐不动直接导致骨骼肌胰岛素抵抗,并迅速蔓延为大脑胰岛素抵抗,世界上根本不存在“既久坐又健康”的特例。 到了 60 岁,这位“久坐的斯蒂芬”不仅认知受损——可能连邻居甚至自己孩子的名字都开始遗忘,丧失宝贵的记忆——其心肺容量也将极度萎缩。日常的简单生理动作将变成巨大折磨:爬几步楼梯便气喘吁吁,甚至连在椅子上连续站起和坐下都会出现运动功能受阻;让他去车里提一袋 15 磅(约 6.8 公斤)的杂货,他都会因力竭而退缩。伴随严重的向心性肥胖(腹部脂肪堆积)与阻塞性睡眠呼吸暂停,大脑和全身代谢将陷入无法逆转的恶性循环。 - **自主控制器官的唯一性**:骨骼肌是人类全身唯一能通过主动意识支配收缩的内分泌器官,直接掌控葡萄糖代谢与肌因子释放。 - **脑健康与 3 型糖尿病**:肌肉退化导致肌肉胰岛素抵抗与脑胰岛素抵抗并行,构成阿尔茨海默病病理恶化的核心动力。 - **60 岁功能性残疾表现**:极度缺乏肌肉力量与心肺耐力,无法轻松提起 15 磅重物,深蹲起立困难,伴随严重向心性肥胖及睡眠呼吸暂停综合征。 ### [01:34:34](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=5674s) 肌肉量、代谢健康与生育能力的隐秘关联 加布丽埃勒·里昂医生(Dr. Gabrielle Lyon)直言不讳地指出,如果一个人一辈子都不进行抗阻训练,睾酮水平很可能处于低位,甚至整个生命周期中的生育能力都会受到严重波及,因为精子质量若缺乏科学训练和优质饮食的支撑,根本无法达到应有的状态。面对史蒂夫·巴特利特(Steve Bartlett)关于“肌肉量与男女生育能力是否存在直接关联”的追问,里昂医生明确肯定了训练、代谢健康与生育力之间的深层纽带,并预言未来关于骨骼肌与生育力的医学文献将会呈井喷式涌现。 谈及多囊卵巢综合征(PCOS)与肌肉的关系时,里昂医生将其病理核心归结为胰岛素抵抗。骨骼肌约占人体总体重的40%,是清除血液葡萄糖的最主要组织。在常规状态下,胰腺分泌的多肽激素胰岛素负责将血糖转运进细胞;然而,当骨骼肌收缩运动时,这一葡萄糖摄取机制可以完全“非胰岛素依赖”(Insulin-independent)。PCOS成因复杂多元,但骨骼肌的胰岛素抵抗是其中的关键推手,因此通过科学管理肌肉量并改善骨骼肌胰岛素敏感度,在诸多临床案例中都能有效缓解甚至逆转PCOS的病症。 史蒂夫随即援引了一项哈佛大学的研究印证这一观点:在工作中经常搬运或举起重物的男性,其精子浓度高出46%,总精子计数高出44%。里昂医生对此表示完全吻合——力量训练直接关乎精子计数与整体活力。两人随即打趣起未来遵循这套方案的画面:倘若史蒂夫到了61岁依然坚持举铁,不仅依然拥有六块腹肌,更会成为一个“势不可挡的猛兽”(a beast)。 ```mermaid flowchart LR accTitle: 骨骼肌收缩与血糖调控及生殖代谢通路 accDescr: 展示肌肉运动如何绕过胰岛素抵抗改善代谢与生殖健康 subgraph Stimulus ["运动干预"] A["抗阻训练 / 肌肉收缩"] end subgraph Pathway ["生理与内分泌改善机制"] B["非胰岛素依赖型<br/>葡萄糖转运"] C["改善胰岛素敏感性<br/>与代谢综合征"] D["内分泌轴优化<br/>睾酮与激素平衡"] end subgraph Clinical ["健康收益与临床表现"] E["缓解 PCOS 症状<br/>改善女性排卵周期"] F["提升精子浓度与总数<br/>增强男性生育活力"] end A --> B B --> C A --> D C --> E D --> F ``` - **哈佛重物劳动研究数据**:日常工作中频繁举起重物的男性,其精子浓度较轻体力工作者高出46%,精子总数高出44%。 - **骨骼肌占体重比例**:约占人体总重的40%,是全身最大的血糖缓冲池与代谢引擎。 - **运动的非胰岛素依赖性**:肌肉在机械收缩状态下无需胰岛素介入即可直接消耗与转运血糖,能从根源上绕开胰岛素抵抗瓶颈。 --- ### [01:37:32](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=5852s) 74岁仍拥有年轻睾酮:里昂医生见过的最健康长者 当史蒂夫问及加布丽埃勒迄今为止见过的最健康高龄长者是谁时,里昂医生的回答出人意料却又充满自豪——正是她74岁的父亲。尽管老人家在肌肉块头上仍有提升空间,但其身体指标惊人:在完全没有接受任何外源性激素替代治疗(TRT)的前提下,他的血清睾酮水平稳定在800 ng/dL左右。 这位父亲十多年来始终严格践行女儿倡导的医学生活方式。里昂医生调侃道,摊上自己这么个当医生的女儿,对父亲而言“既是福气也是种折磨”,因为他必须日复一日接受严苛的健康训诫。十多年的坚持换来了极佳的身体回报:糖化血红蛋白(HbA1c)极其出色,空腹血糖与血脂指标全部达标,整个人在74岁的高龄依然强健如初、行动敏捷。里昂医生强调,这绝非个例,而是长期将肌肉作为健康基石所能带来的切实生命奇迹。 - **父亲的年龄与睾酮指标**:74岁高龄,在零外源激素补充的情况下睾酮达到约 800 ng/dL。 - **代谢与临床指标表现**:空腹血糖、糖化血红蛋白(HbA1c)以及血脂水平全面处于理想参考区间。 --- ### [01:38:19](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=5899s) 肌肉是长寿器官,更是留给下一代的生命榜样 在总结健康哲学的本质时,里昂医生发出了振聋发聩的警示:“没有人能活着离开这个世界,一切最终都取决于我们的抉择。”当下每一项微小的执行选择,都在直接塑造我们未来的生命质量。她再次强调,肌肉不仅负责移动骨骼,它本质上就是人体的“长寿器官”(the organ of longevity),强韧的物理肉身更是铸就强大心智的基础框架。 更深层次的意义在于家庭与下一代。里昂医生表达了对年轻一代身心状况的深切忧虑:现代社会将“超大号”(supersizing)彻底正常化,不仅食物份量无限膨胀,肥胖率攀升,各种电子产品更让人与人之间的真实连接荡然无存。虽然互联网口口声声说在连接世界,但唯有面对面的真实交流才具有无可替代的情感重量。 成年人若无法对自己身体的健康负起责任,便无法为后代树立榜样。里昂医生动情地指出,保护健康不单是为了个体眼前的私利,更是为了那些年幼的孩子,“我们的责任不是空口说教,而是用自己的行动为他们蹚出一条向前的明路。” --- ### [01:39:57](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=5997s) 肌肉流失有多快?卧床、重症与“肌肉记忆”的真相 谈及其著作《坚不可摧》(*Forever Strong*)中关于营养与代谢的精髓,里昂医生重申了碳水化合物与运动的对应关系:“碳水化合物是靠身体活动‘赚’来的。”对于代谢不健康或存在代谢综合征的群体,饮食应从严格控制碳水开始(例如起步控制在100克以内),再根据日常运动消耗与身体耐受度逐步调配。 随后话题转向肌肉流失的惊人速度。史蒂夫好奇如果自己刚在健身房苦练完二头肌,这些成果究竟能维持多久。里昂医生的回答令人触目惊心: - **ICU 重症监护状态**:人体每天可能以惊人的速度流失高达2%的肌肉量。 - **年轻健康人群卧床7天**:在高度分解代谢与完全卧床的极端状态下,仅需短短一周即可纯流失2磅(约0.9公斤)的骨骼肌质量。 - **衰减顺序**:停止锻炼后,身体会首先丧失神经募集带来的“力量”,继而快速流失“肌纤维体积与质量”。 关于健身界常谈的“肌肉记忆”(Muscle Memory),里昂医生证实了其科学性:受过良好力量训练的人,即便因停训而萎缩,复训后肌肉与力量恢复的速度确实远快于初学者。然而,这也极大程度取决于停训时长与机体的分解代谢状态。例如癌症等高度分解消耗性疾病会急剧侵蚀人体组织,充沛的肌肉储备此时就成了对抗死亡率的“装甲”。她特别警告,对于刚刚出院或大病卧床康复的人而言,仅靠散步买菜等日常基本活动(Activities of Daily Living)绝对无法夺回流失的肌肉,必须依赖系统化的抗阻康复训练。 --- ### [01:42:27](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=6147s) 骨骼肌的内分泌奇迹:肌动蛋白如何重塑大脑与情绪 史蒂夫分享了自己在长期久坐阶段的切身体会:在录制投资真人秀节目《龙穴》(*Dragon's Den*,模式类似于美国的《鲨鱼坦克》)时,他常常不得不每天连续枯坐10小时。每逢这类高久坐周期的生活,不仅身体沉重,运动动机与专注力也会急剧跌入恶性下行循环,越不动就越疲惫、越缺乏干劲。 里昂医生随即揭示了背后的神经内分泌机制:骨骼肌本质上是一个巨大的“内分泌器官”(Endocrine Organ)。当肌肉进行有意义的机械收缩时,会根据运动的强度与持续时间分泌大量的“肌动蛋白”(Myokines),包括白细胞介素-6(IL-6)、白细胞介素-15(IL-15)等。 ```mermaid flowchart TD accTitle: 骨骼肌收缩分泌肌动蛋白的多器官互作机制 accDescr: 展现肌动蛋白如何与大脑、肝脏、肾脏交互并调节情绪和炎症 subgraph SkeletalMuscle ["骨骼肌机械收缩 (抗阻/高强度训练)"] M["释放肌动蛋白 (Myokines)<br/>IL-6 / IL-15 等信号分子"] end subgraph SystemicCrossTalk ["多器官交互串扰 (Cross-Talk)"] M -->|"穿透血脑屏障"| B["大脑神经系统"] M -->|"代谢信号网络"| L["肝脏与肾脏代谢"] M -->|"全身免疫调控"| I["抗炎网络平衡"] end subgraph BrainBenefits ["中枢神经收益"] B --> B1["刺激神经发生 (Neurogenesis)"] B --> B2["改善情绪低落、提升驱动力与清醒度"] end subgraph MetabolicBenefits ["外周健康保护"] I --> I1["对抗慢性低度炎症"] L --> L2["优化代谢废物清除与底物分配"] end ``` 这些过去常被简单视作巨噬细胞和炎症细胞产物的细胞因子,在由肌肉收缩自主分泌时,扮演着与中枢神经系统对话的神经调节角色。肌动蛋白能够穿透中枢屏障直接作用于大脑,促进神经发生(Neurogenesis)、改善多巴胺与神经回路反馈、提振情绪并平抑系统性慢性炎症。长期久坐缺乏肌动蛋白刺激,正是史蒂夫感到情绪低迷、动力枯竭的生化根源。 针对史蒂夫“录制10小时极度疲惫且还要吃午饭”的诉苦,里昂医生毫不留情地给出了铁血处方:“不管你有多累,午休时你就该抓紧时间去训练!吃完饭或者饿着肚子也得先练!”只要维持最低限度的肌肉机械刺激,就能彻底阻断久坐带来的动力崩溃恶性循环。 ### [01:44:37](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=6277s) 拒绝做“时间的残留受益者”:为什么必须把锻炼排进日程 加布里埃尔·里昂医生(Dr. Gabrielle Lyon)与史蒂芬·巴特利特(Steven Bartlett)讨论了在高强度日程中保持训练的具体策略。里昂医生直言,即便只有十分钟吃口东西,也必须立刻投入锻炼,哪怕只是做俯卧撑或穿上负重背心,“做你必须做的一切,你的感觉会成倍好转”。她指出,繁重日程是完全可以预见的——比如明知今天需要连续录像十个小时,就必须提前制定切实有效的执行策略。如果缺乏前瞻性规划,后果同样完全可以预见:锻炼被抛在脑后,随之而来的是情绪低落、动力丧失和饮食失控,最后还得耗费心力去收拾这堆烂摊子。 史蒂芬深受触动,坦言自己在交谈中意识到了一个严重的误区:他从未将锻炼排进日程表。他的训练长期处于“时间的残留受益者”地位,只能去分摊一天中剩下的零碎时间,这导致他前一天深夜将近午夜才勉强完成训练,而今天录完播客后又得赶一趟长达十小时的航班。史蒂芬反思道,自己本拥有吩咐助理调整日程的便利与特权,完全可以在统筹安排所有事务的同时,专门锁定一个小时的训练时间,而这种主动规划是每个人都应该且能够做到的。 里昂医生一针见血地回应:“你给我看你的习惯,我就能告诉你从长远来看你能维持怎样的成功。”她表示,自己只需看一个人的日程表,就能准确预见对方十年后的模样。尽管年轻时人们享有身体的“红利与特权”,但拐点终会降临。即使公务缠身,每周固定安排三天训练也是绝不可妥协的底线,因为这关乎自我标准的树立;如果一个人对事业处处设立高标准,那么对于维系长远影响力最为核心的健康管理,就绝不能降低要求。 - **行为与结果的可预测性**:明知极端忙碌的日子即将来临,却不提前规划,随之而来的情绪跌落、自暴自责与健康退化完全是可以预见的因果链条。 - **日历决定未来**:日程表反映了真实的价值优先级,如果健康和力量没有专属时间槽,就必然会被其他琐碎工作彻底挤压。 - **不可妥协的底线**:即使日程再满,每周抽出 3 天进行抗阻力量训练也是最基础的纪律,它决定了个人能否跨越衰老的断崖式拐点。 --- ### [01:46:52](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=6412s) 三十年后的愿景:从肥胖焦虑转向肌肉与力量 当史蒂芬问及如果两人在三十年后重聚,在加布里埃尔眼中何为真正的成功时,她描绘了公众健康认知和个人家庭生活的宏大蓝图。在宏观层面上,她希望三十年后我们能彻底改变整个健康领域的公众对话,不再连篇累牍、令人厌烦地反复念叨“肥胖”,因为肥胖只是表象和副产物;全社会应当将焦点全面转向身心力量,深刻认识到身体机能的衰退本质上是“肌肉问题”,而这也是人类完全有能力主动解决的方案。 在个人生活层面,里昂医生希望自己的孩子们成长得无比出色、身心健康快乐,无论未来遭遇什么风浪都具备强大的抗逆力与适应力;至于她的丈夫,她打趣道希望他到时候能学会把臭袜子收好。当史蒂芬追问,如果她的丈夫开始放弃自我管理不再健身,她会作何反应时,里昂医生直率地表示,虽然内容不宜在镜头前公开,但她一定会说出一些“极不合适且颇具攻击性”的话来当头棒喝。因为这不仅关乎他个人,更关乎他作为父亲对孩子们的责任,他必须成为后代的榜样。 ```mermaid flowchart TD accTitle: 范式转移:从以肥胖为中心到以肌肉力量为核心 accDescr: 展现从过去的肥胖副产物焦虑,转变为以肌肉和力量为核心主动解决健康问题的思维模型。 subgraph PastModel["传统认知模式"] A["聚焦肥胖表象与体重"] --> B["反复陷入饮食限制与节食循环"] B --> C["被动应对代谢衰退与健康恶化"] end subgraph FutureModel["肌肉为中心的健康范式"] D["聚焦骨骼肌质量与身心力量"] --> E["主动进行抗阻训练与优质营养"] E --> F["代谢健康、大脑保护与全面生命自由"] end PastModel -.->|"范式彻底转变"| FutureModel ``` --- ### [01:48:04](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=6484s) 最终提问:有意义的遗憾,与终极追求的“自由” 节目录制接近尾声,史蒂芬拿出了《CEO 日记》的传统闭幕环节:上一位匿名嘉宾留给下一位嘉宾的亲笔提问。本期留给加布里埃尔的问题是:“遗憾可能源于已采取的行动,也可能源于未采取的行动。有鉴于此,你人生中最大且最有意义的遗憾是什么?为什么?”加布里埃尔沉思良久后坦言,自己想不出有什么真正的遗憾,因为她始终坚信“我们必须为自己的选择承担全部责任”。即使史蒂芬建议将“遗憾”替换为“犯过的错误”,她依然觉得难以定义。 若真要挑出一件事,加布里埃尔表示,自己过去一直被“必须行善、必须对世界有所贡献”的强烈责任感所驱使,给自己施加了过于沉重的压力。但她随即反问道:放过自己就算是有意义的遗憾或错误吗?如果当初压力少一些,最终的结果会有不同吗?自己还会像以往那样勤勉拼搏吗?答案显然是否定的。 史蒂芬借此向她致以由衷的敬意,感谢她顶住压力扛起了推广肌肉科学的大旗。他感慨道,世界上不知有几百万人的生活因为她的一句话、一本书而发生了积极改变——或许只是决定多去散一次步,或者每周多做一次抗阻训练。史蒂芬回忆起自己四五岁时,看着母亲在家门外的街上来回奔跑锻炼的画面,那种对健康的重视深深烙印在了他的一生中。这让史蒂芬深刻意识到,父母对自我的要求会潜移默化地塑造下一代。 加布里埃尔对此由衷赞同,并道出了她医学理念的终极真谛:“归根结底,这并不只是关乎肌肉。医学只是一扇大门,肌肉是切入点,但我真正想为人们带来的,是自由(Freedom)。”在史蒂芬看来,这种自由就是幸福,而里昂医生总结道:那正是让人拥有掌控感、随心所欲去过自己想过的人生的极致自由。 --- ### [01:51:48](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=6708s) 尾声:对话卡片与世代回响 在访谈画上圆满句号后,史蒂芬向观众介绍了节目衍生的《CEO 日记》第二版对话卡片(Conversation Cards)。他解释道,节目中每一位重磅嘉宾在离开前写下的私密提问,如今都被制作成了实体卡片,卡片背面配有专属二维码,扫描即可直接观看对应嘉宾亲口作答的视频切片。这套承载着无数深度思考与灵魂拷问的卡片已两度售罄,旨在将这种关于自律、健康、遗憾与人生意义的深度对话,从演播室传递到更多家庭的日常交流之中。 ## Notable quotes > [13:15](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=795s) 如果一个人连关注健康的时间都没有,那他怎么可能有时间去生病? — Gabrielle Lyon > [20:29](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=1229s) 保持勇敢则是一种主动的选择。 — Gabrielle Lyon > [25:11](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=1511s) 如果你想要真正扩大自身的影响力、延续个人传奇并改变这个世界,你就必须回头解决那些被你完全忽视的生理基石。 — Gabrielle Lyon > [37:34](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=2254s) 骨骼肌是长寿的核心器官。 — Gabrielle Lyon > [37:34](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=2254s) 从未有任何一个人在生命终点时遗憾自己当初少做了一次头发造型。 — Gabrielle Lyon > [41:12](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=2472s) 如果你的内心是孱弱的,你绝不可能拥有一具真正强健的身体。 — Gabrielle Lyon > [46:46](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=2806s) 你这一生绝不会后悔让自己变得更强壮。 — Gabrielle Lyon > [55:33](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=3333s) 没有高质量的肌肉,你绝不可能拥有高质量的生命。 — Gabrielle Lyon > [01:04:37](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=3877s) 你无法靠药物来弥补糟糕的行为习惯。 — Gabrielle Lyon > [01:23:40](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=5020s) 我认为我们根本不该设定目标,我们应该设定标准。 — Gabrielle Lyon > [01:39:57](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=5997s) 碳水化合物是靠身体活动‘赚’来的。 — Gabrielle Lyon > [01:44:37](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=6277s) 你给我看你的习惯,我就能告诉你从长远来看你能维持怎样的成功。 — Gabrielle Lyon > [01:48:04](https://www.youtube.com/watch?v=2j3T4oYJPfI&t=6484s) 归根结底,这并不只是关乎肌肉。医学只是一扇大门,肌肉是切入点,但我真正想为人们带来的,是自由。 — Gabrielle Lyon ## Mentioned Gabrielle Lyon, Steven Bartlett, Danica Patrick, Evy Poumpouras, Mayo Clinic, Jim Kwik, Andy Galpin, Mike Israetel, Carlos Mana, Louisa Nicola, Stanford University, Yale University, Harvard University, Navy SEALs, The Diary Of A CEO, Forever Strong, Ozempic, Mounjaro, Zepbound, Paxlovid, Beyoncé, Dragon's Den ## Video description Dr Gabrielle Lyon is the founder of ‘Muscle-Centric Medicine’, an evidence-based method to improve muscle health, and host of ‘The Dr Gabrielle Lyon Show’. She is also the bestselling author of the book, ‘FOREVER STRONG: A New, Science-Based Strategy for Aging Well’. 00:00 Intro 02:39 What Does Gabrielle Do? 04:34 Why Do People Come To Gabrielle? 05:56 Are Your Solutions Easy To Achieve? 09:39 Why Don’t We Take Action On Advice? 12:25 How To Help People Feeling Down 15:02 You’ll Get Sick If You Don’t Do This 18:03 How Stress And Trauma Stop Change 22:17 How To Heal Trauma 25:40 The Best Way To Motivate People For Change 28:00 Lessons From Studying Thousands Of Patients 28:58 Why Gabrielle Does What She Does 33:41 Myths We Tell Ourselves That Block Change 37:34 How To Know You’re On The Right Track 41:12 You Can’t Have A Strong Body Without A Strong Mind 43:53 The Right Training For Your Age 47:15 Why You Should Exercise 3 Days A Week 49:14 Are We Destined To Become Like Our Parents? 52:00 Is Muscle More Important Than Cardio? 56:00 Why Only 6% Of People Meet Activity Guidelines 58:03 Do Other Societies Live Longer And Healthier Than Us? 59:41 The Best Way To Lose Belly Fat 01:02:16 What You Need To Know About Ozempic 01:03:43 Drugs That Boost Muscle Growth 01:05:03 Does Ozempic Cause Muscle Loss? 01:06:21 Who Is Using Ozempic? 01:07:40 The Real Cost Of Hormone Replacement & Ozempic 01:09:57 Do Diets Actually Work? 01:12:55 How Difficult Is It To Build Muscle? 01:13:40 Why Some People Struggle To Gain Muscle 01:14:43 Signs Of Low Testosterone 01:15:15 How To Boost Testosterone 01:16:59 Gabrielle’s Fitness Routine 01:21:30 Daily Tips To Build Muscle 01:23:41 Setting The Right Fitness Goals 01:25:08 What Gabrielle Struggles With 01:25:46 Are People Just Making Excuses? 01:30:05 What Happens When You Follow Gabrielle’s Advice 01:34:52 Is There A Link Between Muscle And Fertility? 01:37:32 The Oldest Healthy Person Gabrielle Has Seen 01:38:19 What’s The Most Important Thing We Haven’t Discussed? 01:39:57 The Most Important Point In Gabrielle’s Book 01:42:27 The Shocking Link Between Muscle And Brain Health 01:46:52 What Will Success Look Like In 30 Years? 01:47:41 The Role Of Relationships In Health 01:48:04 Final Question From The Guest Follow Dr Gabrielle: Instagram - https://g2ul0.app.link/yfkQuVZd1Mb Twitter - https://g2ul0.app.link/MrR7L61d1Mb Website - https://g2ul0.app.link/PTLCOIIi1Mb You can purchase Dr Gabrielle’s book, ‘FOREVER STRONG: A New, Science-Based Strategy for Aging Well’, here: https://amzn.to/4gzsuMH Get your hands on the brand new Diary Of A CEO Conversation Cards here: https://appurl.io/iUUJeYn25v 🌟 Get access to exclusive Diary of a CEO content: https://www.youtube.com/channel/UCGq-a57w-aPwyi3pW7XLiHw/join ZOE - http://joinzoe.com with an exclusive code CEO10 for 10% off [Source](https://www.youtube.com/watch?v=2j3T4oYJPfI)

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[13:15] Gabrielle Lyon: 如果一个人连关注健康的时间都没有,那他怎么可能有时间去生病? [20:29] Gabrielle Lyon: 保持勇敢则是一种主动的选择。 [25:11] Gabrielle Lyon: 如果你想要真正扩大自身的影响力、延续个人传奇并改变这个世界,你就必须回头解决那些被你完全忽视的生理基石。 [37:34] Gabrielle Lyon: 骨骼肌是长寿的核心器官。 [37:34] Gabrielle Lyon: 从未有任何一个人在生命终点时遗憾自己当初少做了一次头发造型。 [41:12] Gabrielle Lyon: 如果你的内心是孱弱的,你绝不可能拥有一具真正强健的身体。 [46:46] Gabrielle Lyon: 你这一生绝不会后悔让自己变得更强壮。 [55:33] Gabrielle Lyon: 没有高质量的肌肉,你绝不可能拥有高质量的生命。 [64:37] Gabrielle Lyon: 你无法靠药物来弥补糟糕的行为习惯。 [83:40] Gabrielle Lyon: 我认为我们根本不该设定目标,我们应该设定标准。 [99:57] Gabrielle Lyon: 碳水化合物是靠身体活动‘赚’来的。 [104:37] Gabrielle Lyon: 你给我看你的习惯,我就能告诉你从长远来看你能维持怎样的成功。 [108:04] Gabrielle Lyon: 归根结底,这并不只是关乎肌肉。医学只是一扇大门,肌肉是切入点,但我真正想为人们带来的,是自由。

Source quotes

[0:00] Dr. Gabrielle Lyon: When it comes down to your health, it shouldn't be about how you look. It should be about how you perform. And there's no replacement for resistance training and skeletal muscle mass. [4:34] Dr. Gabrielle Lyon: As high as you go, after a big launch or event, there's a dip. And you don't go back to baseline... It's a very big high and a very big low. Nothing will take someone off a health journey faster than those lows. [12:25] Dr. Gabrielle Lyon: If people don't have time for health and wellness, how are they going to have time for sickness? That's so much more time-consuming. [28:00] Dr. Gabrielle Lyon: The information was so wrong that I felt a responsibility to say something, and if I didn't, I would be contributing to the same problem. [46:48] Dr. Gabrielle Lyon: If you are in the lower one-third for strength, those that are in the lower one-third... have a 50% greater risk of dying from nearly anything. [356:00] Dr. Gabrielle Lyon: You cannot have a high-quality life without high-quality muscle. [69:57] Gabrielle Lyon: You cannot out-medicate poor behavior. [76:16] Gabrielle Lyon: People and children, they don't care what you say. They care what you do. [78:37] Gabrielle Lyon: Every single time you eat, you have an opportunity to improve your health. [81:30] Gabrielle Lyon: I don't think we should set goals... I think we should set standards. When you set a goal, you can either reach that goal or not. But if you set a standard then you will always keep your standard. [104:42] Gabrielle Lyon: Show me your habits and I will tell you how successful you will be able to continue to be in the long run. [104:42] Gabrielle Lyon: Nothing is going to be more critical for your impact than being able to manage your health. [109:34] Gabrielle Lyon: Muscle is the way in. Medicine is the way in, but what I really want for people is I want them to have freedom. And that freedom is happiness.

Original transcript

[0:00] To this day, everybody focuses on [0:01] obesity, but obesity is not our problem. [0:03] If you are in the lower 1/3 of strength, [0:05] you have a 50% greater risk of dying [0:08] from nearly anything. You have to [0:10] prioritize skeletal muscle. What is [0:11] that? This is the organ of longevity. [0:13] The only organ system that you have [0:15] voluntary control of. And there's only [0:17] two ways to stimulate skeletal muscle. [0:18] Number one, Dr. Gabrielle Lyon is a [0:21] pioneer of muscle science and the [0:22] board-certified physician for athletes, [0:24] CEOs, and Navy SEALs. [0:26] Transforming the way we think about [0:27] muscle and how it can prevent disease, [0:29] optimize your body, and completely [0:31] reshape how we age. When it comes down [0:33] to your health, it shouldn't be about [0:34] how you look. It should be about how you [0:36] perform. And there's no replacement for [0:39] resistance training and skeletal muscle [0:41] mass. But, only 6 to 8% of people are [0:43] meeting the resistance training [0:45] guidelines, and the majority of [0:46] individuals are sedentary. Can you [0:48] describe to me what my life will look [0:50] like as a 61-year-old if I just sit in [0:52] this chair and do zero resistance [0:53] training for the next 30 years? [0:55] you ready? You're 30. So, right now, [0:57] Alzheimer's disease and cardiovascular [0:59] disease is likely. Throughout your [1:00] lifespan, your testosterone is probably [1:02] low, and your sperm quality isn't as [1:04] good as it could have been. [1:05] So, there's a link between my fertility, [1:07] for men and women, and my muscle mass. [1:08] Yes. And then, probably going to be [1:10] extremely winded walking upstairs. [1:12] Likely have obesity and sleep apnea, [1:13] which means you're deteriorating your [1:15] brain and metabolic health, and it's all [1:17] going to come down to choices. Our [1:19] present choices will determine our [1:21] outcomes. So, run me through your day [1:23] cuz I'm just going to copy whatever you [1:24] do. Great. Okay, so, what time do you [1:26] wake up? What do you eat? How long do [1:27] you train for? Are you calorie counting [1:29] at this point? And what time is that [1:30] last meal typically? Well, [1:34] Question. If you could sit at a table [1:36] with any four guests from the Diary of a [1:38] CEO, who would you choose? [1:40] Here's a challenge for the entire Diary [1:42] of a CEO community. If we hit 10 million [1:45] subscribers by the end of 2024, you will [1:48] get to pick four guests for your dream [1:50] conversation, and you can make it weird [1:52] or you can make it wonderful. And here [1:54] is the best part. 3,000 of you that [1:57] subscribe will be invited to join this [1:59] conversation live, in person, and for [2:03] free. [2:04] Subscribe now and let's make this happen [2:06] together. [2:08] [Music] [2:11] Dr. Gabrielle Lyon. [2:13] What is it that you do for people? [2:16] I believe that I take away any physical [2:19] restrictions. [2:20] And I certainly feel privileged to take [2:23] care of people that change the world. [2:25] And when you say physical restrictions, [2:27] give me some flavor and color as to what [2:29] I mean. [2:29] Yeah, you know, when we think about the [2:32] way in which humans are, [2:33] sometimes they have low energy or [2:37] hormonal problems or gastrointestinal [2:39] problems, you name it, but those things [2:42] limit their ability to show up in the [2:43] world. [2:44] No matter how high-performing or how [2:47] high-achieving, [2:48] the common denominator is their health. [2:51] And nobody will ever go higher than [2:54] their own personal health. It is the [2:56] great equalizer, that and age. [2:59] And who do you do it for? Give me a [3:01] flavor of the people you've worked with [3:02] and the walks of life they come from and [3:04] what they do. [3:05] Well, I've been a physician for 20 [3:07] years, and there has been a number of [3:10] patients and kinds from geriatrics. I [3:13] did my fellowship in geriatrics and [3:15] aging. [3:16] And when I finished that, I started a [3:19] concierge medical practice. [3:21] And I take care of, right now, many of [3:23] the guests who have been on this [3:25] podcast, like, um, Evy Poumpouras and, [3:29] um, yeah, woman named Danica Patrick. I [3:31] don't know if you know who that is. [3:33] She's a race car driver extraordinary. [3:36] And many Tier 1 operators, like Navy [3:39] SEALs and CEOs, [3:42] individuals that are out there that are [3:43] mavericks, really trying to change the [3:45] world. [3:46] And one of the things that happens is [3:48] individuals have this capacity to push [3:50] through any way that they are feeling. [3:52] But, the cost of that is very [3:54] predictable. [3:55] And in my clinical practice, and part of [3:58] what I believe that I was put on this [3:59] earth to do, is to help people who help [4:03] change the world. [4:05] So, when people come to you and your [4:07] practice, what is it that they typically [4:08] say? What is it that the most typical [4:11] thing that they're searching for and how [4:12] do they articulate that? [4:14] That is a wonderful question, and one of [4:16] the things that they say is they feel [4:18] like they know they could feel better, [4:20] that they could have more energy, better [4:22] sleep, you name it, that they just have [4:24] this sense that something is still on [4:27] the table. [4:28] And we figure it out. [4:30] We go through whether it's environmental [4:32] testing, again, hormones, blood work. A [4:35] lot of my patients have been deployed [4:37] overseas. They come back, they've been [4:39] to Mayo Clinic and all these other [4:41] places, but [4:43] they still don't get better. And I think [4:46] wellness and health is very holistic [4:49] in [4:51] the approach. [4:52] And I am telling you, once that is taken [4:55] care of, [4:57] these people [4:58] are already making such an impact, but [5:00] then they can go on because they're not [5:02] encumbered [5:03] by [5:04] inflammation or not feeling well, or [5:07] let's say their body composition is off. [5:09] Let's say they are someone who's always [5:11] been a high achiever and high performer, [5:14] I don't know, they hit midlife and all [5:16] of a sudden things have changed. [5:18] It's my job to help remove any of those [5:21] physiological restrictions so that they [5:23] can do what they do best and not worry [5:25] about the other things. [5:27] Is it complicated [5:29] what you propose? Are your solutions [5:31] complicated or are they simple? [5:34] Another great question. It really [5:36] depends on what it is that we're looking [5:38] at. [5:39] The most complicated [5:42] of all of it is actually not the [5:44] physical. [5:45] It is definitely the mental. [5:47] Because you have to understand that I [5:49] think [5:51] a physician needs to be very good at [5:54] being able to [5:55] recognize patterns and diagnose patterns [5:57] of disease. [5:59] But, an effective physician is able to [6:01] recognize patterns of people. [6:04] Because people are extraordinarily [6:06] predictable in their nature. I'm going [6:08] to give you an example. You're looking [6:10] at me. There's an eyebrow raise. Mhm. [6:13] I had, I'll tell you about one one [6:15] patient in particular, and every year he [6:17] put on this massive event. This massive [6:20] event in Vegas, made millions of [6:22] dollars, did well, and every year I [6:26] would wait for the phone call. [6:29] I'm feeling depressed. [6:30] I just did so well. I don't know what's [6:32] wrong with me. I'm off my diet. I don't [6:34] work out. I All the litany of things. [6:37] And [6:38] what he failed to recognize was as high [6:41] as he was going, [6:42] was as low as he was going to fall. [6:44] And I see that with all my Type A [6:47] individuals. I wouldn't say that there's [6:49] a particular [6:50] demographic of patient, whether they're [6:52] SEALs or CEOs or moms, but it is [6:54] definitely a mindset. [6:56] And the individuals that I see, they [6:58] want the best out of themselves. [7:01] And the other side of that, and I'm sure [7:05] you know many of these high performers, [7:07] they drive really hard. [7:10] But, they fail to recognize that as high [7:11] as they go, [7:13] after a book launch, and maybe you [7:14] experienced this with your own book, [7:17] you work so hard, [7:19] you [7:20] launch this book into the world, or [7:21] maybe your first massively successful [7:23] episode, which now maybe a little bit [7:26] less because they're all massively [7:27] successful, [7:28] but right after that, there's this dip. [7:32] And you don't go back to a baseline. [7:33] It's not like any other Tuesday. It's [7:37] a very big high and a very big low. [7:40] And one has to recognize that nothing [7:42] will take someone off any kind of health [7:45] and wellness journey faster than those [7:46] lows. And is that psychology or is that [7:49] physiology? I is that my mind and my [7:51] thoughts or is that my biology and [7:53] what's going on in my head? My [7:55] perspective is that it's physiology. [7:57] There is an internal [7:59] recognition or interpretation of the [8:01] stress, [8:02] but from my perspective, there is a [8:05] physiological response. [8:07] And from what I can tell and what I [8:09] believe and what I've seen is this [8:11] dopamine drive. It's, and of course, [8:13] this is a simplistic way of [8:15] talking about it, but there's this [8:17] drive, and they are so excited, they're [8:21] amped up, they've [8:22] spent a ton of time in preparation [8:25] getting ready [8:26] to do this thing, and they've [8:29] deployed so much importance on this one [8:31] thing that when that thing is over, [8:34] they're constantly grasping for the next [8:35] thing. [8:36] And we all talk about burnout as this [8:38] thing, and burnout happens that way. [8:42] And it's this drive of more. [8:44] And once you can recalibrate that drive [8:47] and understand that you have to have a [8:49] very neutral mindset going into things, [8:53] then people are able to mitigate and [8:56] manage their own physiology. [8:59] The mindset component is probably the [9:02] most important because I could give you [9:04] the perfect plan, [9:06] but if you are unable to to execute [9:08] that, then it doesn't matter. [9:10] There must be so many millions of people [9:12] that listen to my podcast that have [9:13] heard all of this advice [9:15] in terms of how to better themselves, [9:17] their cognition, their performance in [9:19] various aspects, and they still haven't [9:22] put any of it into motion for whatever [9:24] reason. And you must experience that, [9:26] too, in your practice where someone [9:27] comes to you, you tell them what to do, [9:29] but the how part is [9:31] sort of contingent on them having some [9:33] kind of motivation or discipline or [9:35] whatever it is. Um, [9:36] from my perspective, it's worthiness. [9:38] Interesting. It's when it comes down to [9:41] the fundamentals, it's does this person [9:43] feel worthy of having the health and [9:46] wellness Really? that they they Yes, [9:48] that they desire. [9:50] And if a person doesn't feel worthy of [9:52] doing it or worthy of having it, they [9:54] will sabotage themselves. [9:57] Once I explained this predictable human [9:59] nature to this patient of mine, [10:02] the game plan was he was going to be [10:04] neutral. He didn't go too high, he [10:06] didn't go too low, and there's very [10:08] specific strategies that we can talk [10:09] about the way in which one maintains [10:11] neutrality, [10:13] but at the end of the day he felt worthy [10:14] of feeling really good. [10:17] We covered intermittent reward, we [10:19] covered not celebrating every win, [10:22] um conscious [10:24] uh conscious turning it on and turning [10:26] it off, very controlled dynamic [10:28] expression of what the goal was. [10:32] Turning it on, turning it off, right? I [10:33] see this My husband is a former Navy [10:34] SEAL. I see this in this group of [10:37] individuals all the time. They're able [10:38] to have controlled intensity. [10:41] But the other individuals that never [10:43] seem to get better, so the individuals [10:45] listening to this, [10:47] the one thing that they would have to [10:49] really settle in on is do they feel [10:51] worthy? [10:52] And if someone does not address at the [10:55] core that they feel worthy [10:57] of executing the information that you [11:00] and so many others are providing, they [11:02] will never make the change. [11:05] Discipline, motivation, discipline is [11:07] easy. It's not difficult. [11:09] There are constructs in our mind that [11:12] may tell us it's easier to [11:14] oversleep or not go to the gym, but at [11:16] the end of the day discipline can be [11:18] practiced. It's not hard. Motivation is [11:20] another thing, but who waits on [11:22] motivation to execute? Nobody. [11:25] I mean, you shouldn't because that is a [11:27] perishable feeling, [11:30] but understanding that this worthiness [11:32] has to be addressed before people are [11:34] going to make any kind of change [11:37] becomes critical. [11:38] And typically it comes back to [11:42] what they tell themselves on a daily [11:44] basis, how they interpret their [11:45] environment. [11:47] Maybe they experience everything as [11:48] stressful [11:50] and don't feel worthy of taking action [11:54] to get out of that distraction of [11:55] stress. [11:57] So if I came to you and I exhibited [11:59] worthy worthlessness, I didn't think I [12:01] was worth much in my corner and you [12:03] could start to pick up on it. Maybe I [12:04] was [12:05] I don't know, I was carrying myself in a [12:07] certain way, my body language, the way I [12:08] was talking about myself subtly. I was [12:11] putting myself down. Um [12:13] and maybe you maybe there's other things [12:15] going on and you go, "Do you know what? [12:16] This guy doesn't think he's worthy." [12:18] Where would you start with me? Well, [12:19] first of all, I would let you come to [12:21] that conclusion. Okay. The first thing [12:22] that I would do is I would say, "Steven, [12:24] how are you sleeping? [12:26] Are you really sleeping well?" [12:28] And I would guess maybe you're not. [12:30] Maybe you're staying up late, your mind [12:31] is always going, you're really thinking [12:33] about things. [12:35] I would ask you how you're sleeping, how [12:37] are you eating, how's your digestion, [12:38] what are you being exposed to? [12:40] And then I would give you a handful of [12:42] tasks. [12:44] I would tell you you got to get your [12:45] blood work done. You have to do a sleep [12:47] study. [12:48] You know, we have to address what's [12:49] going on gastrointestinally. [12:51] Are you reacting to certain foods? [12:53] And [12:55] maybe you'll get that done or maybe you [12:56] won't. [12:57] But if you came to me and said, "I am [12:59] not feeling the best version of myself." [13:02] I would say, "Are you ready to figure [13:04] out what this is?" And then I give you [13:05] lip service and I say, "Yes, I am, [13:07] doctor." Yeah, and then we would have to [13:09] have a real conversation. [13:11] Because there's this interesting kind of [13:13] segue. [13:15] CEOs, and again, a large portion of my [13:17] population are CEOs, is they will The [13:20] predictable course is they're too busy [13:22] to get it done. [13:23] It's not a worthiness [13:25] aspect, but it is they're too busy. But [13:27] again, health is the great equalizer. [13:29] There will come a point that is very [13:31] predictable [13:33] that they will call me. [13:34] Um again, many of your guests have [13:35] called me saying, "Hey, G, I'm not [13:38] feeling [13:38] well. My stomach is really bothering me. [13:40] I feel like it's sour, I'm not sleeping [13:42] well, you name it." [13:44] And I go, "Okay, well, did you knock out [13:45] these five tests that we had to get [13:48] done?" And they might say, [13:51] "No." [13:53] Six months, [13:54] they will come to a point where they [13:56] will have to get it done. [13:57] Once they get those testing done, [14:00] now we start seeing the worthiness [14:02] aspect. [14:04] Now we have evidence of what needs to [14:06] change. [14:07] And those individuals that execute on [14:09] those change typically will understand [14:12] the importance of [14:14] the long game, right? If you want to be [14:16] as successful as you can, [14:18] be a maverick and make a mark and do all [14:20] of your [14:22] potential, leave all of your potential [14:24] on the table. [14:25] The only way that you are going to be [14:26] able to do that is to liberate your [14:28] health. [14:30] You have to. You cannot push past how [14:33] you are feeling. This worthiness thing [14:35] is really interesting to me. [14:37] Um because I do I can relate when I [14:38] think about certain people in my life [14:40] that have been unable to make the change [14:43] despite having all the resources, the [14:45] time, but it's hard to know if they have [14:47] the time because sometimes people use [14:49] that as an excuse. Well, also, Steven, [14:52] if people don't have time for health and [14:55] wellness, how are they going to have [14:57] time for sickness? [14:59] Mhm. That's so much more time consuming. [15:04] Mhm. [15:05] But they just People don't assume that [15:07] they're going to get sick. [15:09] Getting sick is a surprise. [15:11] But is it? I mean, it is it appears to [15:14] be for most people. They just We all [15:15] kind of live in Think about how we live [15:17] and the decisions we make in the short [15:19] term, it's evident that we don't believe [15:21] we're going to either die or get sick. [15:23] Which is a huge failure of our culture. [15:26] Um you know, when I think about [15:28] longevity and I think about aging and I [15:30] think about the individuals that fall [15:33] and break their hip and end up in a [15:34] hospital bed because they haven't [15:36] trained or haven't taken care of this [15:39] this body which we only get one, [15:42] there is a predictable endpoint. [15:46] It is happening and we spend all this [15:48] time trying to [15:50] increase this concept of anti-aging. We [15:53] are aging. Aging is not a disease. [15:56] How we do it is largely up to us. [16:00] And if we can [16:02] condense this future version of [16:04] ourselves to now [16:06] and understand not just the [16:08] physical [16:10] attributes, but also the mental [16:12] attributes that will require us [16:15] to move forward, then [16:18] people would begin to take action. [16:21] Can you tell when you meet someone if [16:23] they're going to make the changes that [16:25] you describe and that you suggest very [16:27] quickly? Yes. [16:29] And what are the hallmarks of someone? [16:31] They're like archetypes. Okay. You know, [16:33] there is the CEO archetype which I'm [16:35] telling you they are going to put it off [16:37] for good 3 to 6 months [16:39] and eventually they will get it done. [16:40] And once they get it done, they will [16:43] stay on top of it. They will get it done [16:45] because they recognize that their [16:47] physicality is the common denominator [16:49] cuz they are in it to be the best [16:51] version of themselves. Mhm. And then [16:53] there are other people that have gone to [16:55] 13 other physicians and [16:59] have lost hope in the system. Mhm. And [17:02] those individuals or maybe they had a [17:04] physician that said something to them [17:06] and it really scarred them. [17:08] Those individuals will be very resistant [17:11] to execution, but once you earn their [17:14] trust, they'll get the job done. [17:16] Mhm. [17:17] And then there are individuals that [17:20] really struggle with worthiness. [17:22] That part of them wants to evolve, maybe [17:24] they had an old trauma, [17:26] maybe they had a physical trauma or [17:29] something [17:31] that really [17:33] really shook them. [17:34] And the trauma can be like a little T [17:36] trauma or a big T trauma. Yeah. It could [17:38] be a small thing that dad left, they [17:40] Yeah. you know. [17:42] Or it could be something bigger, [17:44] more horrific. Absolutely. And one of [17:46] the things that we see is [17:48] there is this interpretation of stress. [17:51] And people think stress is all fight or [17:53] flight. And we should try to de-stress [17:55] and take a hot bubble bath, but we [17:58] actually evolved to [18:00] manage and mitigate stress as humans. [18:02] We're much stronger than [18:04] we recognize and there are additional [18:06] stress responses that we don't talk [18:08] about. And we know from work out of [18:10] Stanford and [18:12] uh other individuals' labs that what you [18:14] believe about an experience is how your [18:17] physiology will show up about that [18:18] experience. So for example, there was a [18:20] hotel caretaker study. So you could call [18:22] it [18:23] a maid study where they looked at two [18:26] groups of housekeepers. [18:29] One group they said, "What you're doing [18:30] is amazing. [18:31] You are definitely getting physical [18:33] activity. Here's all the positives." And [18:35] the other one the other group they just [18:38] went about their day and you know, maybe [18:40] they were told that they should do [18:41] physical activity or not, but at the end [18:43] of the the housekeeper study, those [18:45] individuals that were told that what [18:48] they were doing [18:49] was in part like physical activity [18:52] showed low and that they didn't need to [18:54] do any more of what they were doing was [18:55] amazing. [18:56] Those individuals had lower blood [18:58] pressure, they had better glucose [19:00] regulation, better [19:02] insulin, they had lost a little bit of [19:04] weight, and it was all their [19:06] interpretation of the environment they [19:08] were in. [19:09] We tell people that the world is so [19:12] stressful [19:13] and that everything your internal [19:15] response is fight or flight. [19:17] But we have one word to describe [19:20] a million different things and we call [19:22] that stress. I'll give you an example. [19:24] A pet dies [19:26] or you have um a white sofa and your [19:29] kids just spilled coffee all over it. [19:33] Or you break up with a loved one or [19:35] there's a death of a spouse. We have one [19:36] word [19:37] and we call that stress. [19:39] That's it. We have one word to define [19:41] a million different things. [19:43] We live in an environment where people [19:45] talk about I'm so stressed and this is [19:47] stressful, but [19:49] that [19:50] we don't have any other word in the [19:52] English language [19:53] to globally define something. [19:56] Maybe that word could be love, but [19:59] not really, not in the way that we talk [20:01] about stress. So, [20:03] people think about stress as fight or [20:04] flight. That severely limits both their [20:07] physiology and their capacity. [20:09] The other two stress responses, which [20:11] are much more enhancing, is tend and [20:14] befriend, which releases oxytocin, which [20:17] makes people more capable. It makes them [20:20] more connected. This is the they're [20:22] stressed, yet they go to help other [20:23] people immediately. That's also a stress [20:26] response. [20:27] Or the courage response. The courage [20:29] response, we see that with a lot of [20:30] military operators. [20:32] A moment of stress, they're immediately [20:35] taking action. I'll give you an example. [20:38] If both myself and my husband were [20:39] getting read ready to jump out of a [20:41] plane, I would be terrified, and he [20:44] would be excited to do it. He would be [20:46] eliciting courage. [20:48] We're both in the same experience, but [20:50] he is having one of courage, and I am [20:54] having one of fight or flight. [20:57] When we both jump out of the airplane, [20:59] who do you think is going to be more [21:00] capable to get up and do the next thing? [21:03] Your husband. That's right. [21:05] I would still be [21:06] in this fear response, probably take me [21:10] at least a couple hours to recalibrate, [21:14] if not [21:15] a day or a week. [21:18] Whereas he has a response, which is [21:20] courageous, [21:22] and can be cultivated. [21:24] His capacity to then not only experience [21:27] new things, but continue on [21:31] will mitigate much of the physiological [21:34] damage that would happen from these [21:37] other fight or flight responses. [21:40] And what I would say to that is fear is [21:43] a normal response, [21:45] but having courage is a choice. You must [21:47] have You must have met people in your [21:49] practice that walk in, and they've got [21:51] some kind of trauma, which has led to [21:53] their state of sort of unworthiness. How [21:56] does one do anything about that when you [21:58] can't go back and write the wrongs of [22:00] their past, and [22:02] you know, I I I don't know if how much [22:03] you want to [22:05] dig into their psychology and become [22:06] their their therapist to try and unpack [22:08] some of that stuff, but if these things [22:10] are so deeply hardwired into them in [22:12] some way, you know, some early childhood [22:14] trauma that's stopping them feeling [22:15] worthy, which is stopping them having [22:17] {quote} and {unquote} motivation to [22:19] change. [22:20] Do you just give up on the person? [22:22] Never. What could you do? And can you [22:23] give me a specific example when that's [22:25] happened? Well, the first thing that I [22:27] would tell you is [22:29] I would turn to a coach. [22:32] I have an extraordinary coach, and his [22:34] name is Jim Kwik. [22:37] He is [22:38] He's worked with myself, helped make [22:40] that book possible, as as well as other [22:43] individuals whom you know. [22:46] And [22:47] that requires someone who is really [22:49] willing to go in and dissect that. [22:51] I have to know where physiology ends and [22:54] psychology begins. [22:56] I will also say I trained in psychiatry [22:57] for 2 years. [22:59] And the mind was, of course, the most [23:02] fascinating part for me at first. That's [23:05] actually what brought me into my work [23:07] with the military that I do today. [23:10] I will tell you that if I were to think [23:13] of [23:14] a very particular [23:17] patient, I will. [23:18] She had a lot of trouble sleeping. [23:22] And this woman, we later found out we [23:24] did everything. We did a sleep test. [23:28] Didn't have sleep apnea. [23:30] Was extremely unsettled. [23:32] Really um [23:34] had hormonal problems, put her on [23:36] hormone replacement, still really [23:37] struggled with sleep. [23:39] Did all of the things that one would [23:42] need to do, like a dark room. [23:45] I know you had Andy Galpin on, he does [23:47] talks about sleep and has absolute rest, [23:49] and you know, we looked at her [23:50] environment, did everything. [23:52] At the end of the day, it turns out that [23:55] the reason she wasn't sleeping is cuz [23:56] she had been assaulted. [23:58] And she had forgotten. [24:00] But every time she would go to bed, her [24:03] heart rate would spike. Um and it was [24:05] something that [24:07] that wasn't my domain, [24:09] but I knew that she had to really [24:12] deconstruct that if she was ever going [24:14] to move forward. [24:16] Part of it is figuring out where [24:20] there are weaknesses and vulnerabilities [24:22] within a person. [24:24] Because we think about the way that [24:25] health care is set up, right, is that [24:27] it's you see a doctor for 15 minutes, [24:29] maybe it's a half an hour intake, and [24:31] then you're on to the next. [24:32] But a real therapeutic relationship is [24:35] exactly that. It is a real relationship. [24:38] It is not transactional. [24:40] If you are a physician, you know, being [24:41] a physician, it used to be a very [24:43] honorable thing, and they were on the [24:46] council for people. It was [24:49] you know, they were your right hand. [24:52] And we have really changed from that. [24:55] You know, I'm talking about maybe in the [24:56] 1800s. [24:58] It was a very honorable, privileged [25:00] position, and I still believe it is [25:02] that. [25:03] And so part of moving people to from [25:06] where they are to a level of wholeness [25:09] requires being a teammate. [25:11] Do you try and motivate people? All the [25:13] time. [25:14] that's part of your your remit [25:16] as a physician to motivate them? Part of [25:18] my [25:20] job as a physician is seeing what they [25:23] are capable of. Mhm. [25:25] Is seeing what their true potential is. [25:28] And to push them? Yeah. [25:31] Do Do some Do sometimes people need a [25:32] bit more pain [25:33] before they [25:34] Yes. And then I mean, this speaks to [25:36] what what's going on with like [25:37] motivation and discipline, because if [25:38] you need a little bit more fear and a [25:40] little bit more pain, then it kind of [25:42] illuminates what this what's actually [25:43] going on with people's motivation. You [25:45] can almost put it into a formula where [25:48] like the strength of their their why [25:50] is at one side of the that equation, and [25:53] then there's some some other factors in [25:56] the equation, but it seems to start with [25:57] the strength of their why, and pain, [25:59] more fear, a bad result seems to amplify [26:03] their why to the point they go, "Okay, [26:04] [ __ ] it, I'm going to do something about [26:05] this now." [26:05] Yes. [26:06] And I think that there is a potential to [26:10] not wait till that happens, because it's [26:11] very predictable. [26:13] You know, and if someone is listening to [26:14] this or thinking about it, you don't [26:16] need to have to wait to get to that [26:18] point, because that point of breakdown's [26:21] going to come. [26:22] And you might as well get ahead of it. [26:24] You can only push so far. [26:27] Your original question is, do I think [26:28] that part of my job is to motivate [26:30] people? Yes. [26:32] Do I think it is also to see their [26:34] weaknesses and vulnerabilities? [26:36] Being a physician and and taking care of [26:39] some of the most extraordinary people [26:42] in the world, you get to see behind the [26:44] scenes. [26:45] And the people that are doing [26:47] extraordinary things, [26:49] their characteristics are actually not [26:52] that different. [26:54] They are often times extremely motivated [26:57] by service. [26:59] They are It's not a self-service, it's [27:02] an other service. [27:04] And when you can tap into say, "Hey, [27:06] listen, in order for you to really be [27:08] able to expand your reach, [27:11] grow this legacy, change the world, [27:14] then we have to fall back on [27:17] the things that you are completely [27:19] ignoring." And again, uh vulnerability [27:21] is hard for people, [27:23] but exposing that and letting them come [27:25] to those conclusions, [27:27] then [27:28] you see a full evolution of a person. [27:31] You How many I mean, how many patients [27:33] do you think you've seen over the last [27:34] Thousands. Why do you do what you do? [27:38] I [27:39] find the greatest joy, [27:41] aside from my kids and my husband and my [27:44] family, [27:45] being able to be of service. Why? Well, [27:48] I would say that I'm always I've always [27:50] been wired to be this way. [27:51] I have always been wired to take care of [27:55] people. [27:56] And I would say right now, when I think [27:58] about [28:00] my patients like Danica, or um some of [28:03] the other entrepreneurs that you've had [28:05] on, [28:06] I believe that no one is going to be [28:08] able to get the job done better than me, [28:11] and is going to care more. [28:14] And [28:16] it feels really good to be able to be [28:18] there for people. [28:20] Are you a happy person? Yes. For the [28:22] most part, I would say I have a very [28:24] positive disposition. [28:26] I do. What are the seasons of [28:27] unhappiness in your life? [28:30] I think during training was very hard [28:33] for me, during my fellowship. [28:35] Saw a lot of death. [28:37] That was really hard. [28:41] Work a lot of hours, see a lot of death. [28:44] That was hard. [28:46] You still remember that? Oh, yeah. [28:48] Changed you? Yeah. [28:50] That's why I got into social media. [28:53] I had just finished my fellowship, um [28:57] 2015, [28:59] and I hadn't been on social media or [29:00] anything. [29:02] And I had just been, you know, you go [29:04] through [29:05] and you see patient after patient, [29:08] and [29:09] you know, none of them are getting out [29:10] of the hospital. They're all going to [29:12] die there. [29:14] Can you imagine? [29:15] So, you're seeing 30 [29:17] 30 patients a day. [29:20] This one is on pain meds, you know this [29:22] one is going to die. This one is [29:24] 18, and she's going to die, and she's [29:26] planning her wedding, but she has um [29:28] She's planning her wedding? She was [29:30] never going to be able to She [29:32] had um cystic fibrosis. [29:34] There was nothing that they could do for [29:35] her. [29:36] And she was never going to have a chance [29:38] to get married or do anything. And she [29:40] was planning her wedding? She wanted to [29:41] pretend like she was going to be able to [29:44] get married. [29:45] Picked her dress to [29:48] have an experience she was never going [29:49] to have. [29:51] And um [29:54] you know, during that time [29:58] I [29:59] you know, as I was coming out of [30:01] fellowship in 2015 [30:03] I was seeing all this BS on social [30:05] media. [30:06] These people talking about you know, [30:09] this cleanse and this fake diet and this [30:12] like all of this stuff and the [30:13] information was so bad. [30:15] That [30:18] I felt responsible. That if I had [30:21] the privilege to have, you know, had a [30:23] 17-year education [30:25] and I've seen all of this stuff and then [30:28] to not say anything that I knew was [30:30] going to make a difference or be [30:31] impactful for people's health and [30:33] wellness. [30:35] The end comes. [30:37] The decisions you make become critical. [30:40] But where it really becomes critical is [30:42] in the beginning. [30:43] The children and then at the end. [30:46] And if you start hearing all of this [30:49] narrative of how we you know [30:52] um [30:54] should reduce our dietary protein and do [30:56] all these other things and destroy our [30:58] skeletal muscle based on this input that [31:00] we're getting. [31:01] The information was so wrong [31:04] that I felt a responsibility to say [31:07] something and if [31:09] I didn't, I would be contributing to the [31:11] same problem. [31:13] But it was very hard. [31:15] It was very hard. [31:17] Does that come at a cost? The the the [31:19] caring. [31:19] Yes. Yes. Yes, it does. Nobody has ever [31:22] asked me that. [31:24] Yes, it does. [31:26] It um and this might not be the best [31:30] trait, but I am [31:32] willing to [31:34] be there at midnight, at 1:00 if someone [31:38] needs something. [31:40] I got it. [31:41] And yes, does that come [31:44] at a cost to myself? It does. And my [31:47] family? It does. [31:49] I am very careful about protecting the [31:51] time. But um [31:55] yeah, it's [31:57] Is there an emotional cost to this as [31:58] well? Because if I if I was every day I [32:00] was waking up and I was [32:01] being involved with other people's [32:03] problems in such a way, other people's [32:05] challenges, their sickness, their [32:06] illness, their [32:07] their death. [32:09] I [32:10] I don't know if I'd need some strategies [32:12] to to cope with that. Like [32:14] getting invested in somebody and then [32:15] seeing a bad outcome. And feel that sort [32:18] of feeling of like, what could I have [32:20] done? Or [32:21] you know. [32:22] Well, luckily um [32:25] my patients are no longer, knock on [32:27] wood, life or death. We are dealing with [32:29] things like um [32:32] hey, you live in a toxic mold [32:34] environment or you have Lyme. Um we can [32:37] move past this or hey, you have COVID [32:40] and you're in Washington, let me get [32:42] some Paxlovid sent to you. Or [32:45] um maybe this person is going through a [32:47] bad breakup or [32:49] their thyroid is off. [32:51] It's light in that way. I mean, [32:53] sometimes I have to send people to the [32:54] hospital. [32:56] But it's no longer caring for end of [32:58] life, but [32:59] now [33:01] it is positive and [33:04] it is challenging. [33:07] But [33:08] again, I've been a physician for 20 [33:10] years. [33:11] You build up capacity. [33:13] I was thinking the other day about some [33:14] of the like mind cuz [33:17] a good idea that infiltrates your mind [33:21] can change your life. Yeah. Because it's [33:22] kind of like corrective. It like it's [33:24] almost like it goes in there like a [33:25] vaccine and it attacks a a mind virus [33:28] that you had. Something that was holding [33:30] you back, some kind of limiting belief [33:32] about the nature of life. [33:35] In your work, what are those kind of [33:36] mind viruses, those myths that people [33:39] carry with them that ultimately inhibit [33:41] their chance of becoming this optimal [33:43] performer that you want them to be? [33:45] There's a handful of things and also we [33:47] have to recognize that we're talking [33:48] about two things, physiology and [33:49] psychology. [33:51] From a [33:54] physiology, from a physical perspective, [33:57] there is a one of the things that is [34:00] extremely detrimental is this [34:02] comparison. [34:03] Individuals that compare themselves [34:06] physically to other people will stay [34:08] hooked in. [34:10] That typically is a comparison of youth. [34:13] As individuals mature in their late 30s, [34:16] 40s, I do see that dissipate. But if [34:19] that doesn't dissipate, they will [34:21] continue to hone in on this physical [34:24] readiness and that allows for certainty. [34:27] So, think about this. [34:29] We all see [34:32] amazing athletes or people that are in [34:34] incredible are incredible shape. And [34:36] your ultimate question is, what are the [34:38] things that limit, whether it's a mind [34:40] virus or something limiting to allow [34:42] somebody to become [34:44] the best version of themselves, an [34:45] uninhibited version of themselves or [34:47] unencumbered from a physical standpoint. [34:50] When an individual is solely focused on [34:52] the physicality Mhm. [34:54] and that can be from a looks perspective [34:58] that can be from, you know, my husband [34:59] always tells me stories about those guys [35:02] that go into SEAL training. [35:04] The first guys to wash out, this is what [35:06] he tells me, were always the great [35:07] athletes. [35:08] Because they had trained physically. [35:11] They were capable of dealing with [35:14] certainty. [35:15] You throw a ball, you know how to do [35:17] that. [35:19] They hadn't prepared themselves for [35:21] mental uncertainty or fortitude. And [35:24] this circles back to this. So, the [35:26] individuals that are fully focused on [35:28] this external comparison, it's about [35:30] looking good, it's about being fit, it's [35:32] about having more plastic surgery, less [35:34] wrinkles, whatever it is. [35:36] Those individuals are chasing a game [35:38] that they will never catch. [35:40] The perspective is wrong. [35:42] We all get older. [35:44] We all will at some point not be as [35:48] physically capable [35:50] as we are now. You're in your How old [35:53] are you? 31. Oof. Getting up there. Mhm. [35:57] You are 31. [35:57] getting up there? You mean I'm getting [35:58] old. [35:59] No, I cannot talk. Um [36:02] but there is this physical capacity that [36:05] if you were to just say, Gabriel [36:08] let's just focus on the physical. [36:10] Then we know by the time you are 50 and [36:12] listen, 50 is not a great number because [36:14] we I a ton of amazing fit 50-year-olds. [36:17] But when you are 80, if all you did was [36:20] look at that physically, by the time you [36:24] were [36:25] more mature [36:27] you [36:29] would become, and I don't want to say [36:31] more depressed, but this if your world [36:33] is purely external [36:35] there is an inevitable decline in that. [36:37] And you know what I'm talking about, [36:38] right? [36:39] Time is against you. It's going to [36:40] happen. [36:41] You know, your skin is going to sag, [36:44] whatever it is. Hopefully it doesn't, [36:45] but [36:46] those individuals that are fully [36:47] externally focused those individuals [36:50] really struggle with aging. [36:52] And you will not focus on the things [36:54] that matter. [36:56] And that is a virus that will happen. [36:57] You will always be comparing cuz it will [36:58] bleed over to everything. [37:01] How you manage your psychology will be [37:03] how you manage your physiology. [37:05] So, what should I be aiming at? [37:07] What should in if I'm not going to be [37:08] aiming at the physical attributes and [37:10] the comparison what what kind of measure [37:13] should I apply to myself to understand [37:15] if I'm doing a good job? [37:17] You should focus on physical readiness. [37:20] But it shouldn't be about how you look. [37:22] Okay. It should be about how you [37:24] perform. [37:25] When you think about gaining physical [37:27] readiness it should be about the [37:30] acquisition of skill the acquisition of [37:33] strength. [37:34] I talk a lot about muscle. I believe [37:36] skeletal muscle is the organ of [37:37] longevity. [37:39] You should be focused on becoming [37:41] physically strong. [37:42] But the physical performance [37:45] outcome, how you look, is not the end [37:48] point. The idea that you are training [37:50] for life able to, whether it is to run [37:53] or to squat or to bench press or to get [37:56] stronger in a meaningful tactical way [38:00] you should continue to move that needle. [38:02] A lot of people though, they we were [38:03] talking before we started recording [38:04] about how people are driven by like [38:05] short-term incentives. [38:07] And it's quite insane for someone to [38:09] focus on a long-term incentive in the [38:12] face of like a short-term incentive. So, [38:14] if I if my short-term incentive is for [38:17] someone in the office to think I'm hot [38:19] or, you know, to find a partner, I'm [38:21] going to be so focused on getting that [38:23] blow dry. [38:24] I'm going to want that like facial. [38:26] And I'm going to if I've got, you know, [38:27] an hour of free in a day, I'm going to [38:29] aim at the facial, the blow dry. How can [38:32] you convince me that that's a bad idea? [38:34] Versus aiming it at, I don't know, [38:36] building muscle or becoming physically [38:38] strong. [38:39] Time is finite. [38:42] And we are given time. [38:45] How we spend our time will determine our [38:48] outcomes. It will determine where we're [38:50] going. How globally strong we become [38:53] because strength is clearly not [38:54] physical. There is a level of global [38:56] strength, which means [38:58] becoming masterful at something. For [39:00] example, you're masterful at business, [39:03] at interviewing, at learning and [39:06] thinking about people. [39:08] If you were distracted and you could [39:10] totally choose a life of distraction [39:13] you could be distracted by the external [39:16] shiny objects. [39:17] Perfectly okay. [39:19] But that outcome, if that becomes [39:21] regretful [39:23] then that becomes devastating. [39:25] You know, um taking care of people at [39:27] the end of life [39:29] you hear a lot of regrets. [39:32] And it wasn't that they wish they'd had [39:34] another blow dry. And I know what you're [39:36] saying is that how do we think about [39:38] later life if we [39:40] can't identify in the short term or take [39:44] in the short term what makes us happy, [39:46] right? We are thinking about I want this [39:49] cake, I want this thing, I want to buy [39:50] this car. Shout out to my husband, no we [39:53] are not getting that Defender. [39:55] But the short term is very limited. [39:59] And we live in very fast-paced society [40:03] that will tell us to embrace that. [40:06] And to fight for that thing. [40:09] But it only takes a moment of spending [40:11] time with the elderly or the aging or [40:14] people that are wiser than us [40:17] to look back and say these are the [40:19] moments that you can fully develop [40:21] yourself. And again, from a physical [40:24] standpoint, should you focus on physical [40:25] readiness? Absolutely. You're 31, do you [40:28] think it's going to be easier at 41? [40:30] I hope so. [40:32] We got to get you on a good program. Um [40:34] I'll call Lane later, but [40:37] you have to do these things. [40:39] And you have to bring back into [40:40] perspective what is important and what [40:42] is valuable. I'm thinking about a [40:44] particular friend of mine who I was [40:46] describing there with the blow dry thing [40:47] and and the like spray tan and the blow [40:49] dry. They're they're you know, [40:52] approaching 40, they're looking for a [40:54] partner. [40:55] They [40:57] are spending any free time they have on [40:59] the on the spray tan and the blow dry. [41:00] Listen, I'm not not judging. I'm just [41:02] saying that as a case study. [41:03] and there's many people like that. And [41:05] they're spending zero time on physical [41:07] strength, don't go to a gym, don't go [41:09] near it, don't do any exercise. [41:11] And I'm just wondering, you know, how [41:12] you make a case to that individual that [41:14] actually to achieve the goal that they [41:15] want to achieve, which might be to find [41:17] a partner, actually it's the inverse. [41:19] It's they should be doubling down on the [41:21] internal versus the sort of surface. The [41:25] first thing that this person is [41:26] obviously driven by the external. Mhm. [41:28] And you have to recognize that you [41:30] cannot have [41:32] a strong physical body if you are [41:35] mentally weak. [41:36] Because you will never feel good about [41:38] what you are doing. You will be [41:39] distracted. You will live a life of [41:41] distraction that will then rob you of [41:43] your future. Mhm. [41:45] And the case I would make to your friend [41:47] is [41:48] these immediate distractions and being a [41:51] good friend would be telling them this [41:53] or allowing them [41:55] to come to that understanding. When you [41:57] say you can't have a strong body unless [41:59] you have a strong mind, how are you [42:00] defining and how do you define a strong [42:03] body? [42:05] You should be able to be physically [42:06] capable in whatever it is that you want. [42:08] Should you be able to do a pull-up? [42:10] Probably. Should you be able to do at [42:11] least 10 push-ups? Yes. [42:15] Is that number different for everybody? [42:18] Yes. [42:19] If I asked you to please run a mile, [42:21] could you do it and do it well? [42:23] I think being and having physical [42:26] sovereignty and being able to be in [42:29] control of your body and to be strong [42:31] and not require someone to help you with [42:33] things. I mean, granted you probably [42:34] couldn't lift a car by yourself or a [42:36] bed, but [42:38] But this [42:39] But this becomes extremely important for [42:41] our aging population and for where we [42:43] are now. [42:44] What do I mean by this? We are becoming [42:46] increasingly weak as a society. [42:50] The majority of individuals are moving [42:53] towards obesity. [42:55] Children are becoming more and more [42:57] obese. [42:59] Are they strong? Are they as strong as [43:01] they could be from a physical [43:02] perspective? I would say no. [43:05] And again, you can choose [43:07] a marker of goals to hit. [43:11] Which I recommend that everyone does, [43:14] whether it's squat, [43:16] deadlift, you name it, run. But you have [43:18] to be able to have accountability for [43:22] your physicality. If you were going to [43:24] be giving me goals to hit, [43:26] right? And I don't necessarily mean like [43:28] 10 reps, whatever, but just [43:30] the types of goals that I should be [43:32] aiming at to have a strong body, [43:34] what what are those types of goals? So, [43:35] you mentioned squatting there, you [43:37] mentioned, you know, maybe being able to [43:39] pull myself to run. Are these the kind [43:41] of goals that you would give to me? So, [43:43] say a 30 40-year-old, what kind of goals [43:46] would you be aiming at? And are the [43:46] goals different if I'm 50 and 60? They [43:48] are. [43:50] You should [43:51] at a minimum [43:53] And I'll give you an example. Um you [43:55] should at a minimum be training 3 days a [43:56] week with with weights, doing resistance [43:59] training. You've had many uh you just [44:01] had my friend Mike Israetel on. I mean, [44:04] that guy, he is jacked. He could [44:06] probably lift you with one hand and me [44:08] with a pinky and he would be [44:10] going all over the place. [44:11] You should be training [44:14] your muscles from a strength and or [44:17] hypertrophy standpoint 3 days a week. [44:20] Okay, so is that everyone? Yes. Everyone [44:23] regardless of age? [44:23] Yes. Yes. So That part is regardless of [44:26] age three to [44:27] Listen, could you get it done in 2 days [44:29] a week, which is the recommendation? [44:31] The current recommendation for activity [44:33] is 150 minutes of moderate to vigorous [44:35] activity and 2 days a week of resistance [44:37] training. Is that going to be enough to [44:40] keep you walking around? Yes. Is that [44:43] going to be enough to evolve your body [44:46] to [44:48] manage and mitigate aging? No, it is [44:51] not. [44:53] We have to call ourselves to a higher [44:54] standard. Three to four days a week. [44:57] Four, you've added a day. [44:58] Okay, well, I was going to say three. I [44:59] was going easy on you. Three days a [45:01] week. You should be doing And I only [45:03] train I do resistance training 3 days a [45:05] week. I might throw a fourth day in [45:06] there. For anyone that doesn't know what [45:08] resistance training is? Moving um [45:11] your body or a load against [45:16] um [45:17] uh resistance. So, it would be for [45:19] example, taking a weight and moving that [45:22] through space, whether it is a squat or [45:25] a bench press. These are all resistance [45:28] training, moving against a resistance of [45:30] some load. It could be body weight, it [45:33] could be a band. Three days a week, [45:35] everybody I mean, I'm I'm okay with 2 [45:37] days a week, [45:39] but in an ideal world, it should be 3 [45:40] days a week. [45:42] My recommendation is you train for [45:44] muscle hypertrophy. Which is? Muscle [45:46] growth. [45:48] 10 to 20 [45:50] sets per muscle group a week. And how [45:52] many reps? [45:54] So, I would say [45:56] um you could do a [45:59] upper body, lower body split. You could [46:01] do [46:02] What's that? Um a push pull, like a [46:04] bench press or a a back row. So, [46:07] back and um chest. You could do full [46:11] body training, which is which I think is [46:13] the best for people. Compound movements [46:15] like a squat or a deadlift. This is full [46:18] body. [46:19] You should be doing some kind of [46:21] movement, but [46:23] Stephen, if someone said, like my dad, [46:26] before I came on this podcast, he [46:28] FaceTimed, he lives in Ecuador, and he [46:29] was doing resistance bands with bicep [46:32] curls. Mhm. I'm okay with that. [46:34] If you want to do that and that's how [46:36] you're going to do your upper body or [46:38] your arms, [46:40] fine. [46:41] So, it could be chest, back, [46:44] you know, glutes, legs. [46:46] Why should I be doing 3 days a week? [46:48] What what am I going to get out of that? [46:50] Make make the case to me. [46:51] Number one, you are never going to [46:53] regret being stronger. [46:55] Period, end of story. [46:56] You need to be physically strong. [46:59] Skeletal muscle is the organ of [47:01] longevity. It is not just about good [47:04] looking good [47:05] in a bathing suit. It helps, it's so [47:07] great. Um your friend who is getting her [47:10] hair blown out and doing all these other [47:11] things, [47:13] put her in some training and listen, [47:15] she's probably going to be a killer. [47:18] Skeletal muscle is your primary site for [47:19] glucose metabolism, fatty acid [47:21] metabolism, it's your glucose sink. [47:24] If you decide that you want to eat [47:26] carbohydrates and you care about [47:28] metabolic health, you have to have [47:29] skeletal muscle. [47:32] You're not convinced yet, are you? I'm [47:33] I'm listening. Okay, well, you're you're [47:35] kind of like [47:36] maybe convinced that you think skeletal [47:38] muscle is important, but if I told you [47:42] that this is your body armor, [47:44] that if you are in the top 1/3 [47:46] of strength [47:49] compared to if you are in the lower 1/3 [47:52] of strength, [47:53] those that are in the lower 1/3 for [47:56] strength [47:57] have a 50% greater risk [48:01] of dying from nearly anything. [48:04] If you are in the lower 1/3 of strength, [48:06] you have [48:08] a roughly 50% chance [48:11] of dying from all cause mortality. [48:14] But I'm getting old, Dr. Lyon. I I'm I'm [48:16] 58. [48:17] Yeah. Um when people get old, they put [48:19] on weight, they they lose muscle, we get [48:22] weaker, we get frailer. This is what [48:24] this is just the nature of life. Don't [48:26] fight life. The first thing that I would [48:28] say is congratulations making it to 58. [48:30] Well done, sir. And then I would say [48:32] that is totally not true. That is not [48:34] what we see in the literature. [48:36] Anyone at any time can get stronger and [48:39] put on muscle. [48:41] Anyone at any time can get stronger and [48:44] put on muscle. Do you know what it is, [48:45] yeah? Part of the reason why I think [48:47] people don't believe that is because we [48:50] look at our parents [48:51] and our parents looked at our parents [48:54] and our parent their parents looked at [48:55] their parents and our parents are like a [48:56] case study of what we what we should [48:58] expect. They set the expectation. And [49:00] when a lot of us look up at our our [49:01] parents, we see people that are maybe [49:04] have had a little bit of weight added, [49:06] um maybe our dads have a bit of a pot [49:08] belly because of all the beer they've [49:09] been drinking or whatever. Yeah. Maybe [49:11] they walk a little bit slower, they [49:12] can't run, they're out of breath. So, we [49:13] kind of just assume that that is normal [49:16] and that's what we should expect of [49:17] ourselves. [49:18] And I think I I did that. I looked at my [49:21] dad who um he's on a bit of a health [49:23] journey at the moment, but before he was [49:25] on that health journey, I did kind of I [49:27] think at some point in my mind I [49:28] conceded maybe that's just what like [49:30] genetics do. They just give you a pot [49:32] belly, they slow you down, you lose your [49:34] muscle, you get weak. Yeah. [49:38] That funny thing about humans is when we [49:41] hear and see things over and over again, [49:44] we believe them to be true whether they [49:45] are or they're not. [49:47] Humans are funny creatures in that they [49:50] experience repetition as truth. [49:52] What do I mean by that? I say, "Steven, [49:55] this is stressful. This is stressful. [49:57] Our fight or flight is the only way." [49:59] And then you go, "You know what, [50:00] Gabrielle? Fight or flight is the only [50:01] way." [50:02] That's all I've ever heard. [50:03] We see our parents age [50:05] and we believe that that's just the way [50:08] that it is. [50:10] But I can show you [50:12] many [50:14] individuals that are aging well and [50:16] strong. Both of my parents are [50:18] incredibly fit. [50:20] Is that genetic? Maybe I picked my [50:22] parents well. [50:23] But what I will say is that the [50:27] traditional [50:28] framework of aging [50:30] is in part the way that it is because we [50:34] have divorced the idea of skeletal [50:36] muscle [50:38] from health. [50:40] The bros got it right. [50:42] You need to be jacked, you need to be [50:43] tan, and [50:45] if you're not jacked and tan or if you [50:46] are, [50:47] resistance training is only for [50:51] the bros. [50:53] Nothing could be further from the truth. [50:55] And because of that thought process, we [50:58] have divorced skeletal muscle health [51:02] from overall health and wellness and [51:04] longevity. [51:05] If I as a trained geriatrician were to [51:08] say, [51:09] and by the way, I did 7 years of [51:11] nutritional science training as well. [51:13] If I were to tell you what is the one [51:15] most important thing to take you through [51:18] life, [51:19] do you know what I would say? Probably [51:20] muscle. That's right. [51:24] Hands down, across the board, [51:26] the weaker you are, the less muscle mass [51:29] you have, the greater chances you will [51:30] die. So, in terms of cardio, is do you [51:34] think muscle mass is more important than [51:36] cardiovascular exercise as you age? [51:39] You're putting me in the hot seat, and I [51:41] would say both we know are important. [51:46] But [51:47] again, both are very important. [51:51] But there is no replacement for [51:54] resistance training [51:56] and muscle mass. There is none. [51:59] You will not get the same stimulus by [52:02] doing cardiovascular activity, and you [52:04] need You mentioned your parents or your [52:07] dad. You see and we see collectively [52:11] our aging population shrink, [52:14] right? They become thinner and and [52:16] scrawnier and [52:18] more sarcopenic. We see this happen. [52:21] There is a transition of fiber types. [52:23] There's different fiber types, and they [52:25] transition from type two fiber types to [52:28] type one. What is that? Type two are the [52:30] big, bulky fibers [52:33] that you train for hypertrophy, strength [52:35] and hypertrophy for. [52:36] There is a transition that happens if [52:39] you are not constantly fertilizing these [52:41] muscles through strength and hypertrophy [52:44] training, through resistance exercise. [52:47] If an individual is solely focused on [52:49] cardiovascular activity, this will not [52:53] maintain in a meaningful way [52:55] these type two or bigger, bulky muscle [52:57] fibers. [53:00] When you lose skeletal muscle mass, [53:02] you also see a change in metabolic [53:05] health. [53:07] Muscle is the primary site for glucose [53:08] disposal. [53:10] It is [53:12] primary site for fatty acid oxidation. [53:15] When you [53:17] lose skeletal muscle, [53:19] you see an increase in [53:22] blood sugar, insulin, type two diabetes. [53:26] Skeletal muscle is what allows us to [53:28] buffer [53:29] the foods that we eat. So, if I'm eating [53:31] lots of sugar and carbs, for example, [53:33] Yeah. and I've got lots of muscle, [53:35] then [53:36] the sh- the sugar and the carbs going to [53:38] be basically stored in my muscle. But if [53:41] I don't have any muscle, then where is [53:42] it going to go? Exactly. [53:44] Liver, fat. You are going to become [53:47] increasingly unhealthy unless you are [53:49] training. [53:51] So, if I if I have more muscle, does [53:52] that mean I can eat more carbs and there [53:54] be less of a consequence? Likely, yes. [53:57] Especially if you are training and you [53:58] have healthy skeletal muscle. [54:01] Um skeletal muscle can be marbled. A- [54:04] You can get an increase in myosteatosis, [54:07] which is fat infiltration in skeletal [54:09] muscle. [54:11] In order for skeletal muscle There is no [54:13] such thing as a healthy sedentary [54:15] person. [54:16] You will look in the literature and you [54:18] will see [54:19] people say, "Oh, healthy sedentary." [54:21] There is no such thing as a healthy [54:23] sedentary person. [54:25] What do I mean by that? [54:26] There was some wonderful work out of [54:28] Yale. They looked at 18-year-old [54:31] college students that were considered [54:33] lean and healthy, [54:36] put them in [54:37] a- [54:39] a time frame of inactivity, and they [54:41] become they became insulin resistant. [54:43] They had skeletal muscle insulin [54:45] resistance [54:47] even though there were no outward signs [54:49] of obesity or fat. [54:51] If you are not active, [54:54] you will not be turning over your [54:56] glycogen stores, which is the stored [54:58] form of carbohydrates. [55:00] You will begin to build up byproducts. [55:03] Your skeletal muscle will be [55:05] increasingly more unhealthy over time. [55:09] You cannot get out of doing resistance [55:13] type exercises. And to be clear, [55:15] you do not have to be doing a one rep [55:17] max. [55:18] You could simply start by body weight [55:20] resistance training. [55:22] It could be yoga, it could be bands. But [55:24] at some point, you will have to [55:26] stimulate that tissue in a meaningful [55:28] way [55:29] to age well. How many people are meeting [55:33] the activity guidelines at the moment, [55:35] and how many people aren't? [55:38] Roughly [55:39] 6 to 8% are meeting the resistance [55:42] training guidelines. [55:43] 6 to 8%? [55:44] Yes, sir. [55:46] Just if you were to look at resistance [55:47] training guidelines. Now, [55:49] 50% of Americans don't even work out. [55:53] Over 70, roughly 75% [55:57] do not meet both recommendations. [56:00] The majority of individuals are [56:02] sedentary individuals. [56:05] It's interesting cuz people will then [56:07] say, "Well, you know, these stats are [56:09] all bad, but our life expectancy seems [56:12] to have gone up, [56:13] you know, year over year for Well, I [56:15] mean, I think it's had a little bit of a [56:16] blip recently because of COVID, but it's [56:18] typically going up into the right, our [56:20] life expectancy. So, we must be doing [56:21] something, right?" Is it about life [56:24] expectancy or is it about quality? [56:27] Could we keep someone alive on bed rest? [56:31] Probably. [56:33] Would one say that [56:36] that would be a good quality of life? [56:38] You cannot have a high-quality life [56:42] without high-quality muscle. [56:45] More specifically, people care about [56:49] autonomy. [56:52] Can you imagine if you couldn't [56:53] physically get your groceries? [56:57] You are young. [56:58] We are young. We take for granted the [57:01] physical capacity [57:03] that one has. [57:05] That is a gift. It is a skill that must [57:09] be [57:11] continuously [57:12] pushed, [57:14] or the trajectory of aging is exactly [57:16] what we see. [57:18] People get to a point where they can no [57:20] longer [57:21] lift their suitcase [57:23] on an airplane overhead. Do you see [57:25] that? Yeah. People struggle to get their [57:28] bag on the belt to go through security. [57:31] Is that normal? That is not normal. [57:34] How do we know this? Are there other [57:36] sort of societies where they just age [57:38] better than us? Um and they're, you [57:40] know, they've got 60-year-olds that are [57:42] being able to lift their bags above [57:43] their head. [57:43] I mean, I can tell you from [57:46] my father's community in Ecuador. [57:49] My dad is 74. [57:52] If something is a 3-hour [57:56] walk or less, he'll walk it. [57:59] I definitely don't like to go visit him, [58:00] as you can imagine. It's a lot of [58:02] walking. [58:03] They are extremely physically active. [58:06] They seem to age well, and I think that [58:10] you will find pockets of individuals [58:13] who [58:15] do things that are very physically [58:17] active throughout their life span, [58:20] which will allow them to maintain a [58:22] muscle span, which is the time in which [58:24] they have quality skeletal muscle. [58:26] I will also say we control our [58:29] environment. [58:30] Everything can be easy for us if we [58:32] choose. [58:34] You can take the escalator, you can take [58:35] the elevator, you can get in the car, [58:36] you can do all of these things. [58:38] Inoculating yourself against muscle [58:41] aging [58:42] takes effort, but it has to be done. [58:47] Each time someone has a choice to either [58:49] do it [58:50] physically themselves or to take the [58:52] easy way, each time an individual [58:55] continues to take the easy way, [58:58] the [58:59] predictable decline [59:01] will [59:02] conti- It's like putting another coin in [59:04] the bank, but maybe that bank is being [59:07] spent on something worthless. That's [59:09] exactly what happens. [59:12] What are the misconceptions people have [59:13] about um weight loss? You've touched on [59:15] it a little bit, but i- if I've come to [59:17] you and I say, "Listen, Dr. Lyon, I'm [59:19] going to be honest with you. I just want [59:21] to lose some of this belly fat. [59:22] I just want to be um lean, and I want to [59:24] be beautiful. [59:26] Um should I get liposuction? [59:29] Um what diet should I go on? What would [59:31] you say to me? [59:33] First thing that we have to figure out [59:34] is your muscle mass. I mean, this is a [59:37] little complicated because I would, of [59:39] course, ask them how we got to where we [59:41] were. [59:42] Right. [59:42] How do we get here? [59:44] Are you [59:46] emotionally eating? Are you, [59:49] I don't know, not sleeping? Or what are [59:51] the Are you drinking too much? What are [59:52] you doing? What are we up against? What [59:54] are the actual tactical behaviors that [59:57] we're up against? Mhm. And then, I would [59:59] say, [60:00] let's go. [60:01] We're going to build some muscle. [60:04] We have to work on some body [60:05] recomposition. [60:06] And really, the two ways that we're [60:08] going to start are the two [60:11] basic, and that is diet and exercise. [60:14] So, no lipo-suction? I mean, Stephen, if [60:16] you wanted to, I do know a great plastic [60:18] surgeon. Okay. But, no, unnecessary. [60:21] And again, this goes back to this [60:23] hyper-fixation on body fat. [60:25] When the conversation should not be [60:28] about [60:30] obesity drugs or body fat, [60:32] the conversation needs to swing back [60:36] to not about making people less obese, [60:38] but to making them have more healthy [60:41] skeletal muscle. [60:43] What's the link there? So, how is having [60:45] more skeletal muscle going to My gluco- [60:47] the [60:48] glucose is going to be stored in it, so [60:50] that means less glucose is going to be [60:51] stored in my belly fat. [60:53] My metabolism's going to be better, you [60:54] said as well, so [60:56] your ability to store glucose Yeah. will [61:00] be from, [61:01] you know, obviously stored in your [61:02] liver, but skeletal muscle is the [61:04] primary site for glucose disposal. [61:06] Am I going to be less hungry? [61:08] Now, that is a great question, and there [61:10] is observational data, and I say this [61:12] very hesitantly, [61:13] because it hasn't been published yet, [61:15] but [61:16] I believe that we are going to begin to [61:19] see that skeletal muscle [61:22] has a role in appetite regulation [61:25] because of receptors on skeletal muscle. [61:28] You will not find anything out there [61:30] yet, [61:31] but I do believe that there is [61:33] observational data from some of my [61:34] colleagues that are doing research, [61:36] that we will see that there is some [61:38] appetite connection [61:40] with skeletal muscle. Well, I burn more [61:43] calories when I'm working out if I have [61:45] more muscles. [61:46] You will. [61:47] What about Ozempic? [61:50] Should I Should I consider a little bit [61:52] of Ozempic on top? It depends on how [61:54] long you've been struggling. [61:56] Okay. I am [61:59] I do recognize that these are [62:02] very complex issues. [62:05] Whether it's Ozempic or Mounjaro, [62:08] GLP-1s, or GIP, [62:10] these drugs, [62:12] these [62:14] drugs are here to stay. [62:15] I do think they play a role. I know you [62:18] had Dr. Tina [ __ ] I am fully in [62:20] alignment with much of what she said. [62:23] There is an absolute role for this. [62:27] I will also say [62:29] that why is it [62:31] that [62:32] within that conversation of body [62:34] composition, [62:36] why is it that it is so much more [62:38] socially acceptable [62:40] to give someone a medication [62:43] to decrease obesity, [62:46] yet the idea of giving someone [62:48] a medication [62:50] or an anabolic like testosterone or a [62:53] testosterone derivative [62:54] would be shocking [62:57] to people. [63:00] I can administer a drug to make an [63:02] individual less obese, [63:04] but there is an incredible amount of [63:06] stigma [63:07] if I wanted to administer a drug to [63:09] allow someone to have stronger, bigger [63:12] muscles. What kind of drugs would you [63:14] administer to give them stronger, bigger [63:15] muscles? Testosterone would be my first [63:17] one. [63:18] How much testosterone though? [63:19] It depends. [63:20] Michael, he was uh on the podcast [63:22] previously, he told me that taking [63:24] testosterone and steroids made him angry [63:28] and gave him really vicious thoughts, [63:30] dark thoughts. But, Michael [63:33] is a professional bodybuilder. [63:35] And we know that there is health and [63:38] wellness, [63:39] and that those that operate at the [63:41] pinnacle of their sport, [63:43] that does not mean that those [63:44] individuals are [63:47] training in a healthy amount, right? [63:49] There is a cost of doing business [63:51] at the peak of anyone's career in [63:53] anything. [63:54] And from a physical standpoint, [63:56] certainly. [63:59] That utilization [64:02] would be different than someone coming [64:05] to say, "Hey, I need to work on my body [64:08] composition." [64:10] The big point here is the dichotomy in [64:13] conversation between the two. [64:15] It's fully skewed [64:18] in the way that it is much more [64:20] acceptable [64:22] to give a medication [64:23] to address obesity, and much less [64:26] acceptable to give a medication to [64:28] address skeletal muscle mass. [64:30] And I personally believe that that [64:33] conversation needs to shift. A lot of [64:35] people say that Ozempic causes muscle [64:37] loss as well. It doesn't. Really? [64:39] I have not seen a direct mechanism of [64:42] action [64:44] that Ozempic [64:46] affects skeletal muscle in a negative [64:47] way. In fact, I have seen the contrary. [64:51] There is evidence to suggest that [64:53] Ozempic and individuals like these drugs [64:56] in this class can actually support [64:58] skeletal muscle health. [65:00] The reason individuals are losing [65:03] muscle mass [65:05] on these drugs [65:07] are because they are not training [65:10] and managing their dietary protein. [65:11] There's only two ways to stimulate [65:13] skeletal muscle, [65:14] and that is through resistance training [65:17] and dietary protein. [65:20] You cannot out-medicate [65:23] poor behavior. [65:24] Oh, but but because they're on a [65:27] appetite suppressant like Ozempic, that [65:29] means that probably just not getting [65:30] their protein. We utilize these drugs in [65:34] my medical practice all the time. [65:37] We track body composition [65:40] all the time. It is routine. [65:42] We track muscle mass. [65:44] We do not see a decrease in skeletal [65:47] muscle mass when individuals are dosing [65:50] protein appropriately and training. [65:53] Does Ozempic and these that category of [65:55] drugs will people of a certain [65:57] psychological mindset benefit? [66:01] That's a wonderful question, and here is [66:03] what I would say as [66:05] a physician who is in practice. [66:08] Removing [66:09] physical obstacles are critical. [66:12] And individuals can spend time obsessing [66:15] about their body, [66:16] um [66:17] just really it can [66:20] infiltrate their thoughts. [66:22] It takes away from their capacity to [66:24] show up in life, [66:26] to be present, because they're worried [66:27] about their weight. [66:29] And can you imagine if [66:33] someone was struggling with that for a [66:34] decade or two or three? [66:37] Now, we have a new class of drugs [66:39] that will take away in part a desire to [66:42] binge eat, or take away in part a desire [66:46] to even potentially drink alcohol. [66:49] What it allows for is physical freedom. [66:52] Do I think that that comes with a cost [66:56] of not doing the hard thing and [66:59] and doing those [67:01] kinds of behaviors? [67:04] It does. It does make things easier. [67:08] However, [67:09] there is utility in that. Yeah, cuz if [67:12] someone suggested it to me, I'd say, the [67:14] first thing I'd say is, "Dr. Lion, [67:15] what's the cost?" [67:16] Cuz nothing's free in life, so and if I [67:18] don't know what the cost is, that's even [67:20] more scary. [67:21] I'd rather be able to balance the [67:23] trade-off, but not many people are [67:25] giving me many costs for Ozempic at the [67:26] moment. [67:27] Well, number one, you don't need it. [67:29] Yeah. You would not be someone who needs [67:32] Ozempic or Mounjaro or Zepbound. You You [67:35] just wouldn't be someone who needs that. [67:38] Um but, I do actually believe that this, [67:42] in combination with hormone replacement [67:44] therapy, is going to be the way of the [67:45] future for longevity. What's the cost? [67:49] I cannot tell you [67:52] what the cost is, and here's why. [67:55] Because people will say it slows down [67:57] gastric emptying. [67:59] Um yes, that's exactly what it is [68:01] supposed to do. Will that have a [68:03] meaningful outcome? [68:05] Not necessarily. These drugs are not new [68:07] drugs. [68:09] This class of drug is not a new drug. It [68:10] has been around for the last 20 years. I [68:12] know at least the last 10. [68:15] There must be a cost though. [68:16] The cost is when you go off of this, [68:19] Yeah. you likely have, and again, this [68:21] is just my perspective, is once you [68:24] titrate off, then normal hunger cues [68:27] should return. [68:28] And if you do not have appropriate [68:30] strategies in place, [68:32] an individual will then begin to [68:33] struggle, [68:34] potentially regain the weight. Have you [68:36] seen this? I haven't. [68:37] We take people off these medications all [68:40] the time. [68:42] And they don't rebound. [68:44] They do not rebound. They do not [68:45] rebound. [68:49] But again, we do very intensive [68:52] lifestyle interventions. We also [68:56] figure out why people got [68:59] into the place or the hole where they [69:02] are starting. Why? [69:04] Right? You say there's no free lunch, [69:06] and maybe the no free lunch is you have [69:08] to address old trauma. [69:09] Maybe one will really have to explore [69:13] the way in which they cope, right? [69:16] Cannot cope with emotional eat like they [69:19] You cannot do these things. [69:21] If you want to maintain [69:23] your body composition as you age, [69:25] you have to be accountable for these [69:27] things. [69:28] Do diets work? [69:30] Do you ever put someone on a diet? [69:33] If they're over consuming calories, [69:34] yeah. And what does that look like? For [69:37] us, I mean, we've been doing this for a [69:39] very long time. [69:41] We The first thing that we decide is [69:42] dietary protein. [69:44] Which is unfortunately seems to be the [69:45] most controversial macronutrient. Which [69:48] by the way, you looked at me crazy and [69:50] you're absolutely right. Why would any [69:51] macronutrient be controversial, but [69:54] dietary protein, again, it wasn't like [69:57] this until the influx of social media. [70:01] And what do I mean by that? Dietary [70:03] protein, it just seems as if there's [70:06] always a reason why people are trying to [70:07] remove it from the diet. Which seems [70:09] somewhat ridiculous and [70:10] counterintuitive. [70:13] The first thing that we do is we [70:15] recognize that dietary protein is what [70:17] the foundation of any solid nutrition [70:19] plan should be built on. [70:21] And that is 0.7 to 1 g per pound ideal [70:24] body weight. [70:26] If you eat high nutrient-dense foods [70:29] like animal products, you could probably [70:30] go to the lower end at 0.7. If you are [70:32] someone who does not eat any kind of [70:34] animal product, you're probably going to [70:36] be closer to 1 g per pound ideal body [70:39] weight of [70:40] um whatever that source of protein is. [70:43] But protein is what is going to maintain [70:46] hunger. [70:47] You know, uh dietary protein does cause [70:50] an increase in GLP. GLP-1 in the body. [70:54] And people will talk about that, [70:55] although it's only meal to meal. Which [70:57] is so you know, you have these GLP-1 [70:59] agonists which improve satiation. So [71:02] like a a Zempic is a GLP-1 agonist which [71:04] makes you less hungry. [71:05] Yes. Dietary protein, in part, works on [71:08] that same kind of mechanism. Also [71:09] releases GLP. [71:12] Which makes me less hungry? [71:13] Yes. Okay. It will improve your improve [71:15] your satiation. Okay. [71:17] Dietary protein, we know, can help [71:19] regulate hunger. [71:20] Can also [71:22] maintain blood sugar, right? If you have [71:24] carbohydrates in in check. Not a very [71:27] efficient way, but your body can [71:28] generate glucose from dietary protein. A [71:30] lot of people associate protein with [71:32] like bodybuilders and stuff like that. [71:33] I know, it's such a mistake. It's a [71:35] mistake. [71:36] Because as individuals age, they need [71:40] double the the minimum recommendation to [71:42] prevent a deficiency. [71:44] The current recommendation is 0.8 g per [71:47] kilogram or 0.37 g per pound. [71:50] If someone was 115 lb, their dietary [71:54] protein recommendation would be 45 g. [71:57] That would be the minimum to prevent a [71:59] deficiency. [72:00] As individuals age, they require more [72:03] dietary protein [72:04] because skeletal muscle becomes what we [72:07] call anabolically resistant. [72:09] It means it becomes less efficient at [72:12] utilizing dietary protein. If you were [72:14] to eat the way you did maybe in your [72:17] teens and 20s. [72:18] Body at that time is extremely anabolic. [72:21] What's that mean? You look like you're [72:22] pretty fit. Have you always been pretty [72:24] fit? No. [72:26] Pretty fit in terms of what though? I've [72:28] not always had as as much muscle mass as [72:30] I have now, but I've always been [72:32] um fit as in playing sports and stuff my [72:35] whole life. And has it been easy to put [72:36] on muscle? [72:37] Generally, I'd say yes. When I was [72:38] younger, it was a it felt a bit more [72:39] difficult, but I just think I had had [72:41] things wrong. I don't think I was [72:42] consuming enough calories. [72:43] Mhm. But as of as I got to sort of 25, [72:45] 26, 27, it became a little bit more [72:47] straightforward. Which is amazing. Your [72:50] body is highly anabolic. You are now [72:53] consuming calories, [72:55] protein, you're able to put on skeletal [72:56] muscle. Mhm. That tissue is very [72:58] anabolic. It's sensitive to the foods [73:00] that you're eating, to the stimulus [73:01] you're providing. As you age, that [73:04] tissue becomes more resistant. [73:07] I've got friends that tell me they can't [73:09] put on muscle easily. [73:10] How old are they? One of them's 27 and [73:12] the other one I think is about 29. Okay. [73:15] And they're men. [73:17] And they've told me that [73:19] no matter what they do, they just can't [73:20] put muscle on. [73:21] Well, [73:22] first things that I would do is ask them [73:24] what they're doing. Are they consuming [73:25] enough calories? Do they have enough [73:26] protein? Where do you think they're [73:27] going wrong when I said that? [73:29] The fir- You want me to be honest? The [73:31] first thing that I thought was [73:33] I am seeing a huge increase in low [73:37] testosterone levels in younger [73:39] individuals. Interesting. [73:41] And um I know it's just me and you and [73:44] not the millions of people that [73:46] watch your show, but um [73:50] the medical answer would be they should [73:53] look at their diet and training and [73:54] sleep. But what I am seeing clinically [73:57] is that young young men have [74:00] increasingly low levels of testosterone. [74:03] And how does that link to them not being [74:05] able to put on muscle? They are [74:08] um less anabolic than they should be. [74:11] What does anabolic mean? Building. They [74:13] are less capable of building. Okay. If [74:15] if I This is a [74:17] problematic question. Um [74:19] is there any way to tell if someone has [74:21] low testosterone just by kind of looking [74:23] at them? [74:24] Some of my colleagues might disagree [74:26] with this. [74:27] I would say you could potentially guess, [74:30] but do they have less um [74:35] hair on their legs? Do they have less [74:37] muscle mass? Do they have um [74:40] what would look like potentially more [74:43] estrogen in a male? You know, you're [74:45] putting me on the spot here, right? [74:46] Yeah, but all those things I was [74:48] thinking of my particular one particular [74:49] person. I think all those things are [74:51] true. [74:52] So maybe it is like low testosterone. So [74:53] my next question becomes is there a way [74:55] that they can stimulate their [74:56] testosterone without having needles [74:58] stuck into them? Absolutely. I mean, the [75:00] first thing is you have to look at [75:01] lifestyle. What is their diet? You do [75:03] need nutrients. If they are not sleeping [75:06] and they're um taking potentially [75:09] uh recreational drugs, this can all [75:12] affect [75:13] testosterone. It could be it can affect [75:15] sleep. It can affect a number of things. [75:19] The first thing that I would do is are [75:20] these guys sleeping? [75:22] Are they eating well? [75:24] Eating well being the protein we talked [75:26] about. Are they eating a diet that is [75:28] fully processed? Are they training? [75:30] Training in and of itself isn't going to [75:32] generate testosterone per se, but it [75:35] would increase the receptors. [75:37] Increase the skeletal muscle receptors. [75:39] Increase those androgen receptors. [75:41] Uh the other thing that I would say, and [75:43] this is what may be a little bit outside [75:44] the box, but what are they being exposed [75:46] to? [75:47] We do a lot of heavy metal testing. Uh [75:50] we see we do see a lot of exposures. [75:52] Those things can affect fertility. [75:55] Whether it's lead or mercury, those kind [75:57] of things, absolutely. [75:59] And where do these things come from, [76:00] these heavy metals? [76:03] I mean, we're drinking out of a metal [76:04] cup here. [76:05] I know. This is stainless steel. I don't [76:06] think that this gets into the water. [76:08] Um they could certainly get it from [76:10] aluminum cans. [76:12] They could get it from eating a lot of [76:14] seafood. They could have exposures. [76:17] Um maybe they're training on weapons. [76:21] Maybe not. Could be getting lead. You're [76:23] in great shape. Thank you. What do you [76:25] eat? [76:26] Diet high protein. And I eat a lot of [76:28] carbs. I train a lot. [76:30] So run me through your day. What time do [76:33] you wake up? [76:34] Between 5:30 and 6:00. My husband wakes [76:36] up at 4:00. Mhm. [76:38] So. [76:39] And then That's the problem. And then [76:41] what do you do? [76:42] I get up. [76:44] Um I see if the kids are asleep or [76:46] awake. Usually one is in the bed, two is [76:49] in bed. And then I get ready to go [76:50] train. [76:52] Get up. Three days a week, I [76:55] head over to meet my coach. Sh- shout [76:58] out to Carlos Mana. He's the man. [77:01] And we hit it hard. And I'm usually 5 [77:03] minutes late every single time. [77:05] Because in the morning, [77:07] one or both children will will decide if [77:09] they're going to come with me or not. I [77:11] include my kids in my training. [77:12] How old are they? Three and five. [77:15] Oh, damn. You're getting them training [77:16] at three and five? [77:17] I am. [77:19] My 5-year-old is in jujitsu. They have [77:21] their own kettlebell sets. [77:23] Um [77:24] because [77:26] people and children, [77:28] they don't care what you say. [77:30] They care what you do. [77:33] So, [77:34] sometimes they decide to come with me, [77:35] sometimes they don't. Um and I train [77:39] fasted. [77:40] Wait. I didn't tell you I [77:42] caffeinate a lot. [77:45] A lot. I am drinking coffee now. I may [77:47] be someone who is tired or drinking [77:49] water or coffee. How long do you train [77:50] for? An hour. And you only do three [77:51] times a week? [77:53] I do three times a week of lifting. [77:56] Okay. [77:57] I try to train as hard as I possibly [77:59] can. [78:01] By that second day, I'm tired. [78:03] It would take a lot for me to do some [78:05] kind of major lifting. I'm in the middle [78:06] of rehab. [78:08] The next day, so I'll train Mondays, uh [78:10] Wednesdays, and Fridays. [78:12] Tuesdays, Thursdays will be [78:15] some kind of [78:16] light cardio. Maybe I'll do 20 minutes. [78:18] Maybe it'll be intense. [78:20] Whatever I'm feeling. I'm very active [78:22] during the day. [78:23] Sometimes I wear a weighted vest. [78:25] I take calls walking. I move a lot. [78:28] My friends joke that I am someone who [78:30] never sits still. Period. End of story. [78:32] You can see me now. I'm moving all over [78:34] the place. [78:35] I have high energy expenditure. [78:37] My first meal of the day will either be [78:39] a shake. It might be 30 to 50 g of a [78:42] whey protein shake. Uh typically, I [78:44] might even have collagen in my coffee. [78:47] Collagen um in coffee doesn't [78:49] necessarily [78:51] stimulate muscle, but I use it for hair, [78:53] skin, and nails. It's an incomplete [78:54] protein and has a protein score of zero. [78:57] I just wanted to clarify. So, am I [78:58] training fasted? Yes. Uh mostly fasted [79:01] might be shot of collagen. [79:03] 30 to 50 g at that first meal. [79:05] I might have some kind of carbohydrate, [79:07] but usually [79:09] I'm running around. Got to get the kids [79:11] to school or whatever it is. [79:14] My my next meal might be some lean beef. [79:18] I'll definitely have carbs. I'll have [79:20] either rice or potato and some kind of [79:22] greens. And that will be another you [79:25] know, if I were to think about how much [79:26] protein, I'm tiny person. I'm maybe 110 [79:28] lb. I might have 120 [79:31] g of protein a day. [79:34] And then the last meal is also between [79:36] 30 and 50 g of [79:38] protein and probably close to 50 g of [79:41] carbs. And what what time is that last [79:43] meal typically? [79:45] If you can help it. Around 7:00. I eat [79:47] with the family. [79:49] Nothing crazy. I'm very consistent. [79:53] I think it's important that one meal or [79:54] one workout doesn't take you off track. [79:58] I don't really think twice about it. I [79:59] know what I have to eat. Food is not um [80:02] complicated. [80:04] It's effective. [80:07] I don't drink alcohol. I don't like the [80:08] way it tastes. I don't really have a [80:10] sweet tooth. Is that the only reason you [80:12] don't drink alcohol? Because of the [80:13] taste? Did you Did you drink alcohol [80:15] before? [80:15] No. You've never drank alcohol? [80:17] No. Taste terrible. I'm sure you've had [80:19] it. Taste like rubbing I mean, taste [80:21] terrible. Maybe I'm lucky. [80:24] But uh also think that [80:27] you know, can be toxic for the brain, [80:29] but I choose not to have it because I do [80:32] think it tastes terrible. [80:33] Every single time you eat, you have an [80:35] opportunity to improve your health. And [80:38] that's why I love Zoe because Zoe helps [80:40] me to make the smartest food choices for [80:42] me and my body. And as you guys will [80:44] know by now, Zoe is a sponsor of this [80:46] podcast and I'm an investor in the [80:47] company. And if you haven't tried Zoe, I [80:49] highly recommend you do because Zoe [80:51] combines my health data with Zoe's [80:53] world-class science. And using those two [80:56] things, Zoe guides me to better health [80:59] every single time I make a food choice [81:00] and eat. Which means that I have more [81:02] energy, better sleep, better mood, and [81:04] I'm less hungry. And the most important [81:06] thing is Zoe actually works. It's backed [81:08] by their recent clinical trial, [81:10] something called the method study, which [81:12] is the gold standard of scientific [81:14] research. I started Zoe just over a year [81:16] ago now and I've been able to track my [81:18] progress week after week so I can learn [81:20] how to be even smarter the following [81:22] week. And if you haven't joined Zoe yet, [81:24] I'm giving you 10% off when you join Zoe [81:26] now. Just use the code CEO10 at [81:29] checkout. [81:31] Are there small parts of your protocol [81:33] that people can implement? You talked [81:34] there about not sitting. [81:36] You know, you said weighted vest. [81:38] Yeah. Um are there anything else that we [81:40] can do that might help us build muscle [81:43] mass without having to go to the gym? [81:44] Yes. What are the key things you think [81:46] about that? If you can [81:48] take a call walking or rocking [81:51] you can load up weight. It is extremely [81:54] easy to do and you can do it slowly. [81:58] Whether you start with [81:59] you could start with 7 lb. [82:02] I have a 5-lb weight vest. I have a 7-lb [82:06] weight vest, 20, and then from there you [82:08] can load up weight. So you can build up [82:10] over time. Um people should be doing [82:13] that. It is effective and easy. Everyone [82:16] can do that. People are taking calls. [82:18] You don't have to do Zoom call. [82:20] Why not? Get on the phone, get moving. [82:24] Human body will like to sit, right? As [82:26] opposed to be forced to move, but you [82:28] become [82:32] It's almost like a wrote activity. If [82:35] you are someone who is sedentary [82:36] it becomes easier to become sedentary [82:38] and stay sedentary. [82:40] It requires friction to change. [82:42] You can mitigate some of that friction [82:45] by incorporating movement into your [82:46] life. [82:47] For example walking with a a weighted [82:50] vest, easy. [82:52] Training with your kids. [82:54] People will say, "I don't have time. I'm [82:56] so busy." [82:57] Pick up your kids after school. We [82:59] instead of go and play video games [83:02] we [83:03] do a push-up challenge or a dance party. [83:06] You know our Have you ever heard of [83:08] Texas Hold'em? [83:09] The poker game? No, the dance. Have you [83:11] ever seen this uh Beyoncé um [83:14] made an amazing song called Texas [83:16] Hold'em and [83:17] I thought she was talking about poker. [83:18] She might be, but there is a line dance [83:20] associated with that. There are a [83:22] million fun ways to do something. [83:25] We just have become accustomed to doing [83:27] less. [83:28] And we'll dance, we'll do whatever, [83:30] push-ups, physical challenges, playing [83:32] outside get the Nerf guns, whatever it [83:35] is. [83:36] Easy. [83:38] I mean, it couldn't get easier than [83:39] that. [83:40] What do you think a good goal is to [83:41] have? What kind of goal? Cuz I It was a [83:44] I've said this before, but there's a [83:45] time in my life where my goals are very [83:46] like superficial. [83:48] Um and they were like [83:50] anchored to a a date. [83:52] What are the best kind of goals that we [83:54] should set ourselves as it relates [83:55] relates to our health? I don't think we [83:57] should set goals. No goals? I think we [83:59] should set standards. [84:00] Okay. [84:02] When you set a goal, you can either [84:03] reach that goal or not. But if you set a [84:06] standard then you will always keep your [84:09] standard. And that standard will allow [84:11] you to reach a goal. But the standard [84:14] won't change. For example, the standard [84:16] is you wake up and you set whatever that [84:19] is, you train every day. [84:21] For me, I train 3 days a week. [84:23] Um depending on how intense that [84:25] training was. [84:26] On Saturday, I might do a fourth day of [84:28] training. And on Sunday, I forgot to [84:30] tell you this, we do a group workout. [84:32] My standard is physical activity [84:35] has defined moments and that is my [84:37] standard, even if I'm traveling. [84:39] I know exactly what that's going to be [84:40] before I get to the hotel. [84:44] That is a standard of physical activity. [84:46] I don't have to think about a goal. I [84:47] don't have to have a goal of [84:49] am I going to hit that or not because I [84:50] know that those are things that I won't [84:53] fall short of. [84:55] My standard is my nutrition plan. I have [84:57] between 110 to 120 g of protein. I have [85:01] between 110 to 120 g of carbs. I know [85:04] what that looks like. That is my [85:05] standard. [85:07] I don't deviate from that. And what are [85:08] you struggling with as it relates to [85:10] your own advice? [85:12] Um sleep. You're struggling with sleep? [85:14] Yeah. [85:15] Is that because of the two little kids [85:16] or It is. Because I have to make a [85:19] choice. [85:20] Am I going to spend time uninterrupted [85:23] and undivided with them [85:25] or am I going to do work? [85:28] And my choice is I spend time with them. [85:31] And then when they go to sleep, I work [85:32] another 2 to 3 hours. [85:37] And I should probably do [85:40] a better job and know that eventually [85:41] everything is going to get done, but I [85:43] set standards. [85:47] Do you find it difficult? You know, cuz [85:49] people always talk about um [85:51] not being able to have everything at [85:52] once. This is what a lot of women have [85:53] said to me. They said they were There [85:55] was a time where we were sold this dream [85:56] that you could have everything. You can. [85:58] You can? I think so. Do you you must see [86:01] a lot of excuses in people. [86:03] I do. Because it's hard to face the [86:06] truth. [86:07] And what's the truth? [86:08] What is the truth? The truth is [86:10] are you doing this [86:12] or are you not doing this [86:15] because of some kind of internal choice? [86:17] There has to be some truth-telling. [86:20] And sometimes that truth is [86:23] uncomfortable. [86:25] And you you can get the job done. [86:28] There might be things that um [86:30] you have to sacrifice. [86:33] But the job that the thing that you want [86:36] the outcome that you want, the standard [86:37] that you set, it can be done. [86:41] It can be done. It's you tell yourself [86:44] you can't do it. I mean, I have a three [86:47] and a five-year-old. [86:49] Do you know what kind of chaos ensues at [86:51] my house? [86:53] You should come over and I guarantee you [86:55] will hold off having any kind of [86:56] children for at least 5 years. [86:59] But nothing is perfect. It can't ever [87:02] Everything cannot be curated. Do I still [87:04] get my training in? Do I still get my [87:05] nutrition in? Am I anything special? I'm [87:07] not. [87:08] But my discipline is. [87:10] I am very disciplined. Have you always [87:12] been? Yes. [87:14] A lot of people aren't and they haven't [87:16] ever been. It's much more difficult to [87:19] not be disciplined. [87:21] The reason I am disciplined is to be [87:23] able to manage my life. How do I get [87:25] your discipline? [87:26] You execute. You don't overthink it. [87:28] There's nothing to think about. What do [87:30] you want? [87:31] I want to be like you. No, what do you [87:33] want? Where are you falling short? [87:35] to be like you. [87:37] You would not be nearly as successful if [87:40] you were undisciplined. You have to be [87:41] disciplined. [87:43] I'm just trying to embody the audience. [87:44] I'm just trying to trying to think [87:45] through all the [ __ ] that people [87:46] tell themselves. And we all tell [87:48] ourselves [ __ ] in various aspects of [87:50] our life. If we're not telling ourselves [87:51] [ __ ] as it relates to like exercise, [87:52] it's something else. It's our [87:53] relationships. It's playing. [87:54] Totally. And we all And there's so many [87:56] people struggle with personal [87:57] responsibility cuz if I was to post if [88:00] you were to post or I was to post [88:01] anything on my story that you just said [88:03] in the last sort of 5 minutes [88:05] They'd be very offended. Yeah, and [88:06] they'd be Well, not every bit There's a [88:07] small group of [88:08] So are they going to edit this out so [88:10] that I'll come Oh, no, don't Don't send [88:12] crazy people after me. No, we will. But [88:14] um it's like the what about tree gang. [88:16] And the what about tree gang, you could [88:17] say anything and they'd say, "Yeah, but [88:18] what about Yeah, but what about?" And I [88:20] understand some people have they have [88:22] legitimate Steven, the truth is [88:25] it is very difficult to do what I do. I [88:27] run three different businesses. I take [88:30] care of some of the most incredible [88:31] humans on the planet. [88:35] I have my own podcast. I'm writing two [88:36] more books. And I don't have full-time [88:38] help. I'm a mom. [88:43] The one thing I don't find [88:45] is I don't find excuses. I figure out [88:47] ways to get it done because if it [88:49] matters [88:50] you find ways to get it done. [88:53] You know [88:54] if I were to say [88:57] and this is an extreme example [88:59] but let's say [89:01] I said to someone who [89:04] I'll just make this up, loved cupcakes. [89:07] I said [89:09] if you eat another cupcake then [89:12] something catastrophic is going to [89:14] happen to your dog. [89:15] Do you think that they would ever touch [89:17] another cupcake? No. Not in a second. [89:19] Just like that. [89:21] So, the consequence is just not [89:23] meaningful enough. [89:24] When you find a meaningful consequence [89:26] and you understand the consequence of [89:28] your actions in that moment, [89:31] it becomes easy. And this goes toward [89:32] what you're saying about the discipline [89:34] and the why part of that equation. You [89:36] You refer to that as consequence. Like, [89:38] why does this matter to you is the [89:40] central part of the equation and deep in [89:41] your head somewhere [89:42] there's you're so clear on why this [89:44] matters. Yeah. Because you've you've [89:46] seen the research, you've studied it, [89:47] you've seen the the consequence of this. [89:49] I've seen the end result. Yeah. You see [89:51] people die. You see people [89:53] die. [89:53] At the end of the day, we are all [89:56] health and age and death, these things [90:00] nobody's getting out of them. [90:02] Like, nobody. [90:04] So, if I follow your protocols [90:06] for the next 30 years, [90:10] at Yeah, then I'll be 60 years old. I'll [90:12] be 61 years old. [90:13] Can you describe to me what you think my [90:16] life will look like as a 61-year-old? [90:18] Versus [90:19] if I just sit in this chair and eat [90:21] processed foods and do zero resistance [90:24] training for the next 30 years. Can you [90:26] describe the two different Steves? We'll [90:28] call it We'll call one sedentary Steve [90:30] and we'll call one um [90:32] Dr. Lyon Steve. [90:33] Okay. [90:35] Let's start with [90:37] sedentary Steve. Mhm. [90:40] I will say [90:42] you're 30. So, right now you're [90:44] sedentary. [90:46] Alzheimer's disease is likely beginning. [90:49] Cardiovascular disease is likely [90:51] beginning. [90:52] Right now at 30? That's right. [90:54] Remember, these diseases that we believe [90:57] are diseases of aging [90:59] are at their core and at their root, in [91:03] part, [91:04] due to the health of skeletal muscle. [91:07] The only organ system that you have [91:09] direct voluntary control over. [91:12] That's it. [91:14] I cannot say, Steven, [91:16] "I want your heart to beat at 45 beats [91:19] per minute. Go." [91:23] I cannot control. You might be able to [91:25] control your respiration, but you can't [91:28] physically [91:29] contract your diaphragm. Go ahead, [91:30] contract. [91:33] Okay. [91:34] Maybe. [91:36] It's a muscle. [91:37] Skeletal muscle is the only organ system [91:41] that you have voluntary control over. [91:42] That's it. [91:44] Now, [91:45] if you decide to not hear what I am [91:48] saying, [91:49] then [91:50] if you are someone [91:52] who [91:53] has a genetic propensity, maybe you have [91:57] I don't know. Uh when you overeat, you [91:59] get high triglycerides or you [92:03] um [92:04] choose not to exercise. [92:07] We will start to deteriorate your brain [92:09] because [92:10] contracting skeletal muscle is an [92:12] endocrine organ. [92:13] Not only does exercise increase blood [92:15] flow to your brain. [92:17] Um I just wrote a narrative review with [92:19] a colleague of mine, um Louisa Nicola, [92:22] amazing. [92:24] We looked at the influence of resistance [92:26] training and brain function. [92:28] I cannot restore your brain, but I'd [92:30] love to be able to prevent from the [92:34] uh connections [92:36] to become weaker and weaker and weaker. [92:39] So, [92:41] you decide not to exercise, I can do [92:43] nothing for your brain. [92:45] Eventually, [92:46] you might [92:48] forget [92:50] I don't know. [92:51] Your neighbor's name, [92:53] your kid's name, [92:54] your [92:56] um [92:57] anything, what you did, any meaningful [92:59] memory. [93:00] If we don't address [93:02] your brain now, [93:05] then [93:06] the potential outcome is clear. [93:08] Right? 2/3 of Alzheimer's, [93:10] um the majority of dementia is [93:11] Alzheimer's dementia, which plays a role [93:14] in [93:16] uh metabolic regulation. [93:18] Type 3 diabetes of the brain. [93:20] If your skeletal muscle is unhealthy, [93:22] you are likely having [93:23] not only skeletal muscle insulin [93:24] resistance, but brain insulin [93:26] resistance. No such thing. You cannot [93:30] be sedentary and be healthy. So, that [93:32] will begin now. [93:33] The other thing is your cardiovascular [93:35] activity, mhm. [93:38] Can't help. Can't help you there. Not [93:40] getting increase in blood flow, you're [93:41] not um moving [93:44] your cardiovascular health the way that [93:46] it should, your lung capacity, your [93:48] cardiovascular capacity. You're probably [93:50] going to be extremely winded walking [93:52] upstairs. [93:53] It might take so much effort for you to [93:55] get up, you might not even be able to [93:58] fully [94:00] stand up and sit down from your chair [94:03] multiple times. You might struggle with [94:04] that. [94:07] If I said, Steven, "I need you to go to [94:09] grab something out of the car for me." [94:11] You'd probably say, "Oh, man. [94:13] Hey, Doc. Um that's going to take a lot [94:14] of effort. I I [94:16] I'm not sure. I'm not sure I could even [94:17] grab that I don't know, 15-lb grocery [94:20] bag." [94:23] You um [94:24] likely have central obesity. [94:28] Probably have sleep apnea, which means [94:29] you're further deteriorating both your [94:31] brain and your metabolic health. [94:34] I would just throw in there you haven't [94:36] trained your entire life, your [94:37] testosterone is probably low and maybe [94:39] throughout your lifespan, who knows? [94:41] Maybe you have challenges with fertility [94:44] because your sperm quality isn't as good [94:46] as it could have been if you were [94:48] training and eating well. [94:50] Are you convinced yet? So, there's a [94:52] there's a link between my fertility, for [94:54] men and women, and my muscle mass. There [94:57] is um a link between [95:01] exercise, training, [95:04] metabolic health, and definitely [95:06] fertility. [95:08] I think we are going to see more and [95:10] more literature come out on this. [95:12] Muscle mass and fertility. [95:16] As um by the time you're 60, we'll [95:18] definitely have more. [95:19] Is there a link between polycystic ovary [95:21] syndrome and muscle mass? You talk about [95:23] that I think in chapter two. I think you [95:24] There is insulin insulin resistance. [95:27] When you think about skeletal muscle and [95:30] insulin resistance, skeletal muscle [95:31] makes up 40% of your body weight or so. [95:34] Depending, for me it might be less, for [95:36] you it might be more. [95:37] When skeletal muscle becomes insulin [95:39] resistant, [95:40] again, which means insulin is a [95:43] uh peptide hormone that is released from [95:44] the pancreas, [95:46] you require insulin [95:48] to move glucose out of the bloodstream [95:51] into cells. [95:53] When you exercise, you do not require [95:55] insulin to move blood glucose out [95:59] of the bloodstream into skeletal muscle [96:01] tissue. [96:03] It can be insulin independent. [96:06] Polycystic ovary syndrome is [96:08] multifactorial. [96:10] There is a component of polycystic ovary [96:12] syndrome that is related to skeletal [96:14] muscle insulin resistance. [96:16] Once an individual [96:18] manages their skeletal muscle mass, [96:21] again, there's a various number of [96:23] reasons as to why someone would have it, [96:25] but [96:26] in part, addressing skeletal muscle mass [96:29] and skeletal muscle insulin resistance [96:31] can help resolve polycystic ovary [96:33] syndrome in certain cases. [96:35] I was reading on the subject of sort of [96:37] um [96:38] PCOS and fertility. I was reading a [96:40] study by uh which was um done at Harvard [96:43] that found that men who reported to [96:45] frequently lift heavy weights and [96:47] objects at work had a 46% higher sperm [96:50] concentration [96:51] and a 44% higher total sperm count [96:54] compared to those with less physical [96:56] jobs. So, you're telling me if I want to [96:57] up my sperm count and have a baby, [97:00] And health. And sperm health. I should [97:02] start lifting some weights. Yes. [97:05] I was thinking about the 61-year-old guy [97:06] that listens to Dr. Lyon's protocols. [97:09] But also, [97:11] let's say you didn't We didn't talk [97:12] about what would happen if you listened. [97:14] Yeah, which is what I'm saying. So, the [97:16] guy that listened, so the 61-year-old [97:18] Steve Bartlett that listens to your [97:19] protocols. [97:19] Holy cow, that guy's a beast. He's now [97:21] taken over the world. [97:24] Because Does he have a six-pack? Of [97:26] course he does. Really? At 61? Yes. Is [97:28] it possible? Yes. [97:32] What's the healthiest [97:33] oldest person you've ever seen? My dad. [97:36] Really? Oh my gosh. [97:38] He's 74. He could put on a little more [97:39] muscle. Okay. [97:41] His testosterone was like 800. He's not [97:43] any hormone replacement. [97:45] He has been following what I've been [97:48] telling him, unfortunate for him because [97:50] I'm his daughter. [97:52] He's been listening to this message. I'm [97:53] just sitting here with you, but we are [97:55] talking about over 10 years [97:59] of talking about this, [98:00] of seeing this with patients and people. [98:03] He has amazing um hemoglobin A1C, [98:08] fasting blood sugar, [98:10] cholesterol is in check. I mean, he is [98:12] strong, he is capable. [98:16] He's 74. [98:19] What is the most important thing that we [98:20] haven't talked about, Dr. Lyon? [98:24] I would say that [98:26] nobody's getting out of this alive. [98:29] And it's all going to come down [98:32] to choices. [98:34] Choices for how [98:36] we execute. [98:37] Our present choices will determine our [98:39] outcomes. [98:41] And it is not difficult, it's not [98:43] complex. [98:45] You have to prioritize skeletal muscle. [98:47] This is the organ of longevity. [98:49] With this physical framework comes [98:53] mental strength. [98:55] And what's most important about this [98:58] isn't for us now. [98:59] Like, this is great, you can do it, [99:02] but it provides [99:04] hope and an example for our children. [99:06] That them, those people, the little [99:09] ones, that is who I am [99:12] truly worried about [99:14] because we have normalized supersizing [99:16] everything including ourselves. [99:20] We have more electronics than ever [99:22] before. We are more disconnected from [99:24] people. [99:26] People will say the internet has done a [99:28] great job at connecting. Face-to-face [99:30] conversations, connection is huge. [99:34] The most important is our youth and how [99:36] we raise them and the messages that we [99:38] give them [99:39] because they are our responsibility. And [99:41] if we cannot advocate for our own [99:44] health, whatever those limitations are [99:47] whether it's personal or worthy, it is [99:50] our responsibility to do a much better [99:52] job [99:53] so that we not tell them but we show [99:55] them the way forward. [99:57] And what's the most important subject in [99:59] your book that we haven't covered? [100:01] Forever Strong, a new science-based [100:03] strategy for aging well, how to reboot [100:05] your body to burn fat, fight heart [100:07] disease, reverse diabetes, stay sharp, [100:09] build muscle, and boost energy. [100:12] I mean, we talked about dietary protein. [100:15] We talked about how that potentially can [100:17] be controversial controversial for some [100:19] people. [100:20] Um [100:22] We discussed carbohydrates. [100:23] Carbohydrates are earned through [100:25] activity. [100:26] If someone is metabolically unhealthy, [100:28] they have to understand that potentially [100:30] starting with 100 g and titrating up or [100:32] down depending on their activity level [100:34] is important. [100:36] How quickly do I lose muscle? [100:38] Uh you if you are in the ICU, you could [100:41] lose 2% of your muscle mass in a day. [100:44] Ugh, god, what? [100:45] If you are in a highly catabolic state [100:48] on bed rest, [100:50] you will lose muscle [100:52] rapidly [100:53] depending on your age. [100:55] Um within 7 days, you could lose if [100:59] you're young and healthy 2 lb of [101:01] skeletal muscle mass. [101:03] Cuz I'm thinking if I go to the gym [101:04] today and I did my biceps and I really [101:06] smashed it, [101:08] how long before those gains were lost? [101:12] I would give you you'll lose strength [101:13] and then mass. [101:15] Um you will lose it rapidly. 7 days of [101:18] bed rest, [101:19] you will lose it. [101:22] And and But it will return if you've [101:24] been well trained. [101:26] And it will return faster the second [101:28] time than it did the first time, right? [101:29] People talk about muscle memory a lot. [101:31] That is a interesting [101:34] perspective. Yes, if you are well [101:36] trained, will it return? Yes. [101:39] It also depends on how long you've been [101:41] untrained for. It also will depend on [101:44] how highly catabolic you are. [101:47] For example, if someone had cancer, [101:48] they're in a highly catabolic state, [101:49] their body is breaking down, skeletal [101:51] muscle mass will improve their [101:54] survivability. [101:55] If someone goes on bed rest, you will [101:57] lose muscle mass and strength extremely [101:59] rapidly. [102:01] Now, [102:03] will you able to improve [102:05] re-return insulin sensitivity? Yes. [102:08] If you decided to just begin [102:12] basic activities of living and not [102:15] exercising, you will not be able to [102:17] recover that muscle. Getting out of the [102:19] hospital, just doing basic things will [102:22] not be enough. [102:23] And now as you can imagine, that happens [102:25] to people. [102:27] I can imagine. Yeah. [102:30] Yeah, I go through periods in my life [102:31] where for whatever reason I have to be a [102:33] bit more sedentary. [102:35] Um [102:36] things like filming TV shows. I filmed a [102:37] show called Dragon's Den where we [102:38] basically sit in a room for 10 hours a [102:40] day. It's like Shark Tank here. [102:42] And whenever I go through that season of [102:43] life, it's very difficult. I I I always [102:45] see this correlation between how much [102:47] activity I have I've been doing and how [102:49] much motivation I have. [102:52] Uh so if I've been sat down and not been [102:54] exercising for a while, I find it harder [102:55] to find the motivation to go again and [102:57] it's this kind of vicious downward [102:58] spiral. [102:58] One thing that we didn't talk about is [103:00] how skeletal muscle mass [103:02] functions as an endocrine organ. [103:04] What's an endocrine organ? An endocrine [103:05] organ is something that produces [103:07] hormones that act systemically, locally, [103:09] and um inter or there's an inter organ [103:12] connection. When you exercise based on [103:15] intensity and duration, you release [103:17] myokines. Myokines like interleukin-6 or [103:20] interleukin-15. [103:22] These are what people typically think as [103:24] cytokines that are released from [103:25] inflammatory cells or macrophages. [103:28] But when you contract skeletal muscle in [103:30] a meaningful way based on the intensity [103:33] and duration, you release myokines from [103:37] skeletal muscle that interface with your [103:39] brain. They affect mood. They affect [103:41] neurogenesis. It also affects your liver [103:44] and your kidney. There's this inter [103:46] organ cross talk. You know, we talked [103:48] about skeletal muscle about how [103:50] important it is from a metabolic [103:51] perspective, as a body armor [103:53] perspective, but also as this endocrine [103:56] organ that can affect mood because of [103:59] the components that it's releasing. [104:01] And that is fascinating. It can [104:03] counterbalance inflammation [104:06] based on the activity duration [104:10] and intensity. So that explains why if [104:12] I've not been moving, I don't feel as [104:13] good in terms of motivation and um [104:16] I feel more fatigued when I've done less [104:18] exercise over a long period of time. I [104:20] mean, yes. And it doesn't take much to [104:23] maintain what you have. For example, if [104:25] you could during those days, [104:27] do you have to be So you're shooting for [104:29] 10 hours, you don't have breaks? [104:30] We have lunch break. [104:32] You should be training on that lunch [104:33] break. I don't care how tired you are. [104:35] I'm hungry. [104:36] Then [104:37] you should eat in 10 minutes and get to [104:40] training. [104:41] It's a good point and you're totally [104:42] right. Push-ups, have a weighted vest, [104:44] do whatever you have to. [104:46] You will feel exponentially better. [104:50] And also this is predictable. So here is [104:51] an example. You know it's coming, right? [104:54] You know that you'll be filming this for [104:55] 10 hours a day. Yeah. What is your [104:58] strategy to execute in a way that is [105:00] effective and meaningful? And that's [105:02] really it, isn't it? It's about forward [105:03] planning. Yeah. [105:05] You know it's coming. It's predictable. [105:07] It's also predictable how you're going [105:08] to feel [105:09] afterwards. And then you are going to [105:11] have to account for how you feel and [105:13] then you are going to have to deal with [105:14] the repercussions of now not being [105:16] motivated, now having to address your [105:18] diet, and now probably feeling a little [105:20] bit more down than you would have. We [105:22] totally know it's coming. It's one of [105:24] the big things I've just real- realized [105:25] as you're talking is I don't schedule my [105:27] workouts. [105:28] So my workouts are kind of this residual [105:31] residual beneficiary. I either get [105:32] whatever time's left over in the day, [105:34] which might mean last night it was super [105:35] late. It was almost at midnight. [105:37] And then today I've got a flight off to [105:40] this. So it's a 10-hour flight. So it's [105:42] like [105:43] but I I could quite easily I have the [105:46] fortune and privilege of just being able [105:47] to ask my assistant to change something. [105:49] So I can say, "While you schedule [105:50] everything else, also schedule an hour [105:52] for me to train." But I think everyone [105:54] could probably do that. I would I wonder [105:55] how many people schedule their workouts. [105:58] Everybody who is [106:00] You show me your habits and I will tell [106:02] you how successful you will be able to [106:04] continue to be in the long run. [106:06] You could probably look at someone's [106:07] calendar and figure out what they're [106:09] going to look like in 10 years' time. [106:10] I definitely can. [106:12] But I will say that there's this [106:15] privilege of youth and then there [106:16] becomes a tipping point. [106:20] Yes, you should be scheduling those [106:21] things. You can And let's say you say to [106:24] me, "Gabrielle, I don't have time to do [106:26] it." [106:27] You are not You could schedule 3 days a [106:29] week. You know that we're filming all [106:30] day. You know that you're doing these [106:31] things. [106:32] That is a non-negotiable because you're [106:34] setting a standard. You set a standard [106:36] for everything in here and everything [106:37] else you do. Mhm. Nothing is going to be [106:39] more critical [106:41] for your impact than being able to [106:42] manage your health because again, there [106:44] comes a point in time where [106:46] um [106:47] it's a very predictable [106:50] turning point, inflection point. [106:53] If we get together again and I don't [106:54] know, say it was 30 years from now and [106:57] I say to you you know, how [107:00] and you've been successful over the next [107:01] 30 years, however you define that. What [107:04] happened? [107:05] We've completely changed the [107:06] conversation. [107:08] We are no longer [107:09] at nauseam. I'm talking about obesity. [107:11] That is a side component. [107:14] We are focused [107:16] on physical and mental strength. We are [107:18] focused on understanding that it is a [107:20] muscle problem and a problem and a [107:22] solution that we can do something about. [107:25] Obesity is an afterthought. [107:27] And personally? [107:29] My kids have done amazing. [107:31] They're happy and adjusted and can [107:35] withstand whatever whatever comes their [107:37] way. And my husband will be picking up [107:38] his socks. [107:40] If he stopped taking care of himself, [107:42] You would never. He doesn't even He [107:43] would never. No, but just say play out [107:44] the scenario. Yeah. [107:46] Would you say something to him? Uh yes. [107:48] What would you say? [107:50] I don't want to put it on camera, but [107:51] it'd be something totally inappropriate [107:54] and somewhat aggressive, but yes, I [107:56] would say something to him. [107:58] But ultimately, [107:59] he has to be an example for our kids. It [108:01] is his responsibility. It's not about [108:03] him. [108:04] We have a closing tradition on this [108:06] podcast where the last guest leaves a [108:07] question for the next not knowing who [108:08] they're going to be leaving it for. [108:10] And the question that's been left for [108:12] you is [108:14] regret can occur [108:16] due to action taken or action not taken. [108:20] In light of that, [108:22] what is your biggest meaningful regret [108:26] and why? [108:28] My biggest meaningful regret and why? [108:33] I don't know if I have a regret. [108:38] I don't know if I have a regret that I [108:40] can think of [108:42] because I think that we are responsible [108:45] for our choices. What if I put the word [108:47] mistake in there? [108:50] I mean, the only thing that I could [108:51] think of is [108:54] I [108:55] Again, this isn't a mistake or I don't [108:58] even know if I consider this meaningful [108:59] is that [109:01] um [109:03] outcomes unfold [109:05] and instead of you know, I was so driven [109:08] and I've been so driven by [109:10] doing good. You know, thinking like [109:13] I have to contribute. I have a [109:14] responsibility to contribute to the [109:16] world. [109:17] I could have put a lot less pressure on [109:19] myself, but is that [109:21] is that meaningful? Is that a meaningful [109:23] regret or a mistake? I can't say that [109:25] that's true. [109:26] Would the outcome have been any [109:27] different? [109:28] Would I have worked any less more [109:31] diligently? I don't know. [109:34] Well, it's a good thing you have because [109:36] um you've really led the charge as it [109:37] relates to muscle and the conversation [109:40] around muscle and these subjects more [109:42] broadly. But when I think of someone [109:43] that is at the very forefront of [109:45] educating the world on muscle and its [109:47] importance and especially as we age that [109:50] we can be [109:51] forever strong um at least strong while [109:54] we're still alive, then that person is [109:55] you. And I can't imagine how many [109:58] millions of people are better for that. [110:00] I can't imagine. It'd be crazy if you [110:01] could put them all in like a stadium or [110:03] something and and get to meet them all [110:04] that just had their lives just subtly [110:07] altered. Even if it's just, you know, [110:09] one decision to go for a walk or to do a [110:12] little bit more resistance training once [110:14] a week. That matters, right? [110:16] And that's a really wonderful thing. And [110:18] that's I kind of guess what your your [110:20] all of your work is really aiming at is [110:21] to find, understand someone, but then [110:23] give them the the missing piece of [110:25] information or inspiration so that they [110:27] can pursue their very best self. And I [110:29] thank you for doing the work that you do [110:31] because [110:32] I I'm sure those millions of people [110:33] can't thank you themselves, but it's um [110:35] it's really altering not just their [110:37] lives, but also as you say the [110:38] generations that are set to come after [110:40] them and their children and so on. And [110:41] that's one of the things I'm actually [110:42] thinking much more about having spoken [110:44] to you is the I've never thought because [110:45] I don't have kids yet about the role [110:47] models that I that I am or aren't to [110:48] those kids that are watching me. And as [110:50] you said it, I had a little flashback of [110:52] my mom outside my house when I was like [110:54] a a four, five year old and just [110:55] watching her run up and down the street [110:58] um over and over again in this tiny [110:59] little sort of circle that she used to [111:01] do and how that stayed with me for [111:03] forever. That she cared about that. And [111:06] that what that meant for us is um how [111:08] children [111:10] And it's a really powerful thing. It's a [111:11] really wonderful thing cuz you know, [111:13] this isn't really about muscle at the [111:14] end of the day. This is [111:15] about much more It's not [111:18] medicine is the gateway to really be [111:21] able to provide freedom for people. [111:22] That's what I want. Mhm. [111:25] Muscle is the way in. Medicine is the [111:27] way in, but what I really want for [111:28] people [111:29] is I want them to have freedom. [111:32] And that freedom is happiness. It is. [111:35] Yeah, or whatever it is that they want [111:36] to do. Mhm. Thank you so much. It's such [111:38] an honor to meet you. Thank you for [111:40] having me. [111:41] [Music] [111:48] Isn't this cool? Every single [111:50] conversation I have here on the Diary of [111:51] a CEO, at the very end of it, you'll [111:53] know I ask the guest to leave a question [111:57] in the Diary of a CEO. And what we've [111:59] done is we turned every single question [112:02] written in the Diary of a CEO into these [112:04] conversation cards that you can play at [112:07] home. So you've got every guest we've [112:09] ever had, their question, and on the [112:12] back of it, if you scan that QR code, [112:15] you get to watch the person who answered [112:18] that question. We're finally revealing [112:21] all of the questions and the people that [112:24] answered the question. The brand new [112:26] version two updated conversation cards [112:29] are out right now at [112:31] theconversationcards.com. [112:33] They've sold out twice instantaneously. [112:35] So if you are interested in getting hold [112:36] of some limited edition conversation [112:38] cards, I really, really recommend acting [112:40] quickly. [112:42] [Music] [113:01] [Music]