在硅谷，Brian Johnson 是一个备受关注也颇具争议的抗衰先锋人物。他把战胜死亡作为人生项目，用极端精确的方式管理自己的身体，称自己是“世界上最被精密量化的人”。他每天轮流追踪上千项健康数据，家中配备各种监测和治疗设备，由一个专业的医生团队协助管理。这些尝试曾让他的抗衰成本高达每年200万美元。根据他的测量，他已经把自己的生物衰老速度拉回了31年，其代谢健康达到18岁年轻人中排名前1.5%的水平，体内炎症指标甚至比普通10岁儿童还要低66%。而仅仅在5年前，他还在遭受肥胖、系统性炎症以及抑郁症的困扰。
翻看 Brian 在 YouTube 上的记录，他的日常生活被拆解成了无数个可测量的步骤：清晨四点半起床，接受红光照射光疗灯以调整生物钟，吃下特定的健康配方早餐，进行力量训练，随后是桑拿、红光治疗和冲击波疗法，甚至会进入高压氧舱边吸氧边工作，并在上午11点结束全天的进食。除了这些日常管理，他还进行了许多更为激进的前沿尝试，例如通过间充质干细胞注射来修复受损组织，以及利用 Follistatin 基因疗法促进肌肉生成、提升运动能力。
然而，这些前沿抗衰方法大多处于探索阶段，缺乏大规模、长期的临床试验来证实其有效性和安全性。Brian 本人也多次强调，他是在把自己当成试验对象，并基于监测数据持续调整方案。他的尝试并不总是带来积极结果。以雷帕霉素为例，这种在动物模型中被证实能延长寿命的“明星抗衰分子”，在 Brian 身上却导致了持续的口腔溃疡、代谢指标异常和心率增加，甚至可能加速了他的衰老并提升了患癌风险，直到停药后才逐渐恢复。此外，为了改善面部胶原蛋白流失，他接受了来自供体的面部脂肪填充，却引发了严重的过敏反应，面部肿胀甚至威胁到视力。他最著名的“换血”试验——与儿子进行年轻血浆置换，在经过六次、每次一升的尝试后，相关的生物标志物和影像学检查也未显示出明确的改善。这些失败的尝试再次表明，前沿抗衰并不等于成熟医学，盲目追逐突破性疗法往往比衰老本身更危险。
Brian 将自己的一些实验性疗法形容为“刺破天花板”（punching through the ceiling）。他以最近完成的桑拿实验为例，指出虽然健康领域普遍认为桑拿对血管内皮功能有益、能释放热休克蛋白来清理体内折叠错误的蛋白质垃圾，但他的团队进行的是“人类历史上测量最精密、最详尽的桑拿实验”。他们不仅观察了血管功能，还检测了体内的微塑料含量。中国此前的一项研究显示，在受检男性的睾丸和精液样本中，100%都检测出了微塑料，这严重影响了男性的睾酮水平和生育能力。在过去50年里，全球的生育率下降了50%，因此找到解决这一污染源的方法至关重要。
抗衰老正在迅速进入主流公共议程。在华盛顿举行的“让美国再次健康”（Make America Healthy Again, MAHA）峰会上，美国卫生部长 Robert Kennedy Jr. 和副总统 J.D. Vance 领衔，议题从健康饮食一路延伸到逆转衰老、AI医疗和脑机接口等前沿方向。Brian Johnson 也受邀出席，与 Neuralink 联合创始人以及专注于细胞重编程的 New Limit 联合创始人同台讨论。在资本和产业层面，大型药企也开始把衰老生物学视为下一条创新管线，例如礼来（Eli Lilly）创投近期领投了 New Limit 的新一轮融资，诺华（Novartis）则与长寿数据平台 Belage Labs 达成了最高5.5亿美元规模的合作。
[24:59](https://www.bilibili.com/video/BV1cBipBpEPw?t=1499s) Building a Multi-Pronged Longevity Business and the China Expansion
Bryan Johnson explains that the core motivation behind Blueprint is to help people achieve "pristine health" so they can experience firsthand how easy and spectacular it feels to sleep, look, and feel better than ever. To make this a reality, Blueprint cannot just be a single-product company. Johnson notes that while most wellness companies focus on a single green juice, supplement, or therapy, Blueprint's ambitious model "requires to stand up like eight or nine businesses at the same time."
The business model is designed to capture a customer's existing lifestyle budget and redirect it toward a structured, evidence-based routine. Instead of spending money on standard groceries, skincare, and healthcare, customers shift their spending to Blueprint's integrated ecosystem. This includes packaged nutrition (such as protein, extra virgin olive oil, and basic supplements), skincare, hair care, biomarker measurement routines, prescription management (such as microdosing GLPs, statins, or blood pressure medications), and telehealth consultations. This entire system is embedded within a community framework, leveraging the social proof that people are highly motivated to maintain good behaviors—like going to bed on time—when they see their friends doing the same.
Addressing the high cost of longevity diagnostics, Johnson reveals how dramatically prices have dropped. In the early days of Blueprint, they spent millions of dollars establishing protocols. For example, their first custom whole-body MRI protocol cost between $200,000 and $300,000 to research, set up, and calibrate with a specialized facility; today, that exact same protocol is commonly available for $1,000 to $2,000. Similarly, measuring microplastics in blood and ejaculate originally required building an entirely custom, plastic-free laboratory from scratch at an immense cost, but those testing prices have now been brought down dramatically.
When asked why Blueprint chose China as its first international clinic location, Johnson expresses immense enthusiasm for the country's energy and ambition. He points out that the Chinese work ethic, famously exemplified by the "996" schedule (9 AM to 9 PM, 6 days a week), reflects a hungry, driven population striving for success. This high-achieving mindset aligns perfectly with the ambition of longevity. From a clinical practice standpoint, Johnson notes that they can achieve the exact same high quality and comprehensive care in China as they do in the US, making it the ideal market to replicate their model due to the expertise, available therapies, and dense city structures.
- **Blueprint's Consumable Offerings:** Packaged nutrition (protein, extra virgin olive oil, basic supplements), skincare, and hair care.
- **Diagnostic Price Drop:** Whole-body MRI protocol costs reduced from ~$300,000 to $1,000–$2,000 (a 10x to 100x decrease).
- **First-of-its-Kind Testing:** Blueprint pioneered measuring microplastics in blood and ejaculate, which required constructing a specialized plastic-free laboratory.
- **China Clinic Alignment:** Chosen for its ambitious culture, strong work ethic (996), and infrastructure capable of replicating the US clinical model.
---
[29:59](https://www.bilibili.com/video/BV1cBipBpEPw?t=1799s) How AI is Revolutionizing Diagnostics and Medical Discovery
The conversation shifts to the role of Artificial Intelligence in scaling longevity medicine. Johnson explains that while a human doctor can easily interpret a single biomarker like inflammation and prescribe a treatment, it is humanly impossible to synthesize 10,000 biomarkers simultaneously. This is especially true when dealing with cutting-edge, complex data sets like proteomics, methylation markers, and multi-organ imaging. AI acts as a pattern-recognition engine, stitching together disparate data points to find connections, design new protocols, and establish measurement structures that human physicians would otherwise miss.
Looking to the future, Johnson emphasizes that AI is transitioning from a data-analysis tool into an active "discovery tool for longevity." He highlights a recent breakthrough by Google, where AI was used to successfully show how to turn a "cold" cancer into a "hot" cancer, allowing the body's immune system to identify and target it. This capability to discover new pathways for treating disease and reversing biological age is why Johnson believes the rise of longevity therapeutics will happen much faster and more robustly than the public anticipates, comparing its upcoming trajectory to the rapid, widespread adoption of GLP-1 agonists.
The narrator then introduces a brief Chinese-language interlude, noting that while Blueprint has captured massive public interest, it has also faced criticism regarding its high product prices, individual variations in user experience, and occasional mild side effects like gastrointestinal discomfort. Some medical experts have also pointed out that certain ingredient combinations in Blueprint products still lack mature, large-scale human clinical trial evidence.
The narrator highlights that Johnson's work is backed by a highly professional medical team of over 30 doctors and health experts since Blueprint's inception. However, this team has undergone adjustments. Notably, Dr. Oliver Zolman, a core physician featured in early Blueprint documentaries, left the team last year. According to a New York Times report, sources claimed Zolman had concerns about some of Blueprint's research directions and results, while the Blueprint team maintained his departure was a standard organizational transition.
To clarify the inner workings of this medical team, the interviewer speaks with Dr. Seger, one of Blueprint's primary physicians. Dr. Seger explains that the medical team was intentionally downsized to operate more efficiently. Instead of keeping a massive in-house staff, they maintain a lean core team consisting of himself, Dr. Mike Mallon, and Dr. Ali (a data scientist and physician based in Germany). This core team then brings in specialized external experts on an as-needed basis—such as hyperbaric oxygen therapy specialists—allowing them to remain highly focused on the interventions proven to be the most effective.
- **AI's Analytical Power:** Synthesizes up to 10,000 biomarkers, including proteomics and methylation data, to find hidden health patterns.
- **Google AI Breakthrough:** Demonstrated how to turn a "cold" cancer "hot" so the immune system can recognize and destroy it.
- **Core Medical Team:** Dr. Mike Mallon, Dr. Seger, and Dr. Ali (Germany-based data scientist/physician), downsized from a larger group of 30+ specialists to focus on high-yield therapies.
---
[34:59](https://www.bilibili.com/video/BV1cBipBpEPw?t=2099s) Longevity Escape Velocity, Cellular Reprogramming, and Personalized Medicine
Dr. Seger addresses Bryan Johnson's ambitious public goal to "not die by 2039." While Dr. Seger admits he would have found this claim impossible five or even two years ago, the rapid acceleration of AI and biotechnology has completely changed his perspective. By aggressively optimizing the basics—nutrition, sleep, and disease risk reduction—the team has successfully slowed Johnson's rate of aging to around 0.48 to 0.5.
Dr. Seger explains the concept of "longevity escape velocity." To achieve this, a person does not need to reduce their rate of aging to absolute zero. Instead, if a person can slow their aging rate to 0.5 (aging only six months for every calendar year), and science develops therapies capable of reversing six months of aging per year, they effectively halt net biological aging. Dr. Seger points to cellular reprogramming (resetting cells to a youthful epigenetic state) and addressing immune system dysfunction (such as regenerating the thymus and reversing T-cell dysfunction) as the most promising "magic switches" to achieve this reversal.
Furthermore, Dr. Seger highlights groundbreaking nanotechnology research aimed at repairing the blood-brain barrier, which naturally degrades over time and leads to cognitive decline. Addressing these complex physiological hurdles now seems highly doable within the next 10 to 15 years.
To mitigate the risks of experimental therapies, Dr. Seger reveals a cutting-edge personalized approach that Bryan Johnson is currently utilizing: growing cells from his own individual organs in a lab to test treatments on them first. This "N-of-1" testing method allows the medical team to observe exactly how Johnson's tissues respond to a therapy before administering it to his body, eliminating the dangerous guesswork and potential catastrophic side effects of experimental medicine.
When asked how the general public should interpret Johnson's highly personalized "one-man FDA" experiments, Dr. Seger reassures listeners that the vast majority of interventions driving the biggest changes in Johnson's aging rate are actually incredibly low-risk and universally applicable. "Going to bed on time is pretty low risk," Dr. Seger notes, emphasizing that basic lifestyle factors like sleep, nutrition, exercise, and early cancer and cardiovascular detection are what compress the aging rate the most for anyone. While Johnson acts as the pioneer "landing on the moon," the ultimate goal is to lower the cost of these technologies so they can eventually be scaled to benefit all of humanity.
- **Bryan Johnson's Best Aging Rate:** Measured at 0.48 to 0.5, meaning he biologically ages roughly six months for every calendar year.
- **Longevity Escape Velocity:** The threshold where technological advancements can reverse the remaining portion of annual biological aging, halting net aging.
- **Organ Cell Testing:** A safety protocol where cells from Johnson's specific organs are grown in vitro to test drug and therapy responses before clinical application.
- **Primary Public Health Targets:** Eliminating cardiovascular disease, early cancer detection, improving metabolic health, reducing systemic inflammation, maintaining bone density and muscle mass, and supporting mental health.
## Notable quotes
> [00:00](https://www.bilibili.com/video/BV1cBipBpEPw?t=0s) 世界上最被精密量化的人 — Brian Johnson
> [04:59](https://www.bilibili.com/video/BV1cBipBpEPw?t=299s) 刺破天花板 — Brian Johnson
> [04:59](https://www.bilibili.com/video/BV1cBipBpEPw?t=299s) 广泛撒网、精密测量 — Brian Johnson
> [09:59](https://www.bilibili.com/video/BV1cBipBpEPw?t=599s) 不要死 — Brian Johnson
> [09:59](https://www.bilibili.com/video/BV1cBipBpEPw?t=599s) 当有人患有高血压时，他们不是自己发明药物的人，而是服用别人制造的药；当你喝到干净的水时，是别人建造了净水系统。 — Brian Johnson
> [09:59](https://www.bilibili.com/video/BV1cBipBpEPw?t=599s) 2039年不要死 — Brian Johnson
科技创业者 Bryan Johnson 通过极端精密的生物数据量化与多项前沿实验探索抗衰老，并以此构建起整合产品、诊所与生活方式的商业生态 Blueprint；然而，其医疗团队与医学界观察指出，前沿疗法仍具试错风险，最稳固的抗衰收益依然来自于低风险的基础生活习惯管理。
极端量化实验与前沿疗法的试错风险 (0:00)
Johnson 每日监测上千项健康数据，此前抗衰年花费曾高达200万美元。他声称已将衰老速度拉回31年，生物衰老速率降至0.48至0.5（相当于每年仅经历约6个月的生物衰老），炎症指标比普通10岁儿童低66%。其日常干预包括4点半起床、红光照射、高压氧舱、力量训练、上午11点前结束全天进食，并辅以间充质干细胞注射与 Follistatin 基因疗法等激进尝试。
然而，这些处于探索阶段的前沿手段伴随显著风险与负面反馈。例如，雷帕霉素实验曾导致其口腔溃疡、代谢异常并增加患癌风险；异体面部脂肪填充引发了严重过敏并威胁视力；其知名的6次（每次1升）年轻血浆置换亦未显示出明确生物标志物改善。为降低风险，其医疗团队目前转向个性化的“N-of-1”体外测试，通过培养其自身器官细胞预先测试疗法反应，以避免盲目试错。
核心标志物监测与基础生活方式干预 (4:59)
在指标管理上，Johnson 建议公众优先关注三大核心生物标志物：炎症（如高敏C反应蛋白 hs-CRP）、血压（涵盖收缩压、舒张压及中心动脉压等5个维度）以及胆固醇（高级LDL与Lp(a)检测）。其主治医生 Dr. Seger 强调，驱动 Johnson 衰老速率降至低位的关键动力，绝大部分是规律作息、营养、运动及早期疾病筛查等低风险基础干预，而非昂贵特权疗法。
在微观环境毒素排泄方面，其团队进行了详尽的桑拿监测实验。数据显示，多次桑拿后测量的15种环境毒素实质性下降，体内的微塑料水平降低了87%。针对高温干蒸桑拿会导致男性生育标志物下降约50%的副作用，其实验方案明确要求男性在桑拿过程中对腹股沟部位使用冰袋冷敷以保护激素与睾酮水平。
Blueprint商业生态与检测成本降维 (24:59)
基于个人实验协议，Johnson 创立了商业公司 Blueprint，试图通过整合包装营养（蛋白质、特级初榨橄榄油）、补剂、护肤护发、处方药管理（如微量GLP-1、他汀类、降压药）及远程医疗，将消费者的日常健康支出重定向到证据支持的标准化流程中。公司近期完成6000万美元融资，投资人包括 Andrei Karpathy 与 Kim Kardashian 等；针对《纽约时报》关于其月亏损超百万美元的报道，团队澄清该财务数据不实。
该商业模式的一大核心是推动前沿检测平民化。例如，Blueprint 初期定制开发全身核磁共振（MRI）协议耗资20万至30万美元，如今同类检测已降至1000至2000美元；用于测定血液微塑料的无塑料检测成本也已显著压缩。此外，Blueprint 将首家海外诊所设在中国，主要看重其高效率的工作文化追求与高标准的临床基础设施匹配度。
AI医疗发现与细胞重编程的科学远景 (29:59)
伴随政商资本对衰老生物学的重视（如礼来、诺华、Altos Labs 及 Sam Altman 支持的 Retro Biosciences 的巨额布局），抗衰正加速进入主流议程。Johnson 透露自己正在微量注射（microdose）GLP-1，纯粹用于降低血糖、全身炎症和改善代谢。在前沿生物技术中，利用山中因子（OSK）进行细胞重编程以及基于 CRISPR 编辑 FOXO3 蛋白的干细胞疗法，展现出了逆转生物组织年龄的潜在路径。
AI 在长寿医学中的角色正从多维数据整合（分析上万项蛋白质组学与甲基化数据）演变为靶点与机制的发现工具。Dr. Seger 据此提出“长寿逃逸速度”概念：只要将年老化速率压制至0.5，结合科学每年逆转6个月衰老的手段，即有望实现净生物衰老停滞，并预测未来10至15年内纳米技术修复血脑屏障和免疫系统重建将逐步成为现实。
尽管 Bryan Johnson 及其团队对2039年实现“不要死”设定了积极的时间表，但目前诸如基因编辑、细胞重编程等突破性疗法仍普遍缺乏大规模临床试验的长期有效性与安全性验证。普通人群在审视其高昂商业协议与激进实验时，仍需在生活方式基本盘与未经充分验证的医学前沿之间保持谨慎区分。
Source quotes
[0:00] Brian Johnson: 世界上最被精密量化的人
[4:59] Brian Johnson: 刺破天花板
[4:59] Brian Johnson: 广泛撒网、精密测量
[9:59] Brian Johnson: 不要死
[9:59] Brian Johnson: 当有人患有高血压时，他们不是自己发明药物的人，而是服用别人制造的药；当你喝到干净的水时，是别人建造了净水系统。
[9:59] Brian Johnson: 2039年不要死
[14:59] 让美国再次健康
[14:59] Brian Johnson: 人类历史上第一款在类别上取得成功的抗衰老药物
[14:59] 全人类: 我们要活着，我们要健康
[14:59] Brian Johnson: 有史以来最扎实、最优秀的实验之一
[14:59] Blueprint: 全球最好的健康服务提供商
[24:59] Bryan Johnson: requires to stand up like eight or nine businesses at the same time.
[29:59] Bryan Johnson: discovery tool for longevity.
[34:59] Dr. Seger: longevity escape velocity
[34:59] Dr. Seger: Going to bed on time is pretty low risk
Original transcript
[0:00] 我们正在见证人类历史上第一次有人用极端透明精密量化的方式公开挑战衰老本身这个人就是Brian Johnson大家好 欢迎来到硅谷101 我是雨珊在硅谷Brian Johnson是一个备受关注也颇具争议的抗衰先锋人物他把战胜死亡作为人生项目用极端精确的方式管理自己的身体他称自己是世界上最被精密量化的人每天轮流追踪上千项健康数据家中配备各种监测和治疗设备由一个医生团队协助管理健康这些尝试曾让他的抗衰成本高达每年200万美元他表示自己的代谢健康达到18岁年轻人中排名前1.5%体内炎症指标比普通10岁儿童还比66%根据他的测量他把自己的生物衰老速度拉回了31年而仅仅5年前他还受到肥胖系统性炎症以及抑郁的困扰最近我们在Brian来中国举办冬代峰会期间不仅到现场感受了他的抗筛体系也有机会与Brian面对面聊了聊他的抗筛事业翻看Brian在YouTube上的记录你会看到一个把日常生活拆解成无数可测量步骤的人清晨四点半起床红光照射光疗灯调整生物钟吃健康配方早餐力量训练香拿红光治疗冲击波疗法进入高压养仓边吸氧边工作并在上午11点结束全天的进食在网站上他公开了各类健康建议和自我实验的记录其中也包括更激进的前沿尝试例如通过溅冲制干细胞注射修复受损组织和改善细胞功能利用Follistatin基因疗法促进肌肉生成提升运动能力等需要强调的是这些前沿抗摔方法大多处于探索阶段目前还没有足够大规模长期的临床试验正是其有效性和安全性Brian本人也多次提到他把自己当成试验对象尝试前沿疗法并基于监测数据持续调整方案这些前沿抗摔尝试并不总是带来积极结果以雷帕梅素为例它最初是一种免疫抑制药物在多种动物模型中被反复证明可以延长寿命因此被视为最有潜力的抗衰分子之一然而在Brian的个人尝试中并未观察到明确的正面收益反而使它持续口腔溃疡代谢指标异常心率增加在停药后这些变化逐渐恢复Brian表示几年的雷帕梅素使用可能反而加速了他的衰老并提升了他的患癌风险此外为了改善面部因为胶原流失而呈现出衰老的特征他接受了来自供体的面部脂肪填充但出现了严重过敏反应面部肿胀甚至威胁到视力而他最为人所知的患血试验其中一次来自他的儿子经过六次每次一生的年轻血浆置换尝试后,相关的生物标志物、影像学检查和设备监测结果并未显示出明确的改善。他的这些不成功的尝试也再次提醒我们,前沿抗衰并不等于成熟医学。在缺乏长期安全性与明确收益之前,盲目追逐突破性疗法,往往比衰老本身更危险。如果有三个重要的重要 biomarkers那会最重要的那会是什么?然后你推荐他们?可能会是伤症,血量,和 cholesterol伤症,伤症,伤症,伤症,伤症就是普通的伤症,伤症,伤症,伤症,伤症有更多的伤症,但这会给你一个伤症的伤症是你的身体症,伤症,伤症,伤症,伤症,伤症你可以做很高的很高的质素你可以做一些比较的质素像是LDL你也可以做更高的质素LPA所以它们的质素但是当然比方的质素所以,血量
[4:59] and systolic, diastolic, and then central blood pressure, then APX, and so like the five markers for central blood pressure. Blood pressure, I've been doing it daily because we've been doing sauna, and that therapy has a lot of changes for vascular functions. You're looking at how the blood vessels are responding to the heat as expanding. On the inflammation, maybe once every few weeks. And what can people do to improve these three most important biomarkers? So the easiest thing to do is to get rid of the bad things in your life. So the things like smoking, drinking, fast food, junk food, not sleeping well, fried foods. Those are the ones that are the immediate obvious ones. And once you bypass that, it gets into more nuanced. For example, air quality, toxins in food, stress can do that. So there's easy wins, which we all know about, than the more granular ones, which take a little bit of investigative work. So you have also described some of your more experimental therapies as punching through the ceiling So I wonder what do you mean by that And how do you choose what are the therapies that you are going to try and experiment For example we just completed with sauna and so if you ask most people in the health world about sauna, they may cite that it's good for vascular function, like endothelial function, like your blood vessels are expanding, you're pumping blood, you're releasing heat shock proteins, which are these proteins that roll around and they pick up garbage and you're like misfolded proteins. But what we did is we, I think we did the most measured sauna experiment in history. And so we looked not just at vascular function, but we looked at, for example, microplastics and not just in my blood, but also in my ejaculate, which is the, there was a Chinese study that showed that of a hundred percent of the samples taken from men, 100% of the people had microplastics in both their testicles and their ejaculate. Now, that's not good because it has negative effects for testosterone, for fertility, all these follow-on effects. And when the world has basically lost 50% of fertility over the past 50 years it good to get to a source of a problem So in our sauna measurement we were measuring does sauna change microplastic levels And nobody in the world had ever done that before And it showed that it lowered mine by 87 We make these discoveries all the time because we combine therapies, we do measurement. And so it leads us to insights that you just can't find anywhere in the scientific literature. What's the rationale for sauna to help you eradicate or reduce the microplastic level? Yeah, we don't know. Okay. So this is, yeah, so this is the thing is we typically will go into an experiment and we start it and we say we're going to cast a really wide net. So in one of our recent experiments, we did 249 biomarkers. So we just say we're going to measure everything, the brain and the heart and the lungs, the microbiome, eyes. Like we just measure everything and then we just see what happens. And sometimes in doing that, you find false positives. So you'll find an effect that it's not really an effect. you have to then do further experimentation. But the value of what we're doing is we're just trying to create intuitions, like where should we point our attention? And then once we make this observation, now that we've shown that sauna was effective in reducing my microplastics, I'm sure others will do follow on experimentation. And probably do it more robustly, which is the ideal scenario How many times of sauna or like how long of the sessions have made you able to achieve that result Listen to these sessions Yeah we had also there was a substantial drop in environmental toxins So we had like 15 toxins we measured and there was a substantial drop in those after 15 sessions. And then more on the micro we did more sessions for microplastics. And then we found other things, for example, like the revascular improvements, which were also good. we also found out that um i did an experiment where men need to ice their growing area if they don't that heat has a negative effect and it will knock out their fertility markers by about 50 percent it's not just and a lot of men will say well i don't care because i'm not trying to have a baby but the problem is it has negative feedback loops on testosterone on hormones and a bunch of other important processes so again that's like something where people understand generally sauna is good, but they don't understand it needs to be done in a dry sauna with ice and the growing, and it's going to address environmental toxins and microplastics and vascular function. And so we just pulled all these variables in and now it's the most comprehensive understanding we've ever had of sauna. So are you trying any new therapies right now and any plans for the next like three, five months? You know, one fun therapy we're planning right now is spicy
[9:59] foods. So we found some evidence that spice has a number of positive health effects. And so we've tried to acquire certain spicy molecules, and we are now doing lab testing to find out which one we can take. So it's low in toxins, and we'll probably start that in the next month or so. But surprisingly, it has pretty interesting effects on slowing down aging and reversing some aging damage. So we'll see. I mean, this is the kinds of stuff we find are, it always really surprises me. They sit in these little pockets that are unexpected, but like sauna, maybe we can figure out what, what kind of spice in what for, in what concentrations or what duration. So that's a fun one. I think a common understanding of taking spicy foods is probably it will increase your inflammation and make you have like little like pimples on your face. How do you take that? why do you think spicy food does it like actually contribute to these issues well so i guess it depends on what the source is so there's there's many things uh that you can probably do for spice so we just started this last week so i not up to speed yet on the entirety of the protocol but just knowing that that coming up let me think of another one um we recently completed hyperbaric oxygen therapy That where you sit in that chamber The air is concentrated very densely It like being underwater by 10 meters And same thing with sauna We did probably the most measured sauna protocol or HBOT protocol in the world We looked at there were benefits we saw in my brain my DNA my microbiome skin It was just like a whole body reset which was really surprising to see. It really is a systematic whole body treatment. So that was neat. The problem is that one's not very accessible. You said yesterday that you're basically using 2039 as your goal to achieve don't die, right? And I think a lot of people will think pursuing longevity and achieving don't die is a privilege. So what do you think the general population can realistically take away from these endeavors? A lot of people think this is about me. They think I'm doing this for immortality. I'm really doing this for humanity because nobody can achieve good health without the help of humanity. So when somebody has high blood pressure, they're not the person that creates the drug They take the drug somebody else made And when you drink clean water someone else built the water purification system to make the water clean And so we all depend upon each other to build systems of health now It also true that if somebody pollutes the water Everybody is negatively affected. So health is actually a shared resource It's something that all of humanity has to participate in and so what I'm trying to do is I'm trying to change our culture to say hey everybody we we haven't been as mindful as we could be about our health and wellness right and that includes the toxins in our environment it includes our culture of scrolling all the time it includes culture of porn and bedding and junk foods and all these bad habits we have it's not good for any one of us or not good for anybody and so my goal of 2039 is to cut is to create a focused point of attention to say, we have a new goal. And in giving people that goal, I think they have motivation to say, I want to also work towards that goal. It doesn't mean that they are going to do a bunch of expensive therapies. It does mean they will say, I'm going to bed on time, and I'm not going to smoke, and I'm not going to drink, and I not going to eat the fried food So I think it really giving people motivation and a specific thing they can focus on that motivates them to try to work hard at it除了自我试验, Brian也把这套方法论发展成了自己的东代事业并创立了公司Blueprint.如今,这家公司已经从最初 Brian的个人实验拓展到包括健康餐饮,补剂,护肤与护发产品,配餐订阅以及周边商品 in the entire product. In the 10th century, Blueprint has received $6,000 million in the new融资. The investors' list is over the technology,娱乐, and the风险投资界. Andrei Karpathy, Kim Kardashian, Joshua Kushner, Naval Ravikant. These names are all about to show the market. The market is not a big fan of the market. However, Blueprint's development is not a big fan of the market. New York Times reported that, the company in 2024 has gained over 4,000 million in the year. It has been over 4,000 million in the year. 但仍面临不小的财务压力,每月亏损超过100万美元。 我们与Blueprint团队求证,Blueprint团队表示财务数据并不属实,属于谣言。 但不可否认的是,过去十年里,硅谷对于延长寿命这件事的兴趣不断上升。 早在2013年,谷歌就成立Calico,研究衰老相关疾病。
[14:59] AutoSlaps获得约30亿美金启动资金把细胞重编程与再生医学推向新的高度由Sam Altman支持的RetroBiosciences在成立之初就融资1.8亿美金如今正在筹集高达10亿美金的新一轮融资目标是让人类健康寿命增加10年与此同时抗衰也越来越多地出现在主流公共议程里11月在华盛顿举行的Make America Healthy Again峰会由美国卫生部长Robert Kennedy Jr.和副总统J.D. Vance领先议题从健康饮食一路延伸到逆转衰老AI医疗脑机接口等前沿方向Brian Johnson也受邀出席与Neuralink联合创始人以及专注细胞重编程的New Limit联合创始人同台讨论长寿与脑机接口的未来在资本和产业层面大型药企也开始把衰老生物学视为下一条创新管线例如Ely Lily旗下创投近期领投了细胞重编程公司New Limit的新一轮融资希望推动针对细胞衰老的表观遗传疗法进入临床而Novartis与专注长寿数据的平台型公司Belage Labs达成最高5.5亿美金规模的合作一起寻找针对衰老相关疾病的新打点可以看到从科技富豪到传统药企再到政策制定者如何延长健康寿命正在被越来越多严肃的参与者纳入议程作为当下最受公众关注的抗衰实验者之一Brian如何看待政界资本与医疗产业对长寿领域日益升温的投入而Blueprint又是如何拿下6千万美元融资又打算如何拓展自己的商业版图呢以及更多的政策,我认为他们的目标,他们是在对方向的进行你只是在研究中,在Maha Summit上,与RFKJr,和主任的 CEO,所以,我认为,从你的观点,在这个动作,和你觉得,在三年中,什么是什么的是什么的进行或是会发生在对方向的 driving this shift and what do you think looking at three to five years what kind of innovation or breakthrough would happen in the longevity field so what i like that's happening is humans have a ravenous appetite to be healthy to look great yeah and to feel great right but they find it very hard to look great and feel great because they feel temptations to do bad things to smoke and drink and not exercise and it's very hard to do those things right and so i think if you look at what happened recently with these glp1s that is i think the first categorically successful anti-aging drug right okay anti-aging it is explain it because you know people associate it with weight weight loss and appetite suppression those are true. Also, it has a lot of benefits for metabolic health, for lower inflammation, it's neuroprotective, and there's more things coming out. So I microdose a GLP-1 now. I microdose towards appetite. Wow. You don't seem to need it, right? It's not from controlling your appetite, your food. Exactly. So I have no need for appetite control. I have no need to lose weight. My body fat and my muscle are top 99 percentile optimal for all men. So I do it for the longevity benefits for lower blood glucose, lower inflammation, better metabolic health. And so this one, I think, is a, these GLP-1s are an example of how fast longevity is going to sweep the world. What I'm bullish on is there's a few technologies in the pipeline right now that could have real, true anti-aging effects. not not like um right now if i'm doing sauna it's good for me like definitely good for me in a whole bunch of areas but it's it's an incremental and i have to work at it a glp1 you take a shot and you lose 30 40 pounds and you just feel like a different person and i think we're going to have our first longevity drugs or or therapies in the coming years and when that happens the world is going to snap overnight and humanity is going to shift its focus to say, we want life. Like I want to be healthy. And so I think we really are on the cusp of a change that is far bigger than anyone's anticipating because it's going to coincide with AI progress. AI is going to change society in ways we can't anticipate. So I think we really is. It's a paradigm shift that is probably the biggest one happening right now. And it's just starting.
[19:59] emerge. And you think in the next three to five years, maybe a new longevity drug could emerge, like the ones like GLP-1? Yeah. And even if it's not, even if the drug is not generally available, I think in the next couple of years, we will see AI-led discoveries, whether it be in animals, or whether it be in small trials, that will show dramatic effects. And so even though it's not a mass market product, it will be very clear from the studies and the evidence that a new era of longevity is here. Have you seen or have you observed any new promising molecules? The biggest ones happening right now are, for example, the transcriptome factors, the OSK, the Yelman-Akin factors. So this is like the idea for most people. So if you have a man and a woman that are each 30 years of age, and they create the man's sperm and the woman's egg come together. The 30-year-old sperm and the 30-year-old egg combine, and then it becomes zero. It goes back to a baby right The embryo becomes day zero And so in our biology we already have the ability to go from 30 years of age to zero And that happens every generation as we make new babies And so that technology exists in our body to take old cells and make them young cells And so the same things have been shown in the labs with the Yamanaka factors. You can take an adult cell and make it a pluripotent stem cell. You take it back to an embryo stage. Now, it's not there yet where there's still some off-target effects. It can still become cancerous. So there's work that needs to be done to make sure it's robust. But in the lab, we're showing you can actually reverse age all the way back. And so that's promising because you can start with things like take a liver and take your liver back. You can do so with your pancreas and other organs. It takes some effort to do a whole body. But yes, like the technology is there and it's being refined, it's being built. And the AI tools we have now are just making that process so much faster to figure out what transcription factors we use and what way and how we structure them. And then there was a study out of China recently where they took the protein FOXO3, they did a CRISPR edit, they put it in a mesenchymal stem cell, they injected it in the vein, and then it showed over 50% of tissues had an equivalent of 10 to 13 years age reversal in humans. So that was one of the most robust demonstrations So that study needs to be replicated again Like first studies good proof of concept but somebody needs to replicate it That was extremely robust one of the best experiments ever done So that would give people hope. So I want to ask you about Blueprint. So you recently raised a round of financing from really a wide range of investors. What do you think these people saw in you and Blueprint? and can you share any stories behind the investment? Basically, it was a round of friends. So they all have a keen interest in health and wellness and we're always having conversations. They're asking me about this and that and I'm sharing what I've learned. So it was just bringing people together that care a lot about longevity who really enjoy this as a sandbox to play in. And what's your plan for Blueprint? What's your long-term vision for it? I'd like us to become the best health provider in the entire world. So right now, if somebody says they want to be healthy, or if somebody has a health issue, trying to either solve your health problem or getting robust care is really hard. So if you rich you can go to a high concierge and they typically want to sell you expensive stuff And not all stuff works So the game is buy stuff But they don address the underlying problem of behavioral change of, you know, can you stop this bad habit? Can you adopt this good habit? And then on the general practitioner side, most doctors just don't know how to deal with health, or they're good at some basic things, but they don't understand nutrition very well, they don't understand longevity therapies very well. And so, and then you go to a longevity doctor, they just don't typically have like the breadth and depth to address the person's, all their needs of nutrition, exercise, prescriptions, all the above. So we've done this with my protocol over the past five years, we basically have built the best health protocol in the entire world. And so if we can take what I've done, what my team has done with me, and we can take that and we can package it up and give it to other people, then we could compete for best in world. So now if someone says, I'm in, I wanna be healthy, we just say, come on in, we'll take care of you. We'll tell you what to eat, when to sleep, what prescriptions to take, how to measure it, how to focus on areas of concern. But we just build out a comprehensive full stack solution where our motivation is not to sell them stuff,
[24:59] Our motivation is to get their body to be in pristine health so that the person knows that our genuine intent is They're in spectacular health. So if that's my goal is that people say it's easy. It's great They've never felt better than to look better. They never slept better So I think we can I think we can do it It requires to stand up like eight or nine businesses at the same time Because most companies will say I'm just going to build you know This green juice or this supplement or this therapy or this service, right? And we have to do everything all at once. So it's a very big lift. It's ambitious, but I think we can do it. So I wonder what could the business model look like? So it's going to be like an annual subscription service, or how do you charge people for that? So one is we have nutrition packaged up, so protein and extra virgin olive oil and your basic supplements. We have skincare, hair care, so all of your basic things you need on a monthly basis of just consumables. Then we have biomarkers, which is get measured, find out if you have any problem areas of concern. Then otherwise, let's keep your biomarkers on a measurement routine so we can see if things are improving or what we need to focus on. Then we have prescriptions. So if you want to start microdosing a GLP if you have a blood pressure medication if you on a statin like whatever that may be We have telehealth so you have a doctor who engaged be like all right let look at the data Let go over what you doing now The protocols So in the context of a community where a lot of people struggle to do things on their own, but they're empowered to do things when others are doing them. So if you go to bed on time and we're friends, I may go to bed on time as well. So you're embedded in a community where good behavior is the norm and you feel more motivated to do it. So basically, we're just taking someone's budget that they allocate towards life. We're saying instead of spending it on these sources, come over and spend the same money with us. So we're hoping to do it in an economical way where people are just shifting where they're spending money on food today. Send it to us, skin care, hair care, prescriptions. And we bring it all together in a way that helps them make sense of all the data and keeps them in a structured routine where they feel like they're at home. they're being watched over, they're being cared for, they're getting the best evidence-based care. And I think you once mentioned that all of doing these measurements, they are the most expensive part of your longevity package. So in the services that will be provided through Blueprint do you think the cost could come down or it still going to be Yeah So even with mine the first couple of years we spent a couple of million dollars Like, for example, when we did our first whole body MRI, we probably spent maybe two or three hundred thousand dollars. We did all the research on all the scientific papers. We built our own customer protocol. We had to find an MRI facility to change all their settings, get it done. We had to do it three times. And so now the protocol we've built is just commonly out there and you can get it for $1,000 or $2,000. So the price has dramatically dropped. That's like 10 times decreased. Exactly. Yeah. And like same when we started measuring microplastics, you know, in both blood and ejaculate, it was the first time anybody in the world had done that. And to do that, you have to have a lab that is non-plastic. Like most labs, like most of the things are built in plastic because you have to rebuild an entire lab without plastics that's very expensive and now you can bring it down dramatically so we've taken all of our uh tests and and protocols and measurements and made them all very economical so yeah it's already dropped like dramatically i think uh in the blueprint um like business scope you also have like clinic here in china and i think they're probably like one of your first clinics in china so i wonder like why do you choose China to be the first stop of your clinic business Yeah And yeah any stories that you can share If you basically just look at countries on planet Earth and you say, what group of humans do we think would be most excited about the potential of health longevity? China is right there at the very, very top. China is youthful and energetic and hungry. You know, the Chinese have a fantastic work ethic. You know, 996 is no joke. Right. Like that is a tough work ethic. Right. And people are hungry for success. They want to climb the ladder. They want to be. So I think it's a really good match for the where China is at as a country that China is an ambitious country. Right. And ambition coincides very well with longevity. So that match for us is just perfect, where we are partnered with China, we want to grow with China, and it's a really fresh place to be. From a practice level, do you observe any differences between China and the US? Very similar. We can basically achieve the same quality, the same comprehensiveness in a single experience. And so, yeah, I think China is a very good experience.
[29:59] is China is probably the best market we could see this in in terms of replicating the model we built in the US. It fits with the expertise here, the therapies available, the size of the cities, and you could actually concentrate this and get people to come in. So it's a good match for us. So I wonder like how has your team use AI to change the way that you do things? Yeah, Yeah. I mean, when you're a doctor and you look at one marker like inflammation, then it's easy for the doctor to say it's high or low. And based upon that, here's what I suggest you do. Right. When you have 10,000 biomarkers, it's much harder for a doctor to say, here's what I think you should do and why. Absolutely. And especially when some of those markers are not well known, they're up and coming, if they're like proteomics or methylation markers, or you're combining a whole bunch of data points from imaging plus biomarkers. And so what the AI has done for us is it helps us find the patterns in these big data sets that you otherwise can't have a human do. And so we've been able to be successful in finding these patterns. Like we've, you know, we talked about sauna and other things We been able to stitch together evidence and new protocols and new insights and new measurement structures because we seeing such a broad view and we can find these connections So we just getting warmed up. I mean these tools are brand new. We're getting our first wins but I think it's very promising that we're no longer limited by the number of biomarkers that you can get and that makes sense of it. And then if we have to look ahead a little bit, what do you think AI could do in addition to what you just said? I mean Google just showed the first AI based breakthrough so a lot of people said the LLMs are cool but they're not doing breakthroughs okay and Google just did their first breakthrough they showed how to turn a cold cancer into hot so you could have the body identify it work on it and so AI is now a a discovery tool for longevity. And so not only is it useful for understanding very large data sets, it's now in the discovery mode, helping us actually find new pathways for treating disease and also reversing age. And I think that combination, this is why I think it's that the rise of longevity will be faster and more robust than anyone's anticipating. Because we saw this the first go around with GLP it going to happen again with longevity and AI is going to be the fuel source for it Blueprint product release after it was quickly brought to the public interest and discussion也有不少人指出产品价格较高 体验差异较大个别情况下还出现胃肠不适等不良反应与此同时 部分医学专家指出目前Blueprint产品的成分组合尚缺乏成熟的人体行政医学证据总体来看Blueprint展现了一种极具探索性的抗衰路径但其有效性与可复制性仍有待更系统长期的科学验证Brian曾提到在他的抗衰事业背后有一个庞大且高度专业化的医学团队之称自Blueprint启动以来他邀请了超过30名医生和健康专家参与这项逆龄实验Brian的医疗团队在发展过程中也经历过人员调整曾在其纪录片中出现的核心医生之一Oliver Zolman已于去年离开团队纽约时报报道指出知情人士称Zolman对Blueprint的部分研究方向和结果表达过担忧而Blueprint团队成员表示Zolman的离开 Could you tell us more about Brian's team of doctors? How many of you are there? What specialties? And how do you work together? Yeah, so great question. So the team used to be a lot bigger. And what we found over time is that that doesn't necessarily make sense. It makes sense to actually have a smaller team that then brings in other individuals who are experts in specific areas. So if we're focusing on hyperbaric, let's talk to an expert in that. But who's overseeing that also? Mike Mallon has been involved. There's other physicians. There's another physician in Ali who's out of Germany, who's really heavy data scientist. We have other data scientists involved, but Mike Mallon, myself, And Ali are the main physicians. And then we're bringing in other people, depending on what we're talking about. So the team has shrunk down significantly because we've really tried out a lot of things in the longevity space and figured out what really works. And now we can focus on bringing
[34:59] in an individual test as we need them, while we're still focused on the main things that we know are the most effective. So Brian said yesterday at the summit that he wants to achieve don't die by 2039. As a doctor, do you think that's actually achievable and how can that be realized? Yeah, it's funny because if you would have said that to me certainly five years ago, maybe even two, three years ago, I probably would have said it's not possible. That has changed. There's some hurdles that are being overcome that are – and how fast AI is going and how it's changing has really changed my opinion about that. And it's made it more where we can see that we've been able to slow down Brian's rate of aging. There's a lot of cool technologies and stuff we've used, but a lot of it has really been the basics. Really honing in nutrition really honing in sleep reducing risk around different disease processes And that has slowed things at such a rate that if you can see imagine in the future if we get that a little bit slower and we're able to bring in these other technologies that actually then reverse that rate at which we're aging, it becomes a reality pretty quick. And so some of the technologies that have started to happen are being able to reset cells into a state of youth. The cell reprogramming, as Brian talked about. Yeah, so that's happened. But also one of the limiting factors has been cognitive decline. We can only right now do so much, but there's been some newer advances and studies that have shown that maybe we can do a lot more. And those things are using like nanotechnologies to repair the blood barrier. So the barrier that exists between your brain and your blood. And that breaks down over time and results in downstream, probably some cognitive decline. And how to do that was how to address that has always been an issue But now we seeing these breakthroughs happen in this space that really have made me kind of stand back and be like oh these problems that I didn five years ago see is really for us as humanity be able to overcome now seem more than doable I'll push you a little bit on that. Sure. So I guess in order to achieve don't die. you probably have to reduce your rate of aging from, I think currently Brian is at 0.5, right? Yeah, he's about 0.5, 0.48, I think was his best ever. Yeah, and you have to reduce that to zero. Is that right? No, no, that's not what I'm saying. So I think we're going to be able to reduce it down to like maybe 0.4. But let's say we keep it at 0.5. And at this point, what happens then is the technologies to reverse that six months of aging that happens every year become the point where they can reverse six months of aging every year. And that's longevity escape velocity. So where you can reduce the rate at which you're aging, but then whatever you are aging, we can reverse. In addition to all the things that you doing on a daily basis to slow the rate of all your cells aging Does that make sense It kind of a hard concept So these kind of reverse aging I don know like therapies approaches are those the ones like cell reprogramming approaches? Yes, that's what we're talking about. Do you think that's like the magic switch where there's like other switches? There's other things too. So I think one of the things is addressing immune dysfunction. So as you age, you get cellular cells, immune cells become dysfunctional and regenerating your thymus. I think the reprogramming, the epigenetic changes in reprogramming is probably going to be the biggest thing. In my opinion, there's going to be other things that I don't foresee and other people don't even foresee. But those couple of hurdles are already being jumped over. And that makes it where I see in, you know, 10, 14, 15 years as possible. So addressing the immune dysfunction, is there any promising methods like therapies out there that could achieve that? There's research right now around addressing T cell dysfunction specifically. None of that is
[39:59] really commercially available or available for individual people. It's really mouse models and cell models, which is another example is what we're able to do now, and Brian's actually doing this now, is to take cells from different organs and grow them and then test on those cells. So one of the risks that I have seen is as humans are, as we're going along this journey, being able to test different, how you respond to different treatments, everybody's going to respond a little differently. There's risk with treatments. And so you could have adverse effects from, from these treatments that we're trying out on each individual. But if we can test that in a way, then that actually changes the game a fair amount. So we're not testing and guessing as much on treatments, and we don't have risk of aging and things going haywire and wrong. We can actually grow out cells, test how you're going to respond, and then feel that it's safe. Are we getting the appropriate response Then let try this in you as opposed to just kind of guessing or in with potential catastrophic events Yeah so you saying that the approach has to be personal It has to adapt to one measurements. So then brings to a next question. So Naval Rappicant calls Brian one-man FDA, things he calls in one-man FDA. I wonder, that implies that these, the experimental approaches that he's taken is based on data on his own body, right? Yep. And probably only applies to his situation, right, given the personal differences. So how do you think people should take away from these approaches? Should people follow them with this N equals one data points? How do you integrate that? Yeah, there's there's certain things that are really and actually the majority of interventions that Brian does are actually really low risk. The ones that make the most difference are really low risk. Going to bed on time is pretty low risk and it's been shown in multiple populations and different in so many ways. It been proven and reproven And those are the things that are really compressing Brian rate of aging the most Right There other things that are like the stem cell injections Not as big of outcomes. Right. But as far as the next level of how personalized we're going to get, that's that's going to happen. We need to get to the point where all these other technologies that Brian is trying, we can individualize them and we can also make the cost of them decrease to where it is more scalable to everyone. But in the meantime, how do we get everyone's rate of aging down so that when we are able to achieve longevity escape velocity, that we can then lower that cost for everyone and make it applicable to everyone? So what are those things? So that really involves, okay, how do we reduce rates of basically obliterate cardiovascular disease? How do we really get good at detecting cancer early? Not just from a mortality rate benefit, but from a functional benefit. If you catch cancer later it more chemotherapy you have that more radiation more bigger surgical intervention So how do we lower those How do we improve people metabolic health How do we decrease people's systemic inflammation? How do we make sure that people aren't atrophying, that their bone density is good, that their muscle mass is good? And how do we help people with mental health? Because it's related to all of those other disease processes. That most of those things are what Brian's talking about. It's the sleep, the nutrition, the exercise really compresses the rate at which people are aging. It's not just about the rate at which you're aging, though. It's about your functional capacity. Because living a long time or longevity is just living a long time. Yeah. Right. But it's living a long time well, doing the things that you want to do late into your life. And that means the more functional you are, the longer you're going to live. Right. And so how do we do that and make that attainable for everyone while Brian is planning on landing on the moon? Yeah. Right. And so once we can get him to the point where he's landing on the moon, then, okay, let's look back as a society, as humanity and say, wow.
[44:59] this now how do we make it go to everybody yeah let's talk about landing on the moon so how do you decide uh what next for brian in terms of like the reversing uh aging therapies yeah that's hard um because there's a lot of things available and i think it is slowly um this is happening so fast yeah um and there's people that are it's really interesting that because I have patients still that I specifically take care of outside of Brian. And we people are bringing me stuff constantly. It's sifting through all that of what where the evidence is good, and where it's not so good. AI is actually really helpful for this, like on what the next steps are, we can list out ideas, and then have data scientists help us say like, okay, is the evidence for whatever intervention? So spicy foods, right? What's the evidence right now? Like I can know some of that. I can't know all of it. Mike Mallon can't know all of it. We come up with lists. We say, okay, this looks like a good intervention. People bring us stuff. I read stuff. Other doctors do. We get a list. We boil it down and say, okay, let's try this. Let's look at all the data around whatever intervention is. So we'll use spicy food. Let's look at all the data that exist and then what are the markers we can check? Okay. What can we look at pre and post intervention? And are there other things that we're not thinking of? Well, what are the other risks? And then do the experiment, the greatest N of one experiment in human history And then let see what happens And there always potential downsides but like how do we mitigate those downsides to make it towards very low risk Okay great Thank you so much for your time Dr Seger It's great talking to you. Yeah, it's really nice talking to you. Thank you. This is the whole information I and Brian talked about with the doctor. As Brian said earlier, in all of the抗衰路径, the most realistic The blueprint is also known as a positive and healthy person. It is important to know that AI and human health are not the same. We'll see you next time.
