Dermatologist Dray Warns Stacking Retinoids Spikes Barrier Damage

Dr Dray

Cosmetic retinaldehyde offers no proven clinical advantage over standard retinol, while layering multiple vitamin A formulas fails to accelerate anti-aging gains and severely increases chemical irritation.

AI-assisted summary of Best Retinol & Retinal Products for 2026 | Dermatologist's Top 3 — original source. Check the original for full context.

Source published: 2026-08-12

Key ideas

Cosmetic retinol and retinaldehyde require two and one enzymatic conversion steps respectively to become active retinoic acid, making them gentler than prescription drugs while still achieving comparable long-term anti-aging results. (1:28)
Dr. Dray's top three cosmetic retinoids for 2026 are Prequel Retinal Renew Retinaldehyde Gel, Anua Collagen Retinol Refining Gua Sha Cream, and Purito Seoul TXA 6 Niacinamide 10 Retinal Serum, each selected for vehicle stability and barrier tolerance rather than raw percentage claims. (5:24)
Beginners should acclimate to retinoids by applying them two nights per week for the first few weeks before building up to nightly use for a full 12 months to capture peak anti-aging remodeling. (13:09)
"Double stacking" multiple retinoids—such as layering retinol with retinaldehyde or prescription tretinoin—does not accelerate results and instead triggers severe barrier irritation, though cosmetic formulas work well on delicate off-face zones like the neck and chest. (16:07)

Detailed notes

## Background Published on YouTube by board-certified dermatologist Dr. Dray on August 12, 2026, this video showcases her top three cosmetic retinol and retinaldehyde product recommendations for the year. According to the description, she breaks down the science behind cosmetic retinoids, examines the pros and cons of formulas from Prequel, Anua, and Purito, and explains why skin tolerance and long-term consistency matter far more than chasing raw product strength.

## TL;DR Dr. Dray outlines the metabolic mechanisms separating retinol, retinaldehyde, and prescription retinoic acid, debunking common marketing myths regarding absolute potency and active-ingredient incompatibility. She reviews Prequel Retinal Renew Gel, Anua Collagen Retinol Refining Cream, and Purito Seoul TXA 6 Niacinamide 10 Retinal Serum, highlighting their vehicle formulations, barrier-supportive ingredients, and optimal off-face uses for sensitive zones like the neck and chest. Emphasizing that over-the-counter options should not replace medical treatments for diagnosed dermatological conditions, she offers clear nighttime application protocols, warns strictly against double-stacking retinoids, and underscores consistent daily sunscreen use as non-negotiable.

## Atmosphere & style The video carries Dr. Dray's trademark clinical, measured, and refreshingly no-nonsense delivery, stripping away skincare marketing theatrics in favor of pragmatic science. Her narrative style is steady and educational, punctuated by dry, candid observations about clumsy packaging and viral internet exaggerations like nonsurgical gua sha facelifts. The presentation feels less like an influencer endorsement and more like an authoritative yet relaxed consultation with a candid dermatologist who values barrier health and minimalist consistency over beauty trends.

## Bulletin - [01:28](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=88s) Cosmetic retinol and retinaldehyde require two and one enzymatic conversion steps respectively to become active retinoic acid, making them gentler than prescription drugs while still achieving comparable long-term anti-aging results. - [05:24](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=324s) Dr. Dray's top three cosmetic retinoids for 2026 are Prequel Retinal Renew Retinaldehyde Gel, Anua Collagen Retinol Refining Gua Sha Cream, and Purito Seoul TXA 6 Niacinamide 10 Retinal Serum, each selected for vehicle stability and barrier tolerance rather than raw percentage claims. - [13:09](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=789s) Beginners should acclimate to retinoids by applying them two nights per week for the first few weeks before building up to nightly use for a full 12 months to capture peak anti-aging remodeling. - [16:07](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=967s) "Double stacking" multiple retinoids—such as layering retinol with retinaldehyde or prescription tretinoin—does not accelerate results and instead triggers severe barrier irritation, though cosmetic formulas work well on delicate off-face zones like the neck and chest.

## Key takeaways - [00:00](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=0s) Cosmetic retinol and retinaldehyde visibly improve signs of skin aging, but unlike OTC adapalene or prescription tretinoin, they are not medications intended to treat dermatological conditions such as acne or rosacea. - [01:28](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=88s) Retinol requires two metabolic conversion steps in the skin to reach active retinoic acid while retinaldehyde requires one, making both gentler than pure retinoic acid at the cost of requiring more patience and consistency. - [01:28](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=88s) Despite requiring fewer conversion steps, retinaldehyde is not clinically proven to be stronger or more effective than standard retinol; real-world performance depends heavily on ingredient stability and the delivery vehicle. - [05:24](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=324s) Prequel Retinal Renew Retinaldehyde Gel uses a stabilized, time-released delivery system paired with barrier-supporting ectoin and soothing vitamin B12, with both available strength levels performing identically in Dr. Dray's testing. - [08:30](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=510s) Anua Collagen Retinol Refining Gua Sha Cream combines standard retinol with glycerin, panthenol, niacinamide, and macadamia seed oil to immediately blur fine lines and gradually smooth crepiness on the neck and forearms without stinging. - [09:11](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=551s) Built-in gua sha applicators can offer mild cooling and depuffing but cannot deliver a nonsurgical facelift, and undisclosed retinol percentages matter far less than overall formulation quality and delivery design. - [10:54](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=654s) Purito Seoul TXA 6 Niacinamide 10 Retinal Serum suspends retinaldehyde, 6% tranexamic acid, and 10% niacinamide in encapsulated micro-beads to prevent oxidation and noticeably reduce blotchiness and discoloration on the chest and décolleté. - [10:54](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=654s) While niacinamide supports barrier repair and tone correction, a 10% concentration exceeds standard clinical thresholds and carries an increased risk of triggering contact irritation in sensitive individuals. - [13:09](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=789s) Proper retinoid application involves protecting the corners of the nose and mouth with petroleum jelly, applying formulas at night from thinnest to thickest consistency, and wearing daily broad-spectrum sunscreen. - [13:09](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=789s) Common internet claims forbidding the concurrent use of retinoids with vitamin C or copper peptides lack empirical backing, though keeping routines simple reduces the probability of moisture barrier breakdown. - [16:07](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=967s) Layering multiple retinoids together provides no additive rejuvenation benefits and drastically increases irritation; users applying prescription tretinoin on the face should reserve cosmetic retinoids for sensitive areas like the neck and décolleté. - [17:57](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=1077s) Unlike pharmaceutical retinoids—such as OTC adapalene or prescription tretinoin, tazarotene, and trifarotene—cosmetic retinoids are not evaluated in head-to-head double-blind clinical trials, making personal tolerability and consistency the key deciding factors.

## Detailed walkthrough ### [00:00](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=0s) Introduction to 2026 Cosmetic Retinoids

Dr. Dray welcomes viewers and introduces her roundup of favorite retinol and retinaldehyde products for 2026. While she has reviewed dozens of over-the-counter options over the years, the skincare market continues to introduce new options. She highlights items released over the past year or so that offer genuine value for those seeking to incorporate vitamin A derivatives into their routines.

While Dr. Dray routinely applies prescription retinoids like tretinoin or adapalene to her facial skin, she frequently reserves cosmetic retinol and retinaldehyde formulas for more sensitive parts of the body. Both retinol and retinaldehyde are cosmetic forms of topical vitamin A. Evidence shows they can visibly improve signs of aging skin. However, she stresses that these cosmetic formulations are not medications and are not intended to treat medical dermatological conditions such as acne or rosacea. While someone with these issues might see mild secondary benefits, patients should follow their dermatologist's prescribed treatment plan rather than relying on over-the-counter alternatives to manage diagnosed conditions.

[01:28](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=88s) Retinol vs. Retinaldehyde vs. Prescription Retinoids

Dr. Dray clarifies the key functional distinctions between prescription retinoids, over-the-counter medications, and cosmetic retinoids. While adapalene is available over the counter without a prescription in the United States, it is still classified as a medication rather than a cosmetic. The major mechanical difference is that cosmetic retinoids require enzymatic conversion steps by the skin cells before transforming into retinoic acid, the biologically active form:

```mermaid flowchart LR accTitle: Metabolic Conversion Pathway of Retinoids accDescr: Diagram demonstrating how retinol requires two conversion steps and retinaldehyde requires one step to reach active retinoic acid.

subgraph Cosmetics["Cosmetic Retinoids"] R["Retinol"] -->|"Step 1"| RAL["Retinaldehyde"] end

subgraph Active["Active Form"] RAL -->|"Step 2"| RA["Retinoic Acid"] end ```

Retinol requires two metabolic conversion steps within the skin, whereas retinaldehyde sits one step closer, needing only a single conversion. Because the skin must do this enzymatic work, cosmetic retinoids are far gentler than pure retinoic acid, though they require more patience before visible improvements appear. Consistency is critical to maintain results.

Dr. Dray outlines three scenarios where choosing a cosmetic retinoid over a medicated formula makes practical sense: - You are strictly aiming to improve the visible signs of skin aging and are not attempting to manage an underlying skin disease. - You have previously tried prescription medications or OTC adapalene and experienced intolerable irritation. - You tolerate prescription-strength retinoids on your face, but require a gentler cosmetic option for more delicate, easily sensitized anatomical areas.

Addressing common consumer skepticism, Dr. Dray notes that existing comparative studies show cosmetic forms achieve clinical results comparable to prescription options for visible aging and wrinkle reduction over the long term, even though cosmetics take longer to show their effects. While cosmetic products cannot legally claim to boost collagen on their packaging, scientific evidence confirms they stimulate collagen production.

Dr. Dray also dispels the persistent industry myth that retinaldehyde is fundamentally stronger or more potent than retinol simply because it requires fewer conversion steps. She emphasizes that this is theoretical speculation rather than an established clinical fact. Real-world efficacy depends heavily on formula vehicle design, ingredient stability, and the biological efficiency of the conversion process. Chasing "strength" at the expense of skin tolerance is counterproductive, as excessive irritation spikes the risk of post-inflammatory hyperpigmentation rather than speeding up anti-aging benefits.

[05:24](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=324s) Prequel Retinal Renew Retinaldehyde Gel Review

The first featured product is Prequel Retinal Renew Retinaldehyde Gel, which Dr. Dray describes as the most straightforward and classic treatment among her top picks. Targeted at photodamage, fine surface lines, and rough skin texture, its standout advantage is its advanced delivery vehicle. Because retinaldehyde degrades quickly when left unencapsulated in a basic emulsion, Prequel employs a stabilized, time-released delivery system that improves stability while reducing peak irritation.

The supporting formulation includes deliberate barrier-supportive ingredients: - **Ectoin**: An extremolyte produced by bacteria to survive harsh conditions like dehydration, UV radiation, and heat. It functions as an antioxidant and anti-inflammatory humectant to shield and repair the moisture barrier. - **Cyanocobalamin (Vitamin B12)**: Gives the gel its signature pink color and works topically to relieve itchiness and soothe sensitivity during retinoid acclimation. - **Fragrance-free formulation**: Completely unfragranced, minimizing common contact allergens.

Prequel offers this gel in two strength percentages. Dr. Dray tested both strengths thoroughly and observed no noticeable difference in real-world performance or irritation: "You could blindfold me and I wouldn't know who I was putting on." She considers the strength variations practically interchangeable.

Texture-wise, the formula stands out because of its rich moisturizing base. It provides an immediate plumping, smoothing, and radiant finish that compensates for the gradual biological turnaround of retinoids. Dr. Dray compares this immediate satisfaction to her long-standing favorite, the Neutrogena Rapid Wrinkle Repair Regenerating Retinol Cream, which pairs stable retinoid technology with immediate, barrier-comforting hydration.

[08:30](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=510s) Anua Collagen Retinol Refining Gua Sha Cream Review

Dr. Dray transitions to her second pick, the Anua Collagen Retinol Refining Gua Sha Cream. This formula utilizes standard retinol (requiring the classic two-step biological conversion) and is tailored specifically for the delicate skin of the neck.

The cream features a deeply moisturizing, restorative profile intended to minimize crepiness: - **Glycerin and Panthenol**: Core humectants that bind water into the upper layers of the epidermis. - **Niacinamide**: Reduces redness, bolsters skin barrier function, and provides antioxidant protection. - **Macadamia Seed Oil**: A rich emollient that replenishes essential lipids. - **Collagen and Adenosine**: Work synergistically to hydrate, soften, and smooth texture.

Dr. Dray notes that the rich, nourishing consistency creates an immediate blurring effect on visible neck lines upon application, giving instant optical improvement alongside the gradual long-term benefits of the retinol.

[09:11](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=551s) Anua Collagen Retinol Cream: Real Results, Gua Sha Gimmicks, and Undisclosed Percentages

While moisturizing formulas can make fine lines appear visibly plumped, deeper-set wrinkles will never be completely erased by a topical cream, though a quality formulation can make them far less obvious. Dr. Dray found the Anua Collagen Retinol Refining Gua Sha Cream to be an exceptionally elegant, well-tolerated formulation that caused zero burning or stinging during testing. She used it extensively across her neck and forearms, observing that with consistent application, the skin became visibly smoother, plumper, and noticeably more even in tone over time.

The integrated gua sha applicator, however, earned mixed reviews. Dr. Dray acknowledges that while gua sha techniques can be relaxing and helpful for mild depuffing, online claims framing them as a nonsurgical facelift are outright nonsense: "people on the internet will have you believing this is going to give you a facelift and it's simply not." Although the metal-tipped applicator feels cool against the skin, she found the actual mechanics of using the built-in tip awkward and clumsy. After several attempts, she abandoned the tool altogether, opting instead to dispense the cream directly into her hands and massage it in manually.

Another frequent consumer grievance is that Anua does not disclose the exact percentage of retinol in the formula. Dr. Dray remains unfazed by undisclosed percentages, explaining that fixating on raw numbers often gives consumers a false sense of security or leads them to prematurely dismiss effective formulas as too weak. In cosmetic chemistry, the vehicle and overarching delivery system dictate efficacy far more than a isolated concentration metric, though she understands why the lack of transparency deters certain buyers.

- **Wrinkle realism:** Hydration significantly softens fine surface lines, but deep structural folds require realistic expectations rather than promises of erasure. - **Application feedback:** Zero stinging or irritation was observed across sensitive test areas like the neck and forearms. - **The gua sha verdict:** The cooling tip provides minor depuffing benefits, but the awkward shape led Dr. Dray to revert to standard hand application. - **Percentage transparency:** The exact retinol concentration is undisclosed, but overall delivery formulation matters substantially more than a standalone percentage figure.

---

[10:54](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=654s) Purito Seoul TXA 6 Niacinamide 10 Retinal Serum: Chest Care and Encapsulated Beads

Introduced to Dr. Dray's routine toward the end of 2025, the Purito Seoul TXA 6 Niacinamide 10 Retinal Serum quickly became a personal Holy Grail. She dedicated several months to applying a full pipette nightly to her chest and décolleté, yielding striking and sustained improvements in an area notoriously prone to sun damage and uneven texture. Her upper chest showed marked reductions in blotchiness and discoloration, alongside a noticeably smoother, plumper skin texture.

The serum’s physical delivery system features suspended micro-spheres that require a thorough shake prior to dispensing to ensure even distribution. These little beads, which can be felt as the serum drops onto the skin, encapsulate the retinaldehyde, tranexamic acid, and niacinamide. This encapsulation stabilizes the notoriously volatile actives within the bottle and facilitates a sustained, gradual release as the spheres dissolve and melt under the warmth of the fingers.

Dr. Dray highlights the synergy of the supporting actives: topical tranexamic acid shows genuine clinical promise for soothing redness and reinforcing the moisture barrier, while niacinamide is a proven powerhouse for barrier repair and tone correction. However, she offers a clear caveat regarding the 10% niacinamide concentration. Percentages that high are not physiologically necessary to reap clinical benefits and carry an increased risk of triggering contact irritation in sensitive individuals. Despite that cautionary note, the product proved so exceptionally effective for her that she has repurchased at least six bottles.

- **Formula composition:** Retinaldehyde paired with 6% tranexamic acid and 10% niacinamide. - **Physical design:** A biphasic-style suspension requiring a vigorous shake before each application. - **Encapsulated micro-beads:** Protect delicate actives against premature oxidation while ensuring slow, continuous release into the skin. - **Personal usage stats:** Applied nightly to the upper chest via one full dropper; repurchased at least six bottles to date. - **Niacinamide warning:** A 10% concentration exceeds standard clinical thresholds and may trigger reactivity in niacinamide-sensitive skin.

---

[13:09](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=789s) Application Guidelines, Layering Truths, and Beginner Acclimation

Proper application technique is essential when introducing any vitamin A derivative, whether an over-the-counter retinol, a cosmetic retinaldehyde, or prescription retinoic acid. Dr. Dray advises placing a protective barrier of petroleum jelly around vulnerable mucosal margins—specifically the corners of the nose and the oral commissures—to prevent irritating product pooling. Retinoids should generally be reserved for the evening on clean, dry skin. While historic guidance prioritized night use due to the extreme photolability of older molecules, modern chemical stabilization has mitigated light degradation; nightly use remains preferred primarily because skin repair physiology peaks overnight.

```mermaid flowchart TD accTitle: Retinoid Acclimation and Application Sequence accDescr: Step-by-step flowchart showing protective prep, layering order from thinnest to thickest, and the multi-month ramping schedule.

subgraph Prep ["Preparation & Protection"] P1["Cleanse Face thoroughly"] --> P2["Apply Petroleum Jelly to corners of nose and mouth"] end

subgraph Layering ["Nighttime Product Layering"] L1["Thinnest Layer: Purito Serum"] --> L2["Thickest Layer: Retinoid Creams / Moisturizer"] end

subgraph Acclimation ["Acclimation Schedule"] A1["Weeks 1 to 4: 2 nights per week"] --> A2["Months 2 to 12: Nightly application"] A2 --> A3["After 1 Year: Optional maintenance frequency"] end

Prep --> Layering Layering --> Acclimation ```

When building a nightly sequence, Dr. Dray urges consumers not to overthink strict rules: the standard rule of thumb is applying formulas from thinnest to thickest consistency. Lightweight serums like Purito go on early, whereas rich retinoid creams serve as the finishing step without requiring an extra moisturizer. She dismisses common internet myths forbidding the concurrent use of retinoids with vitamin C or copper peptides, noting that claims of molecular incompatibility lack empirical backing: "Most of that is just speculation, not evidence-based." Any well-tolerated combination is acceptable, though stacking numerous individual products increases the probability of barrier breakdown. Her guiding philosophy remains: "Fewer products, fewer problems."

For complete retinoid novices, pacing is critical. Beginners should apply the active just two evenings per week for the first few weeks, progressively building tolerance before attempting nightly use. To capture peak anti-aging remodeling, patients should aim to maintain consistent nightly use for a full twelve months, after which they can taper frequency slightly for ongoing maintenance. Non-negotiable daily sunscreen remains the bedrock of any routine, as failing to block daytime UV exposure completely negates any nocturnal retinoid gains.

- **Barrier protection:** A light coating of petroleum jelly on the nostrils and oral corners blocks localized irritation. - **Layering protocol:** Thinnest vehicle to thickest vehicle; dedicated retinoid creams eliminate the need for secondary moisturizers. - **Debunked interactions:** Retinoids can safely share a routine with vitamin C or copper peptides, provided personal skin tolerance allows it. - **Novice schedule:** Start 2 nights weekly for the initial month; transition toward nightly use for 1 year; downshift frequency later for maintenance. - **Sunscreen mandate:** Daily broad-spectrum SPF is non-negotiable to preserve collagen gains.

---

[16:07](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=967s) Choosing Your Retinoid and the Danger of Double Stacking

Choosing among these options ultimately hinges on personal lifestyle factors, budget constraints, and whether an individual wants specific secondary actives like niacinamide or tranexamic acid. Dr. Dray reiterates that head-to-head clinical literature does not demonstrate that retinaldehyde is conclusively superior, stronger, or inherently better tolerated than standard retinol.

Crucially, she issues a firm warning against "double stacking" retinoids. Layering a cosmetic retinol over a retinaldehyde, or sandwiching cosmetic vitamin A formulas alongside prescription tretinoin in hopes of accelerating cellular turnover, is counterproductive. Multiple retinoids compete for identical cellular pathways; stacking them delivers no additive rejuvenation benefits and drastically escalates the likelihood of chemical irritation, peeling, and barrier failure:

> "If you're already using retinol, don't use retinol and retinaldehyde and think that you're going to double stack and get better results. Or don't use these along with your tretinoin and think that you're going to get better vitamin A related results because all that can lead to is just more irritation."

Those currently tolerating a prescription retinoid like tretinoin on their face should maintain that regimen without adding cosmetic retinoids into the facial routine. Instead, cosmetic retinol and retinaldehyde creams and serums represent ideal alternatives for off-face target areas—such as the delicate chest, neck, and décolleté—where prescription formulations are often far too aggressive to tolerate.

- **Evidence parity:** Retinaldehyde has not been proven clinically superior or definitively better tolerated than standard retinol in rigorous direct trials. - **The "double stacking" hazard:** Stacking OTC retinol, OTC retinaldehyde, or prescription tretinoin causes severe barrier dermatitis without amplifying anti-aging results. - **Routine zoning:** Those utilizing prescription tretinoin on the face can repurpose cosmetic retinoid serums and creams for off-face zones like the neck and décolleté.

[17:57](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=1077s) Cosmetic Retinoids vs. Prescription Drugs and Final Recommendations

Dr. Dray points out that for viewers seeking additional recommendations, her older videos remain completely relevant; the products featured in those past reviews are still on the market, and she continues to actively suggest and feature them across different routines. With the market flooded with an overwhelming array of retinoid formulas, selecting the absolute "best" can be challenging. She emphasizes the reality of cosmetic grading: evaluating these over-the-counter options relies heavily on personal experience and testing. Because these items are classified as cosmetics rather than prescription drugs, consumers will never see head-to-head, double-blind, placebo-controlled clinical trials comparing them directly against one another. They simply are not held to the rigid regulatory standards required of pharmaceuticals. Nevertheless, Dr. Dray notes with a touch of humor that her personal evaluation standards are notoriously high, so viewers can take her curated recommendations for what they are worth.

Looking beyond cosmetic serums and creams, she invites viewers to chime in below with their own vitamin A journeys. She is eager to hear whether people are currently using cosmetic retinol or retinaldehyde, or if they have leveled up to pharmaceutical-grade retinoids. In the United States, that includes over-the-counter adapalene, as well as classic prescription powerhouses like tretinoin, tazarotene, or trifarotene—all of which she praises as genuine "anti-aging gems" within the broader vitamin A family tree. Wrapping up the video, she asks viewers to give the video a thumbs up and share it with friends, signing off with her signature daily skincare reminders: don't forget your sunscreen, hit subscribe, and she will see everyone tomorrow.

- **Cosmetic vs. Drug Standards:** Cosmetic retinoids (such as retinol and retinaldehyde formulas) are not subject to head-to-head, double-blind, placebo-controlled trials; evaluations are based on formulation quality, personal testing, and tolerability. - **Over-the-Counter Pharmaceutical Retinoids:** Adapalene is highlighted as an accessible, over-the-counter retinoid medication available without a prescription in the United States. - **Prescription Vitamin A Gems:** Prescription alternatives praised for their proven anti-aging benefits include tretinoin, tazarotene, and trifarotene. - **Dr. Dray's Signature Sign-Off:** Viewers are reminded to protect their skin barrier and results by consistently wearing sunscreen every day.

## Notable quotes > [05:24](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=324s) You could blindfold me and I wouldn't know who I was putting on. — Dr. Dray

> [09:11](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=551s) people on the internet will have you believing this is going to give you a facelift and it's simply not. — Dr. Dray

> [13:09](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=789s) Most of that is just speculation, not evidence-based. — Dr. Dray

> [13:09](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=789s) Fewer products, fewer problems. — Dr. Dray

> [16:07](https://www.youtube.com/watch?v=8rmIw-F7mNc&t=967s) If you're already using retinol, don't use retinol and retinaldehyde and think that you're going to double stack and get better results. Or don't use these along with your tretinoin and think that you're going to get better vitamin A related results because all that can lead to is just more irritation. — Dr. Dray

## Mentioned Dr Dray, Prequel Retinal Renew Retinaldehyde Gel, Anua Collagen Retinol Refining Gua Sha Cream, Purito Seoul TXA 6 Niacinamide 10 Retinal Serum, Neutrogena Rapid Wrinkle Repair Regenerating Retinol Cream, Tretinoin, Adapalene, Tazarotene, Trifarotene, Retinol, Retinaldehyde, Retinoic acid, Niacinamide, Tranexamic acid, Ectoin, Cyanocobalamin (Vitamin B12), Prequel, Anua, Purito Seoul, Neutrogena

## Video description Dr. Dray shares her top 3 retinol and retinaldehyde products for 2026, including the Prequel Retinal Renew Retinaldehyde Gel, Anua Collagen Retinol Refining Gua Sha Cream, and Purito Seoul TXA 6 Niacinamide 10 Retinal Serum.

She explains the differences between retinol and retinaldehyde, how cosmetic retinoids work, and why the strongest product is not necessarily the best choice. Consistency and tolerability are key for getting results.

The video also covers the pros and cons of each formula, who each product may be best suited for, and how Dr. Dray personally uses them, including her experience using the Purito retinal serum on her chest and décolleté.

PRODUCT LINKS:

Prequel Retinal Renew Retinaldehyde Gel https://amzlink.to/az0TKYZKArHou

Anua Collagen Retinol Refining Gua Sha Cream https://amzlink.to/az0gEx7p5uQ2L

Purito TXA 6 Niacinamide 10 Retinal Serum https://amzlink.to/az05CcW6aokLX

TIMESTAMPS:

0:00 Top Retinol & Retinal Products for 2026 0:46 Retinol vs. Retinaldehyde 5:24 Prequel Retinal Renew Review 8:30 Anua Collagen Retinol Gua Sha Cream Review 10:54 Purito TXA 6 Niacinamide 10 Retinal Review 13:09 How to Apply Retinoids 16:07 Which Retinoid Should You Choose? 17:35 Final Thoughts

#retinol #retinaldehyde #retinal #skincare #antiaging #retinoid #dermatologist #skincaretips

FTC: This video is not sponsored. Links are commissionable, meaning I may earn commission from purchases made through links.

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Disclaimer: This video is not intended to provide diagnosis, treatment or medical advice. Content provided on this Youtube channel is for informational purposes only. Please consult with a physician or other healthcare professional regarding any medical or health related diagnosis or treatment options. Information on this Youtube channel should not be considered as a substitute for advice from a healthcare professional. The statements made about specific products throughout this video are not to diagnose, treat, cure or prevent disease.

[Source](https://www.youtube.com/watch?v=8rmIw-F7mNc)

中文简报

皮肤科医生Dray警告：叠加使用维A类成分会加剧屏障损伤护肤级视黄醛相较于普通视黄醇并无经证实的临床优势，而叠加多种维生素A配方不仅无法加速抗衰老收益，还会严重加剧化学刺激。 Dray医生概述了区分视黄醇、视黄醛与处方视黄酸的代谢机制，破除了有关绝对功效及活性成分不相容的常见营销迷思。她评测了Prequel Retinal Renew凝胶、Anua胶原蛋白视黄醇紧致面霜以及Purito Seoul TXA 6烟酰胺10视黄醛精华液，重点介绍了它们的载体配方、屏障支持成分，以及适用于颈部和胸前等敏感区域的最佳面部外使用方式。她强调非处方产品不应替代已确诊皮肤病的医疗手段，并提供了清晰的夜间涂抹方案，严格警告切勿叠加使用多种维A类成分，同时强调每日坚持涂抹防晒霜是不可妥协的前提。护肤级视黄醇和视黄醛分别需要经过两次和一次酶促转化步骤才能转化为活性视黄酸，这使它们比处方药物更温和，同时仍能取得相当的长期抗衰老效果。 (1:28) Dray医生评选出的2026年三款最佳护肤级维A类产品为Prequel Retinal Renew视黄醛凝胶、Anua胶原蛋白视黄醇紧致刮痧霜和Purito Seoul TXA 6烟酰胺10视黄醛精华，其入选均基于载体稳定性与屏障耐受性，而非单纯的浓度宣称。 (5:24) 初学者应在前几周通过每周使用两晚来建立对维A类成分的耐受，随后逐步过渡至每晚使用并坚持满12个月，以获得峰值抗衰老重塑效果。 (13:09) “叠加使用”多种维A类成分（例如将视黄醇与视黄醛或处方维A酸叠加）并不能加快见效，反而会引发严重的屏障刺激，不过护肤配方在颈部和胸部等娇嫩的面部外区域能发挥良好作用。 (16:07)

Reading summary

Dr. Dray evaluates over-the-counter retinol and retinaldehyde formulations for 2026, arguing that cosmetic vitamin A derivatives offer gentler, long-term anti-aging alternatives to prescription treatments, particularly for sensitive body areas. She emphasizes that vehicle stability and skin tolerance dictate real-world outcomes far more than marketing claims regarding active percentages or biological conversion speeds. Cosmetic Retinoid Mechanics and Realistic Efficacy (1:28) Cosmetic retinoids require metabolic conversion within the skin to transform into retinoic acid, the biologically active form. Retinol requires a two-step conversion process, whereas retinaldehyde requires only a single step. Dr. Dray clarifies that despite widespread industry claims, retinaldehyde is not clinically proven to be inherently stronger, superior, or better tolerated than retinol. Clinical performance depends primarily on vehicle formulation, active ingredient stability, and individual enzymatic efficiency rather than theoretical conversion speed. While cosmetic formulations cannot legally claim to treat diagnosed conditions like acne or rosacea, clinical evidence confirms they stimulate collagen production and reduce wrinkles over the long term comparable to prescription options. Dr. Dray advises using cosmetic retinoids when the primary objective is addressing visible photoaging, when prescription-strength options cause intolerable irritation, or when treating delicate anatomical regions that cannot tolerate medications like tretinoin or over-the-counter adapalene. Top Product Formulations and Vehicle Innovation (5:24) Reviewing her top cosmetic picks, Dr. Dray emphasizes that delivery technology and supporting ingredients matter far more than raw concentration percentages. Prequel Retinal Renew Retinaldehyde Gel uses a time-released, encapsulated system paired with barrier-supportive ectoin and soothing cyanocobalamin (vitamin B12). After testing both available strength tiers, Dr. Dray observed no real-world difference in performance or irritation, deeming them practically interchangeable. For chest blotchiness and sun damage, she highlights Purito Seoul TXA 6 Niacinamide 10 Retinal Serum, an encapsulated micro-bead formula combining retinaldehyde with tranexamic acid and niacinamide. However, she cautions that its 10% niacinamide level exceeds clinical necessity and poses an irritation risk for sensitive users. For neck crepiness, the Anua Collagen Retinol Refining Cream blends standard retinol with glycerin, macadamia seed oil, and adenosine. Dr. Dray dismisses consumer skepticism over Anua's undisclosed retinol concentration, noting that vehicle design dictates efficacy. She cautions, however, that topical hydration can only blur fine surface lines rather than erase deep folds, and she characterizes the product's built-in gua sha applicator as an awkward gimmick that will not replicate a surgical facelift. Application Guidelines, Acclimation, and Routine Layering (13:09) Proper application is essential to avoid barrier damage when using vitamin A. Dr. Dray recommends coating vulnerable facial areas, such as the corners of the nose and mouth, with petroleum jelly to prevent irritating formula pooling. Beginners should apply retinoids only two nights per week during the first month, gradually building to nightly application for a full year to achieve optimal cellular remodeling before downshifting to a maintenance schedule. Daily broad-spectrum sunscreen is non-negotiable, as unblocked UV exposure negates retinoid-driven collagen gains. When layering nightly products, Dr. Dray advises following a standard thinnest-to-thickest consistency rule, noting that dedicated retinoid creams eliminate the need for separate moisturizers. She debunks claims that retinoids cannot be paired with active ingredients like vitamin C or copper peptides, characterizing warnings about chemical incompatibility as speculative rather than evidence-based. Nonetheless, she favors a minimalist routine, warning that excessive product stacking elevates the risk of barrier disruption. The Pitfall of Double Stacking and Zoning (16:07) Dr. Dray issues a strict warning against "double stacking" retinoid formulas—such as layering retinol with retinaldehyde or sandwiching cosmetic vitamin A over prescription tretinoin. Because these molecules operate through the same cellular pathways, layering them offers no additive anti-aging benefit and substantially increases the risk of severe chemical irritation, peeling, and post-inflammatory hyperpigmentation. Instead of combining formulas, she recommends routine zoning. Patients currently tolerating prescription retinoids or adapalene on their face should maintain that regimen without adding cosmetic retinoids to their facial steps. Instead, gentler cosmetic retinol and retinaldehyde creams and serums should be reserved for easily sensitized off-face areas, such as the neck, chest, and décolleté, where prescription formulas are generally too aggressive. Dr. Dray emphasizes that cosmetic retinoids are not subject to the double-blind, head-to-head pharmaceutical trials required of prescription medications, making product selection dependent on formulation elegance, ingredient stability, and individual tolerance. While prescription retinoids like tretinoin, tazarotene, and trifarotene remain the gold standard for clinical intervention, well-engineered cosmetic alternatives offer an effective, low-irritation path for ongoing photoaging management.

Source quotes

[5:24] Dr. Dray: You could blindfold me and I wouldn't know who I was putting on. [9:11] Dr. Dray: people on the internet will have you believing this is going to give you a facelift and it's simply not. [13:09] Dr. Dray: Most of that is just speculation, not evidence-based. [13:09] Dr. Dray: Fewer products, fewer problems. [16:07] Dr. Dray: If you're already using retinol, don't use retinol and retinaldehyde and think that you're going to double stack and get better results. Or don't use these along with your tretinoin and think that you're going to get better vitamin A related results because all that can lead to is just more irritation.

Original transcript

[0:00] Well, hey guys, welcome back. If you're [0:01] new here, I'm Dr. Dray. I'm a [0:03] board-certified dermatologist. Today, I [0:05] want to go through my current top [0:08] favorite retinol and retinaldehyde [0:10] products of 2026. Over the years, I have [0:13] reviewed so many cosmetic retinols and [0:15] retinaldehydes trying to guide you guys [0:17] on which ones I think are the best. [0:19] They're constantly coming out with new [0:21] ones, and so in today's video, I want to [0:24] share with you all what has been new [0:26] lately over the past year or so that for [0:29] me personally has really stood out as [0:32] worth considering if this is an [0:33] ingredient you're looking to incorporate [0:35] into your skin care routine. Because I [0:37] do use a topical retinoid on my face, [0:39] such as tretinoin or adapalene I've used [0:42] in the past. Two other body sites I like [0:44] to use retinol and retinaldehyde. A [0:46] reminder, retinol, retinaldehyde, who's [0:49] who, which one's good, which one's [0:51] strong? These are all cosmetic forms of [0:54] topical vitamin A. Both forms, retinol [0:57] and retinaldehyde, they do have evidence [0:59] that they can improve the visible signs [1:00] of skin aging. These are cosmetics, [1:02] they're not drugs, so they're not [1:03] intended to treat any skin diseases like [1:06] acne, rosacea. Not to say that you might [1:08] not derive some benefit from them if you [1:10] have those, but they're not medications. [1:12] So, in other words, if you have those [1:14] diseases, make sure you're following [1:15] with your dermatologist and using the [1:18] prescribed medications appropriately and [1:20] not thinking, "Hmm, maybe I can use this [1:22] cosmetic instead." Probably not going to [1:24] deliver as consistent results, so want [1:27] to emphasize that from the get-go. [1:28] What's the difference though between the [1:30] prescription stuff and these cosmetics, [1:32] aside from them being cosmetics and the [1:34] prescription stuff being actual [1:36] medications? Well, in contrast to the [1:39] prescription stuff or the [1:40] over-the-counter medication to even [1:42] confuse you further, adapalene, which is [1:44] also a medication, not a cosmetic, but [1:46] you can buy it without a prescription [1:48] here in the US at least. In contrast to [1:50] those, the cosmetics like retinol and [1:52] retinaldehyde, your skin needs to do a [1:54] little bit of work on them in order to [1:56] get them to the active form. And the [1:58] amount of work it has to do differs [2:00] depending on the cosmetic ingredient. [2:03] Retinol, your skin has to do two things [2:05] to it. Retinaldehyde on the other hand, [2:07] your skin only has to do one thing to [2:09] it. So, that's kind of the main way in [2:11] which they differ. And because your skin [2:13] has to do a little bit of work on these [2:15] ingredients, they tend to be a lot [2:17] gentler, but they take a little bit [2:20] longer to start, quote unquote, working [2:22] for you to start noticing results. In [2:24] other words, you've got to be patient [2:25] with these. And like the prescription [2:27] stuff, you have to stay consistent in [2:29] order to maintain the results. So, when [2:31] it comes to entertaining the idea of a [2:33] cosmetic versus a medication, probably [2:36] where it makes the most sense is A, if [2:38] you're only trying to improve the [2:39] visible signs of skin aging. You're not [2:41] trying to treat a skin disease, okay? [2:43] Then it makes sense. B, uh you've tried [2:45] the medicated stuff, uh whether it be [2:48] prescription or over-the-counter [2:49] adapalene, and it was just too [2:51] irritating. You're looking for something [2:53] gentler. Or C, you're kind of like me, [2:55] and you tolerate well and enjoy and have [2:58] used consistently for a while the [3:00] prescription stuff on your face, but you [3:02] find that in more delicate areas, uh you [3:05] don't tolerate that as well. And so, you [3:07] want to experiment with something [3:08] cosmetic to see if you get uh better [3:11] tolerance with the benefits along for [3:13] the ride. So, that's kind of the uh [3:16] dividing line right there. And a lot of [3:18] people want to know, are these weaker [3:20] than the prescription stuff? We don't [3:21] have good research showing that they're [3:23] weaker. There are studies that compare [3:26] the cosmetic to the prescription stuff [3:28] and show ultimately, when it comes to [3:30] improving the visible signs of skin [3:31] aging, at the end of the day, you get [3:33] the same results. It may take longer for [3:35] you to get there with the cosmetic than [3:37] the prescription, but the results are [3:39] the same. Can the cosmetics improve [3:41] collagen production? While they cannot [3:43] make that claim, there is evidence that, [3:45] just like the prescription stuff, they [3:47] can improve collagen production. So, [3:49] yeah, you get a reduction in wrinkles [3:51] with long-term consistent, that's key, [3:54] use of these. Now, another little [3:57] misconception between retinol and [3:59] retinaldehyde that we need to clear up [4:01] from the get-go because some people [4:03] might be under the impression that this [4:05] is so. As a result, it will influence [4:07] which one you choose. So, let's just [4:08] clear it up right now. Many people are [4:11] under the impression that retinaldehyde [4:13] must be stronger, more powerful, more [4:16] potent than retinol because, well, your [4:19] skin only has to do one thing to it [4:21] versus two. Objectively, we have no [4:24] research confirming that, establishing [4:26] that. It is merely speculation. Makes [4:29] sense, but we know a lot of things when [4:31] written out on paper as far as how they [4:33] work. It doesn't translate to the same [4:36] expectations in reality because it all [4:39] depends on the overall formulation. It [4:41] depends on to what extent the conversion [4:44] steps happen as efficiently with one [4:46] versus the other. There're just a lot of [4:48] unknowns there. And like I said, end of [4:50] the day, if you choose one and you stay [4:52] consistent with it, the end results are [4:54] going to be the same. So, the best thing [4:56] is for you to choose one that you can [4:58] reasonably stick with and that is not [5:00] too irritating for you so that you have [5:03] better success because unwanted [5:05] irritation doesn't mean that you are [5:07] tougher or stronger or doing something [5:09] more powerful. It just means that your [5:11] skin is irritated. And it just means [5:13] that, well, you're at a greater risk now [5:15] for post-inflammatory hyperpigmentation, [5:18] which a lot of you guys are trying to [5:19] improve of, right? First of all, now [5:21] that we've we've done all of the [5:23] backstory, let's get into PreQuell's [5:26] Retinal Renew Retinaldehyde Gel. This is [5:29] probably the most straightforward of the [5:32] three. It's a retinaldehyde product, of [5:35] course, designed to improve the [5:36] appearance of photodamage, fine lines, [5:39] uneven texture. One of the things I like [5:41] the most about the PreQuell formulation [5:43] is the delivery system. Retinaldehyde [5:45] just floating around in a tube is [5:47] actually not the most stable ingredient. [5:49] This product uses a system to stabilize [5:51] the retinaldehyde and allow for [5:53] efficient delivery. The delivery is more [5:55] controlled, so that can also really help [5:58] to make the product a lot more [5:59] tolerable. And then there are some [6:01] supporting ingredients in this formula [6:03] that to me really stand out and what I [6:05] think helps bring it all together and [6:07] one of them is a newer to me skin care [6:10] ingredient favorite and that is ectoin. [6:12] Ectoin is an extremolite, it's something [6:14] that like bacteria make to help them [6:16] survive extreme conditions like [6:18] dehydration, UV, heat. It's also [6:21] hydrating, it's anti-inflammatory, it's [6:23] an antioxidant, and it's been shown to [6:26] help improve barrier support, which [6:28] ultimately is going to make the formula [6:30] something that helps offset any unwanted [6:33] irritation along with the retinaldehyde [6:35] delivery system that they use. The [6:37] product is fragrance-free as are all of [6:39] these. This also includes [6:40] cyanocobalamin, which is B12, kind of [6:42] imparts a pinkish hue to the formula. [6:44] Vitamin B12 applied topically can [6:46] actually help cut down on itch and so [6:49] that might be something useful here for [6:52] cutting down on unwanted irritation and [6:54] discomfort when getting acclimated to a [6:56] retinaldehyde. One thing I want to point [6:58] out is that Prequel sells this [7:00] formulation in two percentage strengths [7:02] and if you watched my initial review, I [7:04] was using a lower percentage strength [7:06] and what I said at the time was I don't [7:08] think that the higher is likely [7:10] necessarily that stronger or likely to [7:12] give you more potent [7:14] I then went and tried the higher [7:16] percentage and I have made my way [7:18] through a good bit of the tube of it and [7:20] I'm here to tell you I don't notice a [7:21] single difference. You could blindfold [7:23] me and I wouldn't know who I was putting [7:25] on. I didn't develop any irritation, the [7:27] slightest bit of sensitivity with the [7:29] higher. I still maintain that the two [7:31] percentage strengths here are not likely [7:33] that different. What I like the most [7:35] though, just using this product overall, [7:37] is actually how moisturizing it is. It [7:40] almost imparts an immediate plumping and [7:41] smoothing effect and just leaves the [7:43] surface of the skin very radiant, very [7:45] glowing. It's a really nourishing [7:47] formula. If you watch my older video [7:49] from many years ago on the top retinols [7:51] I recommend, one of my holy grail [7:53] favorite retinol products is the [7:55] Neutrogena Rapid Wrinkle Repair [7:57] Regenerating Retinol Cream. Recommended [7:59] that for years and I still do. And one [8:01] of the things about that product is very [8:02] much like this in that not only do you [8:04] get an excellent stable retinol that [8:07] that's retinol, this is retinaldehyde in [8:09] a controlled delivery system to minimize [8:11] irritation, but the moisturizing formula [8:14] that these are in it gives you some [8:15] immediate benefit, too. So, in other [8:17] words, if you're someone who can't [8:19] really do the whole delayed [8:20] gratification thing necessary for [8:22] getting uh you know, the results from [8:24] retinaldehyde, you get a little bit of a [8:26] boost in confidence just from the [8:28] benefits from the moisturizing formula. [8:30] Then I want to mention the Anua Collagen [8:33] Retinol Refining Guasha Cream. This one [8:35] is retinol, so the two conversion steps, [8:38] and it's a formula that is marketed for [8:41] use on the neck. It's got a few really [8:43] good hydrating, skin supporting [8:45] ingredients, glycerin, panthenol. It has [8:48] niacinamide in it, which is good for [8:50] redness and the moisture barrier, and [8:51] it's an antioxidant, macadamia seed oil, [8:54] an emollient. It has collagen, which is [8:56] very hydrating, along with adenosine, a [8:59] moisturizing ingredient. The texture of [9:01] this is rich and nourishing, similar to [9:03] the prequel one. When we're talking [9:05] about the neck area specifically, you [9:07] really do get an almost instant neck [9:09] line blurring effect with this. Mostly [9:11] the little fine lines, but if you have [9:14] some deeper set wrinkles, they're not [9:16] going to be erased, okay? But they will [9:19] be a lot less obvious, okay? That's the [9:21] case with any moisturizer. But this one [9:23] is a really really great formulation. I [9:26] didn't experience any burning or [9:28] stinging. I used this on my neck as well [9:30] as I ended up using it a lot on my [9:32] forearms, and I noticed as I made my way [9:35] through it that I was getting more [9:36] consistently smooth skin where I was [9:38] applying it and that the skin tone [9:41] overall appeared a lot more even. And [9:42] like I said, I got that plumping [9:44] hydrated firming effect. And so, I think [9:46] it's a really excellent formula. I want [9:48] to talk about the gua sha property of it [9:50] cuz you guys have heard me talk about [9:52] how gua sha, you know, find a do, maybe [9:54] relaxing can help depuff a bit. But [9:56] people on the internet will have you [9:57] believing this is going to give you a [9:59] facelift and it's simply not. So, this [10:01] particular retinol, it comes with this [10:03] kind of gua sha tipped applicator which [10:05] is nice. It's cool on the skin. But I [10:07] actually found it a little awkward to [10:09] use and I ended up for the most part [10:11] after attempting to use it several [10:13] times, the gua sha aspect of things, [10:15] just being like, "Okay, I'm just going [10:16] to put it in my hands and rub it on the [10:17] skin. I'm not going to bother with this [10:19] gua sha thing." Now, one limitation and [10:21] a thing that you guys have commented [10:23] below that you don't really care for [10:24] about certain products is that they [10:26] don't disclose with this one the [10:27] percentage of the retinol. I'm not so [10:29] bothered by that per se because a lot of [10:32] times knowing the percentage, it can [10:33] give you a false sense of confidence. [10:35] And a lot of people assume that [10:37] something is a really low percentage, [10:38] there's no way it can work. But in [10:40] reality, the overall formulation is what [10:42] supports the delivery of the ingredient [10:44] and whether or not the ingredient can [10:46] work. But I get where you're coming [10:48] from. So, that would probably be another [10:49] thing holding some people back from [10:51] this, but doesn't stop me from using it. [10:53] I have really liked it. Moving on though [10:56] to the Purito Seoul tranexamic acid 6% [10:59] niacinamide 10% retinal serum. I want to [11:02] say I tried this for the first time [11:03] towards the end of 2025. This is one [11:07] that's really interesting to me because [11:09] of the texture, the delivery system, and [11:11] the supporting players. And I have [11:13] faithfully used this on my chest and the [11:16] décolleté area for several months now [11:20] and I am seeing and have seen and have [11:23] maintained a noticeable improvement in [11:25] the skin on my upper chest. I have [11:27] smoother skin there. I have less uh, [11:31] discoloration, less blotchiness, the [11:34] skin is smooth and plump and hydrated. I [11:37] have really seen an improvement on on [11:39] my, uh, upper chest skin specifically. [11:42] What I love about this is the little [11:44] spheres, okay? So, you shake the product [11:46] up to evenly distribute them cuz it's, [11:48] uh, it it separates out. So, you want to [11:50] give it a little shake and then it has [11:52] these little spheres that come out. You [11:54] can sometimes feel them, um, being [11:56] dropped on the surface of the skin. I [11:57] use a full pipette or the product just [12:00] along my upper chest every single night. [12:02] You feel those little beads coming and [12:04] they are loaded with the retinaldehyde, [12:06] they're loaded with the tranexamic acid [12:08] and with the niacinamide and so it [12:10] encapsulates those ingredients, helps [12:12] keep them stable in the formula and then [12:14] allows for the slow sustained release as [12:16] you, um, melt them into the surface of [12:19] the skin rubbing it in. Now, one thing I [12:21] want to point out when it comes to [12:22] topical tranexamic acid, that shows [12:24] promise actually for improving the [12:26] moisture barrier and cutting down on [12:27] redness. Niacinamide, you guys know, [12:29] also is really good for the moisture [12:31] barrier, for cutting down on redness, [12:33] and for improving overall skin tone. I [12:35] really feel like the product has made a [12:37] visible difference in my overall skin. [12:39] So, I'll continue to use it. You'll also [12:42] know that I often point out 10% [12:44] niacinamide on the higher side, okay? [12:46] That's kind of high and the reason I [12:48] point that out is that I think these [12:50] higher percentages of niacinamide, [12:52] they're not necessary, but they may be [12:55] more likely to irritate you, especially [12:56] if you're someone who is irritated by [12:58] niacinamide. That's another thing I want [13:00] to point out about this. But, of all of [13:01] these, I've repurchased that the most. [13:03] I've probably gone through at this point [13:06] six bottles at least of it every single [13:08] night. It's a staple in my skin care [13:10] routine. When you apply these, whether [13:12] it be retinol, retinaldehyde, or your [13:14] prescription stuff, you want to be [13:15] really careful not to get them the [13:17] corners of your nose, the corners of [13:18] your mouth. It can be too irritating, so [13:20] I always suggest people put a little [13:22] petroleum jelly to these areas to [13:24] prevent the, um, ingredient from [13:26] accessing there. Put these on at night [13:28] generally is what is advised. [13:30] Historically, some family members that [13:32] will say in this ingredient family have [13:33] been known to be [13:35] sensitive to light exposure and and [13:37] susceptible to degradation. So, that's [13:40] kind of part of the recommendation, [13:41] although honestly, you really don't need [13:43] to worry about that as much these days [13:44] with the stabilization. The other reason [13:46] is related to some of the things that [13:49] happen with our skin at night as opposed [13:51] to during the day that really allows for [13:52] maximum benefits from these ingredients. [13:55] So, that's generally why you put it on [13:57] at night time. Put these on um, in your [13:59] night time routine after cleansing. [14:01] Always to a clean face. People over [14:03] fixate on the order of application, like [14:05] when in the routine should these go. [14:07] Generally speaking, when it comes to [14:08] applying products, applying thinnest to [14:10] thickest is a good approach. So, in [14:12] other words, the Pyurito serum would go [14:14] on earlier compared to the creams. They [14:17] might go on like the last step of your [14:18] skin care routine. These creams are [14:21] really moisturizing, so you won't need [14:23] an additional moisturizer with them and [14:25] you can layer them on over other serums [14:28] provided you tolerate the combination. [14:30] There aren't necessarily hard and fast [14:32] rules about you can and cannot use [14:35] ingredients with other ingredients. Most [14:37] of that is just speculation, not [14:39] evidence-based. So, you can use these [14:41] with copper peptides. There's no [14:43] evidence that they compromise one [14:44] another. You can use these with vitamin [14:47] C. There's no evidence that they [14:48] compromise one another. You can use [14:50] these with any ingredient provided you [14:53] tolerate the combination. And the [14:54] general principle is that the more [14:55] products that you're using and you're [14:57] layering, the greater the likelihood is [14:58] that you don't tolerate all the stuff on [15:00] your face. You develop irritation. So, [15:02] just keep that in mind. Um, try and keep [15:04] your skin care routine simple. Fewer [15:06] products, fewer problems generally [15:08] speaking. And so, if you can go with one [15:10] of the creams and find that, hey, I got [15:12] a moisturizer out of this now, then you [15:14] know, that keeps it real streamlined in [15:15] other words. Maybe you were using an [15:17] niacinamide serum and you want to try [15:20] retinaldehyde. Instead of using two [15:21] products now, maybe you could use a [15:22] serum that's got both ingredients in a [15:24] really good formula to deliver both [15:26] effectively to the skin. Cut down on [15:28] products. So, I'm a big fan of that [15:30] approach. Now, I do typically recommend [15:32] for newbies who have never used a form [15:34] of topical vitamin A to the skin to [15:36] start out by using it a couple of nights [15:38] a week for the first few weeks and [15:39] gradually increasing to nightly from [15:42] there. When you're getting used to it [15:43] and you want to derive those benefits, [15:45] it takes time. So, I'd say try and work [15:47] up shortly after getting acclimated to [15:49] it to using it nightly. Use it nightly [15:51] for a year and then after a year you can [15:53] back down to less frequently to maintain [15:56] the anti-aging effects if you'd like. [15:58] That's generally how I would advise to [16:00] use them. Make sure, of course, you are [16:02] applying sunscreen during the day. [16:03] You're not going to improve the [16:04] appearance of aging skin by not [16:06] protecting your skin from the sun. Which [16:09] one should you choose? I don't think [16:10] there's a straightforward answer here. I [16:12] kind of think it depends on personal [16:14] preference. Again, I want to emphasize [16:16] though that the retinaldehyde versus [16:18] retinol, there's really not good [16:20] evidence to say that one is better than [16:21] the other or more potent or stronger or [16:23] better tolerated. I think when it comes [16:25] to choosing one of these, it's A, what's [16:27] in your budget? B, what other [16:29] complimentary ingredients in the formula [16:32] sound like something that you would like [16:33] to also have in there or that you're [16:35] motivated to use? Or C, are you already [16:38] using these ingredients and they're a [16:40] waste of time in your routine? Like, uh [16:41] this is another thing I didn't mention, [16:43] but if you're already using retinol, [16:45] don't use retinol and retinaldehyde and [16:48] think that you're going to double stack [16:49] and get better results. Or don't use [16:51] these along with your tretinoin and [16:53] think that you're going to get better [16:54] vitamin A related results because all [16:57] that can lead to is just more irritation [16:59] and there's no evidence to show that [17:01] combining retinol and tretinoin and [17:03] retinaldehyde or any combination of the [17:05] above together in a routine gets you [17:08] better results, okay? So, um if you're [17:10] already using, say, tretinoin and you're [17:12] tolerating it, stay with that, okay? You [17:14] don't need any of these. But, if you [17:16] want to use these to another body side, [17:19] then choose one that you think would be [17:21] good for you in that body side. I happen [17:23] to really like the serum, but I've also [17:25] tried these creams um to my chest and [17:27] décolleté as well with likewise [17:30] beneficial results. So, I really don't [17:32] think you could go wrong with anyone. It [17:34] just comes down to a matter of which one [17:36] you like. All right, guys. So, that's a [17:37] little update on some standout retinol [17:39] retinaldehyde products from 2026 in [17:42] general. Even though I'm using a topical [17:45] retinoid to my face, you can see I've [17:47] managed to eek these in. So, these stand [17:50] out to me. Of course, the retinols and [17:52] retinaldehydes I've recommended in the [17:53] past videos still are recommendations. [17:57] So, if you want more racks, check out [17:58] those older videos. Those products still [18:00] exist. I still actively recommend them [18:03] and promote them in a variety of videos. [18:04] There's so many options on the market [18:07] that it's definitely hard to pick the [18:09] best ones. And these are cosmetics. So, [18:11] in my opinion, these are some of the [18:13] best in my experience testing and in [18:16] using. But, that's a subjective opinion, [18:18] okay? It's not research-backed. There's [18:21] no double-blind placebo-controlled trial [18:23] comparing any of these objectively. And [18:25] you'll never get that because they're [18:27] cosmetics. They're not drugs. So, they [18:29] are held to different standards. But, uh [18:31] my standards are pretty high. So, [18:33] take it for what it's worth. I really [18:35] hope this video was helpful for you [18:36] guys. Let me know though in the comments [18:38] what vitamin A products, we'll say [18:40] retinol or retinaldehyde, have you [18:43] started using? Or have you started using [18:44] adapalene, which is a uh you know, [18:46] retinoid uh [18:48] medication that you can buy over the [18:49] counter here in the states at least. Or [18:51] are you on uh you know, good old [18:53] tretinoin? Or have you tried uh other [18:55] forms of vitamin A like tazarotene or [18:57] trifarotene? Those are likewise uh [18:59] anti-aging gems as well in this uh grand [19:03] old vitamin A family. I hope today's [19:05] video was informative. If you enjoyed [19:07] it, give it a thumbs up. Share with your [19:08] friends. And as always, don't forget [19:10] sunscreen and subscribe. I'll talk to [19:12] you guys tomorrow. Bye. [19:18] >> [music]