Dr Dray Calls PDRN Skincare a Gimmick as Skin Barrier Blocks Salmon DNA

Dr Dray

Topical polydeoxyribonucleotide cannot penetrate the stratum corneum to duplicate medical wound-healing data, leaving standard hydrators and niacinamide to drive any cosmetic improvement.

AI-assisted summary of PDRN Skincare: Is It Worth the Hype? A Dermatologist Explains — original source. Check the original for full context.

Source published: 2026-08-24

Key ideas

Dr. Dray identifies topical PDRN (polydeoxyribonucleotide/sodium DNA) as a marketing gimmick, noting that medical tissue repair data from in vitro and animal models cannot be extrapolated to topical creams because the intact stratum corneum prevents significant cellular penetration. (2:35)
Caffeine in eye formulations provides functional benefits through temporary vasoconstriction to diminish superficial vascular dark circles and shift morning fluid puffiness, though it cannot alter structural fat loss or orbital bone anatomy. (5:34)
The true efficacy of multi-ingredient cosmetic creams like ANUA's is largely driven by workhorse hydrators and actives like niacinamide, glycerin, and hyaluronic acid rather than novel buzzwords like salmon-derived PDRN. (7:27)
Dedicated eye creams are generally unnecessary for basic hydration, and users should limit application to a single rice-grain-sized amount per periorbital area to avoid ocular irritation and product waste. (10:29)

Detailed notes

## Background Published on YouTube by dermatologist Dr Dray on August 24, 2026, this video reviews the ANUA PDRN Caffeine Rejuvenating Eye Cream and evaluates the emerging PDRN skincare trend. According to the page description, Dr. Dray breaks down the evidence behind topical PDRN (polydeoxyribonucleotide/sodium DNA), assesses supportive ingredients like caffeine and niacinamide, and discusses whether consumers actually need a dedicated eye cream.

## TL;DR Dr. Dray examines the science behind PDRN, explaining that while the ingredient shows promise in medical wound healing and in vitro studies, topical cosmetic formulations cannot penetrate the intact skin barrier to deliver cellular anti-aging miracles. She reviews the ANUA PDRN Caffeine Rejuvenating Eye Cream as a well-formulated, fragrance-free moisturizer whose real benefits stem from workhorse ingredients like caffeine, niacinamide, and humectants rather than salmon-derived DNA. Additionally, she addresses the social media habit of applying excessive amounts of eye cream, demonstrating that a rice-grain-sized portion is plenty. Ultimately, she concludes that while the product is reasonably priced and pleasant to use, a separate eye cream is largely unnecessary when a standard facial moisturizer can accomplish the same task.

## Atmosphere & style The video carries Dr. Dray's signature blend of clinical skepticism, grounded pragmatism, and dry, self-aware humor. Watching feels like having an honest, no-nonsense consultation with an experienced dermatologist who cuts through beauty marketing hyperbole without being overly dogmatic. Her delivery transitions smoothly from serious scientific barrier biology to playful jokes about 'salmon sperm' and the reality that nobody wins a Nobel Prize for having the purest evidence-based skincare routine.

## Bulletin - [02:35](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=155s) Dr. Dray identifies topical PDRN (polydeoxyribonucleotide/sodium DNA) as a marketing gimmick, noting that medical tissue repair data from in vitro and animal models cannot be extrapolated to topical creams because the intact stratum corneum prevents significant cellular penetration. - [05:34](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=334s) Caffeine in eye formulations provides functional benefits through temporary vasoconstriction to diminish superficial vascular dark circles and shift morning fluid puffiness, though it cannot alter structural fat loss or orbital bone anatomy. - [07:27](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=447s) The true efficacy of multi-ingredient cosmetic creams like ANUA's is largely driven by workhorse hydrators and actives like niacinamide, glycerin, and hyaluronic acid rather than novel buzzwords like salmon-derived PDRN. - [10:29](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=629s) Dedicated eye creams are generally unnecessary for basic hydration, and users should limit application to a single rice-grain-sized amount per periorbital area to avoid ocular irritation and product waste.

## Key takeaways - [00:41](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=41s) PDRN (polydeoxyribonucleotide), listed as sodium DNA in cosmetics, is commercially sourced from salmon or trout milt (fish sperm). - [00:41](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=41s) Legitimate PDRN research focuses on cellular benchwork, preclinical animal studies, and medical wound repair (such as diabetic ulcers), not topical cosmetic anti-aging. - [02:35](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=155s) The stratum corneum serves as an impermeable barrier that prevents large foreign DNA fragments from penetrating intact skin down to targeted cellular pathways. - [02:35](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=155s) If topical PDRN had the biological potency to reach and trigger unregulated deep cellular proliferation, it would present cancer concerns, whereas minimal absorption makes it safe but biologically inert. - [05:34](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=334s) Caffeine temporarily constricts superficial blood vessels under the thin eyelid skin, helping reduce bluish vascular discoloration and localized fluid retention. - [05:34](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=334s) Structural under-eye bags caused by orbital bone widening or fat compartment loss cannot be corrected by topical caffeine and require procedural interventions. - [07:27](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=447s) Humectants such as glycerin, hydroxyethyl urea, and sodium hyaluronate provide temporary smoothing and plumping of fine surface dehydration lines. - [07:27](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=447s) Niacinamide acts as a primary active driver by inhibiting melanosome transfer to lighten dark spots, offering antioxidant benefits, and supporting skin barrier synthesis. - [09:20](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=560s) Topical hydrolyzed collagen functions strictly as an external, surface-hydrating humectant and cannot penetrate to replace lost dermal collagen. - [09:20](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=560s) Omitting fragrance from eye formulations protects the thin eyelid skin from the most common contact allergen in cosmetics and prevents burning tear-film migration. - [10:29](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=629s) Slathering excessive eye cream as popularized by beauty influencers wastes product and promotes ocular stinging; a rice-grain-sized portion is clinically sufficient. - [13:08](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=788s) Dedicated eye creams are only necessary when modifying or buffering high-strength actives (like retinoids or ascorbic acid) that thin eyelid skin cannot tolerate at facial concentrations. - [13:08](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=788s) Extending a standard facial moisturizer up to the orbital rim achieves the same physiological moisturizing results as a separate, expensive eye cream. - [13:08](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=788s) The common belief that rich or emollient facial moisturizers cause periorbital milia is a widespread myth. - [17:51](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=1071s) While PDRN lacks robust clinical support as an anti-aging breakthrough, consumers may safely enjoy well-formulated, non-irritating products for ritual and cosmetic hydration.

## Detailed walkthrough ### [00:00](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=0s) Introduction to PDRN and the ANUA Eye Cream

Dr. Dray introduces the latest buzzworthy skincare trend taking social media by storm: PDRN. With curiosity surging around whether this ingredient is worth the hype or even necessary to include in a routine, she sets out to review the ANUA PDRN Caffeine Rejuvenating Eye Cream. The product is exclusively sold at Ulta for $20. Beyond reviewing this specific formulation and its companion ingredients, she raises a fundamental question she frequently revisits: are dedicated eye creams even necessary in the first place?

[00:41](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=41s) What Is PDRN and What Does the Science Actually Show?

PDRN stands for polydeoxyribonucleotide, which describes a mixture of DNA fragments. On cosmetic ingredient lists, it typically appears under the name sodium DNA. While cosmetic brands rarely disclose the exact origin of their supply on the bottle, the ingredient is commercially isolated by distributors from salmon or trout milt—which is fish sperm. PDRN has exploded across the beauty space, particularly within Korean skincare, and has gained viral traction through videos showcasing in-office procedures where the substance is injected directly into patients' skin.

```mermaid flowchart TD accTitle: Research vs Cosmetic Reality of PDRN accDescr: Diagram contrasting medical laboratory research with the cosmetic reality of applying topical PDRN onto an intact skin barrier.

subgraph LAB["Medical & Laboratory Context"] A["In Vitro & Animal Models"] --> B["Cell Signaling Pathways"] B --> C["Tissue Repair & Wound Healing\n(e.g., Diabetic Ulcers)"] end

subgraph TOPICAL["Topical Cosmetic Application"] D["Topical Cream Applied to Skin"] --> E{"Intact Skin Barrier"} E -- "Blocks Penetration" --> F["Minimal to No Deep Cellular Uptake"] E -. "Hypothetical Deep Access".-> G["Risk of Off-Target Proliferation"] end

LAB -. "Unjustified Leap in Marketing".-> TOPICAL ```

Dr. Dray acknowledges that legitimate research exists, but she urges viewers to look closely at what the science has actually evaluated. The bulk of PDRN research is confined to benchwork: - Laboratory studies utilizing isolated cells in petri dishes. - Preclinical animal models designed for hypothesis generation. - Medical clinical trials specifically centered on wound healing, tissue repair, and signaling pathways that facilitate rapid closure, showing future clinical potential for conditions such as diabetic ulcers.

[02:35](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=155s) Why Topical PDRN Is a Skincare Gimmick

There is a vast difference between biologically interesting laboratory observations and proof that a consumer needs to purchase a $20 eye cream. Having reviewed products and analyzed trends on YouTube for a decade, Dr. Dray notes a persistent marketing pattern: brands take an ingredient with intriguing in vitro data, put it into a cream or serum, and assume it will magically duplicate the exact same cellular effects in human tissue. Asking whether PDRN has clinical evidence for medical wound healing is a completely different question from asking whether applying it topically around the eyes yields a cosmetic result.

The fundamental hurdle is human biology: - **The stratum corneum is a fortress:** The skin’s primary physiological role is to act as an impermeable barrier. It does not readily welcome large foreign DNA fragments or allow them to pass through intact. - **Delivery to target compartments:** Even if DNA fragments could penetrate, they must reach specific cellular compartments to trigger biological pathways. - **The paradox of efficacy:** If an ingredient were potent enough to penetrate intact skin and stimulate proliferation pathways without regulation, it would raise concerns about off-target effects—such as prompting pre-cancerous cells to proliferate. However, because skin absorption is so negligible, the risk of developing skin cancer from a topical PDRN cream is virtually non-existent, which simultaneously underscores that it is doing very little biologically.

Because the skin is a complex, three-dimensional living organ rather than an isolated monolayer of cells, Dr. Dray labels topical PDRN a "gimmick." She anticipates that, like previous marketing waves surrounding growth factors, peptides, and stem cells, consumer enthusiasm will eventually run dry once people grow bored and move on to the next trend.

[05:34](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=334s) The Real Potential (and Limits) of Caffeine for the Eye Area

Turning to the second namesake ingredient in the ANUA cream, Dr. Dray examines caffeine. Unlike PDRN, caffeine serves functional, well-understood purposes in under-eye formulations: - **Vasoconstriction:** Caffeine temporarily constricts and narrows superficial blood vessels. Because the skin around the lower eyelids is exceptionally thin and translucent, prominent underlying vasculature often reads as purple or blue discoloration; shrinking these vessels can temporarily brighten the region. - **Fluid displacement:** Vasoconstriction can help shift localized, stagnant fluid collections out of the periorbital tissue, diminishing transient morning puffiness. - **Antioxidant and anti-inflammatory properties:** It neutralizes free radicals and calms the skin, providing subtle perks in overall tone and skin clarity.

Crucially, Dr. Dray emphasizes that caffeine cannot resolve structural or anatomical dark circles. A topical cream has zero ability to reverse age-related bony remodeling, the widening of the orbital socket, or the natural descent and volume loss of deep sub-orbicularis fat compartments. These structural hollows and true under-eye bags create persistent shadowing that can only be altered through in-office procedural interventions. Nevertheless, she considers caffeine a sensible, reasonable addition to skincare.

[07:27](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=447s) ANUA Formula Breakdown: Hydrators, Niacinamide, and Adenosine

Looking beyond the marketing claims, Dr. Dray assesses the overall formula and concludes that it functions as a genuinely solid moisturizer. It relies on a blend of proven humectants and skin-replenishing agents: - **Effective humectants:** Glycerin, hydroxyethyl urea, and sodium hyaluronate (the salt form of hyaluronic acid) pull moisture into the outer layers. Properly hydrating this tissue optimizes light scattering to make the area look naturally brighter, while space-filling hydration smooths down fine surface dehydration lines. - **Niacinamide:** Dr. Dray jokingly refers to niacinamide as "the workhorse of the skincare industry," quipping that it does "99% of the heavy lifting" across the beauty market. When users see dramatic results from multi-ingredient products, niacinamide is often the hidden driver. Mechanistically, it inhibits the transfer of melanosomes from melanocytes to surrounding keratinocytes to fade dark spots, acts as an antioxidant and anti-inflammatory, and supports long-term lipid barrier synthesis. While a subset of individuals experience redness, stinging, or irritation from it, those who tolerate it reap extensive benefits. - **Adenosine:** A soothing, hydrating agent with mild anti-inflammatory qualities. - **Hydrolyzed collagen:** While present, it acts strictly as an external water-binding humectant; it cannot physically penetrate the skin to replace endogenous lost dermal collagen.

[09:20](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=560s) Key Ingredients: Hydrolyzed Collagen, Fragrance Freedom, and Tolerability

Topical hydrolyzed collagen cannot replace lost endogenous collagen or magically fill in the structural deficits that cause fine lines, thinning, or prominent under-eye hollows. However, hydrolyzed collagen is far from useless. In skincare formulations, it serves as an effective moisturizing and hydrating humectant with film-forming properties that help the product lay down smoothly on the skin surface. The ANUA PDRN Caffeine Rejuvenating Eye Cream pairs these humectants and antioxidants with niacinamide, a well-regarded active for supporting barrier function and evening skin tone.

```mermaid flowchart TD accTitle: Eye Area Formulation Factors accDescr: Formulation choices tailored to the thin eyelid barrier versus facial skin. subgraph Barrier ["Delicate Eyelid Anatomy"] A["Thin Stratum Corneum"] --> B["Higher Product Penetration"] B --> C["Elevated Irritation & Allergy Risk"] end

subgraph Design ["Formulation Requirements"] C --> D["Fragrance-Free Formulation"] C --> E["Tolerable Active Strengths"] D --> F["Prevents Watery, Stinging Eyes"] E --> G["Gentle Retinoids / Low Vitamin C"] end ```

A crucial formulation win is the complete omission of fragrance. Fragrance allergy represents the single most common contact allergy in skincare. Because the eyelid skin is exceptionally thin and delicate, ingredients penetrate far more readily than on thicker facial sites, dramatically increasing the risk of both irritation and allergic contact dermatitis over time. While many people tolerate fragranced products without apparent issue, omitting fragrance eliminates unnecessary risks—including runny, irritated, or watery eyes. Brands frequently include fragrance simply to mask the funky baseline odors of raw cosmetic chemicals, so an unfragranced formula demonstrates thoughtful engineering for periorbital safety.

[10:29](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=629s) Application Technique: Social Media Overuse vs. the "Rice-Grain" Rule

Content creators and beauty advertisements have popularized a visual trend of slathering on heavy, dramatic globs of eye cream. While this visual excess makes practical sense for video production—viewers cannot see a microscopic dab on camera, and larger amounts showcase the texture, slip, and finish—it sets an unrealistic and counterproductive standard for daily use. Piling on excessive product rapidly empties the tube, forcing consumers into frequent, expensive repurchases.

Demonstrating on camera, Dr. Dray contrasts the common social media method of stamping several thick dots across the orbital rim with the clinically appropriate dose: roughly a single grain of rice. Because the formula spreads effortlessly, a rice-grain-sized amount provides complete, even coverage across the under-eye area, the crow's feet, and the upper eyelid.

- **Dosage Guideline:** Aim for a single grain of rice for the entire periorbital zone; using slightly more is harmless, but giant dollops are unnecessary. - **Eye Irritation Risks:** Heavy coatings break down with sweat, ambient humidity, and facial movement, causing excess emulsion to migrate into the ocular tear film and induce stinging or burning. - **Product Longevity:** Adopting a conservative rice-grain application makes a single container last significantly longer, cushioning the financial blow of rising cosmetic prices.

[13:08](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=788s) Do You Actually Need an Eye Cream? Price and Necessity

Priced around $20, the ANUA eye cream sits on the relatively affordable end of the eye-care spectrum, where specialized creams frequently command exorbitant price tags. The polarizing debate over whether anyone truly needs a dedicated eye cream comes down to functional necessity versus personal preference. Dedicated periorbital products make pharmacological sense when modifying the delivery or potency of aggressive actives that eyelid skin struggles to tolerate at full facial strength.

When an eye cream acts primarily as a basic hydrator, consumers can safely achieve identical biological results by extending their standard facial moisturizer up to the orbital bone. No biological rule dictates that periorbital skin requires an exorbitant moisturizer packaged exclusively in a tiny tube. Furthermore, the persistent myth that rich, emollient creams cause milia is an unfounded urban legend.

[15:34](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=934s) Final Impressions and the Business of Skincare Trends

The ANUA PDRN Caffeine Rejuvenating Eye Cream is an enjoyable, well-formulated eyelid moisturizer rich in caffeine, niacinamide, and dependable hydrators that caused zero personal irritation. However, consumers should not purchase it under the impression that topical PDRN (polydeoxyribonucleotide) is an anti-aging breakthrough. In topical cosmetic applications, PDRN functions merely as an overhyped marketing hook rather than a cellular regenerator; a regular facial moisturizer will deliver essentially the same clinical outcomes.

This reliance on buzzwords illustrates how cosmetic brands operate. Even high-performing brands like ANUA must "play the game" to survive commercially. Companies operate within a competitive, saturated marketplace driven by consumer trends and retail viability rather than pure philanthropy. Beyond this launch, ANUA offers several effective items, including a previously reviewed retinol eye cream, newly released facial moisturizers, and a retinol neck cream featuring an integrated gua sha applicator tool.

[17:51](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=1071s) Final Verdict on PDRN and Skincare Enjoyment

Dr. Dray closes out the video with a playful reality check regarding the entire PDRN trend. While she personally appreciates the brand, she invites viewers to chime in below if they are completely sold on the ingredient regardless of her skepticism—asking if anyone is sitting there thinking, "I don't care what she says. I love it. It has been a game changer for me and I want all of the salmon sperm on my face possible." She clarifies that her role is simply to break down the science and present the clinical evidence as honestly as possible, but she emphasizes that skincare is also meant to be an enjoyable, personal ritual. If someone is using topical PDRN and experiencing zero irritation, they should never feel like she is personally "coming at" them for incorporating an ingredient that lacks robust clinical backing.

Delivering her trademark dry humor, Dr. Dray reminds her audience that "no one gets an award for using the most evidence-based skin care routine." Sticking strictly to verified dermatological actives will not earn anyone a Nobel Prize, nor will it grant them their own "NIH-funded lab" simply because Dr. Dray labeled an ingredient a gimmick. If consumers genuinely enjoy using an ingredient that leans "a little fluffy" and feel that it works wonders for their complexion, she gives them full permission to keep using it—provided it is not triggering irritation or compromising their skin barrier. After laying out the scientific facts, she encourages viewers to give the video a thumbs up, share it with friends, subscribe to the channel, and as always, never forget their sunscreen before signing off until tomorrow.

- Viewers are encouraged to share their firsthand experiences with PDRN products, even if their results contradict the lack of clinical evidence. - Skincare should remain enjoyable; choosing cosmetic products with unproven or "fluffy" actives is completely fine as long as they do not trigger contact dermatitis or sensitivity. - Dr. Dray signs off with her signature channel reminders: like, share, subscribe, and wear daily sunscreen.

## Notable quotes > [02:35](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=155s) The stratum corneum is a fortress — Dr. Dray

> [02:35](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=155s) gimmick — Dr. Dray

> [07:27](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=447s) the workhorse of the skincare industry — Dr. Dray

> [07:27](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=447s) 99% of the heavy lifting — Dr. Dray

> [15:34](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=934s) play the game — Dr. Dray

> [17:51](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=1071s) I don't care what she says. I love it. It has been a game changer for me and I want all of the salmon sperm on my face possible. — Dr. Dray

> [17:51](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=1071s) coming at — Dr. Dray

> [17:51](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=1071s) no one gets an award for using the most evidence-based skin care routine — Dr. Dray

> [17:51](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=1071s) NIH-funded lab — Dr. Dray

> [17:51](https://www.youtube.com/watch?v=bktMjB3Ke2o&t=1071s) a little fluffy — Dr. Dray

## Mentioned Dr. Dray, ANUA, ANUA PDRN Caffeine Rejuvenating Eye Cream, ANUA Retinol Revitalizing Eye Cream, ANUA Retinol Refining Gua Sha Neck Cream, Ulta, National Institutes of Health (NIH)

## Video description Dermatologist Dr. Dray reviews the ANUA PDRN Caffeine Rejuvenating Eye Cream and takes a closer look at the growing PDRN skincare trend. What exactly is PDRN, does topical PDRN actually work, and is it worth paying for a dedicated PDRN eye cream?

In this evidence-based skincare review, Dr. Dray breaks down the ingredient list, explains what PDRN (polydeoxyribonucleotide) and sodium DNA are, discusses the evidence behind topical PDRN, and explains why the ingredient may be more overhyped in cosmetic skincare than the marketing suggests.

She also discusses caffeine for dark circles and under-eye puffiness, niacinamide, adenosine, hydrolyzed collagen, hyaluronic acid, humectants, emollients, and antioxidants in the ANUA eye cream formula. The video also addresses a common skincare mistake: using far too much eye cream.

Dr. Dray demonstrates why approximately a rice-grain-sized amount per eye is enough for an eye moisturizer and explains whether a dedicated eye cream is actually necessary for healthy, hydrated eyelid skin.

Topics covered:

00:00 Intro 00:35 What is PDRN? 02:35 Why Dr. Dray is skeptical of PDRN in topical skincare 05:34 What can caffeine actually do for the eye area? 07:27 ANUA PDRN Caffeine Rejuvenating Eye Cream ingredient review 10:29 How much eye cream should you use? 13:08 Is a $20 eye cream worth it? 15:34 Does Dr. Dray actually like this eye cream? 17:23 Final verdict

Products discussed:

ANUA PDRN Caffeine Rejuvenating Eye Cream: https://bit.ly/3SRGnyB

ANUA Retinol Revitalizing Eye Cream: https://amzlink.to/az0LewzSYBGXu

ANUA Retinol Refining Gua Sha Neck Cream: https://amzlink.to/az0gEx7p5uQ2L

Dr. Dray's overall take is that the ANUA PDRN Caffeine Rejuvenating Eye Cream is a pleasant, hydrating eye moisturizer, but PDRN should not be viewed as a miracle anti-aging ingredient. Caffeine may have some benefits for the appearance of the under-eye area, but it cannot correct every cause of dark circles, puffiness, or under-eye bags.

The review also explains why a separate eye cream is not necessarily required. A regular moisturizer, hydrating serum, or a small amount of petroleum jelly may be sufficient for many people who simply want to moisturize the delicate skin around the eyes.

For viewers interested in PDRN skincare, Korean skincare, eye creams, anti-aging skincare, dark circles, under-eye bags, eyelid hydration, caffeine skincare, niacinamide, and evidence-based skincare, this review provides a dermatologist's perspective on what the science can and cannot tell us.

Subscribe to Dr. Dray for more dermatologist skincare reviews, ingredient breakdowns, skincare myth-busting, and evidence-based advice.

FTC: This video is not sponsored. Links are commissionable, meaning I may earn commission from purchases made through links.

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Disclaimer: This video is not intended to provide diagnosis, treatment or medical advice. Content provided on this Youtube channel is for informational purposes only. Please consult with a physician or other healthcare professional regarding any medical or health related diagnosis or treatment options. Information on this Youtube channel should not be considered as a substitute for advice from a healthcare professional. The statements made about specific products throughout this video are not to diagnose, treat, cure or prevent disease.

[Source](https://www.youtube.com/watch?v=bktMjB3Ke2o)

中文简报

Dr. Dray称PDRN护肤品为营销噱头，皮肤屏障会阻挡三文鱼DNA 外用聚脱氧核糖核苷酸无法穿透角质层以复现医疗伤口愈合数据，任何美容改善其实都源于常规保湿剂和烟酰胺。 Dr. Dray剖析了PDRN背后的科学原理，解释说虽然该成分在医疗伤口愈合和体外研究中展现出潜力，但外用护肤品配方无法穿透完整的皮肤屏障来实现细胞级的抗衰老奇迹。她在测评ANUA PDRN咖啡因焕活眼霜时指出，这是一款配方良好、无香精的保湿产品，但其真正功效来自咖啡因、烟酰胺和保湿剂等主力成分，而非提取自三文鱼的DNA。此外，她还谈到了社交媒体上涂抹过量眼霜的习惯，并演示了米粒大小的用量就已足够。最后她总结道，尽管这款产品价格合理且使用感舒适，但在普通面部保湿霜就能完成相同任务的情况下，单独使用眼霜在很大程度上是不必要的。 Dr. Dray指出外用PDRN（聚脱氧核糖核苷酸/DNA钠）是一种营销噱头，并表示由于完整的角质层会阻止显著的细胞渗透，来自体外和动物模型的医疗组织修复数据不能直接推及外用乳霜。 (2:35) 眼部配方中的咖啡因能通过暂时收缩血管发挥功效，从而减轻表浅血管型黑眼圈并缓解晨间水肿，但它无法改变结构性脂肪流失或眼眶骨骼解剖结构。 (5:34) 像ANUA这类多成分护肤霜的真正功效，主要是由烟酰胺、甘油和透明质酸等主力保湿剂及活性成分驱动的，而非三文鱼提取PDRN这类新奇的噱头成分。 (7:27) 就基础保湿而言，专门的眼霜通常是不必要的，且使用者应将每侧眼周的涂抹量限制在一粒米大小，以避免眼部刺激和产品浪费。 (10:29)

Reading summary

Dermatologist Dr. Dray evaluates the viral skincare ingredient PDRN (polydeoxyribonucleotide), concluding that while it holds legitimate value in medical wound healing, topical formulations cannot penetrate intact skin and function primarily as marketing gimmicks. Reviewing the $20 ANUA PDRN Caffeine Rejuvenating Eye Cream, she argues that its visible benefits stem from standard hydrators, caffeine, and niacinamide rather than topical fish DNA. The Gap Between PDRN Research and Topical Efficacy (0:41) PDRN, isolated commercially from salmon or trout milt and listed as sodium DNA, gained popularity through Korean beauty trends and in-office injectable procedures. Dr. Dray acknowledges that legitimate scientific research on PDRN exists, but points out that the evidence is restricted to in vitro benchwork, animal models, and clinical trials on acute tissue repair, such as diabetic ulcer closure. These medical findings do not translate to over-the-counter cosmetic creams. The skin's intact stratum corneum acts as an impermeable physiological barrier that blocks large foreign DNA fragments from penetrating into viable cellular compartments. Because delivery across this barrier is negligible, Dr. Dray categorizes topical PDRN as an ineffective gimmick. Paradoxically, she notes that if an over-the-counter ingredient possessed the unchecked potency to penetrate intact skin and trigger cellular proliferation pathways, it would introduce safety risks regarding aberrant tissue growth; its very lack of biological absorption keeps it safe, but cosmically inert. Proven Actives in the ANUA Formulation (5:34) Examining the broader formulation of the ANUA cream, Dr. Dray finds it to be a solid, well-tolerated moisturizer whose real efficacy relies on well-established cosmetic ingredients rather than PDRN. Caffeine provides temporary cosmetic benefits by constricting superficial blood vessels to lessen vascular dark circles and mobilizing fluid to reduce morning puffiness. However, she clarifies that caffeine cannot alter anatomical dark circles caused by age-related orbital bone widening or fat compartment volume loss. The formula's hydration relies on dependable humectants, including glycerin, hydroxyethyl urea, and sodium hyaluronate, along with hydrolyzed collagen functioning as a surface water-binder rather than a structural replacement. Dr. Dray highlights niacinamide as the ingredient doing the heaviest lifting, delivering antioxidant, barrier-supportive, and pigmentation-fading benefits. Additionally, omitting fragrance is a significant clinical advantage, as unfragranced formulas protect thin eyelid skin from common allergic contact dermatitis and burning. Eye Cream Necessity and the Rice-Grain Rule (10:29) Addressing the wider question of whether dedicated eye creams are necessary, Dr. Dray states that individuals seeking general hydration can safely extend their standard facial moisturizer up to the orbital bone, dismissing the belief that rich creams cause milia as an unfounded myth. Dedicated periorbital products are primarily warranted when modifying the potency or delivery of aggressive actives—such as buffering retinoids or low-pH ascorbic acid to avoid eyelid dermatitis—or when targeting local puffiness with caffeine. Dr. Dray also critiques the social media trend of applying large globs of eye cream for visual effect, which wastes product and drives up costs. Heavy coatings risk migrating into the tear film during facial movement and sweating, causing stinging and irritation. Instead, she recommends a single rice-grain-sized amount for the entire periorbital area, which spreads sufficiently across the lower eyelid, crow's feet, and upper lid. Market Dynamics and the Role of Fluffy Actives (15:34) Dr. Dray views the commercial enthusiasm for topical PDRN as the latest wave in a recurring industry pattern previously seen with peptides, stem cells, and growth factors. To survive in a crowded retail marketplace, even reputable cosmetic brands must embrace viral ingredient trends driven by consumer demand rather than dermatological necessity. She anticipates consumer interest in PDRN will fade once the market shifts to a new buzzword. Despite labeling topical PDRN a gimmick, Dr. Dray notes that consumer routines do not need to consist exclusively of scientifically proven ingredients. Skincare serves as a personal ritual, and she concludes that consumers are free to enjoy products containing unproven or 'fluffy' ingredients, provided the formulas cause no irritation or damage to the skin barrier. The ANUA PDRN Caffeine Eye Cream is an effective, affordable moisturizer owing to its inclusion of caffeine, niacinamide, and humectants, but topical PDRN provides no verified cellular anti-aging benefits. Dr. Dray concludes that consumers should base their expectations on barrier support and proper application rather than marketing narratives of deep tissue regeneration.

Source quotes

[2:35] Dr. Dray: The stratum corneum is a fortress [2:35] Dr. Dray: gimmick [7:27] Dr. Dray: the workhorse of the skincare industry [7:27] Dr. Dray: 99% of the heavy lifting [15:34] Dr. Dray: play the game [17:51] Dr. Dray: I don't care what she says. I love it. It has been a game changer for me and I want all of the salmon sperm on my face possible. [17:51] Dr. Dray: coming at [17:51] Dr. Dray: no one gets an award for using the most evidence-based skin care routine [17:51] Dr. Dray: NIH-funded lab [17:51] Dr. Dray: a little fluffy

Original transcript

[0:00] Well, hey guys. Welcome back. If you're [0:01] new here, I'm Dr. Dray. I'm a [0:03] board-certified dermatologist. If you [0:05] have seen PDRN trending in skincare [0:08] products and wondering, what is that? Is [0:10] it something I should be using? Is it [0:12] worth all of this hype and attention [0:14] that it's getting? We're going to get [0:15] into it in today's video. Specifically, [0:17] I'm going to be reviewing the ANEW PDRN [0:20] caffeine rejuvenating eye cream. This is [0:22] exclusively available at Ulta. Retails [0:25] for $20. So, without further ado, let's [0:28] talk about PDRN. As well as the other [0:30] ingredients in this eye cream. Are eye [0:32] creams even really necessary to begin [0:35] with? So, the trendy ingredient du jour [0:38] is PDRN. What exactly is PDRN? PDRN [0:42] stands for polydeoxyribonucleotide. [0:45] It refers actually to a mixture of DNA [0:47] fragments. And in skincare, PDRN [0:50] commonly is on the label as sodium DNA. [0:53] Now, while most skincare products are [0:56] not going to tell you where they sourced [0:58] their PDRN from, in many cases, the [1:00] distributor isolates the PDRN from [1:03] either salmon or trout milt, so sperm. [1:07] Not only has PDRN taken off as far as [1:09] skincare products, especially Korean [1:11] skincare products, you will come across [1:13] videos of people having this stuff [1:15] injected directly into their skin. There [1:18] are a whole host of very interesting [1:20] claims about PDRN. There's actually some [1:23] legitimate research behind it, but [1:25] before you get too excited about it, [1:27] what has the research actually looked [1:30] into at this point though, and what does [1:31] it actually show? Well, the research on [1:33] PDRN, I hate to break it to you, is [1:36] mostly going to be confined to [1:39] laboratory-based studies, like cells in [1:41] a dish, maybe some animal models. And [1:43] that's all well and good for generating [1:45] hypotheses, but without rigorous [1:48] clinical testing, it's really hard to [1:50] say how relevant these are. That being [1:52] said, there are some clinical studies on [1:54] PDRN specifically looking at wound [1:56] healing as well as tissue repair. A lot [1:58] of the research focuses on the potential [2:00] for PDRN to impact signaling pathways [2:04] that ultimately facilitate better and [2:05] more rapid healing. That's all really [2:07] exciting, especially with regards to [2:09] wound healing and the implications this [2:11] could have in the future for say [2:13] diabetic ulcers. But, let's pump the [2:15] brakes because there's a difference [2:17] between interesting, promising, and [2:19] laboratory-based studies and oh, you [2:21] need to buy this $20 eye cream. Because [2:23] something being biologically interesting [2:26] doesn't necessarily mean that it's going [2:28] to yield any sort of cosmetic results [2:31] when put into a skin care product that [2:34] you apply to your skin. As someone who [2:35] has been following skin care products, [2:38] skin care trends, reviewing and testing [2:40] all sorts of things out for the past 10 [2:43] years here on YouTube, I can tell you I [2:45] have seen repeatedly in skin care [2:47] marketing where they'll take an [2:49] ingredient with some interesting [2:50] research behind it in laboratory-based [2:52] studies. Then they make the leap to [2:54] putting that into a cream or serum or [2:57] toner, some sort of skin care product, [2:59] and just assuming or acting like it's [3:02] going to reproduce the same exact things [3:04] that was occurring in that isolated cell [3:07] or animal model. This is where I think [3:09] PDRN especially starts to essentially [3:11] become a gimmick in skin care products. [3:14] The research around PDRN is interesting, [3:16] but we need to ask a specific question. [3:18] What evidence do we have that putting [3:20] PDRN in an eye cream and applying it [3:23] around the eyes leads to some sort of [3:25] clinically meaningful outcome? That's an [3:27] entirely different question than is [3:28] there any research backing up PDRN? [3:31] Because it's really important to [3:32] distinguish evidence that perhaps [3:34] suggests or even fully supports an [3:37] ingredient for a specific medical [3:39] application versus a cosmetic [3:41] indication. Your skin is an incredibly [3:44] effective barrier. That's like one of [3:45] its main jobs. DNA fragments aren't [3:48] something that it notoriously accepts [3:50] with open arms. So, simply putting them [3:53] on the skin doesn't mean a whole lot is [3:55] going to happen. It doesn't mean that [3:57] they're going to penetrate and access [3:59] the cellular compartments needed to [4:02] activate those specific pathways. Not to [4:05] mention, let's say for a second, yeah, [4:07] it does penetrate and access those [4:09] pathways. What's to control it and stop [4:11] it from what we call off-target effects, [4:13] meaning binding to some other cells, [4:16] like maybe pre-cancer cells, and [4:18] stimulating those to go into [4:20] proliferation overdrive. When I say this [4:22] type of thing, I think it scares a lot [4:23] of people, but remember, it's like how [4:26] likely is it that these are even doing [4:28] anything to begin with? Very, very, [4:30] very, very low. So, I wouldn't fear if [4:32] you've been using something with PDRN [4:34] that you're going to cause a cancer. [4:36] But, it also kind of suggests that these [4:38] things, they're probably not really [4:40] working, at least like they should be or [4:43] to the extent that we're seeing in [4:45] laboratory studies. Because if they [4:47] were, if they were actually getting in, [4:49] how is it a specific outcome? How is it [4:51] a targeted outcome? Because with the [4:53] skin, there are different cell [4:55] compartments, there different processes [4:56] going on. It's not an isolated single [4:58] cell type. It's this whole 3D structure. [5:01] I point that out because if you are [5:03] buying a product like this or some other [5:05] skin care product because you think the [5:07] PDRN is going to make a meaningful [5:09] difference, whether it be for anti-aging [5:11] or some other cosmetic skin concern, [5:14] like skin tone, smoothness, suppleness, [5:17] I would hold off on that. In other [5:19] words, to me, PDRN in skin care is a [5:21] gimmick. At least at this point, and I [5:23] really don't see that changing in the [5:25] future. This will just continue to be [5:27] everywhere, and then eventually people [5:29] will get bored and want something else. [5:30] I've seen this with growth factors, [5:32] peptides, stem cells. But, let's talk [5:34] about another feature of this particular [5:36] eye cream, and that is caffeine. [5:38] Caffeine is fairly common in products, [5:40] especially eye creams. There are a few [5:41] reasons why. Caffeine can have [5:43] vasoconstrictive properties. Basically, [5:45] that means that it can cause blood [5:46] vessels to temporarily narrow. And [5:48] because some of the discoloration and [5:50] dark appearance that we often are [5:51] bothered by under our eyes, might in [5:53] some cases be related to the collection [5:56] of prominent blood vessels there that [5:58] are more obvious under the delicate thin [6:00] skin, that vasoconstrictive effect may [6:03] temporarily brighten up the under eye [6:05] area and improve upon the appearance of [6:07] those. There's also some evidence that [6:09] the vasoconstrictive action, [6:10] particularly around the eye, may also [6:13] shift unwanted fluid accumulations away [6:15] and reduce puffiness. Caffeine is also [6:18] an antioxidant, and it may have some [6:19] anti-inflammatory properties. But I want [6:21] to emphasize potential when it comes to [6:23] improving the look of dark under eye [6:25] circles because, as I pointed out in my [6:27] videos on why you have dark circles, [6:29] there are a lot of different causes [6:31] behind having dark circles, many many of [6:34] which will not be touched, modified, [6:36] improved upon by an eye cream. As [6:39] they're often caused by age-related bone [6:40] resorption and widening of the eye [6:42] socket, coupled with redistribution and [6:44] shrinkage of fat compartments that [6:46] ultimately leads to prominent hollowing [6:48] coupled with the thinning under the [6:50] eyes. I mean, these kind of structural [6:52] changes that happen anatomically as it [6:54] relates to aging, they're just not going [6:56] to be improved upon by a cream. It's [6:58] going to be a procedural-based [7:00] interventions to truly change the [7:02] appearance of those things. Those [7:03] structural changes also can be a [7:05] contributing factor to puffiness, under [7:08] eye bags as well. But I do think [7:10] caffeine is a reasonable ingredient to [7:12] pursue in skin care given its role at [7:14] the very least as an antioxidant. I [7:16] happen to have appreciated over the [7:18] years in trying out many skin care [7:20] products a little bit of a perk with [7:21] caffeine and overall improvement in skin [7:23] tone, clarity. And so, I don't [7:26] necessarily think it is a gimmick. When [7:28] I look at the rest of the ingredients on [7:29] the formula and actually use the [7:30] product, it's actually a really good [7:32] moisturizer. Ingredients like glycerin, [7:34] hydroxyethylurea, [7:36] sodium hyaluronate, which is salt of [7:38] hyaluronic acid, these are all [7:39] hydrating. And when you optimize water [7:42] content in the skin, you will get an [7:44] improvement in the appearance of the [7:45] skin around the eyes. It'll look a [7:46] little brighter due to light scattering. [7:48] Little fine wrinkles will appear less [7:50] obvious simply due to space filling and [7:52] hydration. I'm a big advocate of [7:55] consistent moisturizing, especially with [7:57] age as our skin becomes less inclined to [7:59] retain water there. Guess what [8:00] ingredient this has? I bet you'll never [8:03] ever guess. The workhorse of the skin [8:05] care industry, niacinamide. I say that [8:08] because I swear this ingredient does 99% [8:11] of the heavy lifting of the entire [8:12] industry. It's in pretty much anything [8:15] and anytime someone claims that a [8:16] product completely transformed the game [8:18] for them, a lot of times it's likely due [8:21] to niacinamide. Not everyone tolerates [8:23] it though. Some people find it [8:24] irritating. Some people find that it [8:26] makes their face red or burns or stings. [8:28] But if you tolerate it, it actually [8:30] offers multiple evidence-based benefits. [8:33] It's helpful for redness, dark spots. [8:35] There's a good mechanism by which it's [8:36] helpful for dark spots and that it helps [8:38] to inhibit the transfer of melanin [8:40] pigments from the melanocyte to the [8:42] surrounding skin cells, the [8:44] keratinocytes. It's also an antioxidant, [8:46] an anti-inflammatory. So coupled with [8:48] the caffeine, you've got two [8:49] antioxidants now here for, well, the [8:52] price of $20 in an eye cream. [8:54] Niacinamide also helps your skin be a [8:57] better barrier. It helps with the [8:59] moisture barrier long-term and so it's a [9:02] fantastic ingredient for a variety of [9:04] reasons and therefore if you tolerate [9:07] it, a lot of things that people are [9:09] looking for they get from niacinamide [9:11] basically. This also has adenosine, [9:13] which is hydrating and [9:14] anti-inflammatory. It has hydrolyzed [9:16] collagen, which hydrolyzed collagen is [9:18] by no means going to get in and replace [9:20] the lost collagen in your skin that of [9:23] course contributes to wrinkles, thinning [9:24] under the eye and yeah, more prominent [9:26] under eye hollows. However, hydrolyzed [9:28] collagen in skin care products is [9:30] definitely not a gimmick. It's very [9:31] hydrating, it's very moisturizing and it [9:33] also has this film forming property to [9:35] it that allows, well, for the stuff to [9:37] lie down on your skin. So, they're [9:39] antioxidants, they're good humectants in [9:41] this, there's niacinamide which I love, [9:43] and there's no fragrance which I happen [9:45] to think is key when you're using an eye [9:47] cream, even if you're not allergic to [9:49] fragrance. Eyelid skin is very delicate, [9:51] ingredients penetrate a lot more [9:53] readily. Fragrance allergy is the most [9:55] common allergen in skin care. So, if you [9:58] are going to at some point develop an [10:00] allergy to an ingredient, fragrance is [10:03] at the top of the list. And so, avoiding [10:05] it in the eyelid area, I think it's [10:06] great. That being said, many people use [10:09] it there with no problem, and they use [10:10] it that way indefinitely. I'm just [10:12] saying, I think if I were designing an [10:13] eye cream, without a doubt, I would not [10:15] put fragrance in it. Plus, it's a lot [10:17] more likely to cause watery eyes, and [10:20] sometimes they put fragrance though in [10:22] eye creams and skin care products [10:23] because one of the other ingredients in [10:25] the raw materials has a funky odor that [10:27] consumers would not like. One thing I [10:29] want to point out for those of you who [10:31] get down with eye creams, okay? If [10:33] you're like, I don't really care if [10:34] they're worth it or not. I need an eye [10:36] cream, I like them, I use [10:37] [clears throat] them, I I don't want to [10:38] hear a lecture about how they're not [10:39] really worth Okay, I got to tell you [10:41] something though. Um, how much are you [10:42] actually using? Because here's what I [10:44] have observed in watching other people, [10:46] um, their content and advertisements and [10:49] things of that sort. I'm noticing a [10:50] trend over the years of people showing [10:53] application of products more and more [10:56] generously as far as the volumes that [10:58] they're using. And as much as people [11:00] would like to say, "Oh, they're just [11:01] being over the top and crazy." I mean, [11:03] these are visual platforms that rely on [11:06] being eye-catching. I totally understand [11:08] it. If you use a small amount of a [11:10] product, no one's going to be able to [11:11] see it. Using large volumes does convey [11:14] to the audience more about the product's [11:16] texture and what it looks like. So, [11:18] there's actually reason for creators to [11:21] show large volumes of product on their [11:24] fingers, on their skin, to really give [11:26] the audience a good sense of what that [11:28] product is actually going to look like [11:29] and the texture. That being said, the [11:31] more of the eye cream that you are [11:32] using, the faster you're going to go [11:34] through it, the more you're going to [11:35] have to repurchase it, the more stuff [11:36] you're going to buy. And so, that is [11:38] definitely something to factor in when [11:40] you see that. So, how much do you [11:41] actually need? I'm going to show you [11:43] here. First, you're going to see this is [11:44] what I've been noticing as far as how [11:45] people apply eye creams. You see I'm [11:47] putting a couple of dots under the eye [11:49] and it really isn't look like a ton, but [11:51] do you need that much? That's what I'm [11:52] seeing people use. Truthfully, that much [11:54] is a lot, but it's not so much that it's [11:58] like you notice I'm putting on way too [12:00] much. However, watch how I put it on and [12:02] how much you actually need. See how it's [12:04] just maybe, I don't know, a rice grain? [12:07] It's even hard to get it the smallest [12:08] amount out possible, frankly. Ideally, [12:11] it's a rice grain, but a little bit [12:12] more, of course, isn't going to hurt [12:13] you. The main point I'm trying to make [12:15] here is that this product, you really [12:17] don't need very much to get a nice, even [12:20] coating of both the under eye and the [12:22] upper eyelid in total. I mean, all the [12:24] way around, out here by the crow's feet. [12:26] You really do not need a very much [12:28] product. Certainly not as much product [12:30] as is often being shown in many of the [12:33] videos that, you know, you'll come [12:34] across reviewing eye creams. I think [12:36] this product should last you a very long [12:38] time if you take the conservative [12:40] approach and you'll get exactly what you [12:42] need. Those of you who are eye cream [12:44] fans, I mean, stuff is getting [12:46] expensive. Like, do yourself a favor and [12:48] and dial back on the volume. You don't [12:50] need a big glob. The other reason to shy [12:52] away from excessive quantities is that [12:54] it is more likely, if you're using a big [12:57] thick film on the skin, that with sweat, [13:00] humidity, perspiration, that it [13:02] eventually kind of runs into your eye [13:03] and you get burning, stinging eyes, and [13:05] that's not good. We don't want products [13:07] going in our eyes. Now, I mentioned this [13:09] is $20. That is kind of expensive for [13:12] the small tube, but if you go online and [13:14] you search out eye creams, that's kind [13:16] of the going rate. Actually, it's on the [13:18] lower end for many eye creams. Some of [13:20] them can be really out outrageously [13:22] priced. And as I said, if you're using [13:23] that rice grain amount, it really [13:25] shouldn't take you that long. But here's [13:28] the Here's the question. Do you actually [13:30] need an eye cream? And this is an area [13:32] where people like to fight, okay? So, [13:34] let's all realize that not everyone [13:37] is going to need an eye cream, but some [13:39] people enjoy them, and we should just [13:40] let people live and let live, you know? [13:42] When it comes down to the question, do [13:44] you really need an eye cream? I think [13:45] there's definitely a time and a place [13:47] for certain eye creams. Remember, eyelid [13:49] skin is very delicate, and therefore [13:52] ingredients penetrate a lot more [13:53] readily. Some ingredients that could [13:55] lend themselves to a variety of benefits [13:57] around the eyes may need to be a little [13:59] a little light-handed on the strength [14:01] because you may be more likely to get [14:03] irritation as opposed to at other facial [14:06] sites where maybe you need a higher [14:07] concentration or a more potent [14:09] formulation, if you will, in order to [14:11] get that ingredient to an appreciable [14:13] amount. So, for example, retinol or [14:15] retinaldehyde, these are ingredients [14:17] that in eye creams, I think, make sense [14:19] because they can be irritating at [14:21] baseline. So, eye creams kind of factor [14:23] that in and modify accordingly to make a [14:26] product that is better tolerated, [14:28] perhaps, for eyelid skin. Also, another [14:30] one is going to be ascorbic acid, aka [14:33] vitamin C. Many vitamin C serums I find [14:36] to be incredibly irritating, but in an [14:38] eye cream, it makes sense that you may [14:39] not need to have as high a percentage, [14:41] perhaps. Caffeine is an ingredient that [14:44] benefits the eye area specifically. It's [14:46] an ingredient that they don't often put [14:48] in facial moisturizers, so I guess I [14:50] could see this eye cream from that [14:52] perspective if you're interested in [14:54] incorporating caffeine. But at the end [14:55] of the day, the main value of this [14:58] product is as an eyelid moisturizer. [15:00] Moisturizing the eyelids is just as [15:02] important as moisturizing your face. You [15:04] don't need a special moisturizer in a [15:06] small tube to do that. The moisturizer [15:09] you use on your face, you can use around [15:11] the eyes. There isn't some special law [15:14] of biology that says the delicate eyelid [15:17] skin requires moisturizer to come in a [15:19] small tube at a much higher price per [15:22] unit value. Using a heavier eye cream [15:25] also does not cause milia. That is an [15:28] urban legend. Um check out my videos on [15:31] the true causes of milia and why eye [15:33] creams don't cause them for a full [15:34] discussion on that. I actually do really [15:36] like this product. I think it's an [15:38] excellent moisturizer. I really have [15:40] enjoyed using it around my eyes. Didn't [15:42] cause any irritation for me. Of course, [15:44] that's an individualized outcome. It [15:46] could be totally different for you. But [15:47] I would not go buying this because the [15:50] PDRN is going to change the game. That's [15:52] kind of the main point. PDRN is a [15:53] gimmick. PDRN in this is not going to do [15:55] anything. This is a moisturizer. The [15:57] moisturizer you use on your face would [16:00] accomplish the same exact thing most [16:01] likely. Um but they did a good job [16:03] formulating it and it's a nice product. [16:05] Good job Anewa on the eye cream. [16:07] Overall, I I think it's a good eye [16:09] >> [clears throat] [16:09] >> moisturizer with niacinamide and [16:11] caffeine. You know, it's pretty good. [16:14] It's just the PDRN stuff is overhyped [16:16] and a gimmick. But here's one thing I [16:17] want to communicate to you guys when it [16:19] comes to skin care brands, once you're [16:21] in the game and you have a brand, you [16:23] got to play the game. You [16:24] You have to play the game. I always get [16:26] questions, when are you going to come [16:27] out with a skin care brand? If I did, [16:29] which I have no desire to, I'd have to [16:31] start playing the game, okay? I'd have [16:32] to start playing the game and you guys [16:34] would get so annoyed with me as I had to [16:36] play the game. I mean, but in order to [16:38] have a skin care brand, you got to get [16:40] the pieces lined up. You can't just do [16:42] your own thing per se because you got to [16:45] You got to create products that sell and [16:46] you you got to compete and you got to [16:48] compete with other people and all do [16:50] people I mean, it's a game. It's a game. [16:52] No one No one has a skin care brand for [16:54] philanthropic reasons. No one creates a [16:56] skin care brand because they're there to [16:58] save lives or or to fulfill a need. [17:00] Honestly, I mean, a lot of them will get [17:02] on and tell you that, you know, they [17:03] created their brand because of this [17:05] perceived need, but that's marketing, [17:07] okay? There may be some truth to that, [17:08] but at the end of the day, um people [17:10] have a brand because they want to make [17:12] money. It doesn't matter what their [17:13] background is, expertise. People create [17:16] skin care brands because skin care [17:17] brands if they're successful they earn [17:19] the the brand owner a good livelihood. [17:22] Anua has a retinol eye cream which I [17:23] reviewed a couple of weeks ago at this [17:25] point. So if you're interested in that [17:27] because you've heard about the benefits [17:28] of retinol for like crow's feet and [17:30] things of that sort check that video [17:31] out. I love Anua they have fantastic [17:34] skin care products. They also have these [17:36] newer moisturizers which I have been [17:38] trying out behind the scenes. Let me [17:41] know if you want to hear about those. [17:42] They also have a retinol neck cream that [17:45] I reviewed with this jazzy gua sha thing [17:47] on it. Check that video out. I mean I've [17:49] reviewed a lot of Anua because I really [17:51] like the brand but I hope you guys [17:52] enjoyed today's video. Let me know down [17:54] in the comments if PDRN is something [17:56] that you personally are like I don't [17:58] care what she says. I love it. It has [18:00] been a game changer for me and I I I [18:02] want all of the salmon sperm on my face [18:04] possible. Let us know, okay? I'm just [18:06] sharing with you guys the information [18:08] that I can but you know this is skin [18:10] care is fun for people too and as long [18:12] as you're not getting irritated from it [18:14] don't feel as though I'm like coming at [18:16] you because you're using a non evidence [18:18] based ingredient, okay? Not only are you [18:20] not going to get a Nobel Prize but [18:22] you're also, you know, not going to get [18:24] your own NH funded lab, okay? Because [18:26] you've been using PDRN and and Dr. Dray [18:29] says that's a gimmick, all right? No one [18:30] gets an award for using the most [18:32] evidence based skin care routine, okay? [18:34] You want to follow an ingredient that [18:36] might be a little fluffy and you think [18:38] it's helping by all means as long as [18:39] it's not causing you problems. But I got [18:41] to lay it out here. I hope you guys [18:43] enjoyed today's video. If so, give it a [18:44] thumbs up, share it with your friends [18:46] and as always don't forget sunscreen and [18:48] subscribe. I'll talk to you guys [18:49] tomorrow. Bye. [18:55] >> [music] [19:03] [music]